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《肿瘤中医诊疗指南》临床应用评价研究

中国中药杂志 2017年第17期42卷 3247-3251页

作者：史楠楠刘孟宇刘玉祁王跃溪王丽颖宇文亚赵学尧卫东锋寇爽韩学杰王燕平中国中医科学院中医临床基础医学研究所北京100700

评价《肿瘤中医诊疗指南》的适用性和临床应用情况。评价方法包括适用性评价和应用性评价。适用性评价采用调查问卷方法,评价《指南》熟悉和使用情况、质量水平、临床适用情况等;应用性评价采用前瞻性病例调查分析方法,评价《指南》临... 详细信息

评价《肿瘤中医诊疗指南》的适用性和临床应用情况。评价方法包括适用性评价和应用性评价。适用性评价采用调查问卷方法,评价《指南》熟悉和使用情况、质量水平、临床适用情况等;应用性评价采用前瞻性病例调查分析方法,评价《指南》临床应用符合度和应用效果(包括疗效、安全性、经济性)。采用统计学基本描述、构建不同比较组进行交叉或分层统计学检验、多因素分析以及混杂因素处理等多种分析方法。适用性综合性评价结果显示,《指南》内容完全适用和基本适用者为63.03%,不适用者4.24%;应用性综合评价结果显示,《指南》"总体疗效与技术水平"、"满意度"、"在临床实践中的适用性"较好的累计统计分别为85.46%,80.43%,69.40%。该研究表明基地单位医师对《肿瘤中医诊疗指南》的认知度较高,低年资医师是主要使用群体,临床指南总体临床适用、临床应用符合度较好,但《指南》的诊疗方案的质量和适应性等尚需改进。指南在支持证据、方法学规范及临床使用性上有所欠缺,应尽快通过修订进一步提高质量。

关键词：肿瘤中医临床诊疗指南应用评价

维生素D滴丸预防PCI术后造影剂肾病的临床效果

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中国城乡企业卫生 2021年第5期36卷 9-11页

作者：王聪周小波寇双庆渠慎成曹开武刘玉蔡民华李静刘超天津市东丽区东丽医院心内科天津300300

目的观察维生素D滴丸对经皮冠状动脉介入治疗(PCI),术后造影剂肾病(CIN)的预防效果。方法选取2019年1月—2020年1月天津市东丽区东丽医院心内科收治的90例不稳定性心绞痛并行PCI的患者,随机分为观察组和对照组,每组45例。在两组均给予... 详细信息

目的观察维生素D滴丸对经皮冠状动脉介入治疗(PCI),术后造影剂肾病(CIN)的预防效果。方法选取2019年1月—2020年1月天津市东丽区东丽医院心内科收治的90例不稳定性心绞痛并行PCI的患者,随机分为观察组和对照组,每组45例。在两组均给予常规治疗的基础上,观察组给予维生素D滴丸,对照组给予安慰剂。比较两组术前、术后48 h的血肌酐(SCr)、尿肾脏损伤分子-l(Kim-1)、视黄醇结合蛋白(RBP)水平,并观察CIN的发生率。结果PCI术前两组SCr、Kim-1、RBP水平比较,差异无统计学意义(P>0.05)。术后48 h两组SCr、Kim-1、RBP水平均高于术前,观察组低于对照组,差异均有统计学意义(P<0.05)。观察组CIN发生率为2.22%,低于对照组的13.33%,差异有统计学意义(χ^(2)=3.873,P=0.049)。结论维生素D滴丸在PCI术后患者中的应用,可有效降低CIN的发生率。

关键词：维生素D滴丸经皮冠状动脉介入治疗造影剂肾病血肌酐

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重庆页岩气潜在开发区环境特征及保护建议

环境影响评价 2015年第6期37卷 74-78页

作者：闫力源卢培利张虹张代钧寇双伍彭淑婵毛媛媛重庆大学煤矿灾害动力学与控制国家重点实验室重庆400044 重庆师范大学地理科学学院GIS应用研究重庆市高校重点实验室重庆400047 重庆市环境工程评估中心重庆401147

随着我国尤其是重庆市页岩气资源的勘探开发,其带来的生态问题逐步受到关注。根据重庆地区页岩气资源分布的相关信息,通过RO和GIS技术,绘制重庆页岩气资源潜在开发区的相关图件,分析页岩气潜在开发区与重庆功能区划的关系;通过GIS叠图... 详细信息

随着我国尤其是重庆市页岩气资源的勘探开发,其带来的生态问题逐步受到关注。根据重庆地区页岩气资源分布的相关信息,通过RO和GIS技术,绘制重庆页岩气资源潜在开发区的相关图件,分析页岩气潜在开发区与重庆功能区划的关系;通过GIS叠图和理论分析,识别出页岩气资源潜在开发区内特殊生态功能区以及生境敏感区、石漠化敏感区、土壤侵蚀敏感区、生物多样性关键区的分布,分析了潜在影响,提出了防护措施和建议,为重庆市后续页岩气勘探开发布局和生态保护提供参考。

关键词：页岩气生态敏感性保护

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雀麦不同时期茎叶药剂处理防除效果试验

北京农业 2011年第3期 88-90页

作者：车晋滇袁志强张光伟崔秀荣田兆迎邓延海吴继宗寇爽北京市植物保护站北京市通州区植保植检站

在秋季雀麦3～4叶期和春季雀麦返青期,选用70%彪虎,3%世玛药剂分别进行茎叶喷雾处理试验。试验结果表明:70%彪虎不同使用剂量对小麦安全;3%世玛不同剂量在秋季使用对小麦均产生药害,其症状表现为小麦黄化,有少量死苗,春季返青期使用对... 详细信息

在秋季雀麦3～4叶期和春季雀麦返青期,选用70%彪虎,3%世玛药剂分别进行茎叶喷雾处理试验。试验结果表明:70%彪虎不同使用剂量对小麦安全;3%世玛不同剂量在秋季使用对小麦均产生药害,其症状表现为小麦黄化,有少量死苗,春季返青期使用对小麦较安全。2种除草剂的最终防除效果均>90.0%。

关键词：雀麦药剂防效

Tetrandrine suppresses proliferation, induces apoptosis, and inhibits migration and invasion in human prostate cancer cells

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Asian Journal of Andrology 2015年第5期17卷 850-853,I0011页

作者： Wei Liu Bo kou Zhen-Kun Ma Xiao-shuang Tang Chuan Lv Min Ye Jia-Qi Chen Lei Li Xin-Yang Wang Da-Lin He Department of Urology First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an 710061 China Oncology Research Lab Key Laboratory of Environment and Genes Related to Diseases Ministry of Education of the People's Republic of China Xi'an 710061 China Department of Urology First People's Hospital of Jining Jining 272100 China Ophthalmology department The First Affiliated Hospital of Medical School Xi'an Jiaotong University Xi'an 710061 China

Tetrandrine （TET）, a traditional Chinese medicine, exerts remarkable anticancer activity on various cancer cells. However, little is known about the effect of TET on human prostate cancer cells, and the mechanism of function of TET on prostate cancer has not yet been elucidated. To investigate the effects of TET on the suppression of proliferation, induction of apoptosis, and inhibition of migration and invasion in human prostate cancer cell lines, DU145 and PC-3. Inhibition of growth was determined by 3-（4,5-dimethylthiazol-2-yl）-2,5-diphenyltetrazolium bromide assay and clone formation assay, and flow cytometry analysis was performed to detect the induction of apoptosis. Activation of poly （ADP-ribose） polymerase, caspase-3, Akt, phospho-Akt, Bcl-2, and Bax was analyzed by Western blotting. Wound healing assay and transwell migration assay were used to evaluate the effect of TET on migration and invasion of cancer cells. TET inhibited the growth of DU145 and PC-3 cells in a dose- and time-dependent manner. Cell cloning was inhibited in the presence of TET in DU145 and PC-3 cells. TET suppressed the migration of DU145 and PC-3 cells. Transwell invasion assay showed that TET significantly weakened invasion capacity of DU 145 and PC-3 cells. TET exhibited strong inhibitory effect on proliferation, migration, and invasion of prostate cancer cells. In addition, TET induced apoptosis in a dose-dependent manner by activating the caspase cascade and inhibiting phosphoinositide 3-kinase-Akt signal pathway. The accumulating evidence suggests that TET could be a potential therapeutic candidate against prostate cancer in a clinical setting.

关键词： apoptosis invasion migration proliferation prostate cancer tetrandrine

Molecular characterization of H3N2 and H4N6 subtypes avian influenza viruses isolated from mallards in Poyang Lake,China in 2010

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Chinese Science Bulletin 2012年第27期57卷 3586-3594页

作者： ZHU Na ZHAO JiuRu LI YongDong DING ChangQing XIA Han TANG shuang ZHANG Zhong YU JingFeng CHEN Jing FAN ZhaoJun kou Zheng LI TianXian State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of SciencesWuhan 430071China Ningbo Municipal Center for Disease Control and Prevention Ningbo 315010China College of Biology Beijing Forestry University Beijing 100083China

Poyang Lake is the largest inland freshwater lake in China and contains many species of wild birds and *** conducted a survey of avian influenza viruses in nine semi-artificial waterfowl farms in Poyang Lake during January to March of *** of 1036 cloacal swabs collected,three H3N2 and one H4N6 influenza viruses were isolated from healthy *** the isolates were genetically and phylogenetically *** analysis of putative HA cleavage sites showed that all the four isolates possessed the molecular characteristics(QTRGL for H3N2 viruses,PEKASR for H4N6 virus) of lowly pathogenic avian influenza(LPAI) *** phylogenetic analysis of the viral genomes showed that all four virus isolates clustered in the Eurasian clade of influenza *** M gene of the viruses possessed the highest homology with highly pathogenic H5N1 influenza *** addition,co-infection of H3N2 and H4N6 in the same farm was *** interestingly,we isolated two subtypes viruses(H3N2 and H4N6) and their progeny virus(H3N2) with evidence of genome reassortment from the same farm,in which the PB1 and PB2 gene segments of H4N6 replaced those of the H3N2 *** results of animal infection experiments showed that all the four isolated viruses were lowly pathogenic to chickens and not pathogenic to mice,which was consistent with the results of genetic analysis.

关键词：禽流感病毒病毒分离分子特征鄱阳湖野鸭亚型中国系统发育分析

低分子量有机酸影响可变电荷土壤吸附铜的机制

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中国环境科学 2005年第3期25卷 334-338页

作者：徐仁扣肖双成季国亮中国科学院南京土壤研究所江苏南京210008

采用平衡实验法研究了水杨酸和邻苯二甲酸对砖红壤吸附铜的影响,并通过吸附铜的解吸实验探讨了有机酸对铜吸附的影响机制. 结果表明,有机酸可以增加土壤对铜的吸附量,与对照相比,有机酸体系中吸附的铜的解吸量高.有机酸对铜吸附的影响... 详细信息

采用平衡实验法研究了水杨酸和邻苯二甲酸对砖红壤吸附铜的影响,并通过吸附铜的解吸实验探讨了有机酸对铜吸附的影响机制. 结果表明,有机酸可以增加土壤对铜的吸附量,与对照相比,有机酸体系中吸附的铜的解吸量高.有机酸对铜吸附的影响随体系pH值的增加而增大,约在pH4.3(水杨酸体系)或pH4.5(邻苯二甲酸体系)达最大,然后逐渐减小.土壤对有机酸的吸附量越高,有机酸对铜吸附的影响程度越大.有机酸可以通过形成表面三元络合物和改变土壤的表面电荷2种机制影响土壤对铜的吸附.水杨酸体系中铜的解吸增量与吸附增量的百分比在76%～89%之间,说明水杨酸主要是通过增加土壤表面的净负电荷量来增加铜的静电吸附量.

关键词：可变电荷土壤有机酸铜吸附解吸

Spin-down and emission variations for PSR J0742-2822

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Research in Astronomy and Astrophysics 2021年第2期21卷 142-148页

作者： Shi-Jun Dang Na Wang Hui-Hui Wang Jian-Ping Yuan Lun-Hua Shang Rai Yuen Ming-Yu Ge Xia Zhou shuang-Qiang Wang Fei-Fei kou Wen-Ming Yan Jing-Bo Wang Zhi-Gang Wen Jun-Tao Bai Zhi-Yong Liu Zu-Rong Zhou Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China University of Chinese Academy of Sciences 19A Yuquan RoadBeijing 100049China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China School of Physics Huazhong University of Science and TechnologyWuhan 430074China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China

PSR J0742-2822 is known for its quasi-periodic changes in the observed pulse profile and spindown *** this paper,we analyzed 13 years of timing data obtained with the Nanshan 25-m radio telescope and the Parkes 64-m radio *** found that the average values of the spin-down rate((v))of this pulsar changed in four different *** investigated the correlation between v and W50,and ascertained that the correlation changed in different ***,not all the changes in states and correlation can be associated with glitch *** examined the long term evolution ofγ-ray flux(0.1-300 GeV)and the pulse profiles corresponding to the four different states using Fermi-LAT Pass8(P8 R3)data from 2008 August 5 to 2019 October *** did not detect a significant change inγ-ray flux or the pulse *** results suggest that the connection between pulsar rotation and emission is more complex than previously reported for this pulsar.

关键词： pulsars general-stars pulsar-methods timing

Results of 23 yr of Pulsar Timing of PSR J1453-6413

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Research in Astronomy and Astrophysics 2023年第10期23卷 357-366页

作者： Wei Li Shi-Jun Dang Jian-Ping Yuan Lin Li Wei-Hua Wang Lun-Hua Shang Na Wang Qing-Ying Li Ji-Guang Lu Fei-Fei kou shuang-Qiang Wang Shuo Xiao Qi-Jun Zhi Yu-Lan Liu Ru-shuang Zhao Ai-Jun Dong Bin Zhang Zi-Yi You Yan-Qing Cai Ya-Qin Yang Ying-Ying Ren Yu-Jia Liu Heng Xu School of Physics and Electronic Science Guizhou Normal UniversityGuiyang 550001China Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing Guizhou Normal UniversityGuiyang 550001China Guizhou Radio Astronomy Observatory Guizhou UniversityGuiyang 550025China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China School of Physics Science and Technology Xinjiang UniversityUrumqi 830046China College of Mathematics and Physics Wenzhou UniversityWenzhou 325035China National Astronomical Observatories Chinese Academy of SciencesBeijing 100101China CAS Key Laboratory of FAST National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China

In this paper,we presented the 23.3 yr of pulsar timing results of PSR J1456-6413 based on the observations of Parkes 64 m radio *** detected two new glitches at MJD 57093(3)and 59060(12)and confirmed its first glitch at MJD 54554(10).The relative sizes(Δν/ν)of these two new glitches are 0.9×10^(-9)and 1.16×10^(-9),*** the“Cholesky”timing analysis method,we have determined its position,proper motion,and two-dimensional transverse velocities from the data segments before and after the second glitch,***,we detected exponential recovery behavior after the first glitch,with a recovery timescale of approximately 200 days and a corresponding exponential recovery factor Q of approximately 0.15(2),while no exponential recovery was detected for the other two *** interestingly,we found that the leading component of the integral pulse profile after the second glitch became stronger,while the main component became *** results will expand the sample of pulsars with magnetosphere fluctuation triggered by the glitch event.

关键词： Stars (stars:)pulsars:individual(PSR J1453-6413) stars:neutron