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基于改进U-Net和X线片的脊柱侧弯Cobb角自动测量算法研究

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基因组学与应用生物学 2024年第4期43卷 708-718页

作者：禤浚波梁英豪梁淑慧张绿云胡巍柯宝毅马文宇李成广西师范大学广西多源信息挖掘与安全重点实验室桂林541004 南宁职业技术学院人工智能学院南宁530008 广西师范大学计算机科学与工程学院桂林541004 河池学院大数据与计算机学院宜州546300 桂林市人民医院脊柱骨病科桂林541002 柳州市人民医院脊柱外科柳州545006

脊柱侧弯是影响人类健康的疾病之一,Cobb角的准确计算是临床上确定脊柱侧弯分型和制定诊疗方案的关键。针对人工测量Cobb角存在耗时长、不够准确、效率低下等问题,本文设计了一种基于改进U-Net的脊柱侧弯Cobb角自动测量方法。由经验丰... 详细信息

脊柱侧弯是影响人类健康的疾病之一,Cobb角的准确计算是临床上确定脊柱侧弯分型和制定诊疗方案的关键。针对人工测量Cobb角存在耗时长、不够准确、效率低下等问题,本文设计了一种基于改进U-Net的脊柱侧弯Cobb角自动测量方法。由经验丰富的脊柱外科医生使用LabelMe工具对200例脊柱侧弯患者的X线片数据集进行标注。采用ResNet50作为主干网络改进基本的语义分割模型U-Net,并与另外2个语义分割模型DeeplabV3和PSPNet在脊柱侧弯X线片数据集上分别进行训练。实验结果表明,改进的U-Net模型的平均交并比(mean intersection over union,MIOU)值达到了94.72%,分别比PSPNet和DeeplabV3模型的MIOU值提升了5.36%和2.30%。最后,基于改进的U-Net模型设计了脊柱侧弯Cobb角的自动测量算法,并开发了可视化的自动测量软件。经过实际测试,发现在常规的电脑上输入一张患者的X线片,只需6.3 s即可自动计算Cobb角大小,其速度远快于医生手动测量,显著提高了医生的工作效率,表明本文设计的脊柱侧弯Cobb角自动测量方法是有效的。

关键词：脊柱侧弯 X线图像 Cobb角 U-Net 交并比

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不同长度胰管支架对内镜逆行胰胆管造影术后胰腺炎发生率的影响分析

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中华消化内镜杂志 2024年第5期41卷 384-390页

作者：李西娴张恬恬罗辉任贵王向平张林慧梁树辉潘阳林西安医学院西安710068 空军军医大学第一附属医院消化内科西安710032

目的探索不同长度胰管支架对内镜逆行胰胆管造影术后胰腺炎(post-endoscopic retrograde cholangiopancreatography pancreatitis,PEP)发生率的影响。方法回顾性分析2013年1月至2022年1月期间在空军军医大学第一附属医院接受内镜逆行胰... 详细信息

目的探索不同长度胰管支架对内镜逆行胰胆管造影术后胰腺炎(post-endoscopic retrograde cholangiopancreatography pancreatitis,PEP)发生率的影响。方法回顾性分析2013年1月至2022年1月期间在空军军医大学第一附属医院接受内镜逆行胰胆管造影术(endoscopic retrograde cholangiopancreatography,ERCP)且术中置入5 Fr预防性胰管支架的胆道疾病患者(n=299)资料,按使用支架的长度分为5 cm短支架组(n=163)与5 cm以上的长支架组(n=136),分别比较两组的基线资料、术中操作与术后情况,并采用倾向性评分匹配(propensity score matching,PSM)方法进行补充分析。主要研究终点为PEP发生率。采用logistic回归分析置入预防性胰管支架患者发生PEP的危险因素。结果总体PEP发生率为11.0%(33/299)。短支架组和长支架组患者的PEP发生率[11.7%(19/163)比10.3%(14/136),χ^(2)=0.140,P=0.708],中-重症PEP发生率[1.8%(3/163)比2.2%(3/136),χ^(2)=0.000,P=1.000]及2周内支架自发脱落率[81.7%(103/126)比78.4%(87/111),χ^(2)=0.421,P=0.516]差异均无统计学意义。经PSM后,每组样本量为123例,总体PEP发生率为8.9%(22/246)。两组患者的PEP发生率[8.9%(11/123)比8.9%(11/123),χ^(2)=0.000,P=1.000],中-重症PEP发生率[0.8%(1/123)比1.6%(2/123),χ^(2)=0.000,P=1.000]及2周内支架自发脱落率[80.6%(75/93)比78.6%(77/98),χ^(2)=0.126,P=0.722]差异均无统计学意义。logistic回归分析显示肝功能正常(OR=2.36,95%CI:1.01~5.51,P=0.046)与胆管插管失败(OR=7.51,95%CI:2.18~25.96,P=0.001)是胆道疾病患者预防性胰管支架置入后发生PEP的独立危险因素。结论与5 Fr-5 cm胰管支架相比,长度更长的5 Fr胰管支架并不能进一步降低总体PEP和中-重症PEP风险。肝功能正常与胆管插管失败是胆道疾病患者预防性胰管支架置入术后发生PEP的独立危险因素。

关键词：胰胆管造影术,内窥镜逆行胰腺炎预防胰管支架长度

Distributed user pairing and effective computation offloading in aerial edge networks

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Chinese Journal of Aeronautics 2024年第4期37卷 378-390页

作者： Wei liang shuhui WEN Lixin LI Jingjing CUI School of Electronics and Information Northwestern Polytechnical UniversityXi’an CN710072China The State Key Laboratory of Integrated Services Networks Xidian UniversityXi’an CN710126China School of Electronics and Computer Science University of SouthamptonSouthampton SO167NSUK

Future Sixth-Generation (6G) mobile communication networks extremely require the global connectivity and the ground Base Stations (BSs) are difficult to develop in some specific areas,such as mountainous ***,the aerial networks are the key framework for the future communications,in which the aerial vehicle could act as the access ***,Mobile Edge Computing (MEC) is also essential to enhance the data processing capabilities of aerial *** this paper,we study a comprehensive communication-computation resource management problem for jointly optimizing user pairing,power and time allocation in the MEC aided Cognitive Radio (CR) aerial networks,namely CR-MEC aerial ***,this multilevel optimization problem could be decomposed into the user pairing and power allocation as well as time allocation *** the conceived CR-MEC aerial networks,we propose a User Pairing and Computation Offloading Management Algorithm (UPCOMA) based on three-sided matching theory,aiming to minimize the system’s energy *** the first step of UPCOMA,multiple Primary Users (PUs) and Cognitive Users (CUs) on the ground negotiate to each other with the suitable power allocation coefficients and construct the stable user ***,the stable user pairs would match to a high altitude platform who act as the base station,which is for appropriately allocating Transmission Time Slots (TSs) at the second step of ***,a hybrid offloading mode is proposed in our conceived networks in order to support ground users to offload their tasks adaptively according to their individual ***,the simulation results reveal that the relative performance of UPCOMA is close to that of the Brute-Force Search Algorithm (BFSA) with low ***,the hybrid offloading mode with less energy consumption supports much more ground user pairs to offload tasks compared to the binary mode.

关键词： Aerial edge computing Binary offloading Cognitive radio Hybrid offloading Resource management

国家公园官方投射形象与游客感知形象对比研究——以武夷山国家公园为例

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旅游导刊 2024年第2期8卷 47-69页

作者：梁淑惠李佳妮黄梦蝶张海霞浙江工商大学旅游与城乡规划学院浙江杭州310018

国家公园作为我国生态文明成就体现的重要场域之一,促进其投射与感知形象的契合是提高国民认同度的关键点。本研究以武夷山国家公园为例,收集武夷山国家公园官方宣传文本与携程旅行网站游客评论文本,基于旅游凝视理论,利用隐含狄利克雷... 详细信息

国家公园作为我国生态文明成就体现的重要场域之一,促进其投射与感知形象的契合是提高国民认同度的关键点。本研究以武夷山国家公园为例,收集武夷山国家公园官方宣传文本与携程旅行网站游客评论文本,基于旅游凝视理论,利用隐含狄利克雷分布(LDA)主题模型方法,对武夷山国家公园官方投射形象与游客感知形象进行对比分析。结果表明:(1)网络语境下国家公园形象可归纳为自然资源、文化资源、旅游体验、设施服务、价值地位5个维度;(2)“投射—感知”形象的核心高频词重合率仅为1/3,官方宣传内容的广泛性与游客感知体验的具体性有较大差别;(3)分维比较显示,自然资源维度的“投射—感知”形象契合度高,其他维度均存在错位现象。在此基础上,本研究运用二维象限法,构建了国家公园形象的维持区域、优势区域和改进区域,并针对各区域特点提出了基于国家公园管理组织主导的策略建议。

关键词：武夷山国家公园投射形象感知形象旅游凝视 LDA

OsNPF3.1,a member of the NRT1/PTR family,increases nitrogen use efficiency and biomass production in rice

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The Crop Journal 2023年第1期11卷 108-118页

作者： Xinghai Yang Baoxuan Nong Can Chen Junrui Wang Xiuzhong Xia Zongqiong Zhang Yu Wei Yu Zeng Rui Feng Yanyan Wu Hui Guo Haifeng Yan Yuntao liang shuhui liang Yong Yan Danting Li Guofu Deng Guangxi Key Laboratory of Rice Genetics and Breeding Rice Research InstituteGuangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Guangxi Key Laboratory for Polysaccharide Materials and Modifications School of Marine Sciences and BiotechnologyGuangxi University for NationalitiesNanning 530006GuangxiChina Biotechnology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Sugarcane Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina Microbiology Research Institute Guangxi Academy of Agricultural SciencesNanning 530007GuangxiChina

The overuse of nitrogen(N)fertilizer in fields has increased production costs and raised environmental *** the N use efficiency(NUE)of rice varieties is crucial for sustainable *** we report the cloning and characterization of OsNPF3.1,a gene that controls rice *** amino acid mutation in the OsNPF3.1 coding region caused different NUEs in wild and cultivated ***3.1,which is expressed mainly in the aerial parts of rice,also affects rice plant height,heading date,and thousand-grain *** OsNPF3.1 protein is located in the plasma *** OsNPF3.1 was subjected to artificial selection,two naturally varying loci were associated with NUE,of which OsNPF3.1Chr6_8741040differed between indica and japonica ***3.1 can be used as a new target gene for breeding rice varieties with high NUE.

关键词： Rice OsNPF3.1 Functional analysis Evolutionary analysis Natural variation

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广西药用野生稻重要农艺性状遗传多样性分析

热带作物学报 2024年第5期45卷 906-914页

作者：郭辉陈灿张宗琼杨行海梁树辉张晓丽徐志健农保选李丹婷夏秀忠冯锐广西壮族自治区农业科学院水稻研究所/广西水稻遗传育种重点实验室广西南宁530007

药用野生稻具有抗病虫、抗逆境、高生物产量、高光效等优良特性,蕴藏有许多优良基因。本研究用广西所有药用野生稻分布点收集的代表性资源199份,对抽穗期、花药长度、粒宽、粒长与粒重5个重要农艺性状进行遗传多样性、主成分等分析。结... 详细信息

药用野生稻具有抗病虫、抗逆境、高生物产量、高光效等优良特性,蕴藏有许多优良基因。本研究用广西所有药用野生稻分布点收集的代表性资源199份,对抽穗期、花药长度、粒宽、粒长与粒重5个重要农艺性状进行遗传多样性、主成分等分析。结果表明:广西药用野生稻具有丰富的遗传多样性,抽穗期、花药长度、粒宽、粒长和粒重的变异系数分别为9.12%、11.90%、3.39%、4.64%和6.24%,多样性指数分别为1.4878、2.0453、1.7727、1.1567和2.0379。主成分分析表明:第1、第2主成分主要与产量性状相关,累计贡献率达63.759%,第3、第4主成分特征值相近,贡献率分别为16.306%和15.542%,抽穗期与花药长度是影响的决定因子,主要反映植株的生长特征。7个地理居群按遗传多样性大小排序为:梧州市(1.6731)>玉林市(1.5784)>贵港市(1.5070)>南宁市(1.3325)>来宾市(1.2131)>贺州市(0.9629)>钦州市(0.3819),梧州市的多样性指数最高,表明梧州市是广西药用野生稻表型遗传多样性的中心。

关键词：种质资源药用野生稻农艺性状遗传多样性

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Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis

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Chinese Medical Journal 2024年第2期137卷 181-189页

作者： Fangming Liu Yuting Wu Baohui Zhang shuhui Yang Kezhuo Shang Jie Li Pengju Zhang Weiwei Deng Linlin Chen liang Zheng Xiaochen Gai Hongbing Zhang Department of Physiology State Key Laboratory of Common Mechanism Research for Major DiseasesHaihe Laboratory of Cell EcosystemInstitute of Basic Medical Sciences and School of Basic MedicineChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Physiology Institute of Basic Medical Sciences and School of Basic MedicineGraduate School of Peking Union Medical CollegeChinese Academy of Medical SciencesBeijing100005China Department of Physiology School of Life ScienceChina Medical UniversityShenyangLiaoning 110122China School of Life Sciences Westlake UniversityHangzhouZhejiang 310024China Key Laboratory of Pediatric Hematology and Oncology Ministry of HealthInstitute of Pediatric Translational MedicineShanghai Children’s Medical CenterShanghai Jiao Tong School of MedicineShanghai 200127China

Background:Liver cancer is largely resistant to *** study aimed to identify the effective chemotherapeutics forβ-catenin-activated liver cancer which is caused by gain-of-function mutation of catenin beta 1(CTNNB1),the most frequently altered proto-oncogene in hepatic ***:Constitutiveβ-catenin-activated mouse embryonic fibroblasts(MEFs)were established by deleting exon 3(β-catenin^(Δ(ex3)/+)),the most common mutation site in CTNNB1 gene.A screening of 12 widely used chemotherapy drugs was conducted for the ones that selectively inhibitedβ-catenin^(Δ(ex3)/+)but not for wild-type *** metabolomics was carried out to examine the alterations of metabolites in nucleotide *** efficacy and selectivity of methotrexate(MTX)onβ-catenin-activated human liver cancer cells were determined in ***-deficient nude mice subcutaneously inoculated withβ-catenin wild-type or mutant liver cancer cells and hepatitis B virus(HBV);β-catenin^(lox(ex3)/+)mice were used,respectively,to evaluate the efficacy of MTX in the treatment ofβ-catenin mutant liver ***:MTX was identified and validated as a preferential agent against the proliferation and tumor formation ofβ-catenin-activated *** nucleotide synthesis was the major metabolic aberration inβ-catenin-active cells,and this alteration was also the target of ***,MTX abrogated hepatocarcinogenesis of HBV;β-catenin^(lox(ex3)/+)mice,which stimulated concurrent Ctnnb1-activated mutation and HBV infection in liver ***:MTX is a promising chemotherapeutic agent forβ-catenin hyperactive liver *** repurposing MTX has the advantages of lower risk,shorter timelines,and less investment in drug discovery and development,a clinical trial is warranted to test its efficacy in the treatment ofβ-catenin mutant liver cancer.

关键词： Liver cancer β-catenin Methotrexate Nucleotide synthesis Chemotherapy

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CT值鉴别甲状腺钙化病变良恶性的价值研究

中国现代医生 2024年第5期62卷 47-50页

作者：申永超郑家豪张乐星梁淑慧杭州市第一人民医院放射科浙江杭州311000 浙江省中医药大学第一临床医学院浙江杭州311000

目的探讨CT值在鉴别诊断甲状腺良恶性钙化病变中的价值。方法回归性分析经过病理证实的甲状腺良性钙化48例及恶性钙化26例的CT平扫资料,并对74例甲状腺钙化进行CT值测量。通过绘制受试者操作特征(receiver operator characteristic,ROC... 详细信息

目的探讨CT值在鉴别诊断甲状腺良恶性钙化病变中的价值。方法回归性分析经过病理证实的甲状腺良性钙化48例及恶性钙化26例的CT平扫资料,并对74例甲状腺钙化进行CT值测量。通过绘制受试者操作特征(receiver operator characteristic,ROC)曲线确定鉴别甲状腺良恶性钙化的最佳阈值及ROC曲线下最大面积,并算出相应的特异性、敏感度、阳性预测值、阴性预测值、假阳性率、假阴性率、准确度和约登指数。然后以最佳阈值作为鉴别诊断甲状腺良恶性钙化的参数,通过χ2检验分析甲状腺良恶性钙化在CT灰度值方面的差异有统计学意义。结果ROC曲线下方面积为0.814,95%CI:0.712~0.915,当CT值为869.5HU(为计算方便取870HU)时,特异性为69.2%,敏感度为81.3%,阳性预测值为64.3%,阴性预测值为82.6%,假阳性率为20.8%,假阴性率为30.8%,准确度为75.7%,约登指数最大为0.505。当以870HU为鉴别诊断甲状腺良恶性钙化参数时差异有统计学意义(χ2=16.795,P<0.001)。结论当CT值为870HU时,对鉴别诊断甲状腺良恶性钙化病变具有重要价值。

关键词：甲状腺良恶性钙化 CT值

Id2 epigenetically controls CD8^(+)T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1 complex

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Cellular & Molecular Immunology 2024年第3期21卷 292-308页

作者： Yiming Li Mingwei Han Haolin Wei Wan Huang Zhinan Chen Tianjiao Zhang Meirui Qian Lin Jing Gang Nan Xiuxuan Sun shuhui Dai Kun Wang Jianli Jiang Ping Zhu liang Chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of Clinical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases GanzhouJiangxi341000Xi’anShaanxi 710032China School of Medicine Shanghai UniversityShanghai 200444China

CD8^(+)T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6^(+)progenitor exhausted(Tex^(prog))and Tim-^(3+)terminally exhausted(Tex^(term))*** of DNA binding protein 2(Id2)has been shown to play important roles in T-cell development and CD8^(+)T-cell ***,the role of Id2 in CD8^(+)T-cell exhaustion is ***,we found that Id2 transcriptionally and epigenetically regulates the generation of Texprog cells and their conversion to Texterm *** deletion of Id2 dampens CD8^(+)T-cell-mediated immune responses and the maintenance of stem-like CD8^(+)T-cell subpopulations,suppresses PD-1 blockade and increases tumor ***,through its HLH domain,Id2 binds and disrupts the assembly of the Tcf3-Tal1 transcriptional regulatory complex,and thus modulates chromatin accessibility at the Slamf6 promoter by preventing the interaction of Tcf3 with the histone lysine demethylase ***,Id2 increases the abundance of the permissive H3K4me2 mark on the Tcf3-occupied E-boxes in the Slamf6 promoter,modulates chromatin accessibility at the Slamf6 promoter and epigenetically regulates the generation of Slamf6+Texprog *** LSD1 inhibitor GSK2879552 can rescue the Id2 knockout phenotype in tumor-bearing *** of LSD1 increases the abundance of Slamf6^(+)Tim-3^(−)Tex^(prog) cells in tumors and the expression level of Tcf1 in Id2-deleted CD8+T *** study demonstrates that Id2-mediated transcriptional and epigenetic modification drives hierarchical CD8^(+)T-cell exhaustion,and the mechanistic insights gained may have implications for therapeutic intervention with tumor immune evasion.

关键词： Id2 T-cell exhaustion Epigenetic modification Immune evasion