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Preparation of a high-performance synthetic pitch from aromatic hydrocarbons containing N/Cl

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新型炭材料（中英文） 2024年第4期39卷 655-667页

作者： ZHANG Yu-kun LIN Xiong-chao gao Hong-feng XI Wen-shuai WANG Cai-hong WANG Yong-gang School of Chemical&Environmental Engineering China University of Mining and Technology(Beijing)Beijing 100083China

The preparation of a synthetic pitch from aromatic monomers could easily regulate structure orientation at the molecu-lar level,which would be useful in *** isotropic synthetic pitch was prepared by a chlorine-and/or nitrogen-induced sub-stitution polymerization reaction method using aromatic hydrocarbon precursors containing Cl and N,which for this study were chloromethyl naphthalene and *** method was verified by investigating the structural changes under different synthesis conditions,and the synthesis mechanism induced by aromatics containing Cl was also *** result shows that the pyridinic N in quinoline contains a lone pair of electrons,and is an effective active site to induce the polymerization reaction by coupling with aromatic hydrocarbons containing *** reaction between such free radicals causes strong homopolymerization and oligomeriza-tion.A higher reaction temperature and longer reaction time significantly increased the degree of polymerization and thus increased the softening point of the pitch.A linear molecular structure was formed by the Cl substitution reaction,which produced a highly spinnable pitch with a softening point of 258.6℃,and carbon fibers with a tensile strength of 1163.82 MPa were *** study provides a relatively simple and safe method for the preparation of high-quality spinnable pitch.

关键词： Quinoline 1-Chloromethyl-naphthalene Synthetic pitch Spinnability Carbon fiber

The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer

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Genes & Diseases 2024年第2期11卷 542-545页

作者： Jiyan Wang Tao He Qingle gao Hongkai Chang xintong Dai Juze Yang Shuangping Liu shuai Zhang Changliang Shan Chunze Zhang State Key Laboratory of Medicinal Chemical Biology College of Pharmacy and Tianjin Key Laboratory of Molecular Drug ResearchNankai UniversityTianjin 300350China Departments of Pathology Characteristic Medical Center of The Chinese People's Armed Police ForceTianjin 300162China Department of Respiratory Medicine Sir Run Run Shaw Hospital and Institute of Translational MedicineZhejiang University School of MedicineHangzhouZhejiang 310016China Department of Pathology Medical SchoolDalian UniversityDalianLiaoning 116622China School of Integrative Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Colorectal Surgery Tianjin Union Medical CenterNankai UniversityTianjin 300121China

The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy *** instability(MSI)is found in 10%-15%of colorectal cancer(CRC)patients and exhibits different clinical outcomes than microsatellite stable(MSS)***,MSI patients have a better prognosis than patients with stable *** patients exhibit clinical features that are not responsive to chemotherapy,however,Msl patients showed excellent responses to immunotherapy.'Although the subtype classification of MSI is beneficial to the clinical treatment of CRC patients,the mechanism of MSl remains unclear.

关键词： immunotherapy colorectal clinical

Recent Progress of Full‑Field Three‑Dimensional Shape Measurement Based on Phase Information

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Nanomanufacturing and Metrology 2024年第2期7卷 26-41页

作者： Yajing Bai Zonghua Zhang shuai Fu Hongwei Zhao Yubo Ni Nan gao Zhaozong Meng Zeqing Yang Guofeng Zhang Wei Yin School of Mechanical Engineering Hebei University of TechnologyTianjin 300401China School of Mechanical Engineering Xi’an Jiaotong UniversityXi’an 710049ShaanxiChina National Key Laboratory of Strength and Structural Integrity Aircraft Strength Research Institute of ChinaXi’an 710065ShaanxiChina

Full-field three-dimensional(3D)measurement technology based on phase information has become an indispensable part of geometric dimension measurement in modern scientific research and engineering *** field has been developing and evolving for the study of highly reflective phenomena,diffuse reflections,and specular surfaces,and many novel methods have emerged to increase the speed of measurements,enhance data accuracy,and broaden the robustness of the ***,we will discuss the latest research progress in full-field 3D shape measurement based on phase information systematically and ***,the fundamentals of 3D shape measurement based on phase information are introduced,namely,phase-shifting and transform-based ***,recent technological innovations are highlighted,including increases in measurement speed and automation and improvements in robustness in complex *** particular,the challenges faced by these technological advances in solving highly dynamic,composite surface measurement problems are presented,i.e.,with multiexposure techniques proposed for high dynamics that extend the dynamic range of the camera to reduce the effects of overexposure but increase the cost of time and have high hardware requirements,fringe adaptive techniques that overcome light variations but are computationally complex,and multipolarized camera techniques that reduce the effects of light variations but are sensitive to the light ***,the phase-shifting method combined with coding is proposed to improve the measurement speed,but the accuracy is slightly *** learning techniques are proposed to cope with measurements in complex environments,but the dataset computation process is ***,future research directions are suggested,and the challenges are ***,this work provides a reference for researchers and engineers.

关键词： 3D measurement Phase information Fringe projection Phase measuring deflectometry

Analysis on the causes of massive stranding of Yellow Sea green tide on Lianyungang and Rizhao coasts in 2022

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Journal of Oceanology and Limnology 2024年第3期42卷 816-830页

作者： Lingjuan WU Juan HUANG Yi DING Guiyan LIU shuai HUANG Song gao Chao YUAN Jiangling XU Ping WU Rui HUANG Ruobing WEN Jie MEI North China Sea Marine Forecasting and Hazard Mitigation Center Ministry of Natural ResourcesQingdao 266061China Shandong Key Laboratory of Marine Ecological Environment and Disaster Prevention and Mitigation Qingdao 266061China National Engineering Laboratory for Integrated Aero-Space-Ground-Ocean Big Data Application Technology Xi’an 710129China East China Sea Marine Forecasting and Hazard Mitigation Center Ministry of Natural ResourcesShanghai 200136China North China Sea Ecological Center Ministry of Natural ResourcesQingdao 266033China

In 2022,Yellow Sea green tide caused by Ulva prolifera reached a historic minimum and the coastal areas of Shandong Peninsula were less ***,the largest amount of seaweed biomass has been washed ashore on Lianyungang and Rizhao coasts since *** studied the development pattern of Yellow Sea green tide in 2022,and analyzed the key environmental factors on the growth and drifting,then discussed the possible reasons that resulted in the massive stranding of green tide biomass in Lianyungang and *** show under the combined influence of the east to southeast winds and currents with shoreward anomalies,green tide drifted to the coastal waters between Shandong and Jiangsu provinces and the distribution areas located westward compared with previous years(2008–2021).Floating *** rafts from the coastal waters of Binhai and Sheyang drifted continuously into the coastal waters of Lianyungang and Rizhao,providing important supplements for Yellow Sea green *** green tide in 2022 distributed close to the coastal waters,the abundant nutrients might support their continuous high growth *** addition,the amount of rainfall around Shandong Peninsula from late June to early July were significantly higher than in previous years,which might promote the development of green tide to some extent.

关键词： Yellow Sea green tide stranding biomass development pattern environmental factor

A N-CoSe/CoSe_(2)-C@Cu hierarchical architecture as a current collector-integrated anode for potassium-ion batteries

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Rare Metals 2024年第8期43卷 3702-3712页

作者： Zi-Jie Mu Yan-Jun gao Wen-shuai Dong Zong-You Li Qing-Yi Song Han-Jiao Huang Li-Dong xing Jian-Guo Zhang Wei Wang Qi-Yao Yu State Key Laboratory of Explosion Science and Technology School of Mechatronical EngineeringBeijing Institute of TechnologyBeijing 100081China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingBeijing 100083China

The highly reversible insertion/extraction of large-radius K^+into electrode materials remains a tough goal,especially for con version-type ***,we design a current collector-integrated electrode(N-CoSe/CoSe_(2)-C@Cu) as an advanced anode for potassium-ion battery(PIBs).The conductive CoSe/CoSe_(2) heterojunction with rich Se vacancy defects,conductive sp^2 N-doped carbon layer,and the elastic copper foil matrix can greatly accelerate the electron transfer and enhance the structural ***,the well-designed N-CoSe/CoSe_(2)-C@Cu current collector-integrated electrode displays enhanced potassium storage performance with regard to a high capacity(325.1 mAh·g^(-1) at 0.1 A·g^(-1) after 200cycles),an exceptional rate capability(223.5 mAh·g^(-1) at2000 mA·g^(-1)),and an extraordinary long-term cycle stability(a capacity fading of only 0.019% per cycle over1200 cycles at 2000 mA·g^(-1)).Impressively,ex situ scanning electron microscopy(SEM) characterizations prove that the elastic structure of copper foil is merged into the cleverly designed N-CoSe/CoSe_(2)-C@Cu heterostructure,which buffers the deformation of structure and volume and greatly promotes the cycle life during the potassium/depotassium process.

关键词： Potassium-ion battery Integrated collector electrode CoSe CoSe_2 Heterojunction Copper foil matrix N-doped carbon

Dear-DIA^(XMBD): Deep Autoencoder Enables Deconvolution of Data-Independent Acquisition Proteomics

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Research 2024年第1期6卷 707-720页

作者： Qingzu He Chuan-Qi Zhong Xiang Li Huan Guo Yiming Li Mingxuan gao Rongshan Yu Xianming Liu Fangfei Zhang Donghui Guo Fangfu Ye Tiannan Guo Jianwei shuai Jiahuai Han Department of Physics and Fujian Provincial Key Laboratory for Soft Functional Materials ResearchXiamen UniversityXiamen 361005China Oujiang Laboratory(Zhejiang Lab for Regenerative Medicine Vision and Brain Health)and Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325001China School of Life Sciences Xiamen UniversityXiamen 361102China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling NetworkXiamen 361102China Department of Computer Science Xiamen UniversityXiamen 361005China National Institute for Data Science in Health and Medicine School of MedicineXiamen UniversityXiamen 361102China Bruker(Beijing)Scientific Technology Co.Ltd. BeijingChina Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang ProvinceSchool of Life SciencesWestlake University18 Shilongshan RoadHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced Study18 Shilongshan RoadHangzhou 310024China Westlake Omics Ltd. Yunmeng Road 1HangzhouChina Department of Electronic Engineering Xiamen UniversityXiamen 361005China

Data-independent acquisition(DIA)technology for protein identification from mass spectrometry and related algorithms is developing *** spectrum-centric analysis of DIA data without the use of spectra library from data-dependent acquisition data represents a promising *** this paper,we proposed an untargeted analysis method,Dear-DIA^(XMBD),for direct analysis of DIA ***-DIA^(XMBD) first integrates the deep variational autoencoder and triplet loss to learn the representations of the extracted fragment ion chromatograms,then uses the k-means clustering algorithm to aggregate fragments with similar representations into the same classes,and finally establishes the inverted index tables to determine the precursors of fragment clusters between precursors and peptides and between fragments and *** show that Dear-DIA^(XMBD) performs superiorly with the highly complicated DIA data of different species obtained by different instrument platforms.

关键词： Deep Auto Independent

Risk assessment,fitness cost,cross-resistance,and mechanism of tetraniliprole resistance in the rice stem borer,Chilo suppressalis

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Insect Science 2024年第3期31卷 835-846页

作者： Hao Sun shuai Wang Chong Liu Wen-Kai Hu Jin-Wei Liu Ling-Jun Zheng Meng-Yue gao Fang-Rui Guo Song-Tao Qiao Jun-Li Liu Bo Sun Cong-Fen gao Shun-Fan Wu College of Plant Protection Nanjing Agricultural UniversityState&Local Joint Engineering Research Center of Green Pesticide Invention and ApplicationNanjingChina Bayer Cropscience(China)Co. Ltd.HangzhouChina

The rice stem borer(RSB),Chilo suppressalis,a notorious rice pest in China,has evolved a high resistance level to commonly used ***,a new anthranilic diamide insecticide,effectively controls multiple pests,including ***,the potential resistance risk of RSB to tetraniliprole is still *** this study,the tetraniliprole-selection(Tet-R)strain was obtained through 10 continuous generations of selection with tetraniliprole 30%lethal concentration(LC_(30)).The realized heritability(h^(2))of the Tet-R strain was 0.387,indicating that resistance of RSB to tetraniliprole developed rapidly under the continuous selection of *** Tet-R strain had a high fitness cost(relative fitness=0.53).We established the susceptibility baseline of RSB to tetraniliprole(lethal concentration at LC_(50)=0.727 mg/L)and investigated the resistance level of 6 field populations to *** tested strains that had resistance to chlorantraniliprole exhibited moderate-to high-level resistance to tetraniliprole(resistance ratio=27.7-806.8).Detection of ryanodine receptor(RyR)mutations showed that the Y4667C,Y4667D,I4758M,and Y4891F mutations were present in tested RSB field *** mutations were responsible for the cross-resistance between tetraniliprole and ***,the clustered regularly interspaced palindromic repeats(CRISPR)/CRISPR-associated protein 9-mediated genome-modified flies were used to study the contribution of RyR mutations to tetraniliprole *** order of contribution of a single RyR mutation to tetraniliprole resistance was Y4667D>G4915E>Y4667C~~I4758M>*** addition,the I4758M and Y4667C double mutations conferred higher tetraniliprole resistance than single Y4667C *** results can guide resistance management practices for diamides in RSB and other arthropods.

关键词： Chilo suppressalis diamide resistance fitness cost cross-resistance RyR target-site mutations

Response of warm season secondary pollutants to emissions and meteorology in the North China Plain region during 2018-2022

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Atmospheric and Oceanic Science Letters 2024年第4期17卷 58-64页

作者： Yueqi gao Siyu Wang Zhaolei Zhang Wenxuan Yu shuai Wang Shengqiang Zhu Peng Wang Yan Li Yele Sun Hongliang Zhang Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science&EngineeringFudan UniversityShanghaiChina Department of Atmospheric and Oceanic Sciences Fudan UniversityShanghaiChina Shanghai Key Laboratory of Ocean-land-atmosphere Boundary Dynamics and Climate Change ShanghaiChina IRDR ICoE on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health Fudan UniversityShanghaiChina State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina College of Earth and Planetary Sciences University of Chinese Academy of SciencesBeijingChina Institute of Eco-Chongming ShanghaiChina

自2013年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用2018-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在2018-2022年间,PM_(2.5)浓度显著下降31%-37%,O_(3)和NO_... 详细信息

自2013年起中国空气质量虽改善,但华北平原(NCP)重污染仍存在且二次污染加剧,而人们对其成因和变化了解有限.本研究利用2018-2022年数据,借助CMAQ模型探讨此污染响应.结果显示,在2018-2022年间,PM_(2.5)浓度显著下降31%-37%,O_(3)和NO_(2)的年下降速率分别为1%和0.5%SIA和SOA也显著减少,每年分别减少9%和6%PM_(2.5)主要因排放减少而下降,而O_(3)则受气象影响而波动.硫酸盐和铵下降的主因是减排,而硝酸盐对气象变化敏感排放和气象变化对SOA的总体减少同样重要,但人为SOA对排放控制敏感生物SOA易受气象变化影响.研究强调了控制人为排放对缓解NCP地区夏季二次污染的重要性.

关键词： PM_(2.5) 二次污染物人为排放气象华北平原

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Inhibition of the cGAS–STING pathway:contributing to the treatment of cerebral ischemia-reperfusion injury

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Neural Regeneration Research 2025年第7期20卷 1900-1918页

作者： Hang Yang Yulei Xia Yue Ma Mingtong gao shuai Hou Shanshan Xu Yanqiang Wang School of Clinical Medicine Shandong Second Medical UniversityWeifangShandong ProvinceChina Department of Emergency The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina Department of Neurology Ⅱ The Affiliated Hospital of Weifang Medical UniversityWeifangShandong ProvinceChina

The cGAS–STING pathway plays an important role in ischemia-reperfusion injury in the heart,liver,brain,and kidney,but its role and mechanisms in cerebral ischemia-reperfusion injury have not been systematically ***,we outline the components of the cGAS–STING pathway and then analyze its role in autophagy,ferroptosis,cellular pyroptosis,disequilibrium of calcium homeostasis,inflammatory responses,disruption of the blood–brain barrier,microglia transformation,and complement system activation following cerebral ischemia-reperfusion *** further analyze the value of cGAS–STING pathway inhibitors in the treatment of cerebral ischemia-reperfusion injury and conclude that the pathway can regulate cerebral ischemia-reperfusion injury through multiple *** of the cGAS–STING pathway may be helpful in the treatment of cerebral ischemia-reperfusion injury.

关键词： calcium homeostasis cellular autophagy cerebral ischemia-reperfusion injury cGAS–STING pathway ferroptosis gut–brain–microbiota axis inflammatory light chain 3 microglial cells Syntaxin-17 protein