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Late Cenozoic uplift of the Liupan Mountains:Evidence from the Neogene loess deposits

Science China Earth Sciences 2024年第5期67卷 1480-1488页

作者： Zhilin HE Yansong QIAO Zhengtang GUO Chaoqin CHEN Long CHEN Yang FU ye YANG Yanxia LIANG Xinru lin Guoqiao XIAO Tao ZHAN Key Laboratory of Cenozoic Geology and Environment Institute of Geology and GeophysicsChinese Academy of SciencesBeijing 100029China Institute of Geomechanics Chinese Academy of Geological SciencesBeijing 100081China CAS Center for Excellence in Life and Paleoenvironment Beijing 100044China University of Chinese Academy of Sciences Beijing 100049China Institute of Ecological Geology Survey and Research of Heilongjiang Province Harbin 150030China School of Geography and Information Engineering China University of GeosciencesWuhan 430078China School of Earth Sciences China University of GeosciencesWuhan 430074China Natural Resources Survey Institute of Heilongjiang Province Harbin 150036China

The Liupan Mountains,one of the important mountain ranges in western China,are located on the boundary between the northeastern Tibetan Plateau and the Ordos *** uplift history of the Liupan Mountains remains *** deposits are good tracers of regional tectonic and geomorphic changes,because loess is sensitive to erosion and the formation and preservation of loess requires relatively flat highlands and relatively stable tectonic *** investigated the distribution of Neogene loess deposits on the western piedmont of the Liupan Mountains and examined a near-continuous loess section(Nanping section)on the piedmont alluvial *** of magnetic susceptibility stratigraphy with the QA-ⅠMiocene loess sequence dates this 56-m section covering the interval from~8.1 to 6.2 *** lower boundary age of this section,together with previously reported Zhuanglang red clay(sand-gravel layers with intercalated loess during~9–8 Ma and near-continuous loess during~8–4.8 Ma)and Chaona red clay(~8.1–2.58 Ma),indicates that the Liupan Mountains were uplifted in the late Miocene(~9–8 Ma)and basically formed by~8 Ma,attesting to no intense mountain building since that *** addition,based on the information from the Zhuanglang core and the QA-Ⅰsection,we infer that sizable parts of the Liupan Mountains were uplifted during the late Oligocene–early Miocene and did not experience intense uplift during~22–9 Ma.

关键词： Liupan Mountains Mountain building Neogene Loess Chinese Loess Plateau Late Miocene Late Oligocene–early Miocene

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Docking protein 6 (DOK6) selectively docks the neurotrophic signaling transduction to restrain peripheral neuropathy

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Signal Transduction and Targeted Therapy 2024年第3期9卷 1147-1164页

作者： Yan Guo Pan Xiang Xiaojiao Sun Wei Liu Jiafeng Zhou Bin Yin lin Hou Boqin Qiang Huiliang Li Pengcheng shu Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic Medicine Peking Union Medical CollegeBeijingChina State Key Laboratory of Common Mechanism Research for Major Diseases Beijing 100005China Wolfson Institute for Biomedical Research University College LondonGower StreetLondon WC1E 6BTUK Chinese Institute for Brain Research Beijing 102206China State Key Laboratory of Respiratory Health and Multimorbidity Beijing 100005China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

The appropriate and specific response of nerve cells to various external cues is essential for the establishment and maintenance of neural circuits,and this process requires the proper recruitment of adaptor molecules to selectively activate downstream ***,we identified that DOK6,a member of the Dok(downstream of tyrosine kinases)family,is required for the maintenance of peripheral axons,and that loss of Dok6 can cause typical peripheral neuropathy symptoms in mice,manifested as impaired sensory,abnormal posture,paw deformities,blocked nerve conduction,and ***,Dok6 is highly expressed in peripheral neurons but not in Schwann cells,and genetic deletion of Dok6 in peripheral neurons led to typical peripheral myelin outfolding,axon destruction,and hindered retrograde axonal ***,DOK6 acts as an adaptor protein for selectivitymediated neurotrophic signal transduction and retrograde transport for TrkC and Ret but not for TrkA and ***6 interacts with certain proteins in the trafficking machinery and controls their phosphorylation,including MAP1B,Tau and Dynein for axonal transport,and specifically activates the downstream ERK1/2 kinase pathway to maintain axonal survival and *** finding provides new clues to potential insights into the pathogenesis and treatment of hereditary peripheral neuropathies and other degenerative diseases.

关键词： impaired restrain peripheral

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A novel route to enhance high-temperature mechanical property and thermal shock resistance of low-carbon Mgo-C bricks by introducing ZrSiO_(4)

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Journal of Iron and Steel Research International 2024年第6期31卷 1436-1448页

作者： Chun-hui Sun ling-ling Zhu Hao Yan Wei Zhao Jing-xuan Liu lin Ren Xian-tang Zhao Xiao-song Tong shu-wen Yu Beijing Lirr High-Temperature Materials Co. Ltd.Beijing 102211China School of Materials Science and Engineering Henan Province Industrial Technology Research Institute of Resources and MaterialsZhengzhou UniversityZhengzhou 450001HenanChina School of Chemistry and Chemical Engineering Suzhou UniversitySuzhou 234000AnhuiChina

Conventional MgO-C bricks(graphite content>14 wt.%)produce a great deal of greenhouse gas emission,while low-carbon MgO-C bricks have serious thermal shock resistance during high-temperature *** enhance the high-temperature mechanical property and thermal shock resistance of low-carbon MgO-C bricks,a novel route of introducing ZrSiO_(4) powder into low-carbon MgO-C bricks was reported in such refractories with 2 wt.% flaky *** results indicate that the low-carbon MgO-C brick with 0.5 wt.%ZrSiO_(4) addition has the maximum hot modulus of rupture at 1400℃ and the corresponding specimen fired in the carbon embedded atmosphere has the maximum residual strength ratio(98.6%)after three thermal shock *** is found that some needle-like AlON and plate-like Al_(2)O_(3)-ZrO_(2) composites were in situ formed in the matrices after the low-carbon MgO-C bricks were coked at 1400℃,which can enhance the high-temperature mechanical property and thermal shock resistance due to the effect of fiber toughening and particle ***,CO_(2) emission of the newly developed low-carbon MgO-C bricks is reduced by 58.3% per ton steel after using them as the working lining of a 90 t vacuum oxygen decarburization ladle.

关键词： Low-carbon MgO-C brick ZrsiO_(4) Synergistic toughening effect High-temperature mechanical property Thermal shock resistance Vacuum oxygen decarburization ladle

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Restoring force model of assembled piers connected with grouting sleeves and a mortise hybrid joint

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Journal of Traffic and Transportation Engineering(English Edition) 2024年

作者： Shangshun lin Jianshuai Zhang Zhiqing Qin Shiji ye Jinbing Zhao Fujian Provincial Key Laboratory of Advanced Technology and Information in Civil Engineering， Fujian University of Technology Fujian Communications Planning & Design Institute Co.，Ltd. 3. Haoyao Times (Fujian) Group Co.，Ltd.

In order to investigate the simplified calculation method of the rebound model of the grouted sleeve and mortise-and-tenon hybrid-connected assembled reinforced concrete piers， quasi-static tests were conducted on three types of piers: cast-in-place piers (SZT-1)， single-span assembled piers (SG-1)， and double-span assembled piers (SGT-1). It was found that the damage modes and seismic performance of the SGT-1 specimens were similar to those of SG-1， while the seismic performance of the hybrid-connected assembled piers was better than that of SZT-1. Parametric analyses were carried out using experimentally-validated finite-element models to investigate the effects of parameters such as axial compression ratio， slenderness ratio， longitudinal reinforcement ratio， concrete strength， and the dimensions and materials of the protruding tenon and steel pipe on the seismic performance of the piers. In addition， the skeleton curve eigenvalue formula and rebound model are proposed， which can be used for elastic-plastic analysis and calculation of hybrid connection assembled piers.

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Coinfection of SARS-CoV-2 Omicron variant and other respiratory pathogens in children

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World Journal of Pediatrics 2024年第1期20卷 92-96页

作者： Wei Li Bing-Han Wang Bao-Hai Chen Yi Sun lin Li Wen-Qing Xiang Ahmed Faisal Ali lin-Xuan Su Hai-Yan Mao Hong-Qiang Shen Qiang shu Department of Clinical Laboratory Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina School of Public Health Zhejiang University School of MedicineHangzhouChina Department of Information Center Children's HospitalZhejiang University School of MedicineHangzhouChina Zhejiang Provincial Center for Disease Control and Prevention HangzhouChina Department of Thoracic&Cardiovascular Surgery Children's HospitalNational Clinical Research Center for Child HealthZhejiang University School of MedicineHangzhouChina

Since the outbreak of coronavirus disease 2019(COVID-19),the entire world has been affected by the epidemic[1,2].On November 9,2021,a variant of the novel coronavirus B.1.1.529 was detected for the first time from case samples in South *** Omicron strain spread and mutated significantly *** variant has the characteristics of escape immunity,which can induce relatively extreme disease and reduce the neutralization of antibodies in vaccinators,and is more likely to be reinfected[3,4].The clinical presentation of severe acute respiratory syndrome coronavirus 2(SARSCoV-2)in children has mild symptoms and a lower risk of hospitalization and death.

关键词： respiratory immunity acute

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270例单纯胆囊经腹腔镜切除术患者围手术期抗菌药物应用分析

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中华医院感染学杂志 2011年第16期21卷 3462-3463,3520页

作者：叶树林王瑞娟解放军总医院医务部北京100853

目的了解医院腹腔镜胆囊切除术患者围手术期抗菌药物应用情况。方法随机抽取2009-2010年医院肝胆外科腹腔镜胆囊切除术手术患者270例,依据《抗菌药物临床应用指导原则》,调查围手术期抗菌药物的预防性应用情况。结果调查的270例腹腔镜... 详细信息

目的了解医院腹腔镜胆囊切除术患者围手术期抗菌药物应用情况。方法随机抽取2009-2010年医院肝胆外科腹腔镜胆囊切除术手术患者270例,依据《抗菌药物临床应用指导原则》,调查围手术期抗菌药物的预防性应用情况。结果调查的270例腹腔镜胆囊切除术患者在围手术期全部预防性应用了抗菌药物,使用率100.0%;药物种类主要以硝咪唑类、头孢菌素类、青霉素类等为主,抗菌药物使用率排前5位的药物分别是奥硝唑氯化钠注射液、注射用阿莫西林钠氟氯西林钠、注射用头孢甲肟、硫酸异帕米星注射液、甲硝唑注射液注,其使用率分别为26.30%、16.44%、12.80%、8.82%、8.13%。结论应加强围手术期抗感染药物使用的管理和监督,促进临床医师合理用药。

关键词：腹腔镜胆囊切除术围手术期抗菌药物合理使用

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BBX9 forms feedback loops with PIFs and BBX21 to promote photomorphogenic development

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Journal of Integrative Plant Biology 2024年第9期66卷 1934-1952页

作者： Zhaoqing Song Wanying ye Qing Jiang Huan lin Qing Hu Yuntao Xiao yeting Bian Fengyue Zhao Jie Dong Dongqing Xu State Key Laboratory of Crop Genetics&Germplasm Enhancement and Utilization National Center for Soybean ImprovementCollege of AgricultureNanjing Agricultural UniversityNanjing 210095China Institute of Crop Science College of Agriculture and BiotechnologyZhejiang UniversityHangzhou 310058China

Light is one of the most essential environmental factors that tightly and precisely control various physiological and developmental processes in plants.B-box CONTAINING PROTEINs(BBXs)play central roles in the regulation of light-dependent *** this study,we report that BBX9 is a positive regulator of light ***9 interacts with the red light photoreceptor PHYTOCHROME B(phyB)and transcription factors PHYTOCHROME-INTERACTING FACTORs(PIFs).phyB promotes the stabilization of BBX9 in light,while BBX9 inhibits the transcriptional activation activity of *** turn,PIFs directly bind to the promoter of BBX9 to repress its *** the other hand,BBX9 associates with the positive regulator of light signaling,BBX21,and enhances its biochemical ***21 associates with the promoter regions of BBX9 and transcriptionally up-regulates its ***,this study unveiled that BBX9 forms a negative feedback loop with PIFs and a positive one with BBX21 to ensure that plants adapt to fluctuating light conditions.

关键词： Arabidopsis BBX21 BBX9 light signaling photo-morphogenesis phyB PIF

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529例泌尿外科围手术期抗菌药物应用分析

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中华医院感染学杂志 2011年第13期21卷 2785-2787页

作者：叶树林王瑞娟解放军总医院院务部北京100853 解放军总医院医务部北京100853

目的探讨泌尿外科手术患者抗菌药物的使用及其合理性。方法对529例患者围手术期抗菌药物应用进行回顾性分析。结果泌尿外科围手术期患者的抗菌药物总使用率为100.00%,平均用药疗程为11.67 d,主要抗菌药物种类有氨基糖苷类、头孢菌素类... 详细信息

目的探讨泌尿外科手术患者抗菌药物的使用及其合理性。方法对529例患者围手术期抗菌药物应用进行回顾性分析。结果泌尿外科围手术期患者的抗菌药物总使用率为100.00%,平均用药疗程为11.67 d,主要抗菌药物种类有氨基糖苷类、头孢菌素类、硝咪唑类,使用频次最高的抗菌药物前5位分别是硫酸依替米星氯化钠注射液275例占26.37%,注射用头孢孟多酯钠188例占18.02%,注射用头孢甲肟143例占13.71%,注射用硫酸依替米星143例占13.71%,注射用头孢美唑钠81例占7.77%。结论加强抗菌药物的使用管理,规范围手术期抗菌药物的使用原则,进一步提高合理用药水平。

关键词：围手术期泌尿外科抗菌药物合理用药

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FPGA在步进电机单步进给特性测试系统中的应用

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仪表技术与传感器 2007年第8期 78-80页

作者：袁庆丹叶树林佛山科学技术学院机电与信息工程学院广东佛山528000

将FPGA应用于已研制的步进电机单步进给特性测试系统中,实现了以往由单片机完成的信号细分、辨向、计数、串口通讯以及数据读写等功能,进一步提高了测试系统的可靠性和测量精度。对测试系统的结构、工作原理和主要软件模块的设计进行了... 详细信息

将FPGA应用于已研制的步进电机单步进给特性测试系统中,实现了以往由单片机完成的信号细分、辨向、计数、串口通讯以及数据读写等功能,进一步提高了测试系统的可靠性和测量精度。对测试系统的结构、工作原理和主要软件模块的设计进行了较为详细的叙述。

关键词：步进电机 FPGA 单步进给特性光电编码器

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Sorely reducing emissions of non-methane short-lived climate forcers will worsen compound flood-heatwave extremes in the Northern Hemisphere

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Advances in Climate Change Research 2024年第4期15卷 737-750页

作者： Ying-Fang LI Zhi-Li WANG Ya-Dong LEI Xiao-Chao YU lin LIU Hui-Zheng CHE Xiao-ye ZHANG State Key Laboratory of Severe Weather and Key Laboratory of Atmospheric Chemistry of China Meteorological Administration Chinese Academy of Meteorological SciencesBeijing 100081China University of Chinese Academy of Sciences Beijing 100190China

Non-methane short-lived climate forcer(SLCF)or near-term climate forcer(NTCF)emissions,as a significant driver of climate change,can be reduced to improve air *** reductions may contribute to additional warming of the climate system in the short term,thereby strongly affecting the likelihood of climate ***,there has been no quantitative assessment of the impact of non-methane SLCF mitigation on compound flood-heatwave extremes(CFHEs).This study quantitatively investigates the changes in future(2031-2050 versus 1995-2014)CFHEs and the resulting population exposure in the Northern Hemisphere(NH)due to non-methane SLCF *** used multi-model ensemble simulations under two future scenarios from the Aerosol and Chemistry Model Intercomparison Project(AerChemMIP)in the Coupled Model Intercomparison Project Phase 6(CMIP6).The two future scenarios share the same greenhouse gas(GHG)emissions but have weak(Shared Socioeconomic Pathway(SSP)3-7.0)versus strong(SSP3-7.0-lowNTCF)levels of air quality control *** results show that future non-methane SLCF reductions during 2031-2050 results in about a 7.3%±2.3%increase in grid exposure to CFHEs in the NH relative to the period *** frequency,intensity,and duration of CFHEs increase by varying *** the period 2031-2050,the frequency of CFHEs across the NH increases by 2.9±0.9 events per decade due to non-methane SLCF *** increases in CFHE frequency are more pronounced in East Asia,South Asia,Siberia,and northern and eastern North *** East and South Asia,the in-tensities of both heatwaves and floods corresponding to CFHEs increase markedly,where heatwave magnitude(HWM)increases by 0.3±0.2 K in East Asia and weighted average precipitation(WAP)increases by 18.3%±15.3%and 12.0%±4.5%in East Asia and South Asia,*** other regions,rising temperatures dominate the increase in *** regard to the duration of CFHEs,future reductions in non-methane SLC

关键词： Non-methane SLCFs CHFEs Cleaner air Population exposure

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