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miR-194-3p调控模拟微重力条件下致成骨细胞功能异常的实验研究

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医用生物力学 2024年第4期39卷 623-630页

作者：薛进冬程路畅王敏谭彩美邓琪琪朱海美郭勇韩标桂林医学院智能医学与生物技术学院桂林541199 广西高校医药生物技术与转化医学重点实验室桂林541199

目的探讨模拟微重力环境下miR-194-3p对成骨细胞功能变化的调控作用,为极端力学环境下成骨细胞的力学响应机制提供理论基础。方法利用细胞旋转培养系统建立细胞水平微重力环境,分别采用MTT、RT-PCR、Western blot、荧光双染色法和茜素... 详细信息

目的探讨模拟微重力环境下miR-194-3p对成骨细胞功能变化的调控作用,为极端力学环境下成骨细胞的力学响应机制提供理论基础。方法利用细胞旋转培养系统建立细胞水平微重力环境,分别采用MTT、RT-PCR、Western blot、荧光双染色法和茜素红染色法检测转染miR-194-3p抑制剂前后MC3T3-E1成骨细胞增殖、分化、凋亡和矿化的变化情况。结果模拟微重力环境下miR-194-3p表达上调,成骨细胞的增殖、分化和矿化均受到一定程度的抑制,同时促进了成骨细胞的凋亡。转染miR-194-3p抑制剂后,miR-194-3p表达显著下调,且能部分逆转由微重力导致的细胞成骨细胞增殖减弱、成骨分化标志物如ALP、OCN和COL-I基因和蛋白表达降低、骨矿化结节减少和成骨细胞凋亡数目增加的情况,说明miR-194-3p能有效改善微重力暴露下成骨细胞功能异常的情况。结论模拟微重力环境下miR-194-3p可能作为一种负调控因子,通过调控成骨细胞功能参与其力学响应的进程。

关键词：模拟微重力环境 miR-194-3p 成骨细胞细胞增殖细胞分化矿化力学响应

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某排土场在不同工况下边坡稳定性研究

价值工程 2024年第4期43卷 140-142页

作者：于韩浠张雄彪武汉轻工大学武汉430000 新洋丰农业科技股份有限公司荆门448000

为研究某排土场边坡稳定性,结合排土场所在位置工程地质概况,利用GeoStudio软件,采用三种不同的极限平衡法对排土场最不利滑动面进行分析,计算其在自然、强降雨及地震工况的最小边坡安全系数,为排土场边坡稳定性提供数据支撑。

关键词：排土场极限平衡法强降雨地震

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Laboratory insights into the effects of methane hydrate on the anisotropic joint elastic-electrical properties in fractured sandstones

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Petroleum Science 2023年第2期20卷 803-814页

作者： Sheng-biao Liu Tong-Cheng han Li-Yun Fu Shandong Provincial Key Laboratory of Deep Oil and Gas China University of Petroleum(East China)QingdaoShandong266580China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Science and TechnologyQingdaoShandong266071China

Fractured hydrate-bearing reservoirs show significantly anisotropic geophysical properties. The joint application of seismic and electromagnetic explorations is expected to accurately assess hydrate resources in the fractured reservoirs. However, the anisotropic joint elastic-electrical properties in such reservoirs that are the key to the successful application of the joint explorations, remain poorly understood. To obtain such knowledge, we designed and implemented dedicated laboratory experiments to study the anisotropic joint elastic-electrical properties in fractured artificial silica sandstones (with fracture density of about 6.2%, porosity of approximately 25.7%, and mean grainsize of 0.089 mm) with evolving methane hydrate. The experimental results showed that the anisotropic compressional wave velocities respectively increased and decreased with the forming and dissociating hydrate, and the variation in the increasing trend and the decreasing extent of the velocity perpendicular to the fractures were more significant than that parallel to the fractures, respectively. The experimental results also showed that the overall decreasing trend of the electrical conductivity parallel to the fractures was steeper than that perpendicular to the fractures during hydrate formation, and the general variations of the two conductivities with complex trend were similar during hydrate dissociation. The variations in the elastic and electrical anisotropic parameters with forming and dissociating hydrate were also found to be distinct. Interpretation of the experimental results suggested that the hydrate binding to the grains evolved to bridge the surfaces of fractures when saturation exceeded 10% during hydrate formation, and the bridging hydrate gradually evolved to floating in fractures during dissociation. The experimental results further showed that the anisotropic velocities and electrical conductivities were correlated with approximately consistent trends of different

关键词： Fractured hydrate reservoirs Elastic anisotropy Electrical anisotropy Joint elastic-electrical properties Hydrate distribution

Exploring the nature of black hole and gravity with an imminent merging binary of supermassive black holes

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Science China(Physics,Mechanics & Astronomy) 2023年第3期66卷 76-87页

作者： Xingyu Zhong Wen-biao han Ziren Luo Yueliang Wu Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Taiji Laboratory for Gravitational Wave Universe(Beijing/hangzhou) University of Chinese Academy of SciencesBeijing 100049China hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou 310124China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China Shanghai Frontiers Science Center for Gravitational Wave Detection Shanghai 200240China Institute of Theoretical Physics Chinese Academy of SciencesBeijing 100190China International Centre for Theoretical Physics Asia-Paciﬁc University of Chinese Academy of SciencesBeijing 100190China Key Laboratory of Gravitational Wave Precision Measurement of Zhejiang Province Hangzhou 310124China

A supermassive binary black-hole candidate SDSS J1430+2303 reported recently motivates us to investigate an imminent binary of supermassive black holes as potential gravitational wave source, and the radiated gravitational waves at the end of the merger are shown to be in the band of space-borne detectors. We provide a general analysis on the required detecting sensitivity needed for probing such type gravitational wave sources and make a full discussion by considering two typically designed configurations of space-borne antennas. If a source is so close, it is possible to be detected with Taiji pathfinder-plus which is proposed to be an extension for the planned Taiji pathfinder by just adding an additional satellite to the initial two satellites. The gravitational wave detection on such kind of source enables us to explore the properties of supermassive black holes and the nature of gravity.

关键词： gravitation wave SMBHBs Taiji pathfinder

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煤矿短壁工作面水力压裂顶板弱化试验

陕西煤炭 2024年第4期43卷 1-5页

作者：刘兴安韩彪魏斌陕西神木神源煤炭矿业有限公司陕西榆林719000 中煤科工开采研究院有限公司北京100013 天地科技股份有限公司开采设计事业部北京100013

陕西神木某煤矿短壁工作面切眼长度75 m,推采长度240 m,工作面上覆坚硬顶板。针对短壁工作面初采期间采空区顶板冒落不及时这一现象,采用了水力压裂技术对工作面上覆顶板进行有效弱化。通过分析该矿ST5201工作面采用水力压裂弱化顶板的... 详细信息

陕西神木某煤矿短壁工作面切眼长度75 m,推采长度240 m,工作面上覆坚硬顶板。针对短壁工作面初采期间采空区顶板冒落不及时这一现象,采用了水力压裂技术对工作面上覆顶板进行有效弱化。通过分析该矿ST5201工作面采用水力压裂弱化顶板的效果,得出深孔水力压裂强制放顶时裂隙扩展半径可达30 m左右,压裂后工作面初次来压步距为20.5 m左右;从回采期间采空区顶板冒落效果,施工期间人工劳动强度、操作安全角度等方面验证了水力压裂对短壁工作面回采期间的安全可靠性,为短壁工作面坚硬顶板治理提供了有效途径。

关键词：短壁工作面坚硬顶板水力压裂顶板弱化强制放顶

丙胺盐酸盐辅助结合气淬法制备高效宽带隙钙钛矿太阳电池

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物理学报 2024年第15期73卷 243-253页

作者：杨静韩晓静刘冬雪石标王鹏阳许盛之赵颖张晓丹中国长江三峡集团有限公司科学技术研究院北京101199 南开大学光电子薄膜器件与技术研究所天津300350 天津市光电子薄膜器件与技术重点实验室天津300350 薄膜光电子技术教育部工程研究中心天津300350 化学科学与工程协同创新中心天津300072 南开大学可再生能源转换与储存中心天津300072

宽带隙钙钛矿与晶硅电池结合制备叠层太阳电池,其效率可以超越单结太阳电池的理论极限.然而,宽带隙钙钛矿薄膜结晶速率快,导致薄膜结晶质量差且具有大量缺陷,严重降低电池的光电转换性能.本文采用温和的气淬法制备宽带隙钙钛矿薄膜,并... 详细信息

宽带隙钙钛矿与晶硅电池结合制备叠层太阳电池,其效率可以超越单结太阳电池的理论极限.然而,宽带隙钙钛矿薄膜结晶速率快,导致薄膜结晶质量差且具有大量缺陷,严重降低电池的光电转换性能.本文采用温和的气淬法制备宽带隙钙钛矿薄膜,并引入丙胺盐酸盐作为添加剂改善钙钛矿薄膜的结晶质量.丙胺阳离子与钙钛矿组分相互作用生成了二维钙钛矿相,钙钛矿以二维相作为生长模板降低了α相钙钛矿的形成能,同时辅助钙钛矿均匀成核和择优取向生长,增大了晶粒尺寸.使用该策略制备的带隙为1.68 eV的钙钛矿太阳电池实现了21.48%的光电转换效率.此外,制备的8 cm×8 cm的宽带隙钙钛矿薄膜具有良好的均匀性.本工作为高效、大面积钙钛矿基的光伏器件的制备工艺提供了新的策略.

关键词：宽带隙钙钛矿气淬法丙胺盐酸盐结晶

Analytical effective one-body formalism for extreme-mass-ratio inspirals with eccentric orbits

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Communications in Theoretical Physics 2021年第8期73卷 96-113页

作者： Chen Zhang Wen-biao han Shu-Cheng Yang Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai200030China School of Astronomy and Space Science University of Chinese Academy of Sciences Beijing100049China

Extreme-mass-ratio inspirals(EMRIs)are among the most important sources for future spaceborne gravitational wave *** this kind of system,compact objects usually orbit around central supermassive black holes on complicated ***,these trajectories are approximated as the geodesics of Kerr space-times,and orbital evolution is simulated with the help of the adiabatic ***,this approach omits the influence of the compact object on its *** this paper,using the effective one-body formalism,we analytically calculate the trajectory of a nonspinning compact object around a massive Kerr black hole in an equatorial eccentric orbit(omitting the orbital inclination)and express the fundamental orbital frequencies in explicit *** formalism includes the first-order corrections for the mass ratio in the conservative orbital ***,we insert the mass-ratio-related terms into the first post-Newtonian energy *** calculating the gravitational waves using the Teukolsky equations,we quantitatively reveal the influence of the mass of the compact object on the data *** find that the shrinking of geodesic motion by taking small objects as test particles may not be appropriate for the detection of EMRIs.

关键词： gravitational wave extreme-mass-ratio inspiral effective one-body

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一种面向任务的海空跨域网络路由协议

水下无人系统学报 2024年第4期32卷 695-702页

作者：张皓波王彪韩兆越江苏科技大学海洋学院江苏镇江212000

海空跨域网络由水下子网和水上子网构成,为了充分利用资源,多种不同的应用程序共享相同的物理设施,不同的数据包共存于同一网络中,需要差异化的传送策略来满足应用需求,但现有的路由协议往往无法根据应用需求来提供个性化的服务。针对... 详细信息

海空跨域网络由水下子网和水上子网构成,为了充分利用资源,多种不同的应用程序共享相同的物理设施,不同的数据包共存于同一网络中,需要差异化的传送策略来满足应用需求,但现有的路由协议往往无法根据应用需求来提供个性化的服务。针对该问题,文中提出了一种面向任务的海空跨域网络路由协议,该协议根据任务类型的不同,调整转发因子的计算方式,并以此为特定的任务类型选择最合适的下一跳节点。此外,协议中还增加了预处理层来完成异构网络之间的通信。仿真结果表明,与其他典型的协议相比,文中所提协议能够根据任务的特定需求实现最优的传输策略。

关键词：面向任务海空跨域网络通信路由协议

带金属支撑多侧孔与普通超细引流管应用于单孔胸腔镜肺下叶切除术的回顾性队列研究

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中国胸心血管外科临床杂志 2024年第7期31卷 980-984页

作者：韩志伟岳鹏马敏杰刘礼新胡文滕李琼韩彪兰州大学第一临床医学院兰州730000 兰州大学第一医院胸外科兰州730000 胸外科关键技术研发与应用专业甘肃省国际科技合作基地兰州730000 甘肃省胸外科医疗质量控制中心兰州730000

目的比较带金属支撑的多侧孔超细引流管与普通超细引流管在单孔胸腔镜肺下叶切除术中的临床应用效果。方法回顾性分析2021年1月—2022年6月兰州大学第一医院胸外科收治的行单孔胸腔镜肺下叶切除术肺癌根治患者的临床资料。根据术中使用... 详细信息

目的比较带金属支撑的多侧孔超细引流管与普通超细引流管在单孔胸腔镜肺下叶切除术中的临床应用效果。方法回顾性分析2021年1月—2022年6月兰州大学第一医院胸外科收治的行单孔胸腔镜肺下叶切除术肺癌根治患者的临床资料。根据术中使用超细引流管类型的不同,将患者分为试验组(使用带金属支撑的多侧孔10F超细引流管)与对照组(使用普通12F超细引流管)。比较两组患者的临床资料。结果共纳入190例患者,其中男108例、女82例。试验组90例,平均年龄(56.60±10.14)岁;对照组100例,平均年龄(57.07±11.04)岁。试验组术后肺部感染、胸腔积液发生率低于对照组,差异有统计学意义(P0.05)。结论带金属支撑的多侧孔超细引流管相比普通超细引流管可降低单孔胸腔镜肺下叶切除术后肺部感染、胸腔积液并发症发生率,减轻疼痛、经济负担,可在单孔胸腔镜肺下叶切除术中推广应用。

关键词：超细引流管单孔胸腔镜手术肺下叶切除术回顾性队列研究加速康复