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STEROID-BISPORPHYRIN. A NOVEL PORPHYRIN DIMER AS ENZYME MODEL

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Chinese Chemical Letters 1992年第10期3卷 801-804页

作者： Shu hua chen Shang Jun LI Department of Chemistry.Sichuan University.chengdu 610064

In the present communcation a novel steroid-bisporphyrin model compound has been synthesized. The configuration of which is also presented.

关键词： A NOVEL PORPHYRIN DIMER AS ENZYME MODEL STEROID-BISPORPHYRIN AS ppm chen

The role of collateral related donors in haploidentical hematopoietic stem cell transplantation

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Science Bulletin 2018年第20期63卷 1376-1382页

作者： Xiao-Dong Mo Yuan-Yuan Zhang Xiao-Hui Zhang Lan-Ping Xu Yu Wang chen-hua Yan huan chen Yu-Hong chen Ying-Jun Chang Kai-Yan Liu Xiao-Jun huang Peking University People's Hospital Peking University Institute of hematologyBeijing 100044China Peking-Tsinghua Center for Life Sciences Beijing 100871China Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Beijing 100044China

A key issue in the haploiedntical hematopoietic stem cell transplantation(haplo-HSCT) setting is the search for the best donor, because donor selection can significantly impact the clinical outcomes. We aimed to identify the role of collateral related donors(CRDs) in donor selection for haplo-HSCT through comparing the clinical outcomes between CRDs(n = 60) and maternal donors(MDs, n = 296), which were the last choice of donor selection in immediate related donors(IRDs). The cumulative incidence of graft-versus-host disease was comparable between CRDs and MDs. The 5-year cumulative incidence of relapse and non-relapse mortality was 22.0%(95% CI, 11.3%–32.7%) versus 17.4%(95% CI, 13.0%–21.8%)(P = 0.455) and 25.0%(95% CI, 13.9%–36.1%) versus 23.1%(95% CI, 18.2%–28.0%)(P = 0.721) for the CRDs and MDs, respectively. The 5-year probabilities of disease-free survival and overall survival was 53.2%(95% CI, 40.4%–66.0%) versus 59.5%(95% CI, 53.8%–65.2%)(P = 0.406) and 56.5%(95% CI,43.8%–69.2%) versus 61.8%(95% CI, 56.1%–67.5%)(P = 0.458) for the CRDs and MDs, *** donor/male recipient(FDMR) CRDs were associated with the poorest clinical outcomes, and the clinical outcomes of non-FDMR CRDs were comparable to those of MDs. In summary, our results showed that CRDs did not showed superiority over MDs. Thus, IRDs should be the first choice of donor selection, and CRDs could only be the donors for those without IRDs.

关键词： Haploidentical Hematopoietic stem cell transplantation Collateral related donors Paternal donors Maternal donors

Comprehensive benefits assessment of the ecological management model in Hobq Desert of China

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Research in Cold and Arid Regions 2018年第3期10卷 251-260页

作者： Rui Wang Li hua Zhou Yong chen College of Land and Resources China West Normal University Institutes of Science and Development Chinese Academy of Sciences Key Laboratory of Desert and Desertification Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences

The Hobq Desert is the seventh largest desert in China. Since 1988, the effects of ecological management in Hobq Desert have been obvious and a typical desertification control model developed gradually, which is well known as the ＂Hobq model＂. It is important to evaluate the comprehensive benefits of the ＂Hobq model＂, but this has not been addressed in previous studies. Thus, we established an index system to comprehensively evaluate the benefits of the ＂Hobq model＂, using an analytic hierarchy process method from 1988 to 2013. The results show the following： ecological benefits of the ＂Hobq model＂ had a positive trend, but with fluctuations during 2008 and 2009; economic benefits increased by 74% and the maximum value occurred in 2013; and social benefits increased steadily, but with fluctuations in 2010 and 2011. The social benefits were higher than ecological and economic benefits in the same period. Trends in overall benefits of the ＂Hobq model＂ were similar to changes in ecological benefits, which increased each year.

关键词： benefit assessment comprehensive benefit ecological management Hobq model

Niobium and phosphorus behavior during melting-separation process of pre-reduced niobium ore concentrate

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Journal of Iron and Steel Research International 2017年第7期24卷 691-696页

作者： Yu-bao Liu Zhi-hong Zhang Er-xiong Zhao Xian-heng Zhang Xiao-qing Wang Guo-hua chen Inner Mongolia Niobium Metallurgical Engineering Laboratory Baotou Research Institute of Rare Earths State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization

The pre-reduced Bayan Obo ferroniobium（FeNb）ore concentrate block was taken as raw materials for studying the physical properties of niobium-enriched slag and changes in niobium recovery *** addition,the dephosphorization rate of the slag under different melting-separation conditions was investigated using the melting-separation *** research results demonstrate that（i）the niobium recovery rate and dephosphorization rate of the slag decrease with the increase in melting-separation temperature;（ii）the niobium recovery rate of the slag initially increases and then decreases with increase in basicity and time;and（iii）the dephosphorization rate of the slag increases with the increase in basicity and *** the test was performed under the conditions of basicity of 0.6-0.7,time of 7-10min,and temperature of 1400-1450°C,the niobium recovery rate and dephosphorization rate are over 96%and 95%,*** scanning electron microscopy,it is observed that niobium mainly exists in the form of calcium and titanium silicate within the slag phase,with uneven distribution.

关键词： Melting separation Pre-reduced niobium ore concentrate Niobium-enriched slag Iron Dephosphorization rate Niobium recovery rate

Exploration on the Enhancement of Leaders' Capability of Dealing with Public Emergencies

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Exploration on the Enhancement of Leaders' Capability of Dea...

Structural characterization of oligosaccharide from Spirulina platensis and its effect on the faecal microbiota in vitro

2007 International Conference on Public Administration（ICPA 3rd）

作者： WANG Sheng-jun chen hua School of Political Science and Public Administration University of Electronic Science and Technology of China

In the present social environment with great changes,the increasing unpredictable and uncontrollable factors in the process of management of social and public issues have made the new demands and challenges to all ranks of leaders who are the soul and core of *** frequently happened and unexpected public events greatly test the leaders’ ability to cope with *** of tremendous impact brought about by public emergencies,we have to make further research on the issue of "How leaders should respond and deal with public emergencies?" in order to explore effective measures to enhance the leaders’ capability of dealing with public emergencies

关键词： Public emergencies Leaders Capability of dealing with public emergencies Upgrade measures

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Food Science and Human Wellness 2022年第1期11卷 109-118页

作者： Bingna Cai Xiangxi Yi Qian Han Jianyu Pan hua chen Huili Sun Peng Wan Key Laboratory of Tropical Marine Bio-Resources and Ecology Guangdong Key Laboratory of Marine Materia MedicaSouth China Sea Institute of OceanologyChinese Academy of SciencesGuangzhou510301 GuangdongChina Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou) Guangzhou511458 GuangdongChina School of Pharmacy Guangxi University of Chinese MedicineNanning530200 GuangxiChina Innovation Academy of South China Sea Ecology and Environmental Engineering(ISEE) Chinese Academy of SciencesGuangzhou510000 GuangdongChina

In the present study,an oligosaccharide SPO-1 from Spirulina platensis was prepared by glycosidase from a marine *** prebiotic activity of SPO-1 on the growth of Lactobacillus paracasei and Bifidobacterium animalis,and its effect on human gut microbiota were examined in *** molecular weight of the tetrasaccharide SPO-1 was 650.2 Da,and it was mainly composed of glucose with α-type glycosidic *** prebiotic activity score of SPO-1 was the highest for the growth of probiotic strains *** and ***,as fermentation proceeded,SPO-1 was gradually degraded and utilized by intestinal *** results showed that after treatment with SPO-1,carbohydrate consumption and short-chain fatty acids levels were increased,especially those of i-butyric and i-valeric ***,SPO-1 significantly promoted the abundance,diversity and composition of gut microbiota,especially stimulating the growth of Bacteroides,Escherichia-Shigella and *** addition,the change in intestinal microbiota function predicted by phylogenetic investigation of communities by reconstruction of unobserved states(PICRUSt)after treatment with SPO-1 is mainly related to the terms“carbohydrate metabolism”and“amino acid metabolism”.These results suggest that SPO-1 is a potential oligosaccharide in regulation of intestinal microbiota.

关键词： Oligosaccharide Spirulina platensis Gut microbiota In vitro fermentation

改进麻雀搜索算法求解带削峰需求响应的混合流水车间调度问题

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电脑与电信 2024年第6期 16-21页

作者：黄何列黄戈文陈之华姚祖发广东省科技基础条件平台中心广东广州510033 嘉应学院信息网络中心广东梅州514015

电力需求响应是用电高峰时期维护电网供需平衡的重要手段,而削峰是智能电网实现电力需求响应的主要方式。为了使采用混合流水车间生产的企业更好地参与削峰需求响应,优化生产调度,在混合流水车间调度问题中引入了削峰需求响应,建立了新... 详细信息

电力需求响应是用电高峰时期维护电网供需平衡的重要手段,而削峰是智能电网实现电力需求响应的主要方式。为了使采用混合流水车间生产的企业更好地参与削峰需求响应,优化生产调度,在混合流水车间调度问题中引入了削峰需求响应,建立了新的问题模型,并提出了一种改进麻雀搜索算法用于模型求解。针对标准麻雀搜索算法易陷入局部最优的问题,所提算法通过加入K-均值聚类替换策略改进了标准麻雀搜索算法的局部搜索能力。实验结果表明,所提模型和算法能够提供较好的削峰生产调度方案,满足企业实施削峰需求响应调度的需要。

关键词：电力需求响应削峰混合流水车间调度麻雀搜索算法 K-均值聚类

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土木工程专业工程伦理课程建设与教学探索

中国冶金教育 2024年第2期 62-66页

作者：陈静茹田砾宋华张瑾李晓东青岛理工大学土木工程学院山东青岛266033

基于土木工程专业工程伦理课程教学状况分析,确定教学内容、教学资源,改革教学方法和考核方式,构建土木工程特色的工程伦理困境场景,结合综合案例采用启发性教学,提高了教学质量。

关键词：工程伦理专业硕士课程建设案例教学

Absolute ethanol embolization for treatment of peripheral arteriovenous malformations

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Chinese Journal of Plastic and Reconstructive Surgery 2023年第3期5卷 136-140页

作者： Jingwei Zhou chen hua Xi Yang Yuxi chen Yunbo Jin Xiaoxi Lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

Arteriovenous malformations(AVMs)are aggressive congenital high-flow vascular anomalies,in which the feeding artery and draining vein are connected through fistulas without normal capillary *** severe cases,the condition may cause swelling,ulceration,bleeding,and even heart *** treatment options are available for AVMs,including laser,surgical resection,embolization,and targeted drug *** the development of endovascular treatment technology,absolute ethanol embolization of AVMs has become one of the first-line therapies owing to its sustained efficacy and low recurrence ***,administration of this therapy is challenging and may lead to serious complications if inappropriately *** this article,we reviewed and summarized previous clinical articles,literature reviews,and clinical trial data to comprehensively describe clinical manifestations of AVMs,the mechanism of ethanol embolotherapy,key points in treatment and management of complications,and issues that need to be *** expect to provide a reliable information reference source for clinical physicians and researchers.

关键词： Arteriovenous malformation Embolization Ethanol