检索结果-南通市图书馆

Chinese Chemical Letters 2024年第8期35卷 270-277页

作者： shulei hu Yu Zhang Xiong Xie Luhan Li Kaixian Chen Hong Liu Jiang Wang Department of Medicinal Chemistry School of PharmacyChina Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China Lingang Laboratoty Shanghai 200031China School of Life Science and Technology ShanghaiTech UniversityShanghai 200031China

Heterocycle-braced cyclic peptides have demonstrated enhanced metabolic stability,increased potency and ***,we present a rapid synthesis method for constructing Trp(C7)-alkene(E)-crosslinked cyclic peptides with potent anti-proliferative activities against cancer cells,through C-H alkenylation and *** report addresses critical challenges associated with the installation and removal of the directing group N-Piv,configuration selectivity of the olefin,and intramolecular ***-tably,this method exhibits mild reaction conditions,traceless removal of the directing group,and high configuration selectivity.

关键词： C-H functionalization Rh(Ⅲ)-catalyzed Alkenylation Cyclic peptides Macrolactamization

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

在线全文

学校读者我要写书评

暂无评论

Signal Transduction and Targeted Therapy 2024年第4期9卷 1651-1664页

作者： Xiong Xie Qiaoshuai Lan Jinyi Zhao Sulin Zhang Lu Liu Yumin Zhang Wei Xu Maolin Shao Jingjing Peng Shuai Xia Yan Zhu Keke Zhang Xianglei Zhang Ruxue Zhang jian Li Wenhao Dai Zhen Ge shulei hu Changyue Yu Jiang Wang Dakota Ma Mingyue Zheng Haitao Yang Gengfu Xiao Zihe Rao Lu Lu Leike Zhang Fang Bai Yao Zhao Shibo Jiang Hong Liu Drug Discovery and Design Center State Key Laboratory of Drug ResearchCAS Key Laboratory of Receptor ResearchShanghai Institute of Materia MedicaChinese Academy of SciencesShanghai 201203China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Medical Molecular Virology(MOE/NHC/CAMS) School of Basic Medical SciencesShanghai Institute of Infectious Disease and BiosecurityFudan UniversityShanghai 200032China Shanghai Institute for Advanced Immunochemical Studies and School of Life Science and Technology ShanghaiTech UniversityShanghai 201210China State Key Laboratory of Virology Wuhan Institute of VirologyCenter for Biosafety Mega-ScienceChinese Academy of SciencesWuhan 430071China School of Chinese Materia Medica Nanjing University of Chinese Medicine138 Xian Lin RoadJiangsu 210023 NanjingChina School of Pharmaceutical Science and Technology Hangzhou Institute for Advanced StudyUCASHangzhou 310024China National Clinical Research Center for Infectious Disease Shenzhen Third People's HospitalShenzhen 518112China

Respiratory disease caused by coronavirus infection remains a global health *** several SARS-CoV-2-specific vaccines and direct-acting antivirals are available,their effcacy on emerging coronaviruses in the future,including SARS-CoV-2 variants,might be ***-targeting antivirals provide preventive and therapeutic strategies to overcome resistance and manage future outbreak of emerging *** L(CTSL)and calpain-1(CAPN1)are host cysteine proteases which play crucial roles in coronaviral entrance into cells and infection-related immune ***,two peptidomimetic a-ketoamide compounds,14a and 14b,were identified as potent dual target inhibitors against CTSL and *** X-ray crystal structures of human CTSL and CAPN1 in complex with 14a and 14b revealed the covalent binding of a-ketoamide groups of 14a and 14b to C25 of CTSL and C115 of *** showed potent and broad-spectrum anticoronaviral activities in vitro,and it is worth noting that they exhibited low nanomolar potency against SARS-CoV-2 and its variants of concern(VOCs)with ECso values ranging from 0.80 to 161.7 nM in various *** mechanistic exploration indicated that they exhibited anticoronaviral activity through blocking viral ***,14a and 14b exhibited good oral pharmacokinetic properties in mice,rats and dogs,and favorable safety in *** addition,both 14a and 14b treatments demonstrated potent antiviral potency against SARS-CoV-2 XBB 1.16 variant infection in a K18-hACE2 transgenic mouse *** 14b also showed effective antiviral activity against HCoV-OC43 infection in a mouse model with a final survival rate of 60%.Further evaluation showed that 14a and 14b exhibited excellent antiinflammatory effects in Raw 264.7 mouse macrophages and in mice with acute *** together,these results suggested that 14a and 14b are promising drug candidates,providing novel insight into developing pan-coronavirus inhibitors with anti

关键词： calpain overcome entrance

Identifying the origin of porous evolution of microsized bismuth in potassium-ion batteries

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第7期67卷 2234-2239页

作者： Shenxu Chu Kaixiang Lei Qian Yang Jiaxin Li Yuqing Zhao Mengjia Gu Lin Li Xing hu Yu Zhang Zhuo Chen Shuo Shi shulei Chou Shijian Zheng Tianjin Key Laboratory of Materials Laminating Fabrication and Interface Control Technology School of Materials Science and EngineeringHebei University of TechnologyTianjin 300401China Institute for Carbon Neutralization Technology College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Microsized bismuth(Bi)with in-situ constructed three-dimensional(3D)porous network has been considered as a promising anode for high-performance potassium-ion batteries(PIBs).However,the mechanism of the in-situ porous evolution of microsized Bi during the charge/discharge process is still ***,various electrolytes are employed to disclose the origin of porous evolution of microsized Bi in *** and theoretically,the 3D porous network originates from the uniform interfacial charge distribution on the Bi surface in the linear ether-based *** addition,the universality of the interfacial charge distribution mechanism was verified by microsized Sn and *** in-situ constructed 3D porous network of Bi enables a superior potassium storage performance in a wide temperature range from-40 to 40℃.More importantly,the K_(0.9)Mn_(0.7)Ni_(0.3)O_(2)||Bi full cell delivers excellent cycling stability(a high capacity retention of 88.44%even after 2,000 cycles)and good temperature *** work gives a distinct clarification of the origin of the porous evolution of microsized Bi during cycling,which is critical for developing high-performance PIBs.

关键词： potassium-ion batteries microsized Bi porous evolution linear ether-based electrolyte interfacial charge distribution

在线全文

学校读者我要写书评

暂无评论

新自由主义与全球南方国家的过早去工业化

文化纵横 2023年第2期 28-37页

作者：秦北辰胡舒蕾清华大学国际与地区研究院

如何使全球南方国家的经济发展追赶上北方国家,改变全球经济南北发展不平衡的局面,是当代世界经济治理需要直面的重要议题。一国若想实现经济的持续增长,需要实现资源从低生产率活动到高生产率活动的不断转移。在这一过程中,制造业因其... 详细信息

如何使全球南方国家的经济发展追赶上北方国家,改变全球经济南北发展不平衡的局面,是当代世界经济治理需要直面的重要议题。一国若想实现经济的持续增长,需要实现资源从低生产率活动到高生产率活动的不断转移。在这一过程中,制造业因其对关联产业与劳动就业的拉动,有着难以被替代的重要作用。

关键词：全球南方去工业化新自由主义

远红外高光谱遥感技术及其冰云遥感应用(特邀)

同方期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

光学学报 2024年第6期44卷 12-23页

作者：刘磊李书磊胡帅曾庆伟国防科技大学气象海洋学院湖南长沙410073 中国气象局高影响天气重点开放实验室湖南长沙410073

回顾和总结了远红外高光谱大气遥感的理论基础,从大气吸收和冰晶粒子散射敏感性的角度介绍了远红外高光谱遥感冰云参数的优势。对远红外高光谱大气遥感仪器的发展脉络进行了梳理和总结,重点对相关仪器的参数及关键技术问题进行了讨论。... 详细信息

回顾和总结了远红外高光谱大气遥感的理论基础,从大气吸收和冰晶粒子散射敏感性的角度介绍了远红外高光谱遥感冰云参数的优势。对远红外高光谱大气遥感仪器的发展脉络进行了梳理和总结,重点对相关仪器的参数及关键技术问题进行了讨论。概述了远红外高光谱冰云特性遥感的主要方法,展望了远红外高光谱技术未来在冰云探测中的应用潜力,并提出了研究思路与方案,以为后续远红外高光谱大气遥感技术研究提供一定的参考。

关键词：遥感远红外高光谱冰云

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

光声层析重建飞秒光丝二维横向图像仿真研究

光学学报 2024年第12期44卷 101-111页

作者：曾庆伟刘磊胡帅李书磊赵世军国防科技大学气象海洋学院湖南长沙410073 中国气象局高影响天气重点开放实验室湖南长沙410073

准确获取飞秒激光成丝横截面图像及其沉积能量空间分布信息,对于成丝动力机制研究和促进诸多基于光丝的实际大气应用发展具有重要意义。本文基于热传导方程和波动方程构成的光声信号前向仿真模型,理论模拟了利用环阵式光声层析系统接收... 详细信息

准确获取飞秒激光成丝横截面图像及其沉积能量空间分布信息,对于成丝动力机制研究和促进诸多基于光丝的实际大气应用发展具有重要意义。本文基于热传导方程和波动方程构成的光声信号前向仿真模型,理论模拟了利用环阵式光声层析系统接收飞秒激光在空气介质中成丝诱导产生超声脉冲信号的过程;然后,利用延迟叠加算法对飞秒激光大气传输成丝沉积能量横向分布图像进行了反向重建,并分析了测量系统中关键器件超声换能器的中心频率、带宽、表面尺寸和探测表面灵敏度等性能参数对光丝沉积能量分布图像重建结果的影响。结果表明,单丝诱导产生的声压脉冲信号频谱为单峰结构,而多丝声压脉冲信号频谱为多峰结构;相比于单丝图像重建,多丝图像重建受“孔径效应”影响更显著;换能器的性能参数对光丝图像的重建效果有显著的影响,换能器的带宽越大、表面直径越小,以及表面灵敏度系数越大,越有利于光丝沉积能量分布图像重建效果的提升。该研究结果可为真实大气条件下飞秒激光传输成丝沉积能量空间分布的实验测量提供一定的理论支撑。

关键词：飞秒激光激光成丝能量沉积光声信号超声换能器反投影

Delay-constrained sleeping mechanism for energy saving in cache-aided ultra-dense network

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2019年第8期62卷 131-144页

作者： Pei LI shulei GONG Shen GAO Yaoyue hu Zhiwen PAN Xiaohu YOU National Mobile Communications Research Laboratory Southeast University Institute of Space-Terrestrial Intelligent Networks School of Electronic Science and EngineeringNanjing University China Mobile Group Jiangsu Co. Ltd.

We investigate an energy-saving sleeping mechanism in a cache-aided ultra-dense network(UDN)with delay constraints. As in existing works, we consider the video and file contents of the UDN. The video contents are cached at and delivered by a small-cell base-station(sBS). The cache-aided sBS cooperates with a macro-cell base-station(mBS) to service the file contents. The optimal sleeping strategy that conserves energy under the delay constraint is formulated as an energy-consumption minimization problem under the network stability condition with a guaranteed delay constraint. To find its solution, the minimization problem is transformed into a joint optimization problem of energy consumption and delay by the Lyapunov technique.A delay-constrained sleeping algorithm is proposed, and its effectiveness is confirmed by the numerical results of a simulation study. A tradeoff between energy consumption and delay, achieved by adjusting the weighting factor in the cache-aided UDN, is also demonstrated.

关键词： ultra-dense networks sleeping mechanism mean delay caching strategy energy saving

Bifunctional carbon-based cathode catalysts for zinc-air battery: A review

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第2期33卷 683-692页

作者： huimin Liu Qinglei Liu Yarong Wang Yongfei Wang shulei Chou Zhizhi hu Zhiqiang Zhang Key Laboratory for Functional Material School of Chemical Engineering University of Science and Technology LiaoningAnshan 114051China School of Materials and Metallurgy University of Science and Technology LiaoningAnshan 114051China Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhou 325035China

Efficient bifunctional OER/ORR catalysts are crucial for the further development of zinc-air battery. From a sustainable point of view, it is important that electrocatalysts are efficient, low cost, and composed of abundant resources instead of scarce metals. Due to their good conductivity, low cost, and strong durability, carbon-based materials are considered a promising alternative in the field of commercial zinc-air battery catalysts. Herein, we briefly introduce the zinc-air battery and then summarize recent progress in the development of carbon-based bifunctional catalysts by defect engineering, heteroatom doping and metal doping. Finally, we discuss the main challenges and prospects for the future development of carbon-based bifunctional oxygen catalysts.

关键词： Carbon materials Defect Doping Oxygen evolution reaction Oxygen reduction reaction Zinc-air battery

Atomic-level insight of sulfidation-engineered Aurivillius-related Bi_(2)O_(2)SiO_(3) nanosheets enabling visible light low-concentration CO_(2) conversion

在线全文

学校读者我要写书评

暂无评论

Carbon Energy 2023年第2期5卷 1-11页

作者： Kai Wang Yue Du Yuan Li Xiaoyong Wu Haiyan hu Guohong Wang Yao Xiao shulei Chou Gaoke Zhang College of Urban and Environmental Sciences Hubei Key Laboratory of Pollutant Analysis and Reuse TechnologyInstitute for Advanced MaterialsHubei Normal UniversityHuangshiHubeiChina School of Resources and Environmental Engineering Wuhan University of TechnologyWuhanHubeiChina Institute for Carbon Neutralization College of Chemistry and Materials EngineeringWenzhou UniversityWenzhouZhejiangChina

Unraveling atomic-level active sites of layered photocatalyst towards lowconcentration CO_(2) conversion is still ***,the yield and selectivity of photocatalytic CO_(2) reduction of the Aurivillius-related oxide semiconductor Bi_(2)O_(2)SiO_(3) nanosheet(BOSO)were largely improved using a surface sulfidation *** experiment and theoretical calculation confirmed that surface sulfidation of the Bi_(2)O_(2)SiO_(3) nanosheet(S-BOSO,6.28 nm)redistributed the charge-enriched Bi sites,extended the solar spectrum absorption to the whole visible range,and considerably enhanced the charge separation,in addition to creating new reaction active sites,as compared to pristine ***,surface sulfidation played a switchable role,wherein S-BOSO showed a very high CH_(3)OH generation rate(12.78μmol g^(-1) for 4 h,78.6%selectivity)from low-concentration CO_(2)(1000 ppm)under visible light irradiation,which outperforms most of the state-of-the-art photocatalysts under similar *** study presents an atomic-level modification protocol for engineering reactive sites and charge behaviors to promote solar-to-energy conversion.

关键词： [Bi_(2)O_(2)]^(2)+layer Bi_(2)O_(2)SiO_(3) low-concentration CO_(2)reduction photocatalysis sulfidation

Plant drought tolerance trait is the key parameter in improving the modeling of terrestrial transpiration in arid and semi-arid regions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Atmospheric and Oceanic Science Letters 2022年第1期15卷 35-41页

作者： Xintao Liu Xingjie Lu shulei Zhang Zhongwang Wei Nan Wei Shupeng Zhang hua Yuan Wei Shangguan Shaofeng Liu Jianfeng huang Lu Li Xiulan Ye Jinxuan Zhou Wenke hu Yongjiu Dai Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Guangdong Province Key Laboratory for Climate Change and Natural Disaster StudiesSchool of Atmospheric SciencesSun Yat‐sen UniversityGuangzhouChina

The prediction of precipitation depends on accurate modeling of terrestrial *** recent decades,the trait-based plant hydraulic stress scheme has been developed in land surface models,in order to better predict the hydraulic constraint on terrestrial ***,the role that each plant functional trait plays in the modeling of transpiration remains *** importance of different plant functional traits for modeled transpiration needs to be ***,the Morris sensitivity analysis method was implemented in the Common Land Model with the plant hydraulic stress scheme(CoLM-P_(50)HS).Traits related to drought tolerance(P_(50);),stomata,and photosynthesis were screened as the most critical from all 17 plant *** 12 FLUXNET sites,the importance of P_(50);,measured by normalized sensitivity scores,increased towards lower precipitation,whereas the importance of stomatal traits and photosynthetic traits decreased towards drier climate conditions.P_(50);was more important than stomatal traits and photosynthetic traits in arid or semi-arid sites,which implies that hydraulic safety strategies are more crucial than plant growth strategies when plants frequently experience *** variation in drought tolerance traits further proved the coexistence of multiple plant strategies of hydraulic *** the variation in drought tolerance traits may potentially bias the modeling of *** measurements of drought tolerance traits are therefore necessary to help better represent the diversity of plant hydraulic functions.

关键词： Transpiration Land surface process model Sensitivity analysis Plant hydraulic stress scheme Plant traits