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民丰洼陷沙三段孔隙发育特征及储层物性主控因素

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中国石油大学学报（自然科学版） 2009年第4期33卷 10-15页

作者：邱隆伟黄双泉中国石油大学地球资源与信息学院山东东营257061 中石油辽河油田分公司辽宁盘锦124000

通过岩心观察、岩心物性统计和薄片鉴定等方法,对民丰洼陷沙三段储层物性影响因素和孔隙成因进行研究。结果表明:民丰洼陷沙三段各亚段储层物性存在一定的差异,具有中-高孔渗的特点,孔隙类型以粒间溶蚀孔隙为主,储层孔隙结构总体以中-... 详细信息

通过岩心观察、岩心物性统计和薄片鉴定等方法,对民丰洼陷沙三段储层物性影响因素和孔隙成因进行研究。结果表明:民丰洼陷沙三段各亚段储层物性存在一定的差异,具有中-高孔渗的特点,孔隙类型以粒间溶蚀孔隙为主,储层孔隙结构总体以中-细喉为主;岩石分选性控制着储层原始物性发育特征并影响后期成岩作用对储层的改造,分选性的差异是三角洲前缘水下分流河道、河口砂坝原始物性好,而远砂坝和近岸水下扇原始物性相对较差的原因;随埋深增加,在早期压实压溶作用和后期强烈钙质胶结作用影响下储层物性具有明显的降低趋势,但发育2个较明显的次生孔隙发育带;次生孔隙的形成主要是斜长石、岩屑等颗粒发生溶解作用的结果,分选好、原始物性好的储层更有利于次生孔隙的发育;分选、粒径、胶结、溶解等是储层发育的主控因素,据此可将研究区的储层划分为6种成因类型。

关键词：民丰洼陷沙三段储层特征影响因素分选性成岩作用

Jumonji domain-containing 6 (JMJD6) identified as a potential therapeutic target in ovarian cancer

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Signal Transduction and Targeted Therapy 2019年第1期4卷 454-467页

作者： Heng Zheng Yan Tie Zhen Fang Xiaoai Wu Tao Yi shuang huang Xiao Liang Yanping Qian Xi Wang Ruyu Pi Siyuan Chen Yong Peng Shengyong Yang Xia Zhao Xiawei Wei Department of Gynecology and Obstetrics Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of the Ministry of EducationWest China Second HospitalSichuan University610041 ChengduP.R.China Lab of Aging Research and Cancer Drug Targets State Key Laboratory of BiotherapyWest China HospitalSichuan University and Collaborative Innovation CenterNo.17Block 3Southern Renmin Road610041 ChengduSichuanP.R.China

Jumonji domain-containing 6(JMJD6)is a candidate gene associated with tumorigenesis,and JMJD6 overexpression predicts poor differentiation and unfavorable survival in some ***,there are no studies reporting the expression of JMJD6 in ovarian cancer,and no JMJD6 inhibitors have been developed and applied to targeted cancer therapy *** the present study,we found that the high expression of JMJD6 in ovarian cancer was correlated with poor prognosis in ovarian cancer.A potential inhibitor(SKLB325)was designed based on the crystal structure of the jmjC domain of *** molecule significantly suppressed proliferation and induced apoptosis in a dose-dependent manner in SKOV3 cell lines as detected by CCK-8 cell proliferation assays and flow cytometry.A Matrigel endothelial tube formation assay showed that SKLB325 inhibited capillary tube organization and migration in HUVECs in *** also observed that JMJD6 colocalized with p53 protein in the nucleus,with mRNA and protein expression of p53 as well as its downstream effectors significantly increasing both in vitro and in intraperitoneal tumor tissues treated with *** addition,SKLB325 significantly reduced the intraperitoneal tumor weight and markedly prolonged the survival of tumor-bearing *** together,our findings suggest that JMJD6 may be a marker of poor prognosis in ovarian cancer and that SKLB325 may be a potential candidate drug for the treatment of ovarian cancer.

关键词： cancer markedly inhibited

Microwave-Assisted Synthesis and Characterization of Hexagonal DyPO4·1.5H2O Superstructures

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Microwave-Assisted Synthesis and Characterization of Hexagon...

中国化学会第九届全国无机化学学术会议

作者： shuang huang Lei Wang Shengliang Zhong College of Chemistry and Chemical Engineering Jiangxi Normal University

In this paper, a simple, fast and facile trinity microwave method was designed for the selective synthesis of hexagonal Dy PO4·1.5H2 O superstructures. It was found that the microwave conditions, including temperature, time and p H, are very important in determining the crystal phases and morphologies of the final products. A certain temperature and p H（80 oC, p H= 2） are favorable for the formation of the hexagonal Dy PO4·1.5H2 O. Under the ultrasound and ultraviolet light, respectively, products with the same crystal phase（hexagonal Dy PO4·1.5H2O） and different morphologies, such as broom, stick, and flower, could be obtained. Our capability of obtaining hexagonal Dy PO4·1.5H2 O can not only provide some new information in the study of influence of ultrasound /ultraviolet light on nano/microstructure, but also benefits the wide applications of microwave route in selective synthesis of other rare earth nanomaterials.

关键词： Microwave Synthesis Dy PO4·1.5H2O Ultrasound,Ultraviolet light

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微流控芯片中颗粒/细胞磁操控的研究进展

分析化学 2017年第8期45卷 1238-1247页

作者：黄爽何永清焦凤昆明理工大学化学工程学院

微流控芯片中颗粒/细胞的磁操控是当前的热点研究领域。本文详细介绍了微流控芯片中颗粒/细胞磁操控原理及几种主要操控方式,包括分离、集中、捕获与排列组装。其中,基于颗粒/细胞大小、形状以及有无磁性对分离方法展开详述。此外,本文... 详细信息

微流控芯片中颗粒/细胞的磁操控是当前的热点研究领域。本文详细介绍了微流控芯片中颗粒/细胞磁操控原理及几种主要操控方式,包括分离、集中、捕获与排列组装。其中,基于颗粒/细胞大小、形状以及有无磁性对分离方法展开详述。此外,本文还比较了通道几何结构、磁场强度及分布、磁性液体种类(顺磁盐溶液和磁流体)对操控性能的影响。最后,针对微流控芯片中颗粒/细胞磁操控的前景进行了展望。

关键词：微流控芯片磁场颗粒/细胞磁性液体操控评述

Interspecific variation in pollen-ovule ratio negatively correlated with pollination efficiency in a natural community

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Interspecific variation in pollen-ovule ratio negatively cor...

柠檬苦素对营养性肥胖大鼠脂质代谢和肠道菌群的影响

生态文明建设中的植物学：现在与未来——中国植物学会第十五届会员代表大会暨八十周年学术年会

作者： Yan-Bing Gong shuang-Quan huang State Key Laboratory of Hybrid Rice College of Life Sciences Wuhan University

Pollination efficiency (PE) hypothesis has long been proposed as an explanation for interspecific variation in pollen-ovule (P:O) ratios. However, no empirical study on P:O ratios has directly and quantitatively measured PE. Here, we use a PE index, defined as the proportion of pollen grains removed from anthers that are subsequently deposited on conspecific stigmas, as a direct and quantitative measure of PE. We investigated P:O ratios, pollen removal and pollen deposition in 26 plant species in an alpine meadow, over three consecutive years. Our community survey showed that nearly 5% of removed pollen was successfully deposited on conspecific stigmas. The PE index ranged from 0.01% up to 78.56% among species and correlated negatively with the P:O ratio across years. This correlation was not changed by controlling for phylogenetic relationships among species, suggesting that the interspecific variation in P:O ratios can be attributed to the probability of pollen grains reaching a stigma. The results indicate that PE hypothesis can help to explain interspecific variation in P:O ratios.

关键词： Pollen-ovule ratio pollination efficiency pollen removal pollen deposition community phylogeny

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吉林大学学报（医学版） 2022年第4期48卷 858-865页

作者：黄爽陈琛黄波贵州省遵义市第一人民医院遵义医科大学第三附属医院儿童重症医学科贵州遵义563000

目的:探讨柠檬苦素对高脂饮食诱导的营养性肥胖大鼠脂质代谢和肠道菌群的影响,阐明其可能的作用机制。方法:3周龄SD大鼠随机分为对照组、模型组、低剂量(12.5 mg·kg^(-1))柠檬苦素组、中剂量(25 mg·kg^(-1))柠檬苦素组和高剂量(50 mg... 详细信息

目的:探讨柠檬苦素对高脂饮食诱导的营养性肥胖大鼠脂质代谢和肠道菌群的影响,阐明其可能的作用机制。方法:3周龄SD大鼠随机分为对照组、模型组、低剂量(12.5 mg·kg^(-1))柠檬苦素组、中剂量(25 mg·kg^(-1))柠檬苦素组和高剂量(50 mg·kg^(-1))柠檬苦素组,每组10只。除对照组外,其他各组大鼠均采用高脂饲料喂养制备营养性肥胖大鼠模型,造模成功后低、中和高剂量柠檬苦素组大鼠给予相应剂量柠檬苦素干预,每日1次,连续4周。记录给药前后各组大鼠体质量,计算李氏指数(Lee’s指数)和脂肪系数,检测各组大鼠血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平,HE染色观察各组大鼠肝组织病理形态表现和脂肪沉积情况,16S rRNA测序法分析各组大鼠粪便肠道菌群结构。结果:与对照组比较,模型组大鼠体质量、Lee’s指数和脂肪系数均明显升高(P0.05)。结论:柠檬苦素能够通过调节大鼠脂质代谢和肠道菌群结构,达到改善营养性肥胖大鼠肥胖的作用。

关键词：营养性肥胖柠檬苦素脂质代谢肠道菌群高脂饮食

Ocular surface in patients with different degrees of myopia

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1313-1321页

作者： Yan-Yun Lyu shuang Wang Xiao-Niao Chen Zhen-Yu Wang Shan-Shan huang Yan Yuan Hong-shuang Lu Wen-Li Yang Li-Ya Qiao Lei Tian Ying Jie Tongren Eye Care Center Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Institute of Ophthalmology Beijing Tongren Eye CenterBeijing Tongren HospitalCapital Medical University and Beijing Ophthalmology and Visual Sciences Key LaboratoryBeijing 100730China Department of Ophthalmology the Third Medical Center of Chinese People’s Liberation Army General HospitalBeijing 100039China Department of Ophthalmology and Visual Science Tokyo Medical and Dental UniversityTokyo 113-8510Japan

AIM:To investigate the clinical features of the ocular surface in patients with different degrees of ***:A cross-sectional study was conducted involving 122 participants with myopia in Beijing Tongren Hospital from February to June,*** completing the Ocular Surface Disease Index(OSDI)score scale,measurements were taken for refraction,biometric parameters and ocular surface *** prevalence,severity and related parameters of the dry eye among different groups based on axial length(AL)were *** analysis was performed between ocular surface parameters and refraction/biometric measurement ***:Statistically significant differences were observed in refractive error,corneal thickness,anterior chamber depth,and subfoveal choroidal thickness among the groups(all P<0.05).With the increase in AL,the incidence and severity of dry eye increased significantly(P<0.05).Moreover,the tear film break-up time(BUT)shortened(P<0.05),and the corneal fluorescein staining(CFS)points increased significantly(P<0.05).OSDI scores were positively correlated with AL and spherical equivalent(SE;both P<0.05);BUT was negatively correlated with AL,SE,and corneal astigmatism(AST;all P<0.05);Schirmer I test(SIT)results were negatively correlated with AL and SE(both P<0.05).CONCLUSION:AL elongation is a risk factor for dry eye onset in myopic *** longer the AL,the more severe the dry eye is,with the increased CFS spots and tear film ***,SE and AST exhibit negative correlations with dry eye symptom scores and ocular surface parameters.

关键词： myopia axial length ocular surface dry eye

Acoustic Purcell effect induced by quasibound state in the continuum

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Fundamental Research 2024年第1期4卷 57-62页

作者： Sibo huang Shuhuan Xie He Gao Tong Hao shuang Zhang Tuo Liu Yong Li Jie Zhu Institute of Acoustics School of Physics Science and EngineeringTongji UniversityShanghai 200092China Department of Mechanical Engineering The Hong Kong Polytechnic UniversityHong Kong 999077China College of Surveying and Geo-Informatics Tongji UniversityShanghai 200092China Department of Physics The University of Hong KongHong Kong 999077China Key Laboratory of Noise and Vibration Research Institute of AcousticsChinese Academy of SciencesBeijing 100190China The Hong Kong Polytechnic University Shenzhen Research Institute Shenzhen 518057China

We study theoretically and experimentally the acoustic Purcell effect induced by quasi-bound states in the continuum(quasiBICs).A theoretical framework describing the acoustic Purcell effect of a resonant system is developed based on the system’s radiative and dissipative factors,which reveals the critical emission condition for achieving optimum Purcell *** show that the quasiBICs contribute to highly confined acoustic field and bring about greatly enhanced acoustic emission,leading to strong Purcell *** concept is demonstrated via two coupled resonators supporting a Friedrich-Wintgen quasiBIC,and the theoretical results are validated by the experiments observing emission enhancement of the sound source by nearly two orders of *** work bridges the gap between the acoustic Purcell effect and acoustic BICs essential for enhanced wave-matter interaction and acoustic emission,which may contribute to the research of high-intensity sound sources,high-quality-factor acoustic devices and nonlinear acoustics.

关键词： Acoustic Purcell effect Bound state in the continuum Mode coupling Sound emission enhancement High-quality-factor acoustic device

Assessing the current situation and the influencing factors affecting perceived stigma among older patients after leukemia diagnosis

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World Journal of Psychiatry 2024年第6期14卷 812-821页

作者： Xuan Tang shuang-Qin Chen Jiang-Hua huang Cai-Feng Deng Jie-Qiong Zou Juan Zuo Department of Neurology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina Department of Hematology Hengyang Medical SchoolUniversity of South ChinaHengyang 421001Hunan ProvinceChina

BACKGROUND Psychological problems are becoming increasingly prominent among older patients with leukemia,with patients potentially facing stigmatization after ***,there is limited research on the stigma experienced by these patients and the factors that may contribute to *** To investigate the stigma faced by older patients after being diagnosed with leukemia and to analyze the potential influencing *** A retrospective analysis was conducted using clinical data obtained from questionnaire surveys,interviews,and the medical records of older patients with leukemia admitted to the Hengyang Medical School from June 2020 to June *** data obtained included participants’basic demographic information,medical history,leukemia type,family history of leukemia,average monthly family income,pension,and tendency to conceal *** Chinese versions of the Social Impact Scale(SIS),Perceived Social Support Scale(PSSS),Self-Rating Anxiety Scale(SAS),and Self-Rating Depression Scale(SDS)were used to assess indicators related to stigma,social support,and mental health *** used Pearson’s correlation coefficient to analyze the strength and direction of the relationship between the scores of each scale,and regression analysis to explore the factors related to the stigma of older patients with leukemia after *** Data from 120 patients with leukemia aged 65-80 years were *** total score on the SIS and PSSS was 43.60±4.07 and 37.06±2.87,*** SAS score was 58.35±8.32 and the SDS score was 60.58±*** stigma experienced by older leukemia patients was negatively correlated with social support(r=-0.691,P<0.05)and positively correlated with anxiety and depression(r=0.506,0.382,P<0.05).Age,education level,smoking status,average monthly family income,pension,and tendency to conceal illness were significantly associated with the participants’level of stigma(P<0.05).Age,smoking status,social support,anxiety,and depressi

关键词： Senile leukemia Stigma Social support Anxiety Depression Influencing factors