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Germplasm resources and genetic improvement of Akebia:A new fruit crop in China

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Plant Diversity 2023年第6期45卷 712-721页

作者： shuai-yu Zou Chen Feng Pu-Xin Gao Tong-Jian Li Tian-Jiao Jia Hongwen Huang Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China School of Pharmacy and Life Science Jiujiang UniversityJiujiang 332005China South China Botanical Garden Chinese Academy of SciencesGuangzhou 510650China

Akebia species,belonging to Lardizabalaceae,are widespread from subtropical to temperate environments of China,Japan,and *** known Akebia species have medicinal and dietary value and have been widely cultivated as a new fruit crop in many areas of ***,compared with other crop species,the breeding improvement and commercial cultivation of Akebia remain in their *** review systematically introduces the present germplasm resources,geographical distribution,biological characteristics,interspecific and intraspecific cross compatibility,molecular biology,and breeding progress in Akebia *** plants are widely distributed in Shanxi,Henan,Sichuan,Chongqing,Hunan,Hubei,Jiangxi,Zhejiang,and Fujian provinces of China,and wild Akebia plants exhibit abundant phenotypic and genetic diversity due to their wide range of geographical distribution and high adaptability in different *** artificial hybridization experiments have been conducted in our Akebia germplasm resources *** results showed that there was no reproductive isolation between Akebia species,and fertile progeny could be *** synthesis of knowledge on these species provides insights for the rational development and utilization of these germplasm resources,and can facilitate the development of new breeding lines or varieties for commercial cultivation or ***,perspectives on Akebia breeding research are discussed and conclusions are *** review provided breeders with new insights into Akebia domestication and breeding,and we also proposed five basic steps in the domestication of new fruit crops.

关键词： Akebia Geographical distribution Biological characteristics Cross compatibility Breeding strategy

HOTTIP downregulation reduces neuronal damage and microglial activation in Parkinson's disease cell and mouse models

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Neural Regeneration Research 2022年第4期17卷 887-897页

作者： Peng Lun Tao Ji De-Hong Wan Xia Liu Xiao-Dong Chen shuai yu Peng Sun Department of Neurosurgery the Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Department of Neurosurgery Laiyang People’s HospitalYantaiShandong ProvinceChina Department of Endocrine and Metabolic Diseases the Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina Emergency Department the Affiliated Hospital of Qingdao UniversityQingdaoShandong ProvinceChina

HOXA transcript at the distal tip(HOTTIP),a newly identified long noncoding RNA,has been shown to exhibit anti-inflammatory effects and inhibit oxygen-glucose deprivation-induced neuronal ***,its role in Parkinson's disease(PD)remains unclear.1-Methyl-4-phenylpyridium(MPP+)and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)were used to establish PD models in SH-SY5 Y and BV2 cells and in C57 BL/6 male mice,*** vitro,after HOTTIP knockdown by sh-HOTTIP transfection,HOTTIP and FOXO1 overexpression promoted SH-SY5 Y apoptosis,BV2 microglial activation,proinflammatory cytokine expression,and nuclear factor kappa-B and NACHT,LRR and PYD domains-containing protein 3 inflammasome *** of mi R-615-3 p inhibited MPP+-induced neuronal apoptosis and microglial inflammation and ameliorated HOTTIP-and FOXO1-mediated nerve injury and *** vivo,HOTTIP knockdown alleviated motor dysfunction in PD mice and reduced neuronal apoptosis and microglial activation in the substantia *** findings suggest that inhibition of HOTTIP mitigates neuronal apoptosis and microglial activation in PD models by modulating mi R-615-3 p/*** study was approved by the Ethics Review Committee of the Affiliated Hospital of Qingdao University,China(approval ***-2018-042)in June 2018.

关键词： apoptosis inflammation miR-615-3p neuron NLRP3 noncoding RNA Parkinson's disease HOTTIP

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新型工业化促进汽车制造业转型升级路径

湖北汽车工业学院学报 2024年第2期38卷 76-80页

作者：帅钰肖俊涛殷旅江史阳武韩国草堂大学全罗南道务安郡58500 汉江师范学院经济管理学院湖北十堰442000 湖北汽车工业学院经济管理学院湖北十堰442002

基于新型工业化的内涵分析其对汽车制造业转型升级提出的新要求,结合我国汽车制造业发展现状和转型升级的主要制约因素,提出以新型工业化新要求促进汽车制造业转型升级的路径:发展新质生产力、加快企业数字化转型和智能化升级、提升产... 详细信息

基于新型工业化的内涵分析其对汽车制造业转型升级提出的新要求,结合我国汽车制造业发展现状和转型升级的主要制约因素,提出以新型工业化新要求促进汽车制造业转型升级的路径:发展新质生产力、加快企业数字化转型和智能化升级、提升产业链现代化水平和韧性、推进绿色低碳发展、构建产业新生态等。

关键词：新型工业化汽车制造业转型升级新质生产力路径

改良Blumgart胰肠吻合在腹腔镜胰十二指肠切除术中的应用

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中国现代普通外科进展 2024年第7期27卷 568-570页

作者：高帅宇王新建张磊崔夕军威海市中心医院肝胆疝与腹壁外科山东威海264200

收集并回顾分析2017年1月以来77例腹腔镜胰十二指肠切除术患者的临床资料。其中35例行改良的Blumgart吻合(改良组),42例行传统的Blumgart吻合(传统组),分析两组临床资料。改良组平均完全吻合时间(36.9±4.7)min,传统组为(39.0±6.2)min... 详细信息

收集并回顾分析2017年1月以来77例腹腔镜胰十二指肠切除术患者的临床资料。其中35例行改良的Blumgart吻合(改良组),42例行传统的Blumgart吻合(传统组),分析两组临床资料。改良组平均完全吻合时间(36.9±4.7)min,传统组为(39.0±6.2)min,两组比较差异无统计学意义(P>0.05)。改良组术后临床性胰瘘(B级和C级)发生率为11.4%(4/35),传统组为21.4%(9/42),两组比较差异无统计学意义(P>0.05)。改良组术后住院时间(10.7±4.9)d,传统组为(14.5±5.3)d,两组比较差异有统计学意义(P<0.05)。改良Blumgart吻合术简化和促进了腹腔镜胰十二指肠切除术中胰肠吻合术的建立,临床性胰瘘的发生率与传统组相似,减少了患者的住院时间。

关键词：腹腔镜胰十二指肠切除术胰肠吻合术 Blumgart吻合 U型缝合胰瘘

骨科机器人辅助下闭合复位空心钉内固定治疗股骨颈骨折

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中国骨伤 2024年第2期37卷 119-123页

作者：蒋守海张传开贾方腾陈强徐猛杨沛霖张玉帅徐州仁慈医院关节外科江苏徐州221004

目的:探讨机器人导航定位系统辅助下闭合复位空心钉内固定治疗股骨颈骨折的临床初步疗效。方法:回顾分析2019年7月至2020年1月36例闭合性股骨颈骨折患者,根据是否采用机器人系统辅助股骨颈骨折内固定手术分为两组。采用机器人系统导航... 详细信息

目的:探讨机器人导航定位系统辅助下闭合复位空心钉内固定治疗股骨颈骨折的临床初步疗效。方法:回顾分析2019年7月至2020年1月36例闭合性股骨颈骨折患者,根据是否采用机器人系统辅助股骨颈骨折内固定手术分为两组。采用机器人系统导航下闭合复位内固定治疗股骨颈骨折16例(导航组),男7例,女9例,年龄25~72(53.61±5.45)岁;骨折Garden分型,Ⅰ型3例,Ⅱ型3例,Ⅲ型8例,Ⅳ型2例。非导航组(对照组):采用闭合复位空心钉内固定治疗股骨颈骨折20例,男8例,女12例,年龄46~70(55.23±4.64)岁;GardenⅠ型2例,Ⅱ型4例,Ⅲ型11例,Ⅳ型3例。对两组患者手术时间、透视次数、导针钻孔次数、螺钉调整次数、术中出血量等指标进行评价。结果:两组术后均获随访,时间12~18(15.6±2.8)个月。两组骨折均愈合,无骨折延迟愈合及骨不连发生。两组愈合时间比较,差异无统计学意义(P=0.782)。末次随访时两组Harris评分比较,差异无统计学意义(P=0.813>0.05)。两组间手术时间比较,差异无统计学意义(P>0.05)。两组透视次数、导针钻孔次数、螺钉调整次数、术中出血量比较,差异均有统计学意义(P<0.05)。结论:机器人导航系统辅助下闭合复位空心钉内固定治疗股骨颈骨折操作微创化,螺钉置入精准化,而且减少医患术中X线照射损害。

关键词：骨科机器人外科手术计算机辅助股骨颈骨折内固定

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船用核安全级电缆研制

电线电缆 2024年第1期67卷 21-25页

作者：王云帆樊群杨佳昱于帅李永江武汉第二船舶设计研究所武汉430064 南京全信传输科技股份有限公司南京211113

通过分析特殊功能和环境适应性需求下船用核安全级电缆的分类和性能要求,进行了船用核安全级控制和仪表通信电缆的结构设计、材料选择和试制开发,后对试制电缆产品进行全性能测试。结果表明,该产品达到设计要求。

关键词：船用电缆核安全关键性能测试

The mRNA Expression Profiles of Five Heat Shock Protein Genes from Frankliniella occidentalis at Different Stages and Their Responses to Temperatures and Insecticides

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Journal of Integrative Agriculture 2014年第10期13卷 2196-2210页

作者： WANG Hai-hong Stuart R Reitz WANG Li-xia WANG shuai-yu LI Xue LEI Zhong-ren State Key Laboratory for Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Malheur County Extension Oregon State University The General Station of Plant Protection in Shandong

The westem flower thrips, Frankliniella occidental＆（Pergande） is a highly invasive pest that is able to exploit many crops across a wide range of environmental conditions. Five full-length cDNAs of heat shock protein （HSP） genes （Fo-HSP90, Fo-HSP70, Fo-HSP60, Fo-HSP40 and Fo-HSP28.9） were cloned from F. occidentalis, and their expression profiles were investigated under conditions of thermal stress and insecticide exposure, and at different stages during development, using real-time quantitative PCR. All five gene sequences showed high similarity to homologs in other species, indicating the conserved fimction of this gene family. HSP60 represents an informative phylogenetic marker at the ordinal taxonomic level within Insecta, but HSP90, which has two homologous copies in Hymenoptera, was not informative. The expression of Fo-HSPs under thermal stress suggests that Fo-HSP90, Fo-HSP70, and Fo-HSP28.9 are inducible by both cold and heat stress, Fo-HSP40 is only heat-inducible, and Fo-HSP60 is thermally insensitive. There were two patterns of cold induction of Fo-HSPs： one is from 0 to 4℃ and the other is around -8℃. All five Fo-HSPs genes were induced by exposure to sublethal concentrations of the insecticide avermectin. The expression of the five Fo-HSPs during different developmental stages suggests that they all play a role in development of F. occidentalis.

关键词： Frankliniella occidentalis heat shock protein genes environmental stress development expression profile

Neuronal conversion from glia to replenish the lost neurons

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Neural Regeneration Research 2024年第7期19卷 1446-1453页

作者： Shiyu Liang Jing Zhou Xiaolin yu shuai Lu Ruitian Liu National Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijingChina School of Chemical Engineering University of Chinese Academy of SciencesBeijingChina Department of Geriatric Rehabilitation Beijing Rehabilitation HospitalCapital Medical UniversityBeijingChina

Neuronal injury,aging,and cerebrovascular and neurodegenerative diseases such as cerebral infarction,Alzheimer’s disease,Parkinson’s disease,frontotemporal dementia,amyotrophic lateral sclerosis,and Huntington’s disease are characte rized by significant neuronal *** rtunately,the neurons of most mammals including humans do not possess the ability to *** of lost neurons becomes an appealing therapeutic strategy to reve rse the disease *** of pluripotent neural stem cells can supplement the missing neurons in the brain,but it carries the risk of causing gene mutation,tumorigenesis,severe inflammation,and obstructive hydrocephalus induced by brain *** of neural or non-neural lineage cells into functional neurons is a promising strategy for the diseases involving neuron loss,which may overcome the above-mentioned disadvantages of neural stem cell *** far,many strategies to transfo rm astrocytes,fibroblasts,microglia,Muller glia,NG2 cells,and other glial cells to mature and functional neurons,or for the conversion between neuronal subtypes have been developed thro ugh the regulation of transcription factors,polypyrimidine tra ct binding protein 1(PTBP1),and small chemical molecules or are based on a combination of several factors and the location in the central nervous ***,some recent papers did not obtain expected results,and discrepancies ***,in this review,we discuss the history of neuronal transdifferentiation,summarize the strategies for neuronal replenishment and conversion from glia,especially astrocytes,and point out that biosafety,new strategies,and the accurate origin of the truly co nverted neurons in vivo should be focused upon in future *** also arises the attention of replenishing the lost neurons from glia by gene therapies such as up-regulation of some transc ription factors or downregulation of PTBP1 or drug interfe rence therapies.

关键词： astrocytes neural stem cells neurodegenerative diseases neuron polypyrimidine tract binding protein 1 repair reprogramming small molecule transcription factor transdifferentiation

Identification of Suitable Hydrologic Response Unit Thresholds for Soil and Water Assessment Tool Streamflow Modelling

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Chinese Geographical Science 2021年第4期31卷 696-710页

作者： JIANG Liupeng ZHU Jinghai CHEN Wei HU yuanman YAO Jing yu shuai JIA Guangliang HE Xingyuan WANG Anzhi Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Forest Ecology and Management^Institute of Applied Ecology Chinese Academy of SciencesShenyang 110016China Shenyang Arboretum Chinese Academy of SciencesShenyang 110016China

Use of a non-zero hydrologic response unit(HRU) threshold is an effective way of reducing unmanageable HRU numbers and simplifying computational cost in the Soil and Water Assessment Tool(SWAT) hydrologic modelling. However, being less representative of watershed heterogeneity and increasing the level of model output uncertainty are inevitable when minor HRU combinations are disproportionately eliminated. This study examined 20 scenarios by running the model with various HRU threshold settings to understand the mechanism of HRU threshold effects on watershed representation as well as streamflow predictions and identify the appropriate HRU thresholds. Findings show that HRU numbers decrease sharply with increasing HRU thresholds. Among different HRU threshold scenarios, the composition of land-use, soil, and slope all contribute to notable variations which are directly related to the model input parameters and consequently affect the streamflow predictions. Results indicate that saturated hydraulic conductivity, average slope of the HRU, and curve number are the three key factors affecting stream discharge when changing the HRU thresholds. It is also found that HRU thresholds have little effect on monthly model performance, while evaluation statistics for daily discharges are more sensitive than monthly results. For daily streamflow predictions, thresholds of 5%/5%/5%(land-use/soil/slope) are the optimum HRU threshold level for the watershed to allow full consideration of model accuracy and efficiency in the present work. Besides, the results provide strategies for selecting appropriate HRU thresholds based on the modelling goal.

关键词： hydrologic response unit hydrological model streamflow prediction upper Hunhe River watershed watershed representation uncertainty