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Crosstalk between trace elements and T-cell immunity during early-life health in pigs

中国科学:生命科学英文版 2023年第9期66卷 1994-2005页

作者： shunshun jin Liuqin He Chengbo Yang Xinmiao He Heshu Chen Yanzhong Feng Wenjie Tang Jianzhong Li Di Liu Tiejun Li Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation Hunan International Joint Laboratory of Animal Intestinal Ecology and HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Department of Animal Science University of ManitobaWinnipegManitoba R3T2N2Canada CAS Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha 410125China Heilongjiang Academy of Agricultural Sciences Harbin 150086China Animal Breeding and Genetics Key Laboratory of Sichuan Province Sichuan Animal Science AcademyChengdu 610066China

With gradual ban on the use of antibiotics, the deficiency and excessive use of trace elements in intestinal health is gaining attention. In mammals, trace elements are essential for the development of the immune system, specifically T-cell proliferation,and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we summarize the specificity, development, subpopulations, and responses to pathogens of porcine T cells and the effects of functional trace elements(e.g., iron, copper, zinc, and selenium) on intestinal T-cell immunity during early-life health in pigs. Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements as a target to treat various diseases.

关键词： trace elements T cells pig gut immunity

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Glutamate and aspartate alleviate testicular/epididymal oxidative stress by supporting antioxidant enzymes and immune defense systems in boars

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Science China(Life Sciences) 2020年第1期63卷 116-124页

作者： Wenjie Tang Jian Wu shunshun jin Liuqin He Qinlu Lin Feijun Luo Xingguo He Yanzhong Feng Binsheng He Pingping Bing Tiejun Li Yulong Yin Hunan International Joint Laboratory of Animal Intestinal Ecology and Health Laboratory of Animal Nutrition and Human HealthCollege of Life SciencesHunan Normal UniversityChangsha 410081China Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical AgricultureChinese Academy of SciencesHunan Provincial Key Laboratory of Animal Nutritional Physiology and Metabolic ProcessNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionChangsha 410125China National Engineering Laboratory for Deep Process of Rice and Byproducts Hunan Key Laboratory of Grain-oil Deep Process and Quality ControlHunan Key Laboratory of Processed Food for Special Medical PurposeCollege of Food Science and EngineeringCentral South University of Forestry and TechnologyChangsha 410004China Academics Working Station at The First Affiliated Hospital Changsha Medical UniversityChangsha 410219China Sichuan Academy of Animal Sciences Animal Breeding and Genetics Key Laboratory of Sichuan ProvinceChengdu 610066China ^Changsha Green LecrfBiotechnology Co. Ltd.Changsha 610066Hunan Heilongjiang Academy of Agricultural Sciences Harbin 150086China

Several potential oxidative agents have damaging effects on mammalian reproductive *** study was conducted to investigate the effects of glutamate(Glu)and aspartate(Asp)supplementation on antioxidant enzymes and immune defense systems in the outer scrotum of boars injected with H2O2.A total of 24 healthy boars were randomly divided into 4 treatment groups:control(basal diet,saline-treated),H2O2(basal diet,H2O2-challenged outer scrotum(1 m L kg^–1 BW)),Glu(basal diet+2%Glu,H2O2-challenged),and Asp(basal diet+2%Asp,H2O2-challenged).Our results showed that both Glu and Asp supplementation improved testicular morphology and decreased the genital index in the H2O2-treated *** and Asp administration increased the antioxidant enzyme activities and affected the testicular inflammatory cytokine secretion but had no effect on sex hormone ***,the m RNA expression of CAT,Cu Zn SOD,and GPx4 was altered in the testes and epididymis of boars treated with Asp and *** and Asp supplementation also modulated the expression of TGF-β1,IL-10,TNF-α,IL-6 and IL-1βin the testis and *** results indicate that dietary Glu and Asp supplementation might enhance antioxidant capacity and regulate the secretion and expression of inflammatory cytokines to protect the testes and epididymis of boars against oxidative stress.

关键词： glutamate aspartate boars oxidative stress inflammatory cytokines

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Phenotypic Image Recognition of Asparagus Stem Blight Based on Improved YOLOv8

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Computers, Materials & Continua 2024年第9期80卷 4017-4029页

作者： shunshun Ji Jiajun Sun Chao Zhang College of Information Science and Engineering Shandong Agricultural UniversityTai’an271000China

Asparagus stem blight,also known as“asparagus cancer”,is a serious plant disease with a regional *** widespread occurrence of the disease has had a negative impact on the yield and quality of asparagus and has become one of the main problems threatening asparagus *** improve the ability to accurately identify and localize phenotypic lesions of stem blight in asparagus and to enhance the accuracy of the test,a YOLOv8-CBAM detection algorithm for asparagus stem blight based on YOLOv8 was *** algorithm aims to achieve rapid detection of phenotypic images of asparagus stem blight and to provide effective assistance in the control of asparagus stem *** enhance the model’s capacity to capture subtle lesion features,the Convolutional Block AttentionModule(CBAM)is added after C2f in the ***,the original CIoU loss function in YOLOv8 was replaced with the Focal-EIoU loss function,ensuring that the updated loss function emphasizes higher-quality bounding *** YOLOv8-CBAM algorithm can effectively detect asparagus stem blight phenotypic images with a mean average precision(mAP)of 95.51%,which is 0.22%,14.99%,1.77%,and 5.71%higher than the YOLOv5,YOLOv7,YOLOv8,and Mask R-CNN models,*** greatly enhances the efficiency of asparagus growers in identifying asparagus stem blight,aids in improving the prevention and control of asparagus stem blight,and is crucial for the application of computer vision in agriculture.

关键词： YOLOv8 asparagus stem blight image recognition pest

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Excellent energy storage properties in non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3)-based relaxor ferroelectric ceramics

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Chinese Chemical Letters 2024年第7期35卷 470-472页

作者： shunshun Jiang Ji Zhang jing Wang Shan-Tao Zhang School of Materials Science and Engineering Nanjing University of Science&TechnologyNanjing 210094China State Key Laboratory of Mechanics and Control of Mechanical Structures College of Aerospace EngineeringNanjing University of Aeronautics and AstronauticsNanjing 210016China National Laboratory of Solid State Microstructures Department of Materials Science and EngineeringCollege of Engineering and Applied Science&Jiangsu Key Laboratory of Artificial Functional Materials&Collaborative Innovation Center of Advanced MicrostructuresNanjing UniversityNanjing 210093China

The rapid development of high-power and pulsed-power techniques inspires extensive investigates on high-performance ceramic-based ***,the low recoverable energy density(Wrec)hampers their wider ***,the non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3)-based ceramics were designed and *** proper introduction of oxygen vacancies facilitated activating defect dipole,giving rise to reduced remanent ***,the optimal composition exhibited an exceptional high Wrec of 8.3 J/cm^(3),a high efficiency of 85%,and excellent anti-fatigue and thermal *** work provides an efficient approach to explore ceramic capacitors with high capacitive energy storage performances.

关键词： Non-stoichiometric Bi_(0.5)Na_(0.5)TiO_(3) Ceramic capacitor Energy density Thermal stability

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Highly robust zinc metal anode directed by organic–inorganic synergistic interfaces for wearable aqueous zinc battery

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SmartMat 2024年第1期5卷 135-146页

作者： Xixi Zhang Chuanlin Li Guangmeng Qu Chenggang Wang shunshun Zhao Tongkai Wang Na Li Xiaojuan Li Xijin Xu School of Physics and Technology University of JinanJinanChina School of Chemistry and Chemical Engineering Shandong UniversityJinanChina State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijingChina

Flexible aqueous zinc batteries(FAZBs)with high safety and environmental friendliness are promising smart power sources for smart wearable ***,the bare zinc anode usually suffers from damnable dendrite growth and rampant side reaction on the surface,greatly impeding practical applications in ***,a composite polymer interface layer is artificially self‐assembled on the surface of the zinc anode by graft‐modified fluorinated monomer(polyacrylic acid‐2‐(Trifluoromethyl)propenoic acid,PAA‐TFPA),on which an organic–inorganic hybrid(PAA‐Zn/ZnF2)solid electrolyte interface(SEI)with excellent ionic conductivity is formed by interacting with Zn2+.Both the pouch cell and fiber zinc anode exhibit excellent plating/stripping reversibility after protecting by this organic–inorganic SEI,which can be stably cycled more than 3000 h in symmetric Zn||Zn cells or 550 h in fiber Zn||Zn ***,this interface layer preserves zinc anode with excellent mechanical durability under various mechanical deformation(stably working for another 1200 h after bending 100 h).The corresponding PAA‐Zn/ZnF2@Zn||MnO2 full cell displays an ultra‐long life span(79%capacity retention after 3000 cycles)and mechanical robustness(85%of the initial capacity for another 3000 cycles after bending 100 times).More importantly,the as‐assembled cells can easily power smart wearable devices to monitor the user's health condition.

关键词： hybrid SEI mechanical durability wearable zinc battery zinc anode

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中国产业部门碳排放增长的结构性动因--基于SDA与LMDI耦合分解法

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资源科学 2024年第5期46卷 881-894页

作者：杨顺顺湖南省社会科学院(湖南省人民政府发展研究中心)经济研究所长沙410003

[目的]技术进步和需求结构的优化调整使产业部门低碳转型具备结构性动因,通过分解影响碳排放增长的各类因素,从而分析这一变化规律将为宏观减排路线谋划提供理论支撑。[方法]本文耦合结构分解分析(SDA)和对数平均权重Divisia指数法(LMDI... 详细信息

[目的]技术进步和需求结构的优化调整使产业部门低碳转型具备结构性动因,通过分解影响碳排放增长的各类因素,从而分析这一变化规律将为宏观减排路线谋划提供理论支撑。[方法]本文耦合结构分解分析(SDA)和对数平均权重Divisia指数法(LMDI)两类经典分解法,研制2005-2020年可比价投入产出表,对产业部门整体和细分行业部门碳排放增长的驱动因素进行了识别和分析。[结果](1)2005-2020年,产业部门碳排放总量由48.67亿t增长至106.77亿t,但5年平均增速已下降至2%以下;需求侧视角下,高碳部门向产业链下游延伸。(2)涉及技术进步的因素中,能源强度和生产结构效应的负贡献强于能源结构效应;涉及需求结构的因素中,投资扩张效应的正贡献始终强于消费拉动和出口变动效应;“十三五”以来,消费拉动效应的增碳和生产结构效应的减碳作用提升显著,部门间技术进步开始主导碳减排效应。(3)“十三五”时期,资源加工工业、电力热力燃气和水的生产和供应业、服务业整体处碳增长阶段,前者和后两者分别主要受投资扩张和消费拉动效应影响;采掘业、轻纺工业、机械及电子工业均由历史上的碳增长转向碳削减阶段,前者和后两者分别主要受进口替代和生产结构效应影响。[结论]2015年后,产业部门碳排放各类驱动因素的效力变化明显,促进最终需求结构和能源结构调整、产业链协同减排以及涉碳市场优化是未来产业部门碳减排的关注重点。

关键词：产业部门碳排放结构分解分析 LMDI模型驱动因素中国

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丝氨酸对动物机体健康的影响研究进展

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动物营养学报 2020年第10期32卷 4480-4490页

作者：何流琴金顺顺周锡红李铁军印遇龙湖南师范大学生命科学学院动物肠道功能与调控湖南省重点实验室长沙410081 中国科学院亚热带农业生态研究所畜禽养殖污染控制与资源化技术国家工程实验室动物营养生理与代谢过程湖南省重点实验室长沙410125

作为一种功能性氨基酸,丝氨酸在动物体内可由糖酵解产生的中间产物3-磷酸甘油酸或甘氨酸合成,是多个重要代谢过程的中间枢纽;此外,丝氨酸还是一种强效的神经营养因子,有利于调节中枢神经系统或神经元功能,并在调控动物机体免疫功能、炎... 详细信息

作为一种功能性氨基酸,丝氨酸在动物体内可由糖酵解产生的中间产物3-磷酸甘油酸或甘氨酸合成,是多个重要代谢过程的中间枢纽;此外,丝氨酸还是一种强效的神经营养因子,有利于调节中枢神经系统或神经元功能,并在调控动物机体免疫功能、炎症反应、微生态平衡、抗氧化应激、生长发育和治疗代谢疾病等方面发挥着重要的生物学作用。本文主要总结了近年来丝氨酸对动物机体健康影响的研究进展,重点从丝氨酸的生物学功能和代谢,以及其参与抗氧化应激、维持免疫功能、治疗相关疾病和在畜禽饲粮中的应用等方面进行了论述,特别是对丝氨酸营养调控畜禽健康进行了展望,以期把丝氨酸作为一种新型的饲料添加剂应用到畜禽养殖生产实践中,为畜禽的功能性氨基酸营养需要研究与饲养管理提供新的理论依据,同时为治疗神经性疾病、癌症、肿瘤和脂肪肝等疾病提供新的思路。

关键词：丝氨酸氧化应激免疫畜禽养殖氨基酸

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YAP Inactivation by Soft Mechanotransduction Relieves MAFG for Tumor Cell Dedifferentiation

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Research 2024年第2期6卷 401-415页

作者： Jiadi Lv Xiaohan Liu Yabo Zhou Feiran Cheng Haoran Chen shunshun Li Dianheng Wang Li Zhou Zhenfeng Wang Nannan Zhou Jie Chen Bo Huang Department of Immunology&State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical SciencesChinese Academy of Medical Sciences&Peking Union Medical College(PUMC)Beijing100005China Department of Histology and Embryology Basic Medical CllegeChina Medical UniversityShenyangLiaoning 11122China Department of Immunology Basic Medical Cllege China Medical UniversityShenyangLiaoning 110122China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China

Solid tumor cells live in a highly dynamic mechanical *** the extracellular-matrix-generated mechanotransduction regulates tumor cell development and differentiation remains an ***,we show that a low mechanical force generated from the soft matrix induces dedifferentiation of moderately stiff tumor cells to soft stem-cell-like ***,integrin?was identified to transduce mechano-signaling to trigger tumor cell dedifferentiation by recruiting RhoGDI1 to inactivate RhoA and subsequently Yes-associated protein(YAP).YAP inactivation relieved the inhibition of v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G(MAFG),allowing MAFG to transactivate the stemness genes NANOG,SOX2,and *** also restoredβ8 expression,thereby forming a closed mechanical ***,MAFG expression is correlated with worse *** findings provide mechanical insights into the regulation of tumor cell dedifferentiation,which has therapeutic implications for exploring innovative strategies to attack malignancies.

关键词： activation thereby MAF

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Gga-miRNA-181-5p family facilitates chicken myogenesis via targeting TGFBR1 to block TGF-βsignaling

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Journal of Integrative Agriculture 2024年第8期23卷 2764-2777页

作者： Xiaoxu Shen Yongtong Tian Wentao He Can He shunshun Han Yao Han Lu Xia Bo Tan Menggen Ma Houyang Kang Jie Yu Qing Zhu Huadong Yin Key Laboratory of Livestock and Poultry Multi-omics Ministry of Agriculture and Rural AffairsCollege of Animal Science and TechnologySichuan Agricultural UniversityChengdu 611130China Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province Sichuan Agricultural UniversityChengdu 611130China College of Forestry Sichuan Agricultural UniversityChengdu 611130China College of Resources Sichuan Agricultural UniversityChengdu 611130China Triticeae Research Institute Sichuan Agricultural UniversityChengdu 611130China Key Laboratory for Animal Disease Resistance Nutrition of China Institute of Animal NutritionMinistry of Education/Sichuan Agricultural UniversityChengdu 611130China

MicroRNAs(miRNAs)have been demonstrated to control chicken skeletal muscle growth,however,the potential function of the miR-181-5p family in chicken myogenesis remains largely ***,our study identified the two chicken(Gallus gallus;Gga)miR-181-5p family members widely expressed in various tissues,specifically miR-181a-5p and ***,the breast muscles of fast-growing broilers expressed higher levels of miR-181a-5p and miR-181b-5p than those of slow-growing ***,miR-181a-5p and miR-181b-5p both promote the expression level of myogenic factors including myogenin(MyoG),myogenic differentiation 1(MyoD1),and myosin heavy chain(MyHC),meanwhile accelerating the myotube formation of skeletal muscle satellite cells(SMSCs).Mechanistically,miR-181a-5p and miR-181b-5p directly bind to the 3′untranslated region(UTR)of the transforming growth factor beta receptor 1(TGFBR1)mRNA,further reducing the expression of ***1 is a key Transforming growth factor beta(TGF-β)signaling transduction receptor and had a negative function in muscle cell ***,knockdown of TGFBR1 facilitated the expression of chicken myogenic factors,boosted myotube formation,and decreased the SMAD family member 2/3(SMAD2/3)phosphorylation in chicken ***2/3 are downstream of TGF-βsignaling,and miR-181a-5p and miR-181b-5p could reduce the expression of TGFBR1 to further diminish the SMAD2/3 *** findings revealed that the miR-181-5p family targets TGFBR1 to break the TGF-βsignaling transduction,which resulted in promoting chicken skeletal muscle development.

关键词： miRNA-181-5p family SMSCs differentiation TGFBR1 TGF-βsignaling

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Rocking-chair ammonium ion battery with high rate and long-cycle life

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Chinese Chemical Letters 2024年第1期35卷 563-567页

作者： Tongkai Wang Xiaojuan Li shunshun Zhao Hongxia Bu Chuanlin Li Na Li Xixi Zhang Xijin Xu School of Physics and Technology University of JinanJi'nan 250022China State Key Laboratory of Chemical Resource Engineering Beijing Key Laboratory of Electrochemical Process and Technology of MaterialsBeijing University of Chemical TechnologyBeijing 100029China College of Physics and Electronic Engineering Qilu Normal UniversityJi'nan 250200China

Aqueous rechargeable ammonium-ion batteries(AIBs)have drew considerable attention because of their capacity for high rates,low cost,and high ***,developing desired electrodes requiring stable structure in the aqueous fast ammoniation/de-ammoniation becomes ***,an ammonium ion full battery using Cu_(3)[Fe(CN)_(6)]_(2)(CuHCF)acting to be a cathode and barium vanadate(BVO)acting to be an anode is *** excellent electrochemical behavior of Prussian blue analogs and the perfectly matched lattice structure of NH_(4)^(+)is *** the open structure of vanadium compounds satisfies the fast ammoniation/de-ammoniation of NH4+is also *** a result of these synergistic effects,the BVO//CuHCF full cell retains 80.5 percent of its capacity following 1000 *** achievements provide new ideas for developing low-cost and long-life AIBs.

关键词： Copper hexacyanoferrate Vanadium-based compounds Aqueous ammonium ion batteries Long-term cyclability Ammonium ion storage mechanism

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