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A Knowledge-enhanced Two-stage Generative Framework for Medical Dialogue Information Extraction

Machine Intelligence Research 2024年第1期21卷 153-168页

作者： Zefa Hu Ziyi Ni Jing Shi shuang Xu Bo Xu School of Artificial Intelligence University of Chinese Academy of SciencesBeijing 100049China Institute of Automation Chinese Academy of SciencesBeijing 100190China

This paper focuses on term-status pair extraction from medical dialogues(MD-TSPE),which is essential in diagnosis dia-logue systems and the automatic scribe of electronic medical records(EMRs).In the past few years,works on MD-TSPE have attracted increasing research attention,especially after the remarkable progress made by generative ***,these generative methods output a whole sequence consisting of term-status pairs in one stage and ignore integrating prior knowledge,which demands a deeper un-derstanding to model the relationship between terms and infer the status of each *** paper presents a knowledge-enhanced two-stage generative framework(KTGF)to address the above *** task-specific prompts,we employ a single model to com-plete the MD-TSPE through two phases in a unified generative form:We generate all terms the first and then generate the status of each generated *** this way,the relationship between terms can be learned more effectively from the sequence containing only terms in the first phase,and our designed knowledge-enhanced prompt in the second phase can leverage the category and status candidates of the generated term for status ***,our proposed special status"not mentioned"makes more terms available and en-riches the training data in the second phase,which is critical in the low-resource *** experiments on the Chunyu and CMDD datasets show that the proposed method achieves superior results compared to the state-of-the-art models in the full training and low-re-sourcesettings.

关键词： Medical dialogue understanding information extraction text generation knowledge-enhanced prompt low-resource setting dataaugmentation

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Preparation of water-soluble tantalum nanoparticles and their radiosensitization application

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Tungsten 2024年第4期6卷 748-758页

作者： Wang Zhang shuang-Long Du Zhi-Guo Zhang Tao Wang Chun-Jian Su Xing-Hua Dong shuang Zhu Zhan-Jun Gu College of Mechanical and Electronic Engineering Shandong University of Science and Technology CAS Key Laboratory for Biomedical Eff ects of Nanomaterials and Nanosafety Institute of High Energy Physics Chinese Academy of Science GBA Research Innovation Institute for Nanotechnology CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology of China Chinese Academy of Sciences

Radiation therapy(RT) that utilizes high dose of ionizing radiation to kill tumor cells is a common cancer treatment ***,the effectiveness of RT is limited by the tolerance of normal tissue surrounding the *** high atom number(Z) element-based radio sensitizers to increase energy deposit inside tumor cells can achieve better carcinoma *** nanoparticles(Ta NPs) exhibit good radiotherapy sensitization ***,achieving the water solubility of Ta NPs is *** study reported a mechanochemical method for obtaining Ta NPs modified with sodium hexametaphosphate(SHMP) for radiotherapy sensitization *** results showed that the water solubility of Ta NPs modified with SHMP was significantly *** biocompatibility and radio sensitizing ability are also verified at both cellular and animal levels.

关键词： Mechanochemical method Radiotherapy sensitization Sodium hexametaphosphate Tantalum nanoparticles

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Effect of Three-High Rotary Piercing Process on Microstructure,Texture and Mechanical Properties of Magnesium Alloy Seamless Tube

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 953-968页

作者： Xiaofeng Ding Zehao Wu Tong Li Jianxun Chen Yuanhua shuang Baosheng Liu Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan030024China College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China

Mg alloy seamless tubes(MASTs)were prepared through three-high rotary piercing process,effect of billet temperature,feed angle and plug advance on microstructure,texture and mechanical properties of tubes were *** effect on the deformation mechanism and improving mechanical properties mechanism of this process for MASTs were *** results show that the grain size could be refined to 11.3-31.1%of the initial grain size and the microstructure was more uniform due to the accumulation of *** formation of high strain gradient at the grain boundary activated the non-basal *** piercing process could change the grain orientation of as-extruded billet and eliminate the initial basal texture to produce new favorable *** the process could accelerate the continuous dynamic recrystallization *** piercing,yield strength of pierced tubes decreased by 6.7%,ultimate tensile strength(UTS)and elongation increased by 32.4 and 45%,respectively,at optimal *** plate-shapedβ_(1)-Mg_(17)Al_(12) orientation transformed from basal plates to prismatic plates,facilitating the increase in UTS and *** decrease size of nanoscale precipitates could reduce the cracking *** critical resolved shear stress ratios of pyramidal(10−11)slip and(11−22)slip to basal slip for the sample including prismatic plates both decreased compared to that including basal *** could enhance the ductility of tube ***,grain boundary sliding could contribute to a better ductility via coordinating deformation and reducing stress concentration during piercing process.

关键词： Mg alloy tube Rotary piercing Microstructure Texture Mechanical properties

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Green-synthesized, biochar-supported nZVI from mango kernel residue for aqueous hexavalent chromium removal: Performance, mechanism and regeneration

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Chinese Journal of Chemical Engineering 2024年第7期71卷 91-101页

作者： Yuting Zhang Yuwei Tang Ruiping Yan shuang Liang Zhongmou Liu Yadong Yang Key Laboratory of Songliao Aquatic Environment Ministry of EducationJilin Jianzhu UniversityChangchun 130118China School of Environmental Science and Engineering Yancheng Institute of TechnologyYancheng 224051China

A biochar-supported green nZVI(G-nZVI@MKB)composite was synthesized using mango kernel waste with“dual identity”as reductant and biomass of *** G-nZVI@MKB with a Fe/C mass ratio of 2.0(G-nZVI@MKB2)was determined as the most favorable composite for hexavalent chromium(Cr(VI))*** influencing parameters were discussed,and 99.0%of Cr(VI)removal occurred within 360 min under these optimized ***-second order kinetic model and intra-particle diffusion model well depicted Cr(VI)removal *** XRD,FTIR,SEM,and XPS analyses verified the key roles of G-nZVI and functional groups,as well as the primary removal mechanisms involving electrostatic attraction,reduction,and complexation.G-nZVI@MKB2 exhibited good stability and reusability with only a 16.4%decline in Cr(VI)removal after five *** study offered evidence that mango kernel could be recycled as a beneficial resource to synthesize green nZVI-loaded biochar composite for efficient Cr(VI)elimination from water.

关键词： Synthesis Biochar-supported nZVI Hexavalent chromium Reduction Regeneration

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Effects of Heat Transfer on Laminar-to-Turbulent Transition over a Compressor Blade Operating at Low Reynolds Number

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Journal of Thermal Science 2024年第5期33卷 1826-1838页

作者： LU Lehan WANG Mingyang ZHANG Yanfeng SUN shuang HUANG Zhen WANG Maomao Department of aviation Engineering Civil Aviation University of ChinaTianjin 300300China Institute of Engineering Thermophysics Chinese Academy of SciencesBeijing 100190China State Key Laboratory of Aerodynamics CARDCMianyang 621000China

To control the transition process in a laminar separation bubble(LSB)over an ultra-high load compressor blade at a Re of 1.5×10^(5),the effects of wall heat transfer were considered and numerically investigated by large eddy simulations(LES).Compared with the adiabatic wall condition,the local kinematic viscosity of airflow was reduced by wall cooling;thus the effects of turbulent dissipation on the growth of fluctuations were *** such,the transition occurred much earlier,and the size of LSB became *** the cooled surface,the spanwise vortices deformed much more rapidly and the size of hairpin vortex structures was ***,the rolling-up of 3D hairpin vortices and the ejection and sweeping process very close to the blade surface was ***,the aerodynamic losses of the compressor blade were reduced by 18.2%and 38.4%for the two cooled wall *** results demonstrated the feasibility of wall cooling in controlling the transition within an LSB and reducing the aerodynamic loss of an ultra-highly loaded compressor blade.

关键词： heat transfer compressor blade laminar-to-turbulent transition loss generation

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng Li Yuan Yang Hua Yue shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng Li shuang Wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and Delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(LipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and LipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

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Feasible strategy for the nitrogen fixation and humification quality improvement by spent mushroom substrate as conditioning agent

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 235-240页

作者： shuang Ai Yuanbei Zhang Guoxiang Zheng College of Engineering Northeast Agricultural UniversityHarbin 150030China Key Laboratory of Swine Facilities Engineering Ministry of Agriculture and Rural AffairsHarbin 50030China Heilongjiang Key Laboratory of Technology and Equipment for the Utilization of Agricultural Renewable Resources Harbin 150030China

There is an overlooked problem which increasing microbial abundance while reducing nitrogen loss during *** study investigated the viability of spent mushroom substrate(SMS)as conditioners in the aerobic composting of kitchen waste(KW)with cattle manure(CM).The variation of temperature,pH,C/N,organic matter,cellulose,hemicelluloses,germination index(GI),and microflora structure were explored to evaluate the potential in accelerating maturity and nitrogen fixation by SMS *** results showed that the addition of SMS accelerated the heating rate,prolonged the high temperature time,and decreased organic matter,hemicellulose,and cellulose by 17.49%,23.61%,and 18.62%,*** GI reached 105.86%with SMS addition,while 74.17%was found in control treatment after *** changed the microbial community composition and increased the species ***,Clostridium XI and Azomonas were dominant bacteria,which increased the retention of nitrogen,promoted organic matter degradation and reduce compost *** study can provide a feasible strategy for nitrogen fixation in the field of organic waste recycling.

关键词： spent mushroom substrate conditioning agent nitrogen fixation humification quality aerobic composting

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List of 85 typical catastrophic landslides from March 2004 to February 2024

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China Geology 2024年第2期7卷 369-370页

作者： Rui-chen Chen Yong-shuang Zhang School of Engineering and Technology China University of GeosciencesBeijing 100083China Institute of Geosafety China University of GeosciencesBeijing 100083China

Landslides are one of the most dangerous natural hazards that cause significant property damage and loss of *** often destroy farmland,villages,houses,factories,schools,roads and other facilities,injuring humans and ***,entire towns are devastated by *** to their pervasiveness,varied triggering factors,and sudden occurrence,landslides are currently one of the most challenging natural disasters to prevent and mitigate.

关键词： stated farmland catastrophic

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Large isolated fibrous tumors in the upper esophagus: A case report

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 543-549页

作者： Jia-Jia Yu Huan-shuang Pei Yu Meng Department of Anesthesiology The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050000Hebei ProvinceChina

BACKGROUND Solitary fibrous tumors(SFT)are rare spindle cell tumors that are usually benign.A total of 10 cases of SFTs in the upper esophagus have ever been ***,we report the anesthetic management of a patient with a large isolated fibrous tumor of the upper esophagus compressing the tracheal *** also provide a literature review of the current *** SUMMARY We report the case of a 49 year old male with“cough aggravation and wheezing after exercise”,who underwent esophagectomy for a large isolated fibrous tumor compressing the tracheal membrane in the upper *** advise the use of a single-lumen tube with a blocker in patients with difficult airways to reduce the incidence of airway injury and fibrinoscopy at all stages of the perioperative period to guide airway *** case study is the first report of the anesthetic management of a large,isolated fibrous tumor compressing the tracheal membrane in the upper *** This rare case emphasizes the importance of perioperative management of anesthesia in patients with large isolated fibrous tumors of the upper esophagus that compress the tracheal *** use of blocker reduce the incidence of airway injury and fibrinoscopy at the perioperative period to guide airway mana-gement.

关键词： Upper esophagus Isolated fibrous tumor Tracheal membrane Peak airway pressure Case report

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