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DISLOCATION EMISSION AND EQUATION OF ENERGY BARRIERS AT MODEL I CRACK TIP

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Transactions of Nonferrous Metals Society of China 1996年第1期6卷 72-76页

作者： Zou Hongcheng Dai shujuan Liu Furong hu Xiangyang Li Changchun National Laboratory of Plastic Forming Simulation and Die&Mould Technology huazhong University of Science and Technology Wuhan 430074

The propagation for the model I crack in aluminum single crystal has been directly studied by in-situ TEM *** equation of energy barrier of the dislocation building-up and emission at the model I crack tip has been established by means of Peierls-Nabarro dislocation model and starting from angle of *** means of calculation,the critical value of spontaneous emission of the dislocations from tip of the model I crack was obtained.

关键词： emission of dislocation propagation of crack Peierls-Nabarro dislocation model energy barriers model I crack

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水热法制备氧化铝多孔陶瓷材料

中国陶瓷工业 2019年第4期26卷 1-4页

作者：胡淑娟 Faizan Haseeb ASLAM Md Eddris ALI Bisrat Kidane GEBREMESKEL 张跃梧州学院机械与材料工程学院广西梧州543002 北京航空航天大学材料科学与工程学院北京100191

采用胶态成型工艺,以氧化铝粉体为原料,以聚二甲基二烯丙基氯化铵为分散剂,酸性铝溶胶为粘结剂,制备出多孔氧化铝素坯,并对其加以水热处理,以增强其力学性能.研究了分散剂添加量对浆料流变性的影响,溶胶的浓度及水热时间对多孔陶瓷微观... 详细信息

采用胶态成型工艺,以氧化铝粉体为原料,以聚二甲基二烯丙基氯化铵为分散剂,酸性铝溶胶为粘结剂,制备出多孔氧化铝素坯,并对其加以水热处理,以增强其力学性能.研究了分散剂添加量对浆料流变性的影响,溶胶的浓度及水热时间对多孔陶瓷微观结构、力学性能的影响.研究结果表明:分散剂的添加量为0.3 wt.%时,浆料的粘度最低;通过控制溶胶浓度及水热时间可制备出气孔率为57.59%,抗压强度为13.54 MPa的孔隙结构均匀的氧化铝多孔陶瓷材料.

关键词：多孔陶瓷水热法氧化铝溶胶气孔率

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高压耐油胶管的技术现状

橡胶科技 2024年第6期22卷 305-309页

作者：王万程赵志超武淑娟杨海龙张志强胡育林钟启林中国石油石油化工研究院兰州研究中心甘肃兰州730060 中国石油兰州石化公司甘肃兰州730060

介绍高压耐油胶管的技术现状,综述高压耐油胶管的结构、橡胶原材料、配方设计、生产工艺方面的现状及研究进展,分析各胶种在高压耐油胶管中应用的性能特点。我国需要从胶管基础材料、配方设计、生产工艺、胶管总成等上下游全产业链进行... 详细信息

介绍高压耐油胶管的技术现状,综述高压耐油胶管的结构、橡胶原材料、配方设计、生产工艺方面的现状及研究进展,分析各胶种在高压耐油胶管中应用的性能特点。我国需要从胶管基础材料、配方设计、生产工艺、胶管总成等上下游全产业链进行技术升级,尤其是基础材料需要加快国产化进程,使得高压耐油胶管达到耐超高压、耐百万次动态脉冲疲劳和耐频繁屈挠的高性能要求。

关键词：高压耐油胶管钢丝增强胶管橡胶配方设计生产工艺

The Inhibitory Effects of PSS-Loaded Nanoparticles on the Dysfunction of Cardiac Microvascular Endothelia in Rats with Diabetic Cardiomyopathy

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Journal of Ocean University of China 2019年第1期18卷 253-259页

作者： AN Nina YU Luyan hu Yi FENG Wenjing SHI shujuan CHEN Honghua MAO Yongjun Department of Geriatrics the Affiliated Hospital of Qingdao University

Propylene glycol alginate sodium sulfate-loaded nanoparticles(PSS-NP) has been shown potential to prevent the microvascular endothelial injuries caused by diabetic cardiomyopathy(DCM). In this study, we aimed to investigate the effects of PSS-NP on the dysfunction of cardiac microvascular endothelia in streptozotocin(STZ)-induced DCM rat model. Echocardiographic measurements showed a significant improvement of cardiac function in the PSS-NP-treated group. Our results revealed that the abnormalities of cardiac systolic and diastolic functions were suppressed by the treatments of prostaglandin E1(PGE1), low molecular weight heparin(LMWH), PSS and PSS-NP. Our comparison analysis indicated that PSS-NP showed the strongest inhibitory effects on microvascular endothelial injuries. Transmission electron microscopy analysis demonstrated that PSS-NP protected the cardiac microvascular endothelium and further improved endothelium dysfunction in DCM rats. ELISA and Western blot assays further showed a high efficiency of improving cardiac microvascular endothelial dysfunction with PSS-NP. Our results demonstrated that PSS-NP increased the protein expression of phosphatidylinositol 3-kinase(PI3K)-p85 and vascular endothelial growth factor(VEGF)-A, and the phosphorylation of protein kinase B(Akt) and endothelial nitric oxide synthase(eNOS), which were involved in the amelioration of cardiac microvascular endothelial dysfunction. These data suggest that PSS-NP may be a novel approach to the treatment the coronary microcirculation disorder diseases such as DCM.

关键词： PSS-loaded nanoparticles marine drug DCM microvascular endothelial dysfunction

六味地黄汤对IgA肾病大鼠α-SMA及FN表达的影响

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湖南中医药大学学报 2015年第11期35卷 22-26页

作者：彭亚军李旭华何泽云廖春来何雅琴胡淑娟湖南中医药大学第一附属医院湖南长沙410007 湖南中医药大学湖南长沙410208

目的观察六味地黄汤对IgA肾病大鼠α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)及纤维连接蛋白(fibronectin,FN)表达的影响,进一步探讨其可能作用机制。方法 SD大鼠40只随机分为正常对照组、模型组、雷公藤多苷片组,六味地黄汤组... 详细信息

目的观察六味地黄汤对IgA肾病大鼠α-平滑肌肌动蛋白(α-smooth muscle actin,α-SMA)及纤维连接蛋白(fibronectin,FN)表达的影响,进一步探讨其可能作用机制。方法 SD大鼠40只随机分为正常对照组、模型组、雷公藤多苷片组,六味地黄汤组。除正常对照组外均采用牛血清白蛋白+脂多糖+四氯化碳方法建立实验性IgA肾病模型。造模成功后分组干预连续灌胃4周,分别在每周末检测尿蛋白定量及尿红细胞计数,第4周末处死各组大鼠,进行肾功能检测。采用免疫组化、Western blot检测各组α-SMA及FN蛋白表达,进行半定量分析。结果各组尿蛋白定量及尿红细胞计数比较,模型组较正常组显著升高(P<0.05),而六味地黄汤组与模型组比较显著降低(P<0.05),差异有统计学意义;各组α-SMA和FN表达,模型组较正常组表达显著升高(P<0.05),而六味地黄汤组较模型组表达下降,(P<0.05)差异有统计学意义。结论六味地黄汤可减少IgA肾病大鼠尿蛋白及尿红细胞数,改善其肾功能,可能与通过下调α-SMA及FN表达相关。

关键词： IgA肾病六味地黄汤 α-平滑肌肌动蛋白纤维连接蛋白

面向“大工程”的材料现代研究方法专业基础课程教学改革

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中国冶金教育 2021年第5期26卷 66-68页

作者：王哲英莫瀚宁刘莹冯静孙家兴胡淑娟曹宇程汉池梧州学院机械与材料工程学院广西梧州543002

随着工程项目复杂程度的不断提高,出现了大量多学科交融的复杂工程问题,社会对高层次工程应用型人才的需求日益高涨。为使专业基础类课程教育回归大工程教育的本来涵义,有必要研究教育教学方法。以机械与材料工程专业的重要专业基础类... 详细信息

随着工程项目复杂程度的不断提高,出现了大量多学科交融的复杂工程问题,社会对高层次工程应用型人才的需求日益高涨。为使专业基础类课程教育回归大工程教育的本来涵义,有必要研究教育教学方法。以机械与材料工程专业的重要专业基础类课程——材料现代研究方法课程为例,通过紧抓教学核心、因材施教、改革教学模式、完善实践教学体系、加强实验室建设、拓展材料研究实训专项训练、举办各类技能竞赛,以及搭建工程教育实践教学平台等多种具体教学实践手段,提升本科生综合工程实践能力。

关键词：工程教育大工程材料现代研究方法专业实践能力

Analysis of the Mechanism and Effectiveness of Lignin in Improving the High-Temperature Thermal Stability of Asphalt

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Journal of Renewable Materials 2020年第10期8卷 1243-1255页

作者： Cheng Cheng Weiwei Sun Bo hu Guixiang Tao Chao Peng Yanjuan Tian shujuan Wu Yunnan Provincial Key Laboratory of Wood Adhesives and Glued Products Southwest Forestry UniversityKunming650224China School of Civil Engineering Southwest Forestry UniversityKunming650224China Yunnan Tongqu Engineering Testing Co. Ltd.Kunming650500China Key Laboratory for Special Area Highway Engineering of Ministry of Education Chang’an UniversityXi’an710064China School of Civil Engineering Lanzhou University of TechnologyLanzhou730050China

The use of lignin,which is a by-product of the pulp and paper industry,in the development of asphalt binders would contribute to waste reduction,providing environmental,economic,and social *** this study,samples of lignin-modified asphalt binder samples with different content of lignin(3%,6%,9%,12%,and 15%)and unmodified asphalt(control)were tested using Fourier transform infrared spectroscopy(FTIR),dynamic shear rheometer(DSR),and *** mechanism and effectiveness of lignin in improving the thermal stability of asphalt at high temperatures were *** FTIR analysis shows that no new characteristic absorption peak is seen in the infrared spectral of the lignin-modified asphalt binder samples,and some bands characteristic of lignin-related peaks gradually increased with the increase of lignin *** suggests that the modification of lignin-modified asphalt binder samples was due to physical blending rather than chemical *** increase of lignin content in the lignin-modified asphalt samples increases the complex shear modulus G*of the samples and decreases the phase angles of the ***,the anti-rutting performance(G*/sinδ)of the samples improves with the increase in lignin content,but this is not significant after any addition of lignin that exceeds 12%of asphalt *** characterizations show that the thermal decomposition rate of lignin is lower,and its residual amount is higher compared to that of asphalt,which is a major reason for the improved stability of lignin-modified asphalt binders at high *** effect of lignin on the thermal stability of asphalt is dependent on both lignin content and *** has a positive effect on the thermal stability of asphalt at high temperatures within the range of asphalt service temperature(25℃–200℃).Additionally,from the pyrolysis viewpoint,it was explained that excessive lignin addition is not beneficial to the thermal stability of asphalt at

关键词： Lignin modified asphalt high-temperature stability FTIR TG

Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia

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Genomics, Proteomics & Bioinformatics 2022年第1期20卷 177-191页

作者： Yaqiang Hong Dake Zhang Xiangtian Zhou Aili Chen Amir Abliz Jian Bai Liang Wang Qingtao hu Kenan Gong Xiaonan Guan Mengfei Liu Xinchang Zheng shujuan Lai Hongzhu Qu Fuxin Zhao Shuang Hao Zhen Wu Hong Cai Shaoyan hu Yue Ma Junting Zhang Yang Ke Qian-Fei Wang Wei Chen Changqing Zeng CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Beijing Advanced Innovation Centre for Biomedical Engineering Key Laboratory for Biomechanics and Mechanobiology of Ministry of EducationSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing 100191China Tsinghua-Peking Center for Life Sciences School of Life SciencesTsinghua UniversityBeijing 100084China School of Optometry and Ophthalmology and Eye Hospital Wenzhou Medical UniversityWenzhou 325035China The State Key Laboratory of Optometry Ophthalmology and Vision ScienceWenzhou 325035China Key Laboratory of Carcinogenesis and Translational Research(MOE) Laboratory of GeneticsPeking University Cancer Hospital&InstituteBeijing 100142China Skull Base and Brainstem Tumor Division Department of NeurosurgeryBeijing Tian Tan HospitalCapital Medical UniversityBeijing 100050China China National Clinical Research Center for Neurological Diseases Beijing 100050China CAS Key Laboratory of Genome Sciences and Information Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Department of Hematology and Oncology Children’s Hospital of Soochow UniversitySuzhou 215025China Institute of Biophysics Chinese Academy of SciencesBeijing 100101China Collaborative Innovation Center for Genetics and Development Shanghai 200438China University of Chinese Academy of Sciences Beijing 100049China

Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic ***,we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same volunteer as well as the samples from different *** blood,sperm,and muscle cells,we resolved three common types of mutational *** A and B represent clocklike mutational processes,and the polymorphisms of epigenetic regulation genes influence the proportion of signature B in mutation ***,signature C,characterized by C>T transitions at GpCpN sites,tends to be a feature of diverse normal *** of this type are likely to occur early during embryonic development,supported by their relatively high allelic frequencies,presence in multiple tissues,and decrease in occurrence with *** none of the public datasets for tumors feature this signature,except for 19.6%of samples of clear cell renal cell carcinoma with increased activation of the hypoxia-inducible factor 1(HIF-1)signaling ***,the accumulation of signature C in the mutation profile was accelerated in a human embryonic stem cell line with drug-induced activation of HIF-1α.Thus,embryonic hypoxia may explain this novel signature across multiple normal *** study suggests that hypoxic condition in an early stage of embryonic development is a crucial factor inducing C>T transitions at GpCpN sites;and individuals’genetic background may also influence their postzygotic mutation profiles.

关键词： Postzygotic mutation Mutational signature Healthy individual Embryonic development Hypoxia

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湖南中医药大学研究生教育的发展现状及思考

湖南中医药大学学报 2020年第10期40卷 1198-1203页

作者：彭清华喻嵘胡淑娟何文智罗桂香肖岚藏家栋张诗云湖南中医药大学湖南长沙410208

本文从招生规模增长、学位点建设、教学改革实施、创新工程推进、学科评估、就业情况改善6项主要指标的完成情况和改革招生制度、完善招生机制、严控招生录取风险、强化导师队伍、推进医教协同等9项具体任务推进情况,概述了“十三五”... 详细信息

本文从招生规模增长、学位点建设、教学改革实施、创新工程推进、学科评估、就业情况改善6项主要指标的完成情况和改革招生制度、完善招生机制、严控招生录取风险、强化导师队伍、推进医教协同等9项具体任务推进情况,概述了“十三五”以来湖南中医药大学研究生教育事业发展的基本情况,分析了“十三五”期间研究生教育的改革发展举措与成效、存在的困难与问题,并对今后进一步开展研究生教育工作提出了思考与举措。

关键词：研究生教育湖南中医药大学发展现状