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Journal of Energy Chemistry 2024年第11期 383-390页

作者： Qu Yang shuhan fan Haozhe Zhang Zhenhuang Su Xingyu Gao Hui Shen Mingkui Wang Xiu Gong College of Physics & Guizhou Province Key Laboratory for Photoelectrics Technology and Application Guizhou University State Key Laboratory of Public Big Data Guizhou University Shanghai Synchrotron Radiation Facility (SSRF) Shanghai Advanced Research Institute Chinese Academy of Sciences Wuhan National Laboratory for Optoelectronics School of Optical and Electronic Information Huazhong University of Science and Technology

The proper bandgap and exceptional photostability enable CsPbI3as a potential candidate for indoor photovoltaics（IPVs）,but indoor power conversion efficiency（PCE） is impeded by serious nonradiative recombination stemming from challenges in incomplete DMAPbI3conversion and lattice structure ***,the coplanar symmetric structu re of hexyl sulfide（HS） is employed to functionalize the CsPbI3layer for fabricating highly efficient *** hydrogen bond between HS and DMAI promotes the conversion of DMAPbI3to CsPbI3,while the copianar symmetric structure enhances crystalline ***,surface sulfidation during HS-induced growth results in the in situ formation of PbS,spontaneously creating a CsPbI3N-P homojunction to enhance band alignment and carrier *** a result,the CsPbI3&HS devices achieve an impressive indoor PCE of 39.90%(Pin:334.6 μW cm-2,Pout:133.5 μW cm-2) under LED@2968 K,1062 lux,and maintain over 90% initial PCE for 800 h at ～30% air ambient humidity.

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Mannogalactoglucan from mushrooms protects pancreatic islets via restoring UPR and promotes insulin secretion in TIDM mice

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Food Science and Human Wellness 2024年第3期13卷 1390-1401页

作者： Ting Liu Si Chen Yunhe Qu Lujuan Zheng Xiaoxuan Yang shuhan Men Yuanning Wang Hanrui Ma Yifa Zhou Yuying fan Engineering Research Center of Glycoconjugates Ministry of EducationJilin Provincial Key Laboratory of Chemistry and Biology of Changbai Mountain Natural DrugsSchool of Life SciencesNortheast Normal UniversityChangchun 130024China

Type 1 diabetes mellitus(T1DM) lacks insulin secretion due to autoimmune deficiency of pancreaticβ-*** pancreatic islets and enhancing insulin secretion has been therapeutic *** is the main type of polysaccharide from natural mushroom,which has potential medicinal ***,the antidiabetic property of mannogalactoglucan in T1DM has not been fully *** this study,we obtained the neutral fraction of alkali-soluble Armillaria mellea polysaccharide(AAMP-N) with the structure of mannogalactoglucan from the fruiting body of *** and investigated the potential therapeutic value of AAMP-N in *** demonstrated that AAMP-N lowered blood glucose and improved diabetes symptoms in T1DM ***-N activated unfolded protein response(UPR) signaling pathway to maintain ER protein folding homeostasis and promote insulin secretion in *** that,AAMP-N promoted insulin synthesis via upregulating the expression of transcription factors,increased Ca^(2+) signals to stimulate intracellular insulin secretory vesicle transport via activating calcium/calmodulin-dependent kinase Ⅱ(CamkⅡ) and cAMP/PKA signals,and enhanced insulin secretory vesicle fusion with the plasma membrane via vesicle-associated membrane protein 2(VAMP2).Collectively,these studies demonstrated that the therapeutic potential of AAMP-N on pancreatic islets function,indicating that mannogalactoglucan could be natural nutraceutical used for the treatment of T1DM.

关键词： Mannogalactoglucan Mushroom Pancreatic islets Insulin secretion Insulin synthesis Unfolded protein response(UPR) Type 1 diabetes mellitus(T1DM)

Paleontology Knowledge Graph for Data-Driven Discovery

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Journal of Earth Science 2024年第3期35卷 1024-1034页

作者： Yiying Deng Sicun Song Junxuan fan Mao Luo Le Yao Shaochun Dong Yukun Shi Linna Zhang Yue Wang Haipeng Xu Huiqing Xu Yingying Zhao Zhaohui Pan Zhangshuai Hou Xiaoming Li Boheng Shen Xinran Chen shuhan Zhang Xuejin Wu Lida Xing Qingqing Liang Enze Wang School of Resources and Environmental Engineering Hefei University of TechnologyHefei 230009China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and PaleoenvironmentChinese Academy of SciencesNanjing 210008China School of Earth Sciences and Engineering and Frontiers Science Center for Critical Earth Material Cycling Nanjing UniversityNanjing 210023China State Key Laboratory for Mineral Deposits Research Nanjing UniversityNanjing 210023China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China Centre for Research and Education on Biological Evolution and Environment Nanjing UniversityNanjing 210023China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China

A knowledge graph(KG)is a knowledge base that integrates and represents data based on a graph-structured data model or *** have made efforts to construct geosciencerelated KGs to overcome semantic heterogeneity and facilitate knowledge representation,data integration,and text ***,there is currently no comprehensive paleontology KG or data-driven discovery based on *** this study,we constructed a two-layer model to represent the ordinal hierarchical structure of the paleontology KG following a top-down construction *** ontology containing 19365 concepts has been defined up to *** this basis,we derived the synonymy list based on the paleontology KG and designed corresponding online functions in the OneStratigraphy database to showcase the use of the KG in paleontological research.

关键词： paleontology knowledge graph ontology synonymy list OneStratigraphy big data ge-ology.

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社区工作者职业化发展的限制因素

经济研究导刊 2023年第1期 122-124页

作者：樊姝涵上海工程技术大学管理学院上海201620

社区建设是城市建设的重要组成部分,社区工作者作为我国社区事业发展的中坚力量,其职业化发展影响着社会基层治理的成效和社区服务的质量。当前我国社区工作者的职业化发展仍存在诸多问题。在对社区工作者职业化的基本内涵进行分析的基... 详细信息

社区建设是城市建设的重要组成部分,社区工作者作为我国社区事业发展的中坚力量,其职业化发展影响着社会基层治理的成效和社区服务的质量。当前我国社区工作者的职业化发展仍存在诸多问题。在对社区工作者职业化的基本内涵进行分析的基础上,探究制约社区工作者职业化发展的因素,并提出加强社区工作者职业化建设的路径,即增强职业认同感、拓宽职业发展空间、健全福利待遇保障机制、建立职业能力培训机制,以期培养一支专业化、职业化的社区工作者队伍。

关键词：社区工作者职业化限制因素建设路径

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运行车速理论在公路路线设计中的应用

北方交通 2006年第10期 1-3页

作者：樊叔晗北京中汉威交通科技有限公司北京100000

通过对车辆行驶特性以及车辆与公路线形相互关系的分析,论述了运行车速理论在公路路线设计中的应用,提出了以人为本的宽容设计理念。

关键词：运行车速路线设计宽容设计

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重建深时地球生物多样性时空分布模式的思考

科学通报 2024年第22期69卷 3252-3267页

作者：张书涵沈树忠王向东张华樊隽轩南京大学地球科学与工程学院关键地球物质循环前沿科学中心内生金属成矿机制研究国家重点实验室南京210023 中国科学院南京地质古生物研究所现代古生物学和地层学国家重点实验室南京210008

重建地球生物多样性演变历史是了解地球生命演化规律的关键.通过研究地质时期的生物多样性变化,能够追溯生命的起源、演化和灭绝过程,并探索其原因.然而,地球上曾经生活过的99%以上的生物都已经灭亡,其中只有一小部分保存为化石并被人... 详细信息

重建地球生物多样性演变历史是了解地球生命演化规律的关键.通过研究地质时期的生物多样性变化,能够追溯生命的起源、演化和灭绝过程,并探索其原因.然而,地球上曾经生活过的99%以上的生物都已经灭亡,其中只有一小部分保存为化石并被人类发现.因此,如何利用化石记录重建地球生物多样性变化的过程是一个非常复杂的科学难题.为了解决这一难题,需要从多方面入手.首先,建立含有时空信息的全球性大型综合数据库是研究深时生物多样性模式的必要条件,也是识别曾经发生过的重大生物事件的基础,以往的研究多集中在海洋无脊椎动物化石多样性的研究,目前仍然缺乏全球性的陆地生物多样性模式.其次,需要解决化石保存不完整和样本采集时空不均一的难题.近十几年来,随着海量数据的积累,大数据分析技术的发展,通过多学科交叉,在解决时空分辨率低和样本偏差等问题上发展了更有效的分析手段,但仍然任重道远.最后,新的大数据研究结果引发了对深时地球生物多样性变化的时空规律的许多新认识.随着研究的深入,五次生物大灭绝的灭绝幅度和灭绝率明显降低,需要以全球大数据为基础重新精确估算,其中二叠纪末生物大灭绝无疑仍是最大的一次,而泥盆纪晚期F/F和三叠纪末灭绝事件很可能算不上五大生物灭绝之二,白垩纪末生物大灭绝的持续时间和灭绝幅度也需要重新估算.此外,寒武纪-奥陶纪、石炭纪-二叠纪和新生代三大生物辐射事件也需要全球高分辨率化石数据验证.以人工智能和超级计算机等为手段建立的深时生态系统演变模型是实现古今对比的未来方向.这些研究将使我们对地球生物多样性历史有全方位的认识,也为现今的全球生态系统面临的问题提供深时参照.

关键词：深时大数据生物多样性生物大灭绝生态模型

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ALEAP模型在WAF场景下的应用研究

网络空间安全 2020年第7期11卷 97-104页

作者：范舒涵王之梁杨家海清华大学网络科学与网络空间研究院北京100084

文章探究基于深度学习的事件预测模型ALEAP在WAF场景下的应用情况,通过对校园网WAF系统日志数据的统计分析和事件嵌入分析,发现Web攻击事件分布上的聚集性以及上下文之间的关联性;通过WAF历史日志数据对ALEAP模型进行预训练,利用预训练... 详细信息

文章探究基于深度学习的事件预测模型ALEAP在WAF场景下的应用情况,通过对校园网WAF系统日志数据的统计分析和事件嵌入分析,发现Web攻击事件分布上的聚集性以及上下文之间的关联性;通过WAF历史日志数据对ALEAP模型进行预训练,利用预训练模型预测下一个可能发生的Web攻击事件,模型最终达到78%的预测准确率,证实了ALEAP模型在该场景下的适用性,为网络管理者实施防御策略提供可靠性参考依据,同时也说明ALEAP模型在具有上下文关联关系的安全日志事件预测方面的普适性。

关键词：安全事件预测 Web应用防火墙 ALEAP

基于AFCKF的捷联旋转弹视线角速率滤波算法

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航空兵器 2024年第4期31卷 86-92页

作者：夏书涵范军芳纪毅王伟陈仕伟马乾才北京信息科技大学自动化学院北京100192 北京理工大学宇航学院北京100081 西安现代控制技术研究所西安710065

针对捷联旋转弹输出的视线角速率与姿态误差强耦合的问题,提出一种基于自适应渐消容积卡尔曼滤波(AFCKF)的方法。为实现弹目视线角速率的解耦,考虑弹目相对运动特性,构建包含末制导段视线角速率估计模型的状态模型,并根据几何关系建立... 详细信息

针对捷联旋转弹输出的视线角速率与姿态误差强耦合的问题,提出一种基于自适应渐消容积卡尔曼滤波(AFCKF)的方法。为实现弹目视线角速率的解耦,考虑弹目相对运动特性,构建包含末制导段视线角速率估计模型的状态模型,并根据几何关系建立了包含弹目视线角和姿态角的量测模型。为解决旋转弹下传统CKF视线角速率估计结果的发散导致滤波失效,引入基于残差序列的渐消因子对预测状态协方差进行调节以快速收敛估计结果。为验证AFCKF的有效性,考虑姿态角和量测角的典型干扰。仿真结果表明,所提方法的视线高低角速率估计误差均值、方位角速率估计误差均值分别为传统EKF的30.41%和42.18%,有效提升了旋转弹视线角速率估计的精度。

关键词：旋转弹捷联导引头视线角速率 AFCKF 非线性滤波

金盏花苷E通过自噬途径下调GPX4和SLC7A11抑制肝癌细胞的增殖和迁移

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南方医科大学学报 2024年第7期44卷 1327-1335页

作者：陈芊伊尚书涵鲁欢李思思孙志勉范喜瑞戚之琳皖南医学院基础医学院生物化学与分子生物学教研室安徽芜湖241002 皖南医学院活性生物大分子研究安徽省重点实验室安徽芜湖241002 皖南医学院临床医学院安徽芜湖241002 皖南医学院公共卫生学院安徽芜湖241002

目的探讨金盏花苷E抑制肝癌细胞增殖和迁移的分子机制。方法金盏花苷E处理肝癌细胞,CCK-8检测细胞活力;Western blotting检测GPX4、SLC7A11、LC3、P62的表达以及Akt/mTOR的磷酸化。自噬抑制剂LY294002和激活剂Rapamycin与金盏花苷E联合... 详细信息

目的探讨金盏花苷E抑制肝癌细胞增殖和迁移的分子机制。方法金盏花苷E处理肝癌细胞,CCK-8检测细胞活力;Western blotting检测GPX4、SLC7A11、LC3、P62的表达以及Akt/mTOR的磷酸化。自噬抑制剂LY294002和激活剂Rapamycin与金盏花苷E联合处理肝癌细胞,EdU和Transwell实验分别检测肝癌细胞的增殖和迁移能力。TCGA数据库分析GPX4和SLC7A11在肝癌及正常肝组织中的表达水平,以及与肝癌患者存活之间的关系。Western blotting和qPCR分别检测GPX4和SLC7A11在肝癌细胞和正常肝细胞中的表达水平。结果金盏花苷E能够显著抑制肝癌细胞的存活(P<0.05);GPX4和SLC7A11在肝癌组织和肝癌细胞中均显著高表达;GPX4和SLC7A11的表达与肝癌患者存活呈显著负相关(P<0.001);金盏花苷E显著抑制GPX4和SLC7A11蛋白的表达,激活Akt-mTOR通路,增强LC3Ⅱ的表达(P<0.01);自噬激活剂Rapamycin显著增强金盏花苷E对GPX4和SLC7A11的抑制作用,而自噬抑制剂LY294002则明显逆转了金盏花苷E对GPX4和SLC7A11的抑制作用(P<0.05);抑制自噬途径能够逆转金盏花苷E对肝癌细胞增殖和迁移的抑制作用,增强自噬途径则发生相反的变化(P<0.01)。结论金盏花苷E经自噬途径下调GPX4和SLC7A11抑制肝癌细胞的增殖和迁移。

关键词：金盏花苷E 谷胱甘肽过氧化物酶4 溶质转运蛋白第7家族11成员自噬肝细胞癌

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Multidisciplinary and multiscale nanoscience research roadmap based on large scientific facilities

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Science China Chemistry 2024年第8期67卷 2497-2523页

作者： Yuan Zeng shuhan Zhang Yuecong Guo Yalin Cong Xu Ding Peihua Li Yunxiang Lin Wenzhi Ren Hui Su Weigang Sun Liuxin Xu Guikai Zhang Shihua Chen Yu Chen Weiren Cheng Shengqi Chu Yong Guan Jinru Han Jie Lin Hengjie Liu Zheyi Liu Pan Luo fanchun Meng Sicong Qiao Zongyin Song Ying Wang Zhao Wu Chenyu Yang Meng Yang Shirui Yang Zi Yin Zhibin Yin Pengjun Zhang Hongyu Zhang Pingping Zheng Jia Zhou Wanlin Zhou Pengfei An He Cheng Chunhai fan Xingjiu Huang Yong Lei Lina Li Mu Li Qinghua Liu Shuming Peng Li Song Zhihu Sun Yangchao Tian fangjun Wang Lihua Wang Liming Wang Shiqiang Wei Aiguo Wu Chunlei Xiao Xueming Yang Panchao Yin Jing Zhang Mingxin Zhang Yaling Wang Chunying Chen CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety New Cornerstone Science LaboratoryNational Center for Nanoscience and TechnologyBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230029China Institute of Solid State Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China Institutes of Physical Science and Information Technology Anhui UniversityHefei 230601China Ningbo Key Laboratory of Biomedical Imaging Probe Materials and Technology Zhejiang International Cooperation Base of Biomedical Materials Technology and ApplicationCAS Key Laboratory of Magnetic Materials and DevicesNingbo Cixi Institute of Biomedical EngineeringZhejiang Engineering Research Center for Biomedical MaterialsNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China Advanced Energy Science and Technology Guangdong Laboratory Huizhou 516000China College of Chemistry and Chemical Engineering Hunan Normal UniversityChangsha 410081China State Key Laboratory of Luminescent Materials and Devices South China Advanced Institute for Soft Matter Science and TechnologySouth China University of TechnologyGuangzhou 510640China Beijing Synchrotron Radiation Facility Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of Separation Sciences for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China Institute of Advanced Science Facilities Shenzhen 518107China State Key Laboratory of Coal Conversion Institute of Coal ChemistryChinese Academy of SciencesTaiyuan 030001China State Key Laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Acade

With the advancement of modern science and technology, large scientific facilities are increasingly oriented toward demand and application, and can be used for basic research as well as serving multiple disciplines. Developing large scientific facilities and related analytical technologies enhances understanding of large scientific facilities and popularizes their application in research across multiple disciplines. The combination of light or neutron sources from large scientific facilities and advanced analytical technologies can be achieved for materials structure information, dynamics study of chemical reactions, high dissociation of biomolecules, 3D visualization of energy materials or biological samples, etc. We first introduce the progress of domestic large scientific facilities of synchrotron radiation(SR) and free electron lasers(FELs) with different wavelengths and neutron *** further discuss the comparison between Chinese and typical foreign facilities in X-ray radiation from X-ray tubes, synchrotrons, X-ray FELs, and neutron sources based on physical parameters of light and neutron sources. In addition, we focus on the technological progress and perspectives combined with advanced X-ray radiation and neutron sources of large scientific facilities in China, especially in the nanoscience fields of energy catalysis and biological science. We hope that this roadmap will provide references on technology and methods to experimental users, as well as prospects for future development of technologies based on large research infrastructure facilities. Comprehensive studies and guidelines for basic research to practical application in various disciplines can be made with the assistance of large scientific facilities.

关键词： large scientific facilities synchrotron radiation FEL light sources neutron sources spectroscopic analysis methods X-ray imaging techniques structural information chemical dynamics