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Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin

World Journal of Gastroenterology 2007年第26期13卷 3634-3637页

作者： Yoshihiro Shibata Eishi Baba Hiroshi Ariyama Ryusuke Miki Nobumichi Ogami shuji arita Baoli Qin Hitoshi Kusaba Kenji Mitsugi Hirokazu Noshiro Takashi Yao shuji Nakano First Department of Internal Medicine and Department of Biosystemic Science of Medicine Graduate School of MedicineKyushu UniversityFukuokaJapan Department of Surgery and Oncology Graduate School of Medical SciencesKyushu UniversityJapan Department of Anatomic Pathology Graduate School of Medical SciencesKyushu UniversityJapan

Basaloid squamous cell carcinoma （BSC） of the esophagus is a rare malignant disease. We report here a patient with recurrent esophageal BSC, who was successfully treated by systemic chemotherapy containing 5-fluorouracil （5-FU） and cisplatin （CDDP）. A 57-year-old woman was diagnosed as having SCluamous cell carcinoma of the esophagus upon endoscopic examination. Curative esophagectomy with lymph node dissection was performed under the thoracoscope. The pathological diagnosis of the surgical specimen was BSC. Five months after operation, the patient was diagnosed as having a recurrence of the BSC with metastases to the liver and spleen, and a right paraclavicular lymph node. She was given systemic chemotherapy consisting of continuous infusion of 800 mg/d of 5-FU and 3 h infusion of 20 mg/d of CDDP for 5 consecutive days every 4 wk. The metastatic lesions in the spleen and right paraclavicular lymph node disappeared, and the liver metastasis was apparently reduced in size after 2 courses of chemotherapy. The tumor regression was seen over 6 courses, with progression afterwards. Although subsequent treatment with CPT-11 and CDDP was not effective, docetaxel and vinorelbine temporarily controlled the tumor growth for 2 mo. 5-FU and CDDP combination may be useful for the patients with advanced BSC.

关键词： Basaloid-squamous cell carcinoma Esophagus Chemotherapy

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