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Graphene reinforced nanoarchitectonics of 3D interconnected magnetic-dielectric frameworks for high-efficient and anti-corrosive microwave absorbers

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Journal of Materials Science & Technology 2024年第1期168卷 194-207页

作者： Chenchen liu Xiaofang Feng shuning liu Guo Lin Zhongxiang Bai Lingling Wang Ke Zhu Xiulan Li Xiaobo liu School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu611731China Sichuan Province Engineering Technology Research Center of Novel CN Polymeric Materials Chengdu611731China School of Chemical Engineering Northwest UniversityXi’an710069China Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation Technology School of Environmental Science and EngineeringSun Yat-sen UniversityGuangzhou510275China

The combination of high efficiency and environmental stability is vital to promote the commercial appli-cations of microwave absorption(MA)materials,yet remains challenging in the absence of facile ***,we put forward a graphene-reinforced construct approach for one-pot synthesis of 3D intercon-nected magnetic-dielectric frameworks via pre-functionalization and subsequent *** in-teractions among discrete precursors are capable of manipulating the confined growth and interfacial *** enhancements in MA properties are triggered in a straightforward manner us-ing ultralow feeding fractions of graphene oxide *** minimum reflection loss is up to-60.1 dB(99.9999%wave absorption)and the effective absorption bandwidth reaches 5.9 GHz(almost covering the Ku band).Remarkably,based on the optimization by ultralow concentrations of graphene,the as-prepared nanoarchitecture simultaneously integrates strong absorption,broad bandwidth,and low matching *** embedded graphene nanosheets serve as high-speed electron transmission channels and hollow resonance cavities,facilitating multimode attenuations and impedance-matching ***-while,the graphene-reinforced framework suppresses the corrosion of magnetic components,whose cor-rosion rate reduces by an order of *** study provides a simple procedure to boost magnetic-dielectric absorbers for comprehensive MA performances and enhanced corrosion resistance.

关键词： 3D Magnetic-dielectric framework Graphene nanosheet Microwave absorption Anti-corrosion

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Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2 variants including JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian Li Mengxin Xu Jingyi Yang Li Zhou Lin liu Min Li Shasha Wang Mei-Qin liu Zhixiang Huang Zhen Zhang shuning liu Yunqi Hu Haofeng Lin Bowen liu Ying Sun Qingguo Wu Zheng-Li Shi Ke Lan Yu Chen Huimin Yan Yao-Qing Chen Wuhan Institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of Chinese Academy of Sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina State Key Laboratory of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration Key Laboratory for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2 is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2 for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagellin protein(KFD)(3R-NC+KFDi.n).In mice,the vaccination elicited RBD-specific broad-neutralizing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-lived RBD-specific IgG-and IgA-producing plasma cells,alongside the Th17 and Tfh17-biased T-cell responses driven by the KFD *** upon these preclinical findings,an open labeled clinical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2(IAV)*** a favorable safety profile,the 3R-NC+KFDi.n boost elicited enduring broad-neutralizing IgG in plasma and IgA in salivary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutralize the newly emerging variants,including *** findings highlight the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2 infection.

关键词： vaccination vaccine sustained

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聚丁二酸丁二醇酯和聚辛二酸丁二醇酯及聚(丁二酸-co-辛二酸丁二醇)共聚酯的酶促降解

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高分子材料科学与工程 2024年第1期40卷 66-73页

作者：刘姝宁宋力苏婷婷辽宁石油化工大学石油化工学院辽宁抚顺113001

以1,4-丁二醇与不同链长二元酸单体为原料,合成了聚丁二酸丁二醇酯(PBS)和聚辛二酸丁二醇酯(PBSub)2种均聚酯和4种不同比例聚(丁二酸-co-辛二酸丁二醇)共聚酯。以上述6种聚酯为降解底物,利用角质酶对其进行降解研究。通过衰减全反射傅... 详细信息

以1,4-丁二醇与不同链长二元酸单体为原料,合成了聚丁二酸丁二醇酯(PBS)和聚辛二酸丁二醇酯(PBSub)2种均聚酯和4种不同比例聚(丁二酸-co-辛二酸丁二醇)共聚酯。以上述6种聚酯为降解底物,利用角质酶对其进行降解研究。通过衰减全反射傅里叶变换红外光谱、核磁共振波谱仪、差示扫描量热仪、X射线衍射仪和热重分析仪等对聚酯及其降解产物进行表征分析。6种聚酯的晶体结构、熔点、结晶度和热稳定性变化不大。研究表明,聚酯的结晶度和熔点温度是影响其酶降解的重要因素。角质酶降解共聚酯的结晶区和非结晶区,但优先降解非结晶区。丁二酸/辛二酸投料摩尔比为4/6和6/4的降解效果最好,但摩尔比为6/4的样品熔点较高,为最佳比例。

关键词：聚(丁二酸-co-辛二酸丁二醇) 角质酶降解

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Effect of Na^(+)and Sr^(2+)Substitution on the Formation of the Oxygen Vacancies in Y_(3)Al_(2)Ga_(3)O_(12):Ce^(3+)Phosphor

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Journal of Wuhan University of Technology(Materials Science) 2023年第5期38卷 1221-1230页

作者： YANG Ting JIANG Hongyi DONG Ye GAO Shuai liu shuning School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China

The low-valence cations Na^(+)and Sr^(2+)were selected as the co-dopants to increase the vacancies concentration in the Y_(2.982)Ce_(0.018)Al_(2)Ga_(3)O_(12)*** successful incorporation of Na^(+)and Sr^(2+)was confirmed by the X-Ray Difiraction(XRD)*** the samples show 5d-4f green persistent luminescence of Ce^(3+)after 450 nm *** decay curves demonstrate that the persistent luminescence is efiectively enhanced with Na+and Sr2+*** thermoluminescence glow curves also show not only does the trap concentration increase,but also the distribution of trap depths is *** addition,the air-and H_(2)/Ar-annealing treatments were conducted on every as-made *** experimental results prove that the increased traps after the Na^(+)/Sr^(2+)doping are mainly attributed to the oxygen vacancies,and the traps have a continuous and broad distribution of trap *** hope this work could give new inspiration for designing a high-performance persistent phosphor.

关键词： persistent luminescence YAGG Na^(+) Sr^(2+) oxygen vacancy charge compensation solidstate reaction

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Ultra-lightweight ceramic scaffolds with simultaneous improvement of pore interconnectivity and mechanical strength

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Journal of Materials Science & Technology 2023年第6期137卷 247-258页

作者： Ye Dong Annan Chen Ting Yang Shuai Gao shuning liu Hongyi Jiang Yusheng Shi Chenglong Hu School of Materials Science and Engineering Wuhan University of TechnologyWuhan 430070China State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Engineering Research Center of Ceramic Materials for Additive Manufacturing Ministry of EducationWuhan 430074China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China

The high porosity and interconnectivity of scaffolds are critical for nutrient transmission in bone tis-sue engineering but usually lead to poor mechanical ***,a novel method that combines acid etching(AE)with selective laser sintering(SLS)and reaction bonding(RB)of Al particles is pro-posed to realize highly improved porosity,interconnectivity,mechanical strength,and in vitro bioactivity in 3D Al_(2)O_(3) *** controlling the oxidation and etching behaviors of Al particles,a tunable hol-low spherical feature can be obtained,which brings about the distinction in compressive response and fracture *** prevention of microcrack propagation on the in situ formed hollow spheres results in unique near elastic buckling rather than traditional brittle fracture,allowing an unparalleled compressive strength of 3.72±0.17 MPa at a high porosity of 87.7%±0.4%and pore interconnectivity of 94.7%±0.4%.Furthermore,scaffolds with an optimized pore structure and superhydrophilic surface show excellent cell proliferation and adhesion *** findings offer a promising strategy for the coexistence of out-standing mechanical and biological properties,with great potential for tissue engineering applications.

关键词： Ceramic scaffolds Selective laser sintering Acid etching Hollow spherical feature Mechanical strength In vitro bioactivity

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基于CUACE分等级的空气质量预报研究

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科学技术创新 2024年第3期 68-71页

作者：石霖晟杰刘姝宁秦闻通吴瑕内蒙古自治区气象科学研究所内蒙古呼和浩特内蒙古自治区包头市气象局内蒙古包头内蒙古自治区根河市气象局内蒙古根河

本文针对2021年6月—2022年7月中国气象局研制的CUACE地面沙尘浓度和空气质量AQI数据进行了相关分析,使用K-means聚类算法将CUACE沙尘浓度按300、1 000、3 000、5 000划分为五层,基于随机森林模型建立了空气质量等级的预报模型,结果表明... 详细信息

本文针对2021年6月—2022年7月中国气象局研制的CUACE地面沙尘浓度和空气质量AQI数据进行了相关分析,使用K-means聚类算法将CUACE沙尘浓度按300、1 000、3 000、5 000划分为五层,基于随机森林模型建立了空气质量等级的预报模型,结果表明:CUACE越大,AQI≥300的数据量占比也越大;当CUACE≥5 000时,AQI全部大于300,当5 000>CUACE≥3 000时,AQI出现两级分化,AQI在200—400之间的数据量不超过1%;一至三层的数据中,AQI<100的比例明显增多,分别占86.2%、68%、41.8%;模型整体效果优于CUACE,其中第五层和第四层表现出了更好的预测效果。

关键词： CUACE 空气质量预报随机森林

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Monitoring NAD(H) and NADP(H) dynamics during organismal development with genetically encoded fluorescent biosensors

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Cell Regeneration 2022年第1期11卷 44-54页

作者： Ting Li Yejun Zou shuning liu Yi Yang Zhuo Zhang Yuzheng Zhao Optogenetics&Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor EngineeringShanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismEast China University of Science and Technology130 Mei Long RoadShanghai 200237China Shanghai Key Laboratory of New Drug Design School of PharmacyEast China University of Science and Technology130 Mei Long RoadShanghai 200237China Research Unit of New Techniques for Live-cell Metabolic Imaging Chinese Academy of Medical SciencesBeijingChina

Cell metabolism plays vital roles in organismal development,but it has been much less studied than transcriptional and epigenetic control of developmental *** difficulty might be largely attributed to the lack of in situ metabolite *** encoded fluorescent sensors are powerful tools for noninvasive metabolic monitoring in living cells and in vivo by highly spatiotemporal *** all living organisms,the NAD(H)and NADP(H)pools are essential for maintaining redox homeostasis and for modulating cellular ***,we introduce NAD(H)and NADP(H)biosensors,present example assays in developing organisms,and describe promising prospects for how sensors contribute to developmental biology research.

关键词： Cell metabolism NAD(H)and NADP(H) Genetically encoded fluorescent sensors Real-time monitoring Organismal development

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A triple-RBD-based mucosal vaccine provides broad protectionagainst SARS-CoV-2 variants of concern

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Cellular & Molecular Immunology 2022年第11期19卷 1279-1289页

作者： Jingyi Yang Mei-Qin liu Lin liu Xian Li Mengxin Xu Haofeng Lin shuning liu Yunqi Hu Bei Li Bowen liu Min Li Ying Sun Yao-Qing Chen Zheng-Li Shi Huimin Yan Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan University201508 ShanghaiChina Wuhan Institute of Virology Chinese Academy of Sciences430071 WuhanChina University of Chinese Academy of Sciences 100049 BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107 GuangdongChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhou 215123 JiangsuChina Key Laboratory of Tropical Disease Control(Sun Yat-sen University) Ministry of EducationGuangzhouChina

The rapid mutation and spread of SARS-CoV-2 variants urge the development of effective mucosal vaccines to provide broadspectrum protection against the initial infection and thereby curb the transmission ***,we designed a chimeric tripleRBD immunogen,3Ro-NC,harboring one Delta RBD and two Omicron RBDs within a novel protein scaffold.3Ro-NC elicits potent and broad RBD-specific neutralizing immunity against SARS-CoV-2 variants of ***,intranasal immunization with 3RoNC plus the mucosal adjuvant KFD(3Ro-NC+KFDi.n)elicits coordinated mucosal IgA and higher neutralizing antibody specificity(closer antigenic distance)against the Omicron *** Omicron-challenged human ACE2 transgenic mice,3Ro-NC+KFDi.n immunization significantly reduces the tissue pathology in the lung and lowers the viral RNA copy numbers in both the lung(85.7-fold)and the nasal turbinate(13.6-fold).Nasal virologic control is highly correlated with RBD-specific secretory IgA *** data show that 3Ro-NC plus KFD is a promising mucosal vaccine candidate for protection against SARS-CoV-2 Omicron infection,pathology and transmission potential.

关键词： SARS-CoV-2 Mucosal vaccine Intranasal immunization Triple-RBD Flagellin adjuvant Variant of concern

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碲镉汞红外光电探测器局域场表征研究进展(特邀)

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红外与激光工程 2022年第7期51卷 36-48页

作者：刘书宁唐倩莹李庆国科大杭州高等研究院物理与光电工程学院浙江杭州310024 中国科学院上海技术物理研究所上海200083

碲镉汞材料(HgCdTe)是第三代红外探测系统中使用的重要探测材料,其发展水平能基本反映当前红外探测器最优性能指标。近年来,天文、遥感和民用设备对探测器性能提出了更高的要求,这对HgCdTe红外探测器的设计和制备提出了新的挑战。HgCdT... 详细信息

碲镉汞材料(HgCdTe)是第三代红外探测系统中使用的重要探测材料,其发展水平能基本反映当前红外探测器最优性能指标。近年来,天文、遥感和民用设备对探测器性能提出了更高的要求,这对HgCdTe红外探测器的设计和制备提出了新的挑战。HgCdTe红外探测器更精细的设计和加工技术为提高HgCdTe红外探测器性能提供解决思路。抑制器件的有害局域场、调控器件的有益局域场可以实现器件性能进一步的突破。但是,如何对HgCdTe光电器件局域场进行表征与分析,澄清HgCdTe光电器件中局域场相关的噪声及暗电流起源,是推动器件性能突破需解决的重要关键科学与技术问题。文中将总结HgCdTe红外光电探测器局域场表征与分析的研究进展,为新一代HgCdTe红外光电探测器发展提供基础支撑。

关键词：碲镉汞器件微区光电流扫描技术局域场暗电流

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High BRCA1 expression is an independent prognostic biomarker in LUAD and correlates with immune infiltration

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Cancer Innovation 2023年第2期2卷 91-95页

作者： Fengzhu Guo Cong Li shuning liu Zhijun Li Jingtong Zhai Zhiwu Wang Binghe Xu Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Medical Oncology Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijingChina Department of Chemoradiotherapy Tangshan People's HospitalTangshanChina

Non-small-cell lung cancer(NSCLC)is the primary histopathological subtype of lung cancer and accounts for around 82%of all pulmonary neoplasms[1].Breast cancer susceptibility gene 1(BRCA1)is a tumor suppressor gene that regulates cellular responses to stress through DNA damage repair and is frequently mutated in breast and ovarian cancers[2].Furthermore,previous studies have increasingly shown that the expression of BRCA1 and the relevant poly(ADP-ribose)polymerase inhibitors is related to the prognosis and therapeutic response of other tumors,including lung cancer[3,4].However,previous findings on the prognostic value of BRCA1 for NSCLC have been inconsistent or conflicting,which may be attributed to the small number of patients from a single center or disparity in the ratio of patients with lung adenocarcinoma(LUAD)versus squamous cell carcinoma(LUSC)[5].The aim of this study was to determine the prognostic value of BRCA1 in NSCLC and its association with immune infiltration.

关键词： bioinformatics analysis lung adenocarcinoma meta-analysis non-small-cell lung cancer prognosis

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