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IQ67 DOMAIN protein 21 is critical for indentation formation in pavement cell morphogenesis

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Journal of Integrative Plant Biology 2023年第3期65卷 721-738页

作者： Xinhua Feng shujuan pan Haifu Tu Junjie Huang Chuanlei Xiao Xin Shen Lei You Xinyan Zhao Yongqiang Chen Danyun Xu Xiaolu Qu Honghong Hu National Key Laboratory of Crop Genetic Improvement Hubei Hongshan LaboratoryHuazhong Agricultural UniversityWuhan 430070China Frontier Science Center for Immunology and Metabolism Medical Research InstituteWuhan UniversityWuhan 430070China Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 201602China Key Laboratory of Horticultural Plant Biology(MOE) College of Horticulture and Forestry SciencesHuazhong Agricultural UniversityWuhan 430070China

In plants, cortical microtubules anchor to the plasma membrane in arrays and play important roles in cell shape. However, the molecular mechanism of microtubule binding proteins, which connect the plasma membrane and cortical microtubules in cell morphology remains largely unknown. Here, we report that a plasma membrane and microtubule duallocalized IQ67 domain protein, IQD21, is critical for cotyledon pavement cell(PC) morphogenesis in Arabidopsis. iqd21 mutation caused increased indentation width, decreased lobe length, and similar lobe number of PCs, whereas IQD21 overexpression had a different effect on cotyledon PC shape. Weak overexpression led to increased lobe number, decreased indentation width, and similar lobe length, while moderate or great overexpression resulted in decreased lobe number, indentation width, and lobe length of PCs. Live-cell observations revealed that IQD21 accumulation at indentation regions correlates with lobe initiation and outgrowth during PC development. Cell biological and genetic approaches revealed that IQD21 promotes transfacial microtubules anchoring to the plasma membrane via its polybasic sites and bundling at the indentation regions in both periclinal and anticlinal walls. IQD21 controls cortical microtubule organization mainly through promoting Katanin 1-mediated microtubule severing during PC interdigitation. These findings provide the genetic evidence that transfacial microtubule arrays play a determinant role in lobe formation, and the insight into the molecular mechanism of IQD21 in transfacial microtubule organization at indentations and puzzle-shaped PC development.

关键词： IQD21 KTN1 lobe outgrowth pavement cell interdigitation transfacial microtubules

FT3/FT4和一碳单位代谢物与重度精神疾病代谢综合征相关性的研究

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中华预防医学杂志 2024年第3期58卷 298-305页

作者：王晓宇谭云龙潘淑娟北京回龙观医院医学检验中心北京大学回龙观临床医学院北京100096 北京回龙观医院院办公室北京大学回龙观临床医学院北京100096

目的:探讨游离三碘甲状腺原氨酸/游离甲状腺素(FT3/FT4)和一碳单位代谢物对重度精神疾病(SMI)患者代谢综合征(MetS)的影响。方法:采用回顾性病例对照研究,选取2022年1月至2023年8月在北京回龙观医院住院治疗的328例SMI患者作为研究对象... 详细信息

目的:探讨游离三碘甲状腺原氨酸/游离甲状腺素(FT3/FT4)和一碳单位代谢物对重度精神疾病(SMI)患者代谢综合征(MetS)的影响。方法:采用回顾性病例对照研究,选取2022年1月至2023年8月在北京回龙观医院住院治疗的328例SMI患者作为研究对象,包括精神分裂症(SZ)180例、双相情感障碍(BD)74例、重度抑郁症(MDD)74例,另选取同期74名健康体检者作为对照组,比较两组甲状腺激素和一碳单位代谢物[叶酸,维生素B12(VitB12)和同型半胱氨酸(HCY)]水平。同时收集SMI患者临床资料及MetS相关信息,分别采用偏相关分析、logistic回归分析研究FT3/FT4和一碳单位代谢物与SMI患者MetS危险因素及胰岛素抵抗的关系。结果:SMI患者中SZ、BD、MDD三组之间性别、年龄、病程、吸烟率、体重指数(BMI)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)/HDL-C、低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)、抗精神病药物使用率、情绪稳定剂使用率、抗抑郁药物使用率、降糖治疗比较,差异具有统计学意义( P均<0.05);与对照组比较,SMI患者FT3/FT4,叶酸和VitB12明显降低( Z=-4.315, P<0.001;Z=-8.216, P<0.001;Z=-6.021, P<0.001),而HCY明显增高( Z=-8.789, P<0.001);偏相关分析显示SMI患者FT3/FT4与TG( r=0.303, P<0.001)、TG/HDL-C( r=0.228, P<0.001)、胰岛素抵抗指数(HOMA-IR)( r=0.204, P<0.001)、甘油三酯葡萄糖乘积指数(TyG)( r=0.284, P<0.001)、甘油三酯葡萄糖体重指数(TyG-BMI)( r=0.211, P<0.001)、BMI( r=0.154, P=0.005)呈正相关,与胰岛素敏感指数(QUICKI)( r=-0.205, P<0.001)呈负相关。VitB12与HDL-C( r=0.144, P=0.009)、QUICKI( r=0.115, P=0.038)呈正相关,与TyG-BMI( r=-0.122, P=0.028)、BMI( r=-0.127, P=0.022)呈负相关。HCY与TyG( r=0.114, P=0.039)、TyG-BMI( r=0.188, P=0.001)呈正相关;多元有序logistic回归分析显示吸烟( OR=1.602,95% CI=1.004~2.558),女性( OR=1.736,95% CI=1.041~2.895),FT3/FT4( OR=17.811,95% CI=1.596~198.764),HCY( OR=1.026,95% CI=1.009~1.043)和BD( OR=2.150,95% CI=1.092~4.232)是SMI患者MetS危险因素数量影响因素,而VitB12( OR=0.997,95% CI=0.995~0.998)是保护因素;二元logistic回归分析显示长病程( OR=1.024,95% CI=1.008~1.041)和高水平HCY( OR=1.033,95% CI=1.014~1.052)的SMI患者更有可能出现MetS。结论:动态监测FT3/FT4和一碳单位代谢物水平有助于识别SMI患者MetS风险,为预防及治疗提供参考依据。

关键词：甲状腺激素同型半胱氨酸精神障碍代谢综合征胰岛素抵抗

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耳甲腔毛母细胞瘤1例并文献复习

临床耳鼻咽喉头颈外科杂志 2024年第5期38卷 448-452页

作者：李雪雪卫旭东李淑娟王倩茹潘鑫兰州大学第一临床医学院兰州730000 甘肃省人民医院耳鼻咽喉头颈外科甘肃中医药大学

毛母细胞瘤(trichoblastoma,TB)是一种罕见的毛发生殖细胞皮肤附件肿瘤,罕见的皮肤滤泡肿瘤,分化于毛胚上皮,常被视为良性皮肤肿瘤,但局限性差且具有局部浸润性生长模式。TB好发于头部和颈部区域,尤其是面部,临床表现为生长缓慢、边界... 详细信息

毛母细胞瘤(trichoblastoma,TB)是一种罕见的毛发生殖细胞皮肤附件肿瘤,罕见的皮肤滤泡肿瘤,分化于毛胚上皮,常被视为良性皮肤肿瘤,但局限性差且具有局部浸润性生长模式。TB好发于头部和颈部区域,尤其是面部,临床表现为生长缓慢、边界清晰及隆起的结节。TB常规以手术治疗为主,由于目前缺乏普遍接受的治疗指南或方案,术后复发率高,为临床治愈增加了一定的难度。本研究报道1例65岁女性患者,发现右侧外耳道口及耳甲腔肿物并反复破溃流脓,最初误诊为外耳道炎,以常规抗感染治疗,症状未缓解并逐渐加重后来我院就诊。该病例所展现的病症极为罕见,因此,及时且准确的诊断与治疗对此类疫病的诊疗和预后至关重要。

关键词：毛母细胞瘤毛源性肿瘤耳甲腔良性肿瘤诊断治疗

社区老年糖尿病患者自我忽视的诠释性现象学研究

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中华护理杂志 2024年第2期59卷 203-209页

作者：骆雅萍于淑娟朱苗苗潘红英浙江大学医学院杭州市310016 杭州市上城区望江街道社区卫生服务中心浙江大学医学院附属邵逸夫医院护理部

目的探索社区老年糖尿病患者自我忽视的体验和原因,为社区护理人员识别和干预老年糖尿病患者自我忽视行为提供参考。方法采用诠释性现象学方法,通过目的抽样,2023年3月—5月,选取浙江省杭州市3个社区卫生服务中心登记的老年糖尿病患者... 详细信息

目的探索社区老年糖尿病患者自我忽视的体验和原因,为社区护理人员识别和干预老年糖尿病患者自我忽视行为提供参考。方法采用诠释性现象学方法,通过目的抽样,2023年3月—5月,选取浙江省杭州市3个社区卫生服务中心登记的老年糖尿病患者进行半结构式访谈,采用Van Manen方法分析质性资料。结果社区老年糖尿病患者自我忽视的体验共归纳为4个主题和10个亚主题,包括忽视个人健康(自我价值感较低、自尊水平过高、担心拖累家庭),忽视血糖管理(健康意识薄弱、血糖管理困难),自我照护能力不足(经济状况不佳、个人时间有限、活动能力减弱)和支持感知不足(社会支持较低、情感支持不足)。结论社区老年糖尿病患者自我忽视的体验和原因是多元化的,社区卫生服务机构及护理人员需重视老年糖尿病患者自我忽视行为的表现,并积极探索有效的防治措施。

关键词：自我忽视糖尿病老年护理社区护理质性研究

以LiB_(3)O_(5)为模板设计深紫外零级波片材料

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Science China Materials 2024年第3期67卷 914-920页

作者：张志远徐蝶 Abudukadi Tudi 杨志华韩树娟潘世烈 Research Center for Crystal Materials State Key Laboratory of Functional Materials and Devices for Special Environmental ConditionsXinjiang Key Laboratory of Functional Crystal MaterialsXinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing 100049China

以著名的LiB_(3)O_(5)为模板,通过增强其结构中B_(2)O_(5)的夹角使双折射更小,在封闭体系中通过高温溶液法获得了两种新的用于制造零级波片的双折射晶体Li_(2)MLaB_(18)O_(30)(M=Rb,Cs).有趣的是,相邻的B_(2)O_(5)接近垂直排列,使得它... 详细信息

以著名的LiB_(3)O_(5)为模板,通过增强其结构中B_(2)O_(5)的夹角使双折射更小,在封闭体系中通过高温溶液法获得了两种新的用于制造零级波片的双折射晶体Li_(2)MLaB_(18)O_(30)(M=Rb,Cs).有趣的是,相邻的B_(2)O_(5)接近垂直排列,使得它们表现出比商用石英晶体(Δn~0.0092在可见光区域)小得多的双折射率(分别为0.0032@532 nm和0.0027@532 nm).此外,Li_(2)MLaB_(18)O_(30)(M=Rb,Cs)晶体的紫外截止边均低于200 nm,表明它们可用作深紫外区域的零级波片材料.

关键词： tiny birefringence zero-order waveplate deep-ultraviolet region angle of B_(2)O_(5)

An excellent deep-ultraviolet birefringent material based on[BO2]∞ infinite chains

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Light(Science & Applications) 2022年第9期11卷 2217-2224页

作者： FANGFANG ZHANG XINGLONG CHEN MIN ZHANG WENQI JIN shujuan HAN ZHIHUA YANG SHILIE pan Research Center for Crystal Materials CAS Key Laboratory of Functional Materials and Devices for Special EnvironmentsXinjiang Technical Institute of Physics and ChemistryCAS40-1 South Beijing RoadUrumqi 830011China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences100049 BeijingChina

Birefringent materials play indispensable roles in modulating the polarization of light and are vital in the laser science and technology.Currently,the design of birefringent materials operating in the deep-ultraviolet region(DUV,λ≤200 nm)is still a great challenge.In this work,we developed a new DUV birefringent crystal LiBO_(2) based on[BO2]∞infinite chains in the Li-B-O system,which simultaneously achieves the shortest UV cutoff edge(164 nm)and the largest birefringence(≥0.168 at 266 nm)among all the reported borate-based DUV birefringent materials.Single crystals of LiBO_(2) with dimensions up to Ø55×34 mm^(3) were grown by the Czochralski method,providing access to large-sized single crystal with low cost.Moreover,it has a high laser damage threshold and stable physicochemical properties.These outstanding characters unambiguously support that LiBO_(2) can be an excellent birefringent material for DUV application.

关键词： birefringent polarization ultraviolet

基于医院药师核心能力的实习生培训课程体系的构建

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中国医院药学杂志 2024年第2期44卷 221-226页

作者：陈哲孟艳莎郝洁潘豹张哲王淑娟王宇辉杜书章郑州大学第一附属医院药学部河南郑州450052

目的:构建基于医院药师核心能力的药学实习生培训课程体系,为规范今后药学生实习带教工作提供参考。方法:结合文献调研和质性研究,拟定基于医院药师核心能力的实习生培训课程体系指标池。再采用德尔菲专家函询法进行验证,并运用优序图... 详细信息

目的:构建基于医院药师核心能力的药学实习生培训课程体系,为规范今后药学生实习带教工作提供参考。方法:结合文献调研和质性研究,拟定基于医院药师核心能力的实习生培训课程体系指标池。再采用德尔菲专家函询法进行验证,并运用优序图法确定各指标权重。结果:最终制定的实习生培训课程体系包括三部分,培训主题及培训目标9项、培训内容21项、培训方式及考核方式9项。参与本研究德尔菲法函询的专家共21人,两轮问卷的回收率均为100%,两轮专家函询的权威系数分别为0.80和0.78,各指标的肯德尔协调系数为0.368~0.639,χ^(2)检验P值均小于0.05,具有显著性,专家咨询的协调程度较好。结论:该研究构建的基于医院药师核心能力的实习生培训课程体系内容全面、方法科学、结果可靠,可保障药学实习生带教的培训质量。

关键词：医院药师核心能力实习生课程体系质性研究德尔菲法

A settling curve modeling method for quantitative description of the dispersion stability of carbon nanotubes in aquatic environments

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Journal of Environmental Sciences 2015年第3期27卷 1-10页

作者： Lixia Zhou Dunxue Zhu shujuan Zhang Bingcai pan State Key Laboratory of Pollution Control and Resource Reuse School of the Environment Nanjing University

Understanding the aggregation and deposition behavior of carbon nanotubes （CNTs） is of great significance in terms of their fate and transport in the environment. Attachment efficiency is a widely used index for well-dispersed CNT solutions. However, in natural waters, CNTs are usually heterogeneous in particle size. The attachment efficiency method is not applicable to such systems. Describing the dispersion stability of CNTs in natural aquatic systems is still a challenge. In this work, a settling curve modeling （SCM） method was developed for the description of the aggregation and deposition behavior of CNTs in aqueous solutions. The effects of water chemistry （natural organic matter, pH, and ionic strength） on the aggregation and deposition behavior of pristine and surface-functionalized multi-walled carbon nanotubes （MWCNTs） were systematically studied to evaluate the reliability of the SCM method. The results showed that, as compared to particle size and optical density, the centrifugal sedimentation rate constant （ks） from the settling curve profile is a practical, useful and reliable index for the description of heterogeneous CNT suspensions. The SCM method was successfully applied to MWCNT in three natural waters. The constituents in water, especially organic matter, determine the dispersion stability of MWCNTs in natural water bodies.

关键词： Settling curveCarbon nanotubesHeterogeneousCentrifugal sedimentationrate constant

Application potential of carbon nanotubes in water treatment:A review

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Journal of Environmental Sciences 2013年第7期25卷 1263-1280页

作者： Xitong Liu Mengshu Wang shujuan Zhang Bingcai pan State Key Laboratory of Pollution Control and Resource Reuse School of the EnvironmentNanjing University

Water treatment is the key to coping with the conflict between people＇s increasing demand for water and the world-wide water shortage. Owing to their unique and tunable structural, physical, and chemical properties, carbon nanotubes （CNTs） have exhibited great potentials in water treatment. This review makes an attempt to provide an overview of potential solutions to various environmental challenges by using CNTs as adsorbents, catalysts or catalyst support, membranes, and electrodes. The merits of incorporating CNT to conventional water-treatment material are emphasized, and the remaining challenges are discussed.

关键词： carbon nanotube adsorption catalysis membrane water treatment