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Efficient flexible perovskite solar cells and modules using a stable SnO_(2)-nanocrystal isopropanol dispersion

Nano Research 2024年第4期17卷 2704-2711页

作者： Zhiwei Su Jing Li Ruixuan Jiang shujie zhang Chengkai Jin Feng Ye Bingcan Ke Mengjun Zhou Jinhui Tong Hyesung Park Fuzhi Huang Yi-Bing Cheng Tongle Bu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Material Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering Graduate School of Semiconductor Materials and Devices EngineeringGraduate School of Carbon NeutralityLow Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Foshan 528200China

The outstanding advantages of lightweight and flexibility enable flexible perovskite solar cells(PSCs)to have great application potential in mobile energy devices.Due to the low cost,low-temperature processibility,and high electron mobility,SnO_(2) nanocrystals have been widely employed as the electron transport layer in flexible PSCs.To prepare high-quality SnO_(2) layers,a monodispersed nanocrystal solution is normally used.However,the SnO_(2) nanocrystals can easily aggregate,especially after long periods of storage.Herein,we develop a green and cost-effective strategy for the synthesis of high-quality SnO_(2) nanocrystals at low temperatures by introducing small molecules of glycerol,obtaining a stable and well-dispersed SnO_(2)-nanocrystal isopropanol dispersion successfully.Due to the enhanced dispersity and super wettability of this alcohol-based SnO_(2)-nanocrystal solution,large-area smooth and dense SnO_(2) films are easily deposited on the plastic conductive substrate.Furthermore,this contributes to effective charge transfer and suppressed non-radiative recombination at the interface between the SnO_(2) and perovskite layers.As a result,a greatly enhanced power conversion efficiency(PCE)of 21.8%from 19.2%is achieved for small-area flexible PSCs.A large-area 5 cm×5 cm flexible perovskite solar mini-module with a champion PCE of 16.5%and good stability is also demonstrated via this glycerol-modified SnO_(2)-nanocrystal isopropanol dispersion approach.

关键词： tin oxide isopropanol dispersion colloid stability flexible perovskite solar cells

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Celastrol promotes apoptosis of breast cancer MDA-MB-231 cells by targeting HSDL2

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Acupuncture and Herbal Medicine 2024年第1期4卷 92-101页

作者： Li Liu Yanqing Liu shujie zhang Junzhe zhang Yuqing Meng Dandan Liu Liwei Gu Ying zhang Liting Xu Ziyue zhang Minghong Zhao Yinkwan Wong Qixin Wang Yongping Zhu Jigang Wang College of Pharmacy Gannan Medical UniversityGanzhouChina State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijingChina Department of Pharmacological Sciences Yong Loo Lin School of MedicineNational University of SingaporeSingaporeSingapore

Objective:Celastrol is a pentacyclic triterpenoid extracted from the traditional Chinese medicinal herb,Tripterygium wilfordii.This study aims to provide a scientific basis for the rational development and use of celastrol in breast cancer.Method:A quantitative chemical biology approach was used to investigate the protein targets and molecular mechanisms of celastrol in breast cancer cells.Results:Low-concentration celastrol exerted an anti-tumor effect by directly binding to hydroxysteroid dehydrogenase-like 2(HSDL2)and inhibiting its expression.Moreover,the expression of the pro-apoptotic protein,Bcl-2-associated X(BaX),increased,the level of the anti-apoptotic protein,B-cell lymphoma-2(Bcl-2),decreased,and the rate of apoptosis increased.After the transfection of cells with si-HSDL2,the apoptosis rate was similar to that observed after the administration of celastrol.However,apoptosis was reversed by the overexpression of HSDL2.Furthermore,our mass spectrometry(MS)data indicated a relationship between HSDL2 and the mitogen-activated protein kinase(MAPK)signaling pathway.We also found that the expression of HSDL2 was directly related to the degree of extracellular signal-regulated kinase(ERK)phosphorylation.Conclusion:Celastrol may promote apoptosis by suppressing the HSDL2/MAPK/ERK signaling pathway.

关键词： Activity-based protein profiling Apoptosis Celastrol HSDL2

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Erratum to:Efficient flexible perovskite solar cells and modules using a stable SnO_(2)-nanocrystal isopropanol dispersion

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Nano Research 2024年第5期17卷 4641-4642页

作者： Zhiwei Su Jing Li Ruixuan Jiang shujie zhang Chengkai Jin Feng Ye Bingcan Ke Mengjun Zhou Jinhui Tong Hyesung Park Fuzhi Huang Yi-Bing Cheng Tongle Bu State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of TechnologyWuhan 430070China School of Material Science and Engineering Wuhan University of TechnologyWuhan 430070China Department of Materials Science and Engineering Graduate School of Semiconductor Materials and Devices EngineeringGraduate School of Carbon NerutralityLow Dimensional Carbon Materials CenterUlsan National Institute of Science and TechnologyUlsan 44919Republic of Korea Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratry Foshan 528200China

Erratum to Nano Research,2024,17(4):2704-2711 https://***/10.1007/s12274-023-6115-y(1)In the article,the table of contents(TOC)image was unfortunately mispresented.

关键词： perovskite dispersion modules

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Highly efficient 1D p-Te/2D n-Bi_(2)Te_(3) heterojunction self-driven broadband photodetector

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Nano Research 2024年第3期17卷 1864-1874页

作者： Chenchen Zhao Dongbo Wang Jiamu Cao Zhi Zeng Bingke zhang Jingwen Pan Donghao Liu Sihang Liu shujie Jiao Tianyuan Chen Gang Liu Xuan Fang Liancheng Zhao Jinzhong Wang School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China School of Astronautics Harbin Institute of TechnologyHarbin 150001China Center for High Pressure Science and Technology Advanced Research Shanghai 201203China State Key Laboratory of High Power Semiconductor Lasers Changchun University of Science and TechnologyChangchun 130022China

Broadband photodetectors with self-driven functions have attracted intensive scientific interest due to their low energy consumption and high optical gain.However,high-performance broadband self-driven photodetectors are still a significant challenge due to the complex fabrication processes,environmental toxicity,high production costs of traditional 3D semiconductor materials and sharply raised contact resistance,severe interfacial recombination of 2D materials and 2D/3D mixed dimension heterojunction.Here,1D p-Te/2D n-Bi_(2)Te_(3) heterojunctions are constructed by the simple and low-cost hydrothermal method.1D p-Te/2D n-Bi_(2)Te_(3) devices are applied in photoelectrochemical(PEC)photodetectors,with their high performance attributed to the good interfacial contacts reducing interface recombination.The device demonstrated a broad wavelength range(365–850 nm)with an Iph/Idark as high as 377.45.The R_(i),D^(*),and external quantum efficiency(EQE)values of the device were as high as 12.07 mA/W,5.87×10^(10) Jones,and 41.05%,respectively,which were significantly better than the performance of the prepared Bi_(2)Te_(3) and Te devices.A comparison of the freshly fabricated device and the device after 30 days showed that 1D p-Te/2D n-Bi_(2)Te_(3) had excellent stability with only 18.08%decay of photocurrent.It is anticipated that this work will provide new emerging material for future design and preparation of a high-performance self-driven broadband photodetector.

关键词： topological insulating states interfacial recombination self-driven 1D p-Te/2D n-Bi_(2)Te_(3) photodetector

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3-Hydroxybutyrate ameliorates insulin resistance by inhibiting PPARγSer273 phosphorylation in type 2 diabetic mice

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Signal Transduction and Targeted Therapy 2023年第6期8卷 3158-3167页

作者： Yudian zhang Zihua Li Xinyi Liu Xinyu Chen shujie zhang Yuemeng Chen Jiangnan Chen Jin Chen Fuqing Wu Guo-Qiang Chen School of Life Sciences Tsinghua UniversityBeijing100084P.R.China Department of Medical Genetics and Cell Biology School of Basic Medical Science of Ningxia Medical UniversityYinchuanNingxia750004P.R.China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing100084China MOE Key Lab of Industrial Biocatalysis Dept of Chemical EngineeringTsinghua UniversityBeijing100084P.R.China

3-Hydroxybutyrate(3HB)is a small ketone body molecule produced endogenously by the body in the liver.Previous studies have shown that 3HB can reduce blood glucose level in type 2 diabetic(T2D)patients.However,there is no systematic study and clear mechanism to evaluate and explain the hypoglycemic effect of 3HB.Here we demonstrate that 3HB reduces fasting blood glucose level,improves glucose tolerance,and ameliorates insulin resistance in type 2 diabetic mice through hydroxycarboxylic acid receptor 2(HCAR2).Mechanistically,3HB increases intracellular calcium ion(Ca^(2+))levels by activating HCAR2,thereby stimulating adenylate cyclase(AC)to increase cyclic adenosine monophosphate(cAMP)concentration,and then activating protein kinase A(PKA).Activated PKA inhibits Raf1 proto-oncogene serine/threonine-protein kinase(Raf1)activity,resulting in a decrease in extracellular signal-regulated kinases 1/2(ERK1/2)activity and ultimately inhibiting peroxisome proliferator-activated receptorγ(PPARγ)Ser273 phosphorylation in adipocytes.Inhibition of PPARγSer273 phosphorylation by 3HB altered the expression of PPARγregulated genes and reduced insulin resistance.Collectively,3HB ameliorates insulin resistance in type 2 diabetic mice through a pathway of HCAR2/Ca^(2+)/cAMP/PKA/Raf1/ERK1/2/PPARγ.

关键词： PPARγ thereby ketone

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新质生产力的时代内涵、战略价值与实现路径

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重庆大学学报(社会科学版) 2024年第1期30卷 112-128页

作者：姚树洁张小倩重庆大学经济与工商管理学院辽宁大学李安民经济研究院

加快形成新质生产力，是新时代背景下中国经济社会发展从传统要素驱动向创新驱动转型，提升生产效率和质量，促进经济增长持续健康发展，把握新工业革命浪潮，构筑新竞争优势、赢得发展主动权的题中应有之义。本文明确新质生产力的概念... 详细信息

加快形成新质生产力，是新时代背景下中国经济社会发展从传统要素驱动向创新驱动转型，提升生产效率和质量，促进经济增长持续健康发展，把握新工业革命浪潮，构筑新竞争优势、赢得发展主动权的题中应有之义。本文明确新质生产力的概念及内涵，揭示其理论逻辑、战略价值和实现路径。结合新质生产力的提出背景与相关论述，文章认为新质生产力必须具有“科技创新驱动”“产业高效低耗和环境可持续”“高品质生活和社会服务均等化”“数字赋能”和“国家治理能力现代化”等特征。解构改革开放以来中国新质生产力发展所积累的物质技术基础和政策环境保障，对比分析中国与全球主要国家数字经济发展水平与高科技产品的出口现状，以客观把握中国新质生产力的发展优势与不足。分析在内部面临产业升级滞后与创新能力不足、资源与环境约束、区域城乡发展不平衡、人口结构老龄化与劳动力成本上升、政府治理效率还需提升等“中等收入陷阱”的挑战，外部遭受贸易争端、技术封锁、人权和意识形态威胁、国家领土争端等“修昔底德陷阱”的压力下，新质生产力破解经济高质量发展难题的战略指导意义。进一步地，指出新质生产力的提升是实现国家安全的重要基础，为国家提供了强大的安全保障，有助于构建坚固的国家安全体系。在此基础上，国家安全稳定也是发展新质生产力的必要条件，两者相得益彰。最后，提出为发展新质生产力，尤其注重新质生产力的均衡布局；从内部加强自我建设，释放新质生产力的发展潜能，破除“中等收入陷阱”魔咒；打造安全稳定的外部环境，给新质生产力的发展提供基础保障，破除“修昔底德陷阱”魔咒，支撑构建强劲有力的“双循环”新发展格局。

关键词：新质生产力经济高质量发展区域均衡发展国家安全

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The Spatial-Temporal Characteristics of Meteorological Disasters in the Southwest Region of Zhejiang Province during 1953-2022

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Journal of Geoscience and Environment Protection 2024年第3期12卷 16-27页

作者： Qi zhang Yifan Wang Zhidan Zhu Hongxia Shi Wenhao Yang shujie Yuan Longyou Meteorological Administration Quzhou China School of Atmospheric Sciences Chengdu University of Information Technology Chengdu China

Meteorological disasters are some of the most serious and costly natural disasters, which have larger effects on economic and social activity. Liuchun Lake is an ecotourism area in the southwest region of Zhejiang province, where also has experienced meteorological disasters including rainstorm and cold wave. Understanding the temporal-spatial characteristics of meteorological disasters is important for the local tourism and economic development. Based on the daily temperature and precipitation from 18 meteorological stations in the southwest of Zhejiang province during 1953-2022 and some statistical approaches, the temporal and spatial characteristics of meteorological disasters (Freezing, Rainstorm, Cold wave) are analyzed. The results indicate that 1) Rainstorm occurred frequently around the Liuchun lake, the frequency was about 8 times/a, it can also reach about 3 times/a in the other region. Freezing and cold wave (including strong cold wave and extremely cold wave) had the same spatial distribution as rainstorm, however, except for Liuchun lake, they occurred less than one time in the other regions;2) The trend of rainstorm had larger spatial difference, it increased in all the study area, but it increased more significantly around the study area than around Liuchun lake. Freezing was on the downtrend in the whole region, with 93.3% of the stations passed the 95% significant level. Cold wave also showed a declined trend, but it was insignificantly at most of the stations, only 33% of the stations passed the 90% significant level. Compared with cold wave, strong cold wave and extremely strong cold wave had weaker decline in all the regions. In general, from 1953 to 2022 rainstorm showed an increasing trend, it was the main meteorological disaster in the study area, cold wave displayed a decreasing trend, but it still occurred about 2 - 3 times/a in most regions.

关键词： Southwest of Zhejiang Province Rainstorm Cold Wave Spatial Distribution Trend Analysis

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Intravenous route to choroidal neovascularization by macrophage-disguised nanocarriers for mTOR modulation

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Acta Pharmaceutica Sinica B 2022年第5期12卷 2506-2521页

作者： Weiyi Xia Chao Li Qinjun Chen Jiancheng Huang Zhenhao Zhao Peixin Liu Kai Xu Lei Li Fangyuan Hu shujie zhang Tao Sun Chen Jiang Chen Zhao Department of Ophthalmology and Vision Science Eye&ENT HospitalShanghai Medical SchoolFudan UniversityShanghai 200031China Key Laboratory of Smart Drug Delivery Ministry of EducationDepartment of PharmaceuticsSchool of PharmacyFudan UniversityShanghai 201203China

Retinal pigment epithelial(RPE) is primarily impaired in age-related macular degeneration(AMD), leading to progressive loss of photoreceptors and sometimes choroidal neovascularization(CNV). mTOR has been proposed as a promising therapeutic target, while the usage of its specific inhibitor,rapamycin, was greatly limited. To mediate the mTOR pathway in the retina by a noninvasive approach, we developed novel biomimetic nanocomplexes where rapamycin-loaded nanoparticles were coated with cell membrane derived from macrophages(termed as MRaNPs). Taking advantage of the macrophage-inherited property, intravenous injection of MRaNPs exhibited significantly enhanced accumulation in the CNV lesions, thereby increasing the local concentration of rapamycin. Consequently, MRaNPs effectively downregulated the mTOR pathway and attenuate angiogenesis in the eye. Particularly, MRaNPs also efficiently activated autophagy in the RPE, which was acknowledged to rescue RPE in response to deleterious stimuli. Overall, we design and prepare macrophage-disguised rapamycin nanocarriers and demonstrate the therapeutic advantages of employing biomimetic cell membrane materials for treatment of AMD.

关键词： Choroidal neovascularization Age-related macular degeneration Biomimetic nanoparticles Targeted drug delivery mTOR signaling Rapamycin Macrophage membrane Inflammation

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Integrative Zoology 2021年第3期16卷 390-403页

作者： Xiaocheng SHEN shujie zhang Qi SHEN Guilin HU Jiqi LU Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouChina Henan Academy of Agricultural Sciences Institute of Plant ProtectionZhengzhouChina The First Clinical School Henan University of Chinese MedicineZhengzhouChina

A new method,multivariate similarity clustering analysis(MSCA)method,was established for biogeographical distribution analyzing.General similarity formula(GSF),the core of MSCA method,can be used to calculate the similarity coefficients between 2 and among any≥3 geographical units.Taking the global insects as example,we introduced the steps to use of GSF and consequent clustering processes of this method in details.Firstly,geographical distributions of certain taxa(e.g.Insecta)were categorized into basic geographical units(BGUs);Secondly,similarity coefficients between 2 and among n BGUs were calculated using GSF.Thirdly,hierarchical clustering was conducted according to values of similarity coefficients(from high to low);then a clustering diagram was generated.Finally,a framework of biogeographical division map was established for the target taxa(e.g.Insecta).We concluded that the MSCA method was efficiently applied in analyzing the biogeographical distribution of given biological taxa;the geographical regions regarding global insects were categorized into 7 Realms with 20 sub-Realms based on the results of MSCA method.

关键词： biogeographical division insects new method similarity coefficient

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大型薄壁件多点位自动化柔性支撑系统的位置优化研究

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机床与液压 2024年第1期52卷 115-120页

作者：刘淑杰张磊东北大学冶金学院辽宁沈阳110819 东北大学机械工程与自动化学院辽宁沈阳110819

为解决多点位柔性工装系统在夹持大型薄壁件过程中需要满足定位形变量控制问题,基于“N-2-1”定位原理,针对均布算法局限,提出一种不依赖于外部操作者就能按照自生成原理实现系统的位置优化方法,并通过有限元软件Abaqus建立了大型薄壁... 详细信息

为解决多点位柔性工装系统在夹持大型薄壁件过程中需要满足定位形变量控制问题,基于“N-2-1”定位原理,针对均布算法局限,提出一种不依赖于外部操作者就能按照自生成原理实现系统的位置优化方法,并通过有限元软件Abaqus建立了大型薄壁件多点定位数值模型,采用先整体再局部依次进行位置优化。结果表明:优化后的支撑点位布局合理,系统资源利用率高,与单一整体位置优化相比,添加局部位置优化能够以最少支撑点位使得航空薄壁件更易达到工程要求;而对于局部存在缺陷无法进行支撑,则需考虑特定情况,调整相应支承机构点沿减小工件加工变形的最敏感方向移动,在局部变形较大的地方优化支撑点的数目,使得其变形相对于初始变形量显著下降,并且吸附压力也满足工程要求。

关键词：大型薄壁件多点定位数值模型位置优化变形量

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