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Overexpression of low-density lipoprotein receptor prevents neurotoxic polarization of astrocytes via inhibiting NLRP3 inflammasome activation in experimental ischemic stroke

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Neural Regeneration Research 2025年第2期20卷 491-502页

作者： shuai feng Juanji Li Tingting Liu Shiqi Huang Xiangliang Chen Shen Liu Junshan Zhou Hongdong Zhao Ye Hong Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Jinling HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina

Neurotoxic astrocytes are a promising therapeutic target for the attenuation of cerebral ischemia/reperfusion ***-density lipoprotein receptor,a classic cholesterol regulatory receptor,has been found to inhibit NLR family pyrin domain containing protein 3(NLRP3)inflammasome activation in neurons following ischemic stroke and to suppress the activation of microglia and astrocytes in individuals with Alzheimer’s ***,little is known about the effects of low-density lipoprotein receptor on astrocytic activation in ischemic *** address this issue in the present study,we examined the mechanisms by which low-density lipoprotein receptor regulates astrocytic polarization in ischemic stroke ***,we examined low-density lipoprotein receptor expression in astrocytes via immunofluorescence staining and western blotting *** observed significant downregulation of low-density lipoprotein receptor following middle cerebral artery occlusion reperfusion and oxygen-glucose deprivation/***,we induced the astrocyte-specific overexpression of low-density lipoprotein receptor using astrocyte-specific adeno-associated ***-density lipoprotein receptor overexpression in astrocytes improved neurological outcomes in middle cerebral artery occlusion mice and reversed neurotoxic astrocytes to create a neuroprotective ***,we found that the overexpression of low-density lipoprotein receptor inhibited NLRP3 inflammasome activation in oxygen-glucose deprivation/reoxygenation injured astrocytes and that the addition of nigericin,an NLRP3 agonist,restored the neurotoxic astrocyte *** findings suggest that low-density lipoprotein receptor could inhibit the NLRP3-meidiated neurotoxic polarization of astrocytes and that increasing low-density lipoprotein receptor in astrocytes might represent a novel strategy for treating cerebral ischemic stroke.

关键词： inflammation ischemia/reperfusion injury ischemic stroke low-density lipoprotein receptor neuroprotective astrocytes neurotoxic astrocytes NLRP3 inflammasome polarization

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Universal design of three-dimensional porous graphene-iron based promotors for kinetically rationalized lithium-sulfur chemistry

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Journal of Energy Chemistry 2025年第1期100卷 192-200页

作者： Hua Gao Yunfeng Zhang Menglei Wang Ruoxuan Yang shuai feng Xuan Cao Yaping Zhang Zhongyuan Lu Yingze Song State Key Laboratory of Environment-Friendly Energy Materials School of Materials and Chemistry Southwest University of Science and Technology School of Material Science and Engineering Henan University of Technology College of Chemistry and Chemical Engineering Taishan University

Lithium-sulfur （Li-S） batteries are widely deemed to be one of the most potential candidates for future secondary batteries because of their remarkable energy ***,notorious polysulfide shuttling and retarded sulfur reaction kinetics pose significant obstacles to the further application of Li-S *** rationally designed highly active electrocatalysts can facilitate polysulfide conversion,the universal and scalable synthesis strategies need to be ***,a universal synthetic strategy to construct a series of three-dimensional （3D） porous graphene-iron （3DGr-Fe） based electrocatalysts involving 3DGr-FeP,3DGr-Fe3C,and 3DGr-Fe3Se4is exploited for manipulating the Li-S redox *** has been observed that the implementation of a 3D porous Gr architecture leads to the well-designed conductive networks,while the uniformly dispersed iron nanoparticles introduce an abundance of active sites,fostering the lithium polysulfide conversion,thereby bolstering the overall electrochemical *** Li-S battery with the 3DGr-Fe based electrocatalyst exhibits remarkable capacity retention of 94.8%upon 100 times at 0.2 ***,the soft-packaged Li-S pouch cell based on such a 3DGr-Fe electrocatalyst delivers superior capacity of 1060.71 mA h g-1and guarantees for the continuous 30 min work of fan *** investigation gives comprehensive insights into the design,synthesis,and mechanism of 3DGr-Fe based electrocatalysts with high activity toward efficient and durable Li-S batteries.

关键词： Lithium-sulfur battery Universal synthesis 3D graphene-iron based promotor Electrocatalysis

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人工智能与政治安全形态演变:一项系统研究的尝试

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国际安全研究 2025年第1期43卷 54-72,156,157页

作者：封帅薛世锟上海国际问题研究院网络空间国际治理研究中心上海国际问题研究院上海200233

在人工智能时代,政治安全的内涵正在被不断深化和持续拓展,各国面临的政治安全风险也愈发复杂。根据系统科学理论,政治安全可以构建为一种政治安全系统,包含正反要素、四大结构面与动态稳定的功能。人工智能在经历从游离到输入的时序过... 详细信息

在人工智能时代,政治安全的内涵正在被不断深化和持续拓展,各国面临的政治安全风险也愈发复杂。根据系统科学理论,政治安全可以构建为一种政治安全系统,包含正反要素、四大结构面与动态稳定的功能。人工智能在经历从游离到输入的时序过程后,作为一种新的要素与政治安全系统发生互动。人工智能与政治安全的互动遵循“技术—应用—风险—系统”的逻辑过程,并实现对系统内其他要素的影响。这种影响全面且深刻,使得人工智能开始大面积嵌入政治安全系统,重构了政治安全结构。政治安全正在面临人工智能所带来的更复杂的风险形态,包括权力安全、制度安全与价值安全在内的政治安全内部生态都将发生深刻变化,推动整个政治安全形态经历深刻的变革。

关键词：人工智能政治安全国家安全系统科学

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A Reliability Evaluation Method for Intermittent Jointed Rock Slope Based on Evolutionary Support Vector Machine

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Computer Modeling in Engineering & Sciences 2021年第10期129卷 149-166页

作者： shuai Zheng An-Nan Jiang Kai-shuai feng College of Transportation Engineering Dalian Maritime UniversityDalian116026China

The randomness of rock joint development is an important factor in the uncertainty of geotechnical engineering *** this study,a method is proposed to evaluate the reliability of intermittent jointed rock *** least squares support vector machine(LSSVM)evolved by a bacterial foraging optimization algorithm(BFOA)is used to establish a response surface model to express the mapping relationship between the intermittent joint parameters and the slope safety *** training samples are obtained from the numerical calculation based on the joint finite element method during this *** the randomness of the intermittent joint parameters in the actual project,each parameter is evaluated at different locations on the site,and its distribution characteristics are *** to these statistical results,a large number of parameter combinations are obtained through Monte Carlo *** trained machine learning mapping model is used to obtain the slope safety factor corresponding to each group,and these results are then used to obtain the slope *** the research results were applied to slope disaster treatment along the Yalu River in China’s Jilin Province,it was found that the joint length and joint inclination angle both play key roles in rock slope stability,which should receive more attention in the slope *** summary,this study establishes a method for evaluating the reliability of intermittent jointed rock slope based on an evolutionary SVM model,and its feasibility is verified by engineering application.

关键词： Slope reliability intermittent joint safety factor intelligent algorithm parameter sensitivity

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Meteoroid and Space Debris Risk Assessment for Satellites Orbiting the Earth/Moon

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空间科学学报 2023年第4期43卷 724-735页

作者： feng shuai WANG Ronglan National Space Science Center Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 State Key Laboratory of Space Weather National Space Science CenterChinese Academy of SciencesBeijing 100190 Key Laboratory of Science and Technology on Environmental Space Situation Awareness Chinese Academy of SciencesBeijing 100190

Interplanetary meteoroids and space debris can impact satellites orbiting the Earth or spacecraft traveling to the *** China Space Station(CSS),7 satellites selected from the constellation of Beidou Navigation Satellite System Phase III(BDS-3),and 3 spacecraft orbiting the Moon,we have adopted in the paper the Meteoroid Engineering Model 3,Divine-Staubach meteoroid environment model,and Jenniskens-McBride meteoroid steam model to analyze the meteoroid environment with the mass range of 10–6~10 *** Debris Engineering Model 3.1 space debris model is used to analyze the orbital debris environment faced by these *** flux of space debris with a size larger than 100μm is compared with that of the *** results show that the space debris flux encountered by China Space Station is much higher than that of the meteoroids with sizes in the above *** quite the opposite,the meteoroids flux impacting the 7 satellites from the BDS-3 is *** adopting the double-layer Whipple protection measure,the catastrophic collision flux of these satellites encountering meteoroids is about 10–6 times of that without protection,or even less,implying that the Whipple protection effectively guarantees the safety of the satellites in ***,it is also found that the flux of the high-density meteoroid population encountered by each satellite is greater than that of the low-density population,whereas the impact velocity is lower for each *** results can aid the orbit selection and the protection design for satellites and spacecraft.

关键词： Meteoroid environment model Space debris model Ballistic limit equation Impact risk assessment

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Experimental Study and Simulation of Cavitation Shedding in Diesel Engine Nozzle using Proper Orthogonal Decomposition and Large Eddy Simulation

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Journal of Thermal Science 2023年第4期32卷 1487-1500页

作者： HE Jiajun AN Qingsong JIN Jiangshan feng shuai ZHANG Kemu Key Laboratory of Medium-Low Temperature Thermal Energy Efficient Utilization of Ministry of Education School of Mechanical EngineeringTianjin UniversityTianjin300350China Shanghai Marine Diesel Engine Research Institute Shanghai201108China

The unsteady cloud cavitation shedding in fuel nozzles greatly influences the flow characteristics and spray break-up of fuel,thereby causing erosion *** the application of high-pressure common rail systems in diesel engines,this phenomenon frequently occurs in the nozzle;however,cloud cavitation shedding frequency and its mechanism have yet to be studied in *** this study,a visualization experiment and proper orthogonal decomposition(POD)method were used to study the variations in the cavitation shedding frequency and analyze the cavitation flow structure in a 3 mm square *** addition,large eddy simulation(LES)was performed to explore the causes of cavitation shedding,and the relationship between cavitation and *** the increase of the inlet and outlet pressure differences,and fuel temperatures,the degree of cavitation intensified and the frequency of cavitation cloud shedding gradually *** demonstrated the relationship between the vortices,and the development,shedding,and collapse of the cavitation ***,the re-entrant jet mechanism was found to be the main reason for the shedding of cavitation *** comparative experiments,the fluctuation of the vapor volume fraction in the nozzle hole accurately predicted the regions with stable cavitation,re-entrant jet,cavitation cloud shedding,and *** frequency of cavitation shedding can then be *** study employed an instantaneous POD method based on instantaneous cavitation images,which can distinguish the evolution process and characteristics of cavitation in the nozzle hole of diesel engines.

关键词： diesel engine proper orthogonal decomposition cavitation shedding cavitation collapse large eddy simulation

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Engineering the near-field imaging of a rectangular-lattice photonic-crystal slab in the second band

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Science China(Physics,Mechanics & Astronomy) 2009年第1期52卷 87-91页

作者： feng shuai AO Ling WANG YiQuan College of science Central University for NationalitiesBeijing 100081China

Imaging properties of a two-dimensional rectangular-lattice photonic crystal (PC) slab consisting of air holes immersed in a dielectric are studied in this work. The field patterns of electromagnetic waves radiated from a point source through the PC slab are calculated with the finite-difference time-domain method. Comparing the field patterns with the corresponding equifrequency-surface contours simulated by the plane-wave expansion method, we find that an excellent-quality near-field image may be formed through the PC slab by the mechanisms of the simultaneous action of the self-collimation effect and the negative-refraction effect. Near-field imaging may be obtained within two different frequency regions in two vertical directions of the PC slab.

关键词： photonic crystal negative refraction subwavelength imaging

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Global Phase Portraits of Uniform Isochronous Centers System of Degree Six with Polynomial Commutator

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Acta Mathematicae Applicatae Sinica 2024年第3期40卷 577-599页

作者： Li-na GUO Ai-yong CHEN shuai-feng ZHAO School of Mathematics and Statistics Henan University of Science and TechnologyLuoyang 471023China Department of Mathematics Hunan First Normal UniversityChangsha 410205China School of Mechatronics Engineering Henan University of Science and TechnologyLuoyang 471023China

This paper studies the global phase portraits of uniform isochronous centers system of degree six with polynomial *** systems have the form x=-y+xf(x,y),y=x+yf(x,y),where f(x,y)=a_(1)x+a_(2)xy+a_(3)xy^(2)+a_(4)xy^(3)+a_(5)xy^(4)=xσ(y),and any zero of 1+a_(1)y+a_(2)y^(2)+a_(3)y^(3)+a_(4)y^(4)+a_(5)y^(5),y=y is an invariant straight *** last,all global phase portraits are drawn on the Poincare disk.

关键词： global phase portraits uniform isochronous center polynomial commutator invariant straight lines

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Biped walking on level ground with torso using only one actuator

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Science China(Information Sciences) 2013年第11期56卷 256-264页

作者： feng shuai Al Yahmadi Amur S. SUN ZengQi State Key Laboratory of Intelligent Technology and Systems Tsinghua National Laboratory for Information Science and Technology Department of Computer Science and TechnologyTsinghua University Beijing Institute of Control Engineering Department of Mechanical and Industrial Engineering College of Engineering Sultan Qaboos UniversityAl-Khod 123 P.O. Box 33Sultanate of Oman

It is well known that a biped robot needs actuators to walk stably on level *** now,a biped robot with torso has needed at least two actuators to achieve *** it be possible for this kind of robot to walk on level ground with only one actuator?This paper responds in the afrmative and proposes a simple control strategy for a planar biped robot with *** this control method,there is only one low gain proportional-derivative(PD)controller between the torso and the stance leg,while the swing leg remains totally *** PD controller utilizes states of both the torso(angle and angular velocity)and the stance *** numerical simulations show that,by adopting this controller,a planar biped robot with torso can walk stably on level ground,and that the robot can walk with a wide range of speeds and high energy efciency by changing the control *** period-one gaits,one of which is stable while the other three are unstable,are found by *** to the literature surveyed,we are the first to have a torso only driven biped robot walk stably on level ground.

关键词： biped robot torso control passive dynamic walking PD controller

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Confluence and cold shut computation based on time field in casting simulation

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China Foundry 2021年第2期18卷 101-109页

作者： Yong-shuai feng Dun-ming Liao Tao Chen State Key Laboratory of Materials Processing ami Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Wuhan Chenxi Yunfeng Technology Co. Ltd.Wuhan 430074China

Numerical simulation technology has been widely used in the foundry industry to analyze and improve casting *** the casting filling process,many filling-related defects form easily at the confluences of liquid metal *** main filling-related defects are cold shut *** calculate the positions of casting defects,the characteristics of liquid metal confluences were *** flow front of liquid metal was captured by the volume-of-fluid algorithm to obtain a time field,which was used to calculate the time derivatives of the liquid front position and the confluences of liquid metal *** distinguish small confluences from the main confluences,the concept of confluent scale was developed,which was used to filter the small confluences based on a *** calculation process was demonstrated through the post-processing of numerical simulation.A "W" shaped casting and a steering wheel casting were calculated to validate the accuracy of the method developed in this *** positions of cold shut defects were predicted by calculating the confluences of liquid metal *** method was proved to be practical by comparing the calculation results with the positions of cold shut defects in an end cover *** computation of confluences and cold shut defects can improve the analysis efficiency and provide assurance for the optimization of a casting process plan.

关键词： numerical simulation casting defects flow front time field confluence cold shut

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