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Pathogen Spectrum of Hand,Foot,and Mouth Disease Based on Laboratory Surveillance—China,2018

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China CDC weekly 2020年第11期2卷 167-171页

作者： Fengfeng Liu Minrui Ren shumin chen Taoran Nie Jinzhao Cui Lu Ran Zhongjie Li Zhaorui Chang Division of Infectious Disease Key Laboratory of Surveillance and Early Warning on Infectious DiseaseChinese Center for Disease Control and PreventionBeijing102206China Xuancheng City Center for Disease Control and Prevention Xuancheng CityAnhui Province242000China Miyun District Center for Disease Control and Prevention Miyun DistrictBeijing101500China

What is already known about this topic?Enterovirus 71(EV-A71)is the main causative pathogen for severe and fatal patients with Hand,Foot,and Mouth Disease(HFMD)in China's Mainland from 2008 to ***-EV-A71 and non-CV-A16(other enterovirus)serotypes were the major causativeserotypes for mild HFMD in years of 2013,2015,and *** is added by this report?In 2018,other enterovirus serotypes replaced EV-A71 for the first time as the major cause of severe HFMD with a proportion of 70.7%.However,at the national level,only a small proportion of the other enterovirus serotypes were further identified as CV-A6 and *** are the limitations for public health practice?Further identification of other enterovirus serotypes is highly recommended for provincial CDCs,especially for severe *** contributing to a multivalent vaccine for HFMD should be prioritized.

关键词： mainland limitations Disease

Genome Assembly and Population Resequencing Reveal the Geographical Divergence of Shanmei(Rubus corchorifolius)

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Genomics, Proteomics & Bioinformatics 2022年第6期20卷 1106-1118页

作者： Yinqing Yang Kang Zhang Ya Xiao Lingkui Zhang Yile Huang Xing Li shumin chen Yansong Peng Shuhua Yang Yongbo Liu Feng cheng Institute of Vegetables and Flowers Chinese Academy of Agricultural SciencesKey Laboratory of Biology and Genetic Improvement of Horticultural CropsMinistry of Agriculture and Rural AffairsSino-Dutch Joint Laboratory of Horticultural GenomicsBeijing 100081China Biotechnology Research Center Xiangxi Academy of Agricultural SciencesJishou 416000China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China State Environmental Protection Key Laboratory of Regional Eco-process and Function Assessment Chinese Research Academy of Environmental SciencesBeijing 100012China

Rubus corchorifolius(Shanmei or mountain berry,2n=14)is widely distributed in China,and its fruits possess high nutritional and medicinal ***,we reported a highquality chromosome-scale genome assembly of Shanmei,with contig size of 215.69 Mb and 26,696 *** comparison among Rosaceae species showed that Shanmei and Fupenzi(Rubus chingii Hu)were most closely related,followed by blackberry(Rubus occidentalis),and that environmental adaptation-related genes were expanded in the Shanmei *** resequencing of 101 samples of Shanmei collected from four regions in the provinces of Yunnan,Hunan,Jiangxi,and Sichuan in China revealed that among these samples,the Hunan population of Shanmei possessed the highest diversity and represented the more ancestral ***,the Yunnan population underwent strong selection based on the nucleotide diversity,linkage disequilibrium,and historical effective population size ***,genes from candidate genomic regions that showed strong divergence were significantly enriched in the flavonoid biosynthesis and plant hormone signal transduction pathways,indicating the genetic basis of adaptation of Shanmei to the local *** high-quality assembled genome and the variome dataset of Shanmei provide valuable resources for breeding applications and for elucidating the genome evolution and ecological adaptation of Rubus species.

关键词： Rubus corchorifolius Genome assembly Resequencing Divergence Genome evolution

Unstable Allotetraploid Tobacco Genome due to Frequent Homeologous Recombination, -. Segmental Deletion, and Chromosome Loss

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Molecular Plant 2018年第7期11卷 914-927页

作者： shumin chen Feihong Ren Lei Zhang Yong Liu Xuejun chen Yuanmei Li Liang Zhang Bin Zhu Pan.Zeng Zaiyun Li Robert M. Larkin Hanhui Kuang Key Laboratory of Horticultural Plant Biology Ministry of Education Key Laboratory of Horticultural Crop Biology and Genetic Improvement (Central Region) MOA College of Horticulture and Forestry Sciences Huazhong Agricultural University Wuhan 430070 People's Republic of China Yunan Academy of Tobacco Agricultural Science Kunming Yunnan Province People's Republic of China College of Plant Science Huazhong Agricultural University Wuhan 430070 People's Republic of China These authors contributed equally to this article.

The types of mutations and their corresponding frequencies are difficult to measure in complex genomes. In this study, a high-throughput method was developed to identify spontaneous loss-of-function alleles for the resistance gene N and the transgenic avirulence gene P50 in allotetraploid tobacco. A total of 2134 loss- of-function alleles of the N gene were identified after screening 14 million F1 hybrids. Analysis of these mutants revealed striking evolutionary patterns for genes in polyploids. Only 14 of the loss-of-function mutations were caused by spontaneous point mutations or indels, while the others were caused by home- ologous recombination （with a frequency of 1/12 000） or chromosome loss （1/15 000）. Loss of the chromosome with the PS0 insertion occurred at a similar frequency （1/13 000）, and the frequency of spon- taneous segmental deletion in this chromosome was 1/16 000. Both homeologous recombination and chromosome loss considerably decreased the viability of the mutants. Our data suggest that the high mutation rate in polyploids is probably due to the occurrence of homeologous recombination and the toler- ance of large mutations such as chromosome loss in polyploid genomes. Frequent mutations tend to drive polyploids to extinction unless a novel mutation helps the polyploid to effectively compete with diploids or find a new ecological niche.

关键词： polyploid genome evolution homeologous recombination chromosome loss spontaneous mutation

基于改进K-Means算法的电动汽车充电负荷特性分析

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云南电力技术 2024年第3期52卷 10-13,19页

作者：李俊达陈姝敏王天安张玎一吴全才云南电网能源投资有限责任公司云南昆明650011 云南电网有限责任公司云南昆明650011

电动汽车充电行为具有较大的随机性,一定程度上影响电网的稳定运行和规划。为更准确地分析电动汽车充电负荷的特性,提出一种基于改进K-Means算法的聚类分析方法。针对K-Means算法在初始聚类中心选取上的随机性和不稳定性,首先利用Mini B... 详细信息

电动汽车充电行为具有较大的随机性,一定程度上影响电网的稳定运行和规划。为更准确地分析电动汽车充电负荷的特性,提出一种基于改进K-Means算法的聚类分析方法。针对K-Means算法在初始聚类中心选取上的随机性和不稳定性,首先利用Mini Batch K-Means算法的随机抽样能力优化初始聚类中心的选择,随后结合K-Means算法进行迭代优化,有效解决K-Means算法聚类结果不稳定的问题。以云南某城市充电桩负荷数据进行算例分析,结果表明,所提算法相比传统方法相比能更加准确地对多个不同负荷特性的用户进行分类,从而更有效地指导有序用电管理策略的制定。

关键词： K-Means算法 Mini Batch K-Means算法负荷特性分析

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Petroleum Geological Map of Igneous Rocks in the Basins of China and Adjacent Areas

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Acta Geologica Sinica(English Edition) 2016年第S1期90卷 24-25页

作者： SHI Yongmin chen shumin WANG Lei SHI Xiang DU Shuheng School of Earth and Space Sciences Peking University Daqing oil company

There are much information such as fault structure,stratigraphic distribution and filling features,basal features and igneous rock distribution which are concealed inside the basins of China and adjacent ***

关键词： rock

The CREB Regulated Transcription Coactivator 2 Suppresses HIV-1 Transcription by Preventing RNA PolⅡfrom Binding to HIV-1 LTR

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Virologica Sinica 2021年第4期36卷 796-809页

作者： Ling Ma shumin chen Zhen Wang Saisai Guo Jianyuan Zhao Dongrong Yi Quanjie Li Zhenlong Liu Fei Guo Xiaoyu Li Pingping Jia Jiwei Ding chen Liang Shan Cen Institute of Medicinal Biotechnology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100050China Department of Blood Transfusion The Affiliated Hospital of Qingdao UniversityQingdao 266000China Lady Davis Institute Jewish General HospitalMcGill UniversityMontrealQC H3T 1E2Canada Institute of Pathogen Biology Chinese Academy of Medical Sciences and Peking Union Medical SchoolBeijing 100176China Beijing Shijitan Hospital Capital Medical UniversityBeijing 100038China CAMS Key Laboratory of Antiviral Drug Research Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing 100050China Beijing Friendship Hospital Capital Medical UniversityBeijing 100029China

The CREB-regulated transcriptional co-activators(CRTCs),including CRTC1,CRTC2 and CRTC3,enhance transcription of CREB-targeted *** addition to regulating host gene expression in response to cAMP,CRTCs also increase the infection of several *** human immunodeficiency virus type 1(HIV-1)long terminal repeat(LTR)promoter harbors a cAMP response element and activation of the cAMP pathway promotes HIV-1 transcription,it remains unknown whether CRTCs have any effect on HIV-1 transcription and HIV-1 ***,we reported that CRTC2 expression was induced by HIV-1 infection,but CRTC2 suppressed HIV-1 infection and diminished viral RNA *** studies revealed that CRTC2 inhibited transcription from HIV-1 LTR and diminished RNA PolⅡoccupancy at the LTR independent of its association with ***,CRTC2 inhibits the activation of latent ***,these data suggest that in response to HIV-1 infection,cells increase the expression of CRTC2 which inhibits HIV-1 gene expression and may play a role in driving HIV-1 into latency.

关键词： Human immunodeficiency virus(HIV) RNA polymeraseⅡ(RNA PolⅡ) Viral transcription Infection Virology CREB regulated transcription coactivator 2(CRTC2) Long terminal repeat(LTR) Latency

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中国东、西部火山岩油气藏运聚成藏机理

天然气工业 2015年第4期35卷 16-24页

作者：陈树民中国石油大庆油田有限责任公司勘探开发研究院

目前对火山岩油气藏储层形成的控制因素、油气运聚机理认识不清,现有油气勘探理论不能有效指导火山岩油气藏勘探,导致其勘探潜力被严重低估。为此,通过剖析中国东、西部典型火山岩油气藏的成盆背景、储层形成与分布、油气运聚规律等,明... 详细信息

目前对火山岩油气藏储层形成的控制因素、油气运聚机理认识不清,现有油气勘探理论不能有效指导火山岩油气藏勘探,导致其勘探潜力被严重低估。为此,通过剖析中国东、西部典型火山岩油气藏的成盆背景、储层形成与分布、油气运聚规律等,明确了中国东、西部火山岩油气藏不同的形成机制,首次提出了"相—面控储、断—壳控运、复式聚集"的火山岩油气藏运聚成藏机理,即岩性岩相界面、不整合面或火山旋回界面、期次界面控制了优质储层的发育;油源断层控制油气垂向运移,风化壳则控制油气侧向运移(火山岩油气运聚成藏过程的数值模拟实验结果表明,断裂与裂缝控制了天然气的输导通道,裂缝改善了低孔隙度、低渗透率火山岩的孔渗特征,提高了油气运移效率);火山多期次喷发,各期喷发界面(喷发间断界面、岩性岩相界面)顶部发育风化淋滤作用形成的有效孑L隙,纵向可形成多层有效储层,从而使得同一成藏背景下发育多层系、多类型火山岩油气藏。该创新性研究成果拓展了火山岩油气勘探层系和领域,丰富和完善了油气藏勘探理论。

关键词：中国东、西部火山岩运聚成藏机理风化作用溶蚀作用相-面控储断-壳控运活塞式排驱运聚复式聚集

Improved outcomes in E2A::HLF positive B-cell acute lymphoblastic leukemia by chimeric antigen receptor T cell therapy and BCL-2 inhibitor

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Chinese Medical Journal 2023年第11期136卷 1382-1384页

作者： shumin chen Ye Li Zheng Wang Lin Feng Yueping Jia Xiaodong Mo Yu Wang Qian Jiang Xiaojun Huang Yueyun Lai Peking University Institute of Hematology Peking University People’s HospitalBeijing 100044China Department of Pediatrics Peking University People’s HospitalBeijing 100044China Research Unit of Key Technique for Diagnosis and Treatments of Hematologic Malignancies Chinese Academy of Medical Sciences(2019RU029)Beijing 100044China

To the Editor:The fusion gene E2A::HLF(TCF3::HLF)is formed by t(17;19)(q21-22;p13),which presents in<1%of B-cell acute lymphoblastic leukemia(B-ALL)and mainly occurs in older children and adolescents.[1]Such patients were often accompanied by drug resistance and early relapse,which confer an extremely poor prognosis,and even intensive chemotherapy and hematopoietic stem cell transplantation(HSCT)cannot improve their survival.[2]A few studies suggested that chimeric antigen receptor T(CAR-T)cell therapy or BCL-2 inhibitors might benefit such patients.

关键词： HLF lymphoblastic acute

Broadband high-efficiency dielectric metalenses based on quasi-continuous nanostrips

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Opto-Electronic Advances 2024年第5期7卷 43-51页

作者： Xiaohu Zhang Qinmiao chen Dongliang Tang Kaifeng Liu Haimo Zhang Lintong Shi Mengyao He Yongcai Guo shumin Xiao Key Laboratory of optoelectronic Technology and Systems of the Education Ministry of China Chongqing UniversityChongqing 400044China Ministry of Industry and Information Technology Key Lab of Micro-Nano Optoelectronic Information System Guangdong Provincial Key Laboratory of Semiconductor Optoelectronic Materials and Intelligent Photonic SystemsHarbin Institute of TechnologyShenzhen 518055China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education&Hunan Provincial Key Laboratory of Low-Dimensional Structural Physics and Devices School of Physics and ElectronicsHunan UniversityChangsha 410082China

Benefiting from the abrupt phase changes within subwavelength thicknesses,metasurfaces have been widely applied for lightweight and compact optical *** broadband and high-efficiency characteristics are highly attractive for the practical implementation of ***,current metasurface devices mostly adopt discrete micro/nano structures,which rarely realize both merits *** this paper,dielectric metasurfaces composed of quasi-continuous nanostrips are proposed to overcome this *** quasi-continuous nanostrips metasurface,a normal focusing metalens and a superoscillatory lens overcoming the diffraction limit are designed and experimentally *** quasi-continuous metadevices can operate in a broadband wavelength ranging from 450 nm to 1000nm and keep a high power *** average efficiency of the fabricated metalens reaches 54.24%,showing a significant improvement compared to the previously reported metalenses with the same *** proposed methodology can be easily extended to design other metadevices with the advantages of broadband and high-efficiency in practical optical systems.

关键词： broadband high-efficiency metalens sub-diffraction quasi-continuous