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Relationships between endothelial nitric oxide synthase gene polymorphisms and osteoporosis in postmenopausal women

Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2009年第8期10卷 609-618页

作者： shun-zhi liu Hong YAN Wei-kun HOU Peng XU Juan TIAN Li-fang TIAN Bo-feng ZHU Jie MA She-min LU Department of Public Health School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi 'an Jiaotong University Xi 'an 710061 China Department of Genetics and Molecular Biology School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Department of Bone and Joint Diseases of Xi 'an Red Cross Hospital Xi 'an 710054 China Department of Forensic Medicine School of Medicine Xi 'an Jiaotong University Xi'an 710061 China

Objective： To investigate the relationships between endothelial nitric oxide synthases （eNOS） G894T and 27 bpvariable number tandem repeat （VNTR） gene polymorphisms and osteoporosis in the postmenopausal women of Chinese Han nationality. Methods： In the present study, 281 postmenopausal women from Xi＇an urban area in West China were recruited, and divided into osteoporosis, osteopenia, and normal groups according to the diagnostic criteria of osteoporosis proposed by World Health Organization （WHO）. The bone mineral density （BMD） values of lumbar vertebrae and left hips were determined by QDR-2000 dual energy X-ray absorptiometry. Blood samples were tested for plasma biochemical indicators including testosterone, estradiol, calcitonin, osteocalcin, and procollagen type I amino-terminal propeptide by enzyme-linked immunosorbent assay （ELISA）, tartrate-resistant acid phosphatase by spectrophotometric method, and the content of nitric oxide by Griess method. Genome DNA was extracted from whole blood, and G894T polymorphism of eNOS gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism （PCR-RFLP） method and 27 bp-VNTR polymorphism of eNOS gene was genotyped by PCR method. Then the relationships between genotypes and biochemical indicators, genotypes and osteoporosis, and haplotypes and osteoporosis were analyzed. Results： The average BMD values of the femoral neck, ward＇s triangle and lumbar vertebrae 1-4 （LI-L4） in the subjects with T/T genotype in eNOS G894T locus were significantly higher than those in the subjects with G/T and G/G genotypes （P〈0.05）. The average BMD of the femoral neck in the subjects with a/a genotype of eNOS 27 bp-VNTR locus was evidently higher than that in the subjects with b/b genotype （P〈0.05）. The plasma testosterone and osteocalcin concentrations in the subjects of eNOS G894T G/T genotype were evidently higher than those in the subjects of other genotypes （P〈0.05）; the plasma estradiol concentration in

关键词： Postmenopausal women Osteoporosis Endothelial nitric oxide synthase Gene polymorphisms Bone mineral density

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Effect of electroacupuncture for reducing the frequency of recurrent cystitis:A case report

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World Journal of Acupuncture-Moxibustion 2021年第4期31卷 251-253页

作者： Wei-na ZHANG Huan CHEN zhi-shun liu Beijing University of Chinese Medicine Beijing 100029China Department of Acupuncture Guang'anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Tianjin University of Traditional Chinese Medicine Tianjin 301617China

Introduction:Recurrent cystitis,defined as at least two episodes within six months or three episodes within one year,presented among about one fifth to one-third of women with history of cystitis or urinary tract infection(UTI) according to previous ***,the use of antibiotics can only resolve the urinary symptoms but not reduce the frequency of urinary symptoms recurrence,and meanwhile increasing rates of adverse effect of repetitive antimicrobial therapy and bacterial antimicrobial resistance became clinical *** case report aims to present a case of recurrent cystitis treated by electroacupuncture(EA) in reducing recurrent frequency,amount of antibiotics used and urinary *** presentation:A 42-year-old woman diagnosed with recurrent cystitis for five years presented mainly with recurrent dysuria,urine frequency and *** received EA treatment 3 to 5 sessions a week and 30 min per session from August 2019 to August 2020 with 3-month suspension due to Coronavirus Disease 2019(COVID-19).During the treatment,both the frequency of recurrent urinary episode and symptoms were *** there was some fluctuation,the mean frequencies of daytime voiding reduced dramatically from 17.7 to 8.3,and night-time voiding from 4 to 1,and the number of voiding with moderate urgency was reduced from 17.7 to 2.3,and severe urgency dropped from 2.7 to *** patient’s scores of overactive bladder symptom score(OABSS) and overactive bladder questionnaire short form(OAB-q SF) were also *** postvoid residual urine volume(PVR) reduced from 42 mL to less than 10 mL Conclusion:This case of individual effect of EA for a woman with frequent recurrent cystitis suggested a plausible benefit of EA on reducing frequency,amount of antibiotics used and symptoms of recurrent cystitis,but further research is necessary to proof the efficacy and effectiveness among a wider population.

关键词： Urinary tract infection Recurrent cystitis Electroacupuncture

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Distributions of HLA-A and-B alleles and haplotypes in the Yi ethnic minority of Yunnan, China: relationship to other populations

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第2期11卷 127-135页

作者： Bo-feng ZHU Guang YANG Chun-mei SHEN Hai-xia QIN shun-zhi liu Ya-jun DENG Shuan-liang FAN Li-bin DENG Feng CHEN Ping ZHANG Jie FANG Li-ping CHEN Hong-dan WANG Zhen-yuan WANG Rudolf LUCAS Department of Forensic Medicine School of Medicine Xi 'an Jiaotong University Xi 'an 710061 China Key Laboratory of Environment and Genes Related to Diseases of Ministry of Education Xi'an Jiaotong University Xi 'an 710061 China Vascular Biology Center Medical College of Georgia Augusta Georgia 30912 USA Shaan'xi Blood Center Xi 'an 710061 China Institute of Molecular Medicine and Genetics Medical College of Georgia Augusta Georgia 30912 USA Department of Public Health School of Medicine Xi'an Jiaotong University Xi'an 710061 China Center of Forensic Sciences Beijing Genomics Institute Beijing 101300 China Faculty of Basic Medical Science Nanchang University Nanchang 330006 China

Objective: To investigate the distributions of human leukocyte antigen (HLA)-A and-B alleles and HLA-A-B haplotypes in the Yi ethnic minority of the Yunnan Province, situated in southwestern China. Methods: DNA typing for HLA-A and-B loci was performed using the polymerase chain reaction-sequence-based typing (PCR-SBT) method on 114 randomly selected healthy individuals of the Yi population. The allelic frequencies of HLA-A and-B loci were calculated by direct counting and HLA-A-B haplotypes were estimated using the expectation maximization algorithm. Results: A total of 17 HLA-A and 38 HLA-B alleles were found in the Yi population. The most frequent alleles were A2402 (32.46%), A1101 (26.32%), and A0203 (10.09%) at the HLA-A locus and B4601 (12.28%), B1525 (10.09%), B4001 (8.77%), and B3802 (7.89%) at the HLA-B locus. The predominant HLA-A-B haplotypes were A2402-B1525 (7.86%) and A0203-B3802 (5.64%), followed by A1101-B4001 (4.69%). Phylogenetic analysis indicates that the Yi population in the Honghe, Yunnan Province of China basically belongs to groups of southeastern Asian origin, but shares some characteristics with northeastern Asian groups. Conclusion: The present study may add to the understanding of HLA polymorphism in the Yi ethnic group that was poorly defined previously, and provide useful information for bone marrow transplantation, anthropological research, and forensic sciences as well as for disease-association studies.

关键词： Yi ethnic minority Human leukocyte antigen (HLA)-A HLA-B Allele Haplotype Polymerase chain reaction-sequence-based typing (PCR-SBT)

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2020年中国高等教育规模预测偏差成因分析及重估

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复旦教育论坛 2017年第4期15卷 10-16页

作者：胡顺顺刘志民南京农业大学公共管理学院江苏南京210095 江苏教育现代化研究院江苏南京210013

2010年公布的《国家中长期教育改革和发展规划纲要(2010-2020年)》明确提出:"到2020年,高等教育毛入学率达到40%。"但是,教育部最新统计数据显示,我国2015年的高等教育毛入学率已经提前5年超前实现了40%的目标。为什么会出现如此大的偏... 详细信息

2010年公布的《国家中长期教育改革和发展规划纲要(2010-2020年)》明确提出:"到2020年,高等教育毛入学率达到40%。"但是,教育部最新统计数据显示,我国2015年的高等教育毛入学率已经提前5年超前实现了40%的目标。为什么会出现如此大的偏差?结合对各学者预测内容的梳理,笔者认为原因主要有三:一是信息更新约束与模型差异;二是理性偏误;三是不可预测的政策因素。在连续毛入学率预测数据中,预测误差较小的学者使用了Logistic模型、GM(1,1)灰色预测模型及高等教育规模滚动回归模型。本文使用方差-协方差组合预测法,辅以改进后的三种模型来重新估计2020年高等教育毛入学率。结果显示,2020年我国高等教育毛入学率将达到且超过50%。

关键词：高等教育规模预测偏差组合预测

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Acupuncture versus oral medicine for women with diminished ovarian reserve:A cohort study

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World Journal of Acupuncture-Moxibustion 2021年第3期31卷 176-180页

作者： zhi-yi XIONG Yang WANG Xiao-xu liu Shu-dan YU Yan-hong LI Xin-min liu zhi-shun liu Beijing University of Chinese Medicine Beijing 100029China Acupuncture Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China Gynecology Department Guang’anmen HospitalChina Academy of Chinese Medical SciencesBeijing 100053China

Objective:To observe whether electro-acupuncture(EA) is better in improving hormone levels among women with diminished ovarian reserve(DOR) compared with oral medicine [Chinese herbs with or without hormone replacement therapy(HRT)] that is often used in gynecology clinics in ***:Eligible participants entered the EA group or medication group according to their *** in the EA group received EA treatment,and participants the medication group received herbal decoction alone or combined with *** hormone levels of the participants were tested before and during treatment in both ***:A total of 80 women with DOR were screened and 57 cases were included(29 in the EA group and 28 in the medication group) in the final *** differences in the change from baseline between the EA and medication group in mean follicle-stimulating hormone(FSH) levels were-6.6(95% Cl,-17.03 to 3.72),(P=0.848) and-7.09(95% CI,-15.86 to 1.66),(P=0.539) at weeks 12 and 24,*** proportion of women with regular FSH levels in the EA and medication group was 51.3% vs 32.1% at week 12(P=0.134) and 51.3% vs 25.0% at week 24(P=0.038).Conclusion:EA might influence regulating the levels of FSH,luteinizing hormone(LH),estrogen and the FSH/LH ratio,and no difference was found between the effects of EA and oral medicine in changes of reproductive hormone levels.

关键词： Diminished ovarian reserve Electro-acupuncture Progesterone capsules Progynova Chinese herbal medicine Cohort study

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Extending the CONSORT Statement to moxibustion

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Journal of Integrative Medicine 2013年第1期11卷 54-63页

作者： Chung-wah Cheng Shu-fei Fu Qing-hui Zhou Tai-xiang Wu Hong-cai Shang Xu-dong Tang zhi-shun liu Jia liu zhi-xiu Lin Lixing Lao Ai-ping Lü Bo-li Zhang Bao-yan liu Zhao-xiang Bian School of Chinese Medicine Hong Kong Baptist University Changhai Hospital of Traditional Chinese Medicine Secondary Military Medical University Chinese Evidence-based Medicine Center Evidence-based Medicine Certer Tianjin University of Traditional Chinese Medicine Department of Gastroenterology Xiyuan Hospital China Academy of Chinese Medical Sciences Department of Acupuncture Guang'anmen Hospital China Academy of Chinese Medical Sciences School of Chinese Medicine the Chinese University of Hong Kong Center for Integrative Medicine University of Maryland School of Medicine Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences Academy of TCM Tianjin University of Traditional Chinese Medicine Clinial Evaluation Center China Academy of Chinese Medical Sciences

The STandards for Reporting Interventions in Clinical Trials Of Moxibustion （STRICTOM）, in the form of a checklist and descriptions of checklist items, were designed to improve reporting of moxibustion trials, and thereby facilitating their interpretation and replication. The STRICTOM checklist included 7 items and 16 sub-items. These set out reporting guidelines for the moxibustion rationale, details of moxibustion, treatment regimen, other components of treatment, treatment provider background, control and comparator interventions, and precaution measures. In addition, there were descriptions of each item and examples of good reporting. It is intended that the STRICTOM can be used in conjunction with the main CONSORT Statement, extensions for nonpharmacologic treatment and pragmatic trials, and thereby raise the quality of reporting of clinical trials of moxibustion. Further comments will be solicited from the experts of the CONSORT Group, the STRICTA Group, acupuncture and moxibustion societies, and clinical trial authors for optimizing the STRICTOM.

关键词： moxibustion randomized controlled trials guidelines

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Electroacupuncture for the prevention of postoperative gastrointestinal dysfunction in patients undergoing vascular surgery under general anesthesia: study protocol for a prospective practical randomized controlled trial

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Journal of Integrative Medicine 2014年第6期12卷 512-519页

作者： Ying Li Hui Zheng Qian-hua Zheng Ling Zhao Er-qi Qin Yu Wang Qian Zeng Hua-bin Zheng Yu Zhao Wei Sun Xiao-xia Zhang zhi-shun liu Bao-yan liu Chengdu University of Traditional Chinese Medicine General Hospital of Chengdu Military Region of the Chinese People's Liberation Army First Affiliated Hospital of Chengdu University of Traditional Chinese Medicine Chengdu Integrated TCM & Western Medicine Hospital Guang'anmen Hospital China Academy of Chinese Medical Sciences

BACKGROUND： Postoperative gastrointestinal dysfunction（PGD） is one of the most common complications following major surgeries under general anesthesia（GA）. Despite ongoing research and new drug treatments, abdominal distension within 24 h postoperatively occurs in 8%–28% of all surgeries. We aim to analyze the effectiveness of preventing PGD by preoperatively stimulating Neiguan（PC6）, Zusanli（ST36） and Shangjuxu（ST37） bilaterally twice a day compared with sham-acupuncture treatment and standard *** AND DESIGN： This is a single-center, prospective practical randomized controlled trial. All groups will be given standard treatments. Patients undergoing vascular surgery under GA will be included from the Vascular Surgery Unit in West China Hospital of Sichuan University, China, and divided into three groups. The experimental group will receive routine treatments and acupuncture at PC6, ST36 and ST37 bilaterally with electrical stimulation twice a day for 20 min preoperatively. The sham-acupuncture group will receive pseudo-electroacupuncture at sham acupoints of PC6, ST36 and ST37, which are 1 cun away from the real acupoints. The routine-treatment group will not receive electroacupuncture. The outcomes include the incidence of abdominal distention, abdominal circumference, the degree of abdominal distension, the fi rst time of fl atus and defecation, and hospitalization duration. DISCUSSION： The results from this study will demonstrate whether preoperative electroacupuncture is an effective method for the prevention of PGD in patients undergoing vascular surgery under GA. This study may also provide a standardized acupuncture treatment for reduction of PGD. TRIAL REGISTRATION： This study is registered with the Chinese Clinical Trial Registry： Chi CTR-TRC-13003649.

关键词： electroacupuncture gastrointestinal dysfunction vascular surgery study protocol

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Physical Layer Security Scheme With AoI-Awareness for Industrial IoT Based on Covert Communications

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IEEE/CAA Journal of Automatica Sinica 2025年第1期 276-278页

作者： Yaping Li zhi-Xin liu Jia-Wei Su Ya-Zhou Yuan the Key Laboratory of Industrial Computer Control Engineering of Hebei Province Yanshan University

Dear Editor,Industrial Internet of things(IIoT) is a typical application of cyberphysical system(CPS). In the IIoT, wireless communication is an inevitable trend to replace the deployment-limited wired transmission for cases with large-scale and mobile devices. However, wireless communication gives rise to critical issues related to physical security, such as malicious detections and attacks [1].

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Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang Yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-liu Wang Department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China Department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

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Pivotal Factors Concerned in Design of Acupuncture Clinical Research:From Two Articles in JAMA

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Chinese Journal of Integrative Medicine 2017年第11期23卷 809-811页

作者： WU Jia-ni QIN Zong-shi liu zhi-shun Department of Acupuncture Guang anmen HospitalChina Academy of Chinese MedicaI Sciences Beijing(100053)China

Two randomized controlled trials of acupuncture concerning polycystic ovary syndrome（PCOS） and stress urinary incontinence（SUI） were published simultaneously in the 24 th issue, 2017 of The Journal of the American Medical Association（JAMA）. A trial involving PCOS indicated that active acupuncture did not increase live birth compared with sham acupuncture; meanwhile, another trial referring to SUI showed that electroacupuncture resulted in less urine leakage compared with sham electroacupuncture. With an eye to the negative and positive results of acupuncture, three pivotal factors should be contemplated：（1） proper illness for acupuncture, that is, a problem need to be solved in current medical science, and acupuncture may really work for it;（2） proper pre-studied primary outcome, which is better be objective and repeatedly measurable to reveal the therapeutic effect of acupuncture truly and objectively;（3） proper sham control, which can blind the patients to the upmost extent with minimal biological effects. Through the publication of clinical trials of acupuncture in high-impact journals in recent years, researchers should have confidence in their clinical trials by pondering over these three pivotal factors.

关键词： acupuncture clinical trials study design high impact journal

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