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Genetically modified pigs: Emerging animal models for hereditary hearing loss

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Highly selective photocatalytic reduction of CO_(2) to CH_(4) on electron-rich Fe species cocatalyst under visible light irradiation

Zoological Research 2024年第2期 284页

作者： Xiao Wang Tian-Xia Liu Ying Zhang Liang-Wei Xu shuo-long yuan A-long Cui Wei-Wei Guo Yan-Fang Wang Shi-Ming Yang Jian-Guo Zhao

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Carbon Energy 2024年第1期6卷 255-266页

作者： Qianying Lin Jiwu Zhao Pu Zhang shuo Wang Ying Wang Zizhong Zhang Na Wen Zhengxin Ding Rusheng yuan Xuxu Wang Jinlin long State Key Laboratory of Photocatalysis on Energy and Environment College of ChemistryFuzhou UniversityFuzhouChina

Efficient photocatalytic reduction of CO_(2) to high-calorific-value CH4,an ideal target product,is a blueprint for C_(1)industry relevance and carbon neutrality,but it also faces great ***,we demonstrate unprecedented hybrid SiC photocatalysts modified by Fe-based cocatalyst,which are prepared via a facile impregnation-reduction method,featuring an optimized local electronic *** exhibits a superior photocatalytic carbon-based products yield of 30.0μmol g^(−1) h^(−1) and achieves a record CH_(4) selectivity of up to 94.3%,which highlights the effectiveness of electron-rich Fe cocatalyst for boosting photocatalytic performance and ***,the synergistic effects of directional migration of photogenerated electrons and strongπ-back bonding on low-valence Fe effectively strengthen the adsorption and activation of reactants and intermediates in the CO_(2)→CH_(4) *** study inspires an effective strategy for enhancing the multielectron reduction capacity of semiconductor photocatalysts with low-cost Fe instead of noble metals as cocatalysts.

关键词： artificial synthesis of CH_(4) electronic structure optimization Fe species cocatalyst photocatalytic CO_(2) reduction SiC

Lipid metabolism, amino acid metabolism, and prostate cancer: a crucial metabolic journey

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Asian Journal of Andrology 2024年第2期26卷 123-134页

作者： Lin Chen Yu-Xin Xu yuan-shuo Wang Jian-Liang Zhou School of Pharmacy Hangzhou Normal UniversityHangzhou 311121China Key Laboratory of Elemene Class Anti-Cancer Chinese Medicines Collaborative Innovation Center of Traditional Chinese Medicines of Zhejiang Province Hangzhou Normal UniversityHangzhou 311121China School of Pharmacy Guangxi Medical UniversityNanning530021China

Prostate cancer(PCa)is one of the most common malignancies in males worldwide,and its development and progression involve the regulation of multiple metabolic *** in lipid metabolism affect the proliferation and metastatic capabilities of PCa *** cells increase lipid synthesis and regulate fatty acid oxidation to meet their growth and energy ***,changes occur in amino acid metabolism in *** cells exhibit an increased demand for specific amino acids,and they regulate amino acid transport and metabolic pathways to fulfill their proliferation and survival *** changes are closely associated with disease progression and treatment response in PCa ***,a comprehensive investigation of the metabolic characteristics of PCa is expected to offer novel insights and approaches for the early diagnosis and treatment of this disease.

关键词： amino acid metabolism lipid metabolism metabolic pathways prostate cancer treatment strategies

Single-atom Ag-loaded carbon nitride photocatalysts for efficient degradation of acetaminophen:The role of Ag-atom and O_(2)

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Journal of Environmental Sciences 2024年第5期139卷 12-22页

作者： Yi yuan Wen-long Wang Zhi-Wei Wang Jin Wang Qian-yuan Wu Key Laboratory of Microorganism Application and Risk Control of Shenzhen Guangdong Provincial Engineering Research Center for Urban Water Recycling and Environmental SafetyInstitute of Environment and EcologyShenzhen International Graduate SchoolTsinghua UniversityShenzhen 518055China Shenzhen Environmental Science and New Energy Technology Engineering Laboratory Tsinghua-Berkeley Shenzhen InstituteShenzhen 518055China College of Materials Science and Engineering Shenzhen UniversityShenzhen 518071China

Carbon nitride has been extensively used as a visible-light photocatalyst,but it has the disadvantages of a low specific surface area,rapid electron-hole recombination,and relatively low light *** this study,single-atom Ag was successfully anchored on ultrathin carbon nitride(UTCN)via thermal polymerization,the catalyst obtained is called *** Ag hardly changed the carbon nitride's layered and porous physical *** exhibited efficient visible-light photocatalytic performances in the degradation of various recalcitrant pollutants,eliminations of 85% were achieved by visible-light irradiation for *** with Ag improved the photocatalytic performance of UTCN by narrowing the forbidden band gap from 2.49 to 2.36 e V and suppressing electron-hole pair *** addition,Ag doping facilitated O_(2) adsorption on UTCN by decreasing the adsorption energy from -0.2 to -2.22 e V and favored the formation of O_(2)^(·-).Electron spin resonance and radical-quenching experiments showed that O_(2)^(·-)was the major reactive species in the degradation of Acetaminophen(paracetamol,APAP).

关键词： Ag single atom Carbon nitride Photocatalysis Visible light Adsorption energy Reactive species

Uptrend of the Western North Pacific Tropical Cyclone Outflow Height during 1959-2021

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Journal of Meteorological Research 2024年第2期38卷 339-350页

作者： yuan SUN Zhihao FENG Wei ZHONG Panmao ZHAI Yanluan LIN shuo LYU College of Advanced Interdisciplinary Studies National University of Defense TechnologyNanjing 211100 College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073 State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesChina Meteorological AdministrationBeijing 100081 Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084

Relatively little is known about the impact of global warming on the tropical cyclone(TC)outflow,despite its large contribution to TC *** this study,based on the International Best Track Archive for Climate Stewardship(IBTrACS)dataset and ERA5 reanalysis data,we show that the TC outflow height has risen significantly(48.20±22.18 m decades-1)in the past decades(1959-2021)over the western North Pacific,and the rising trend tends to be sharper for stronger TCs(the uptrend of severe typhoon is 61.09±40.92 m decades-1).This rising trend of the outflow height explains the contradiction between the decrease trend of the TC outflow temperature and the increase trend of the atmospheric troposphere ***,possible contribution of the TC outflow height uptrend to TC intensity has also been *** results show that the rise of outflow height leads to the decrease of outflow temperature,and thus an increased difference between underlying sea surface temperature(SST)and TC outflow temperature,which eventually favors the increase of TC intensity.

关键词： tropical cyclone outflow height global warming western North Pacific

An Active Deception Defense Model Based on Address Mutation and Fingerprint Camouflage

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China Communications 2024年第7期21卷 212-223页

作者： Wang shuo Chu Jiang Pei Qingqi Shao Feng yuan Shuai Zhong Xiaoge State Key Laboratory of Astronautic Dynamics Xi’an Satellite Control CenterXi’an 710043China State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an 710071China Shaanxi Key Laboratory of Blockchain and Secure Computing Xidian UniversityXi’an 710071China

The static and predictable characteristics of cyber systems give attackers an asymmetric advantage in gathering useful information and launching *** reverse this asymmetric advantage,a new defense idea,called Moving Target Defense(MTD),has been proposed to provide additional selectable measures to complement traditional ***,MTD is unable to defeat the sophisticated attacker with fingerprint tracking *** overcome this limitation,we go one step beyond and show that the combination of MTD and Deception-based Cyber Defense(DCD)can achieve higher performance than either of *** particular,we first introduce and formalize a novel attacker model named Scan and Foothold Attack(SFA)based on cyber kill ***,we develop probabilistic models for SFA defenses to provide a deeper analysis of the theoretical effect under different defense *** models quantify attack success probability and the probability that the attacker will be deceived under various conditions,such as the size of address space,and the number of hosts,attack analysis ***,the experimental results show that the actual defense effect of each strategy almost perfectly follows its probabilistic ***,the defense strategy of combining address mutation and fingerprint camouflage can achieve a better defense effect than the single address mutation.

关键词： address mutation deception defense fingerprint camouflage moving target defense probabilistic model

Two thin middle-crust low-velocity zones imaged in the Chuan-Dian region of southeastern Tibetan Plateau and their tectonic implications

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Science China Earth Sciences 2024年第5期67卷 1675-1686页

作者： long LI Xin WANG Guangbing HOU yuan LING Yinshuang AI Key Laboratory of Earth and Planetary Physics Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijing 100049China Innovation Academy for Earth Science Chinese Academy of SciencesBeijing 100029China

Intracrustal low-velocity zones(LVZs)indicate a mechanically weak crust and are widely observed in the southeast margin of the Tibetan ***,their spatial distributions and formation mechanisms remain *** investigate their distribution and detailed morphology of the LVZs in the southeastern Tibetan Plateau,here we used teleseismic events and continuous waveform data recorded by 40 broadband seismic stations newly deployed in the Sichuan-Yunnan region from December 2018 to October 2020.A total of 12,924 high-quality P-wave receiver functions and 5–40 s fundamental Rayleigh surface wave phase velocity dispersion curves from ambient noise cross-correlation functions were *** Swave velocity model at a depth interval of 0–100 km in the study area was inverted by using the trans-dimensional Markov chain Monte Carlo strategy to jointly invert the complementary data of the receiver function waveform and Rayleigh surface wave phase velocity *** results show that there are two separate LVZs(~3.5 km/s)surrounding the rigid Daliangshan subblock at crustal depths of approximately 30–40 km,providing new constraints on the geometry of the LVZs in our study *** two LVZs obtained in this study may represent the middle crustal flow channels,through which the material in the center of the Tibetan Plateau extrudes to its southeast *** by the rigid Sichuan Basin and the spindle-like Daliangshan subblock,the material continues to flow southward through the mechanically weak middle crustal channels surrounding the Daliangshan *** addition,the existence of thin LVZs in the middle crust plays an important role in understanding the decoupling between the upper and lower crust in the study *** also provides new constraint on the complex tectonic deformation process of the southeastern margin of the Tibetan Plateau caused by the collision and compression of the Indian and the Eurasian plates.

关键词： Southeastern Tibetan Plateau Joint inversion Intracrustal low-velocity zone Mid-crustal channel flow

Evolutionary Decision-Making and Planning for Autonomous Driving Based on Safe and Rational Exploration and Exploitation

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Engineering 2024年第2期33卷 108-120页

作者： Kang yuan Yanjun Huang shuo Yang Zewei Zhou Yulei Wang Dongpu Cao Hong Chen College of Electronic and Information Engineering Tongji UniversityShanghai 201804China Shanghai Institute of Intelligent Science and Technology Tongji UniversityShanghai 201210China School of Automotive Studies Tongji UniversityShanghai 201804China School of Vehicle and Mobility Tsinghua UniversityBeijing 100084China

Decision-making and motion planning are extremely important in autonomous driving to ensure safe driving in a real-world *** study proposes an online evolutionary decision-making and motion planning framework for autonomous driving based on a hybrid data-and model-driven ***,a data-driven decision-making module based on deep reinforcement learning(DRL)is developed to pursue a rational driving performance as much as ***,model predictive control(MPC)is employed to execute both longitudinal and lateral motion planning *** constraints are defined according to the vehicle’s physical limit to meet the driving task ***,two principles of safety and rationality for the self-evolution of autonomous driving are proposed.A motion envelope is established and embedded into a rational exploration and exploitation scheme,which filters out unreasonable experiences by masking unsafe actions so as to collect high-quality training data for the DRL *** with a high-fidelity vehicle model and MATLAB/Simulink co-simulation environment are conducted,and the results show that the proposed online-evolution framework is able to generate safer,more rational,and more efficient driving action in a real-world environment.

关键词： Autonomous driving Decision-making Motion planning Deep reinforcement learning Model predictive control

pH Induced Self-assembly of AIE Fluorescent Probe for Tumor Imaging

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Chinese Journal of Polymer Science 2024年第1期42卷 7-13,I0005页

作者： Jing-yuan Xiang Wen-long Zhang He-Ting Li Ya-Ning He Department of Chemical Engineering Key Laboratory of Advanced Materials(MOE)Tsinghua UniversityBejing 100084China

This work reported an AIE fluorescent probe for tumor imaging based on the p H induced self-assembly strategy. The fluorescent probe was composed of an acid-responsive soluble copolymer PEG-b-PAMA-DMMA with a maleic acid amide group and an anionic soluble aggregation-induced emission fluorogen(AIEgen) TPE-2SO_(3)^(-). The polymer could be transformed into a protonated amine-containing polymer after the hydrolysis of maleic acid amide in acidic tumor microenvironment, which would be further self-assembled with TPE-2SO_(3)^(-)to form aggregated nanoparticles. The transition of TPE-2SO_(3)^(-)from dispersed state to aggregated state led to an obvious increase in fluorescence intensity due to its AIE characteristics.

关键词： p H-responsive Self-assembly Fluorescent probe AIE Tumor imaging