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长链非编码RNA烟酰胺核苷酸转氢酶-反义RNA1在肺癌发生发展中的作用研究进展

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新乡医学院学报 2024年第4期41卷 388-391,396页

作者：熊常州韩坤余刘宁马帅牛华涛成都中医药大学临床医学院四川成都610075 云南中医药大学第一临床医学院云南昆明650021 云南省肿瘤医院神经外科云南昆明650118

肺癌是世界上致死率最高的恶性肿瘤,其主要治疗手段为外科手术、化学治疗、放射治疗、靶向治疗等。烟酰胺核苷酸转氢酶-反义RNA1(NNT-AS1)作为新发现的长链非编码RNA(lncRNA)分子,通过miR-3666/E2F2、miR-22-3p/YAP1、miR-22/FOXM1、miR... 详细信息

肺癌是世界上致死率最高的恶性肿瘤,其主要治疗手段为外科手术、化学治疗、放射治疗、靶向治疗等。烟酰胺核苷酸转氢酶-反义RNA1(NNT-AS1)作为新发现的长链非编码RNA(lncRNA)分子,通过miR-3666/E2F2、miR-22-3p/YAP1、miR-22/FOXM1、miR-1236-3p/ATG7、miR-129-5p、丝裂原活化蛋白激酶/Slug等信号通路,与肺癌细胞的凋亡、增殖、迁移、侵袭有关,还参与介导肺癌细胞的顺铂耐药性,与肺癌的不良生存结局和较差的临床病理特征显著相关,可以为肺癌提供新的治疗靶点及预后标志物。本文就lncRNA NNT-AS1在肺癌发生发展中的作用研究进展进行综述。

关键词：肺癌长链非编码RNA烟酰胺核苷酸转氢酶-反义RNA1 增殖耐药性

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引射器数值模拟与关键结构参数优化设计

机械工程与自动化 2024年第4期 55-57页

作者：马帅王晓雨北京航天试验技术研究所北京100074

针对发动机高空模拟试验的需求,以数值模拟软件为基础,结合流体的物性参数、进出口总温总压等条件,对两级引射器进行了气动流场分析,通过仿真结果指导引射器关键结构的参数优化,最终实现了气动流场与试验工况的良好匹配。研究结果表明:... 详细信息

针对发动机高空模拟试验的需求,以数值模拟软件为基础,结合流体的物性参数、进出口总温总压等条件,对两级引射器进行了气动流场分析,通过仿真结果指导引射器关键结构的参数优化,最终实现了气动流场与试验工况的良好匹配。研究结果表明:采用多级引射的方式可以实现引射器增压能力,但一级引射器的混合室等直段内径太大会造成二级引射器发生喘振流动或者倒流现象。

关键词：发动机引射器数值模拟气动流场结构优化

生态系统服务多功能区时空变化及其影响因素分析:以青藏高原生态屏障区为例

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生态与农村环境学报 2024年第8期40卷 1038-1046页

作者：李昊瑞马帅殷允可王良杰姜姜南京林业大学南方现代林业协同创新中心江苏南京210037 南京林业大学江苏省水土保持与生态修复重点实验室江苏南京210037

生态功能分区是生态系统管理的重要环节,基于生态系统服务簇进行生态功能分区对维持生态系统的可持续性具有重要意义。以青藏高原生态屏障区为例,采用生态系统服务和权衡的综合评估模型(Integrated Valuation of Ecosystem Services and... 详细信息

生态功能分区是生态系统管理的重要环节,基于生态系统服务簇进行生态功能分区对维持生态系统的可持续性具有重要意义。以青藏高原生态屏障区为例,采用生态系统服务和权衡的综合评估模型(Integrated Valuation of Ecosystem Services and Trade-offs,InVEST)、修正通用土壤流失方程模型(Revised Universal Soil Loss Equation,RUSLE)和卡内基-阿梅斯-斯坦福模型(Carnegie-Ames-Stanford Approach,CASA)评估产水量、土壤保持、固碳和生境质量,在县域尺度上基于主导的生态系统服务类型将研究区划分3个生态系统服务多功能区(生态调节多功能区E1、生态供给多功能区E2和生态支持多功能区E3),并分析了生态系统服务多功能区的时空变化及影响因素。结果表明:(1)与2000年相比,2015年青藏高原生态屏障区产水量和土壤保持减弱,固碳和生境质量提高;(2)青藏高原生态系统服务多功能区时空变化主要是E1和E3之间的相互转化;(3)降水是影响青藏高原生态系统服务多功能区空间格局形成的最主要因素,人口密度是增幅最明显的因素。社会经济因素和自然因素的共同作用加强了多功能区的相互转化。该研究结果可为青藏高原土地多功能属性的管理和国土空间整体功能的提升提供价值参考。

关键词：生态系统服务多功能区时空变化影响因素青藏高原生态屏障区

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柴油机喷油器喷孔内流穴蚀风险分析

车用发动机 2024年第1期 21-27页

作者：郭勍曹健张翼郑智锋郑丹马帅海军装备部山西太原030051 中北大学能源与动力工程学院山西太原030051 山西柴油机工业有限责任公司山西大同037036

针对柴油机喷油器喷孔内空化流动及穴蚀磨损问题,建立了孔内燃油流动的仿真三维模型,并且通过可视化试验验证了模型的准确性。在R_(rs)冲蚀风险预测模型的基础上,将微射流速度、水锤压力和侵蚀强度系数引入公式,建立了喷油器喷孔内流穴... 详细信息

针对柴油机喷油器喷孔内空化流动及穴蚀磨损问题,建立了孔内燃油流动的仿真三维模型,并且通过可视化试验验证了模型的准确性。在R_(rs)冲蚀风险预测模型的基础上,将微射流速度、水锤压力和侵蚀强度系数引入公式,建立了喷油器喷孔内流穴蚀风险预测模型,实现了穴蚀损伤位置的定量表征。采用该模型研究了喷孔不同当量入口圆角半径、不同喷孔倾角和不同当量表面粗糙度对喷油器喷孔穴蚀磨损的影响。计算结果表明,穴蚀磨损区域主要位于喷孔入口处和喷孔上侧表面,且当量入口圆角半径对穴蚀磨损的影响大于当量表面粗糙度和喷孔倾角,因此可以优先考虑增加喷孔入口圆角半径以减小穴蚀磨损,提升喷油器寿命。

关键词：喷油器空化流动穴蚀风险预测预测模型

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CREB磷酸化介导半枝莲黄酮改善BI-D1870所致大鼠记忆障碍

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中国医院药学杂志 2024年第5期44卷 520-529页

作者：张超洁马帅李佳慧商亚珍承德医学院中药研究所/河北省中医药抗痴呆重点研究室/河北省中药研究与开发重点实验室/河北省神经损伤与修复重点实验室河北承德067000

目的:探讨半枝莲黄酮(SBFs)通过促进CREB磷酸化改善BI-D1870所致大鼠记忆障碍。方法:腹腔注射BI-D1870建立大鼠记忆障碍模型,Morris水迷宫筛选记忆障碍成功模型,模型成功大鼠随机分为模型组、SBFs组和CREB磷酸化激活剂Rolipram组,SBFs... 详细信息

目的:探讨半枝莲黄酮(SBFs)通过促进CREB磷酸化改善BI-D1870所致大鼠记忆障碍。方法:腹腔注射BI-D1870建立大鼠记忆障碍模型,Morris水迷宫筛选记忆障碍成功模型,模型成功大鼠随机分为模型组、SBFs组和CREB磷酸化激活剂Rolipram组,SBFs组大鼠灌胃140 mg·kg-1 SBFs,Rolipram组大鼠腹腔注射0.5 mg·kg-1 Rolipram。Morris水迷宫检测大鼠学习记忆能力;苏木精-伊红(HE)染色观察海马皮层神经元形态;免疫组化(IHC)检测海马回与神经再生相关蛋白DCX表达;免疫荧光(IF)检测海马和皮层p-CREB-Ser142蛋白表达;实时荧光定量(qPCR)检测海马和皮层BDNF、TrkB和CREB的mRNA表达;Western blot检测海马和皮层BDNF、TrkB和p-CREB-Ser133蛋白表达。结果:腹腔注射BI-D1870可引起大鼠学习记忆障碍,神经病理学改变,海马回DCX蛋白表达降低,海马和皮层p-CREB-Ser142蛋白表达增加,BDNF、TrkB和CREB的mRNA及蛋白表达皆降低。SBFs可逆转BI-D1870所致大鼠上述异常改变,作用与Rolipram相平行。结论:SBFs与Rolipram作用相一致,能够改善BI-D1870所致的记忆障碍,其作用机制与其影响CREB磷酸化有关。

关键词：半枝莲黄酮 BI-D1870 CREB磷酸化记忆障碍

Evaluation of the applicability of multiple drought indices in the core zone of “westerlies-dominated climatic regime”

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Science China Earth Sciences 2023年第7期66卷 1504-1520页

作者： Huiwen GUO Wei HUANG Tingting XIE shuai ma Key Laboratory of Western China’s Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China

Drought indices are frequently used to measure the intensity,start and end of ***,the performances of these indices depend on regions and the type of ***,it is necessary to evaluate whether these indices are applicable for a given *** study evaluated the ability of the self-calibrating Palmer Drought Severity Index(sc PDSI),the Standardized Precipitation Evapotranspiration Index(SPEI),and the Standardized Moisture Anomaly Index(SZI) to describe the dry-wet conditions and drought events in the core zone of the “westerlies-dominated climatic regime”.The results showed that the 12-month SZI(SZI12) and SPEI(SPEI12) have good correlations with precipitation and PET respectively,while the sc PDSI can capture the changes in precipitation and soil *** Xinjiang region of China,the SZI12 and sc PDSI showed that this region gradually became wetter during 1961–2014,which was consistent with increased precipitation,decreased PET,and improved ***,the SPEI12 showed significant drying due to the strong influence of the PET,suggesting that this index exaggerated the drought conditions in this *** in Kazakhstan and the southern Central Asian regions has increased slightly over the past 50 years,but the PET has greatly increased,altogether,all three indices suggested a drying trend in Central *** evaluation of the ability of these drought indices to identify typical drought events in Xinjiang region of China suggested that the sc PDSI can better detect the typical drought events compared with the *** conclusion,the sc PDSI is the most suitable index for characterizing the long-term trend of hydroclimate conditions and drought events in the core zone of the “westerlies-dominated climatic regime”.This study provides a theoretical basis for the rational utilization and improvement of the drought index,which is critical for monitoring,attributing,and predicting of drought events in arid areas.

关键词： Drought index Applicability of the drought index Hydroclimate conditions Potential evapotranspiration Drought events

Quantification of emission variability for off-road equipment in China based on real-world measurements

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Frontiers of Environmental Science & Engineering 2022年第2期16卷 125-136页

作者： Kaili Pang Kaishan Zhang shuai ma Xiangrui Meng Department of Environmental Science and Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China

The objective of this paper is to quantify the variability in emissions of off-road equipment using a portable emission measurement system.A total of 53 commonly used equipment for agriculture,base construction,paving construction,and material handling were ***-based and fuel-based emissions were quantified by different duty and engine *** duty modes(idling,moving,and working)were *** engine modes were defined based on normalized engine revolutions-per-minute and manifold absolute pressure,*** emission factors taking into account both duty modes and its corresponding time percentage during a typical duty cycle were *** showed that there existed a large off-road equipment variability in *** on duty and engine modes,time-based NO emissions ranged from 3.1 to 237.9,29.1‒1475.6,83.2‒681.6,and 3.2‒385.2 g/h for agriculture,base construction,paving construction and material handling equipment,respectively while for fuel-based NO emissions these ranges were 5.3‒52.0,11.7‒69.0,4.8‒30.8,and 11.0‒54.6 g/kg,***,emission factors derived from this study exhibited a much larger variability compared to those used in NONROAD by US EPA and National Guideline for Off-road Equipment of *** implied that localized measurements of emissions are needed for improvement of accuracy of emission ***,both equipment types and operations should be considered for development of emission inventory and control strategy.

关键词： Off-road equipment Portable emission measurement system(PEMS) Real-world emissions Diesel engine

Preserving details in semantics-aware context for scene parsing

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Science China(Information Sciences) 2020年第2期63卷 79-92页

作者： shuai ma Yanwei PANG Jing PAN Ling SHAO Tianjin Key Laboratory of Brain-Inspired Intelligence Technology School of Electrical and Information EngineeringTianjin University School of Electronic Engineering Tianjin University of Technology and Education

Great success of scene parsing(also known as, semantic segmentation) has been achieved with the pipeline of fully convolutional networks(FCNs). Nevertheless, there are a lot of segmentation failures caused by large similarities between local appearances. To alleviate the problem, most of existing methods attempt to improve the global view of FCNs by introducing different contextual modules. Though the reconstructed high resolution output of these methods is of rich semantics, it cannot faithfully recover the fine image details owing to lack of desired precise low-level information. To overcome the problem, we propose to improve the spatial decoding process through embedding possibly lost low-level information in a principled way. To this end, we make the following three contributions. First, we propose a semantics conformity module to make low-level features variations agnostic. Second, we introduce semantics into the conformed low level features through guidance from semantically aware features. Finally, we institute the availability of various possible contextual features at feature fusion to enrich context information. The proposed approach demonstrates competitive performance on challenging PASCAL VOC 2012, Cityscapes,and ADE20K benchmarks in comparison to the state-of-the-art methods.

关键词： fully convolutional networks semantic segmentation cityscapes semantic-aware context

Calcitonin gene related peptide modified mesenchymal stem cells reduce restenosis after carotid balloon injury in rats

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BIOCELL 2022年第8期46卷 1903-1909页

作者： PANKE CHEN shuai ma Department of Cardiology Affiliated Hospital of Zunyi Medical UniversityZunyi563003China

This work aimed to investigate the effects of calcitonin gene-related peptide(CGRP)-modified mesenchymal stem cells(MSCs)on vascular stenosis in carotid balloon-injured *** CGRP gene labeled with EGFP was transfected into bone marrow MSCs,and CGRP protein expression in MSCs was confirmed by immunofluorescence assays.A rat carotid balloon injury model was established using a ***-modifiedMSCs were orthotopically transplanted into the injured area of the *** 28 days after cell transplantation,EGFP and CD31 expression was detected by immunofluorescence ***-eosin(H&E)staining was used to detect the intima/media area of the injured carotid artery stenosis site,and the expression of proliferating cell nuclear antigen(PCNA)was detected by *** from rat bone marrow positively expressed CD29 and negatively expressed *** vivo immunofluorescence staining showed that EGFP expression was significantly increased at the vascular injury site of rats transplanted with MSC_CGRP compared with the control group on the 28th day after cell transplantation and that the damaged vessels exhibited continuous CD31 expression.H&E staining showed that the vascular intimal proliferation area of rats transplanted with MSC_CGRP was significantly reduced compared with that of other ***,the immunohistochemistry results showed that PCNA expression in the endothelium of the MSC_CGRP group was lower than that of the other ***,MSCs transfected with the CGRP gene can express the CGRP protein,and the implantation of CGRPmodified MSCs at the damaged site after carotid balloon-induced injury can reduce the neointimal area.

关键词： Mesenchymal stem cells Calcitonin gene-related peptide Lentiviral transfection Cell transplantation Restenosis