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Is irreversible electroporation safe and effective in the treatment of hepatobiliary and pancreatic cancers?

Hepatobiliary & Pancreatic Diseases International 2019年第2期18卷 117-124页

作者： Li-Ming Wu Le-Le zhang xin-Hua Chen shu-Sen Zheng Division of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital Zhejiang University School of Medicine

Background: Irreversible electroporation(IRE) is a novel ablative technique for hepatobiliary and pancreatic cancers. This review summarizes the data regarding the safety and efficacy of IRE in the treatment of hepatobiliary and pancreatic cancers. Data sources: Studies were identified by searching Pub Med and Embase for articles published in English from database inception through July 31, 2017. For inclusion, each clinical study had to report morbidity and survival data on hepatobiliary and pancreatic cancers treated with IRE and contain at least 10 patients. Studies that met these criteria were included for analysis. Two authors assessed each clinical study for data extraction. The controversial parts were resolved through discussion with seniors. Results: A total of 24 clinical studies were included. Fourteen focused on hepatic ablation with IRE comprising 437 patients with 666 lesions of different tumor types. Two patients(0.5%) died after the IRE procedure. Morbidity of hepatic ablation with IRE ranged from 7% to 35%. Most complications were mild. Complete response for hepatic tumors was reported as 57%–97%. Ten studies with 455 patients focused on pancreatic IRE. The overall mortality of IRE in pancreatic cancer was 2%. Overall severe morbidity of IRE in pancreatic cancer ranged from 0 to 20%. The median overall survival after IRE ranged from 7 to 23 months. Patients treated with IRE combined with surgical resection showed a longer overall survival. Conclusions: IRE significantly improves the prognosis of advanced hepatobiliary and pancreatic malignances, and companied with less complications. Hence, IRE is a relatively safe and effective non-thermal ablation strategy and potentially recommended as an option for therapy of patients with hepatobiliary and pancreatic malignances.

关键词： Irreversible electroporation Hepatic cancer Pancreatic cancer

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基于立式工业锅炉爆炸水汽泄漏过程的数值模拟

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工业锅炉 2016年第5期 6-10页

作者：韩树新金樟民祝新伟赵辉沈志斌施子福浙江省联合特种设备研究院浙江杭州310019 温州市特种设备检测研究院浙江温州325007 嘉兴市特种设备检测院浙江嘉兴314050 浙江大学热能工程研究所浙江杭州310027

针对中小型立式工业锅炉,利用Fluent软件对锅炉缺水爆炸和超压爆炸水汽泄漏过程进行非稳态数值模拟,分别设定泄漏孔径为10 mm和20 mm,得到不同泄漏孔径下从泄漏开始到不同时刻的蒸汽速度分布情况,结果显示:蒸汽由孔口喷出,形成约400 m/... 详细信息

针对中小型立式工业锅炉,利用Fluent软件对锅炉缺水爆炸和超压爆炸水汽泄漏过程进行非稳态数值模拟,分别设定泄漏孔径为10 mm和20 mm,得到不同泄漏孔径下从泄漏开始到不同时刻的蒸汽速度分布情况,结果显示:蒸汽由孔口喷出,形成约400 m/s高速射流,距离孔口越远,速度越低;在10 mm孔口和20 mm孔口情况下,1 s时,距离孔口30 cm处,速度分别为117 m/s和237 m/s,是初始速度的30%和60%;孔口越大,射流刚性越强,速度衰减越慢,蒸汽速度场充满整个空间耗时越短。此研究真实形象地还原了锅炉爆炸水汽泄漏过程,为工业锅炉仿真技术研究提供了借鉴。

关键词：立式工业锅炉蒸汽泄漏数值模拟

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Rapid Phase Ambiguity Elimination Methods for DOA Estimator via Hybrid Massive MIMO Receive Array

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Chinese Journal of Electronics 2024年第1期33卷 175-184页

作者： Xichao ZHAN Zhongwen SUN Feng shu Yiwen CHEN xin CHENG Yuanyuan WU Qi zhang Yifan LI Peng zhang School of Information and Communication Engineering Hainan University School of Electronic and Optical Engineering Nanjing University of Science and Technology

For a sub-connected hybrid multiple-input multiple-output(MIMO) receiver with K subarrays and N antennas, there exists a challenging problem of how to rapidly remove phase ambiguity in only single time-slot. A direction of arrival(DOA) estimator of maximizing received power(Max-RP) is proposed to find the maximum value of K-subarray output powers, where each subarray is in charge of one sector, and the center angle of the sector corresponding to the maximum output is the estimated true DOA. To make an enhancement on precision, Max-RP plus quadratic interpolation(Max-RP-QI) method is designed. In the proposed Max-RP-QI, a quadratic interpolation scheme is adopted to interpolate the three DOA values corresponding to the largest three receive powers of *** achieve the Cramer Rao lower bound, a Root-MUSIC plus Max-RP-QI scheme is developed. Simulation results show that the proposed three methods eliminate the phase ambiguity during one time-slot and also show low computational complexities. The proposed Root-MUSIC plus Max-RP-QI scheme can reach the Cramer Rao lower bound,and the proposed Max-RP and Max-RP-QI are still some performance losses 2–4 d B compared to the Cramer Rao lower bound.

关键词： Phased arrays Interpolation Wireless sensor networks Direction-of-arrival estimation Simulation Receiving antennas Massive MIMO

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Synthesis of energetic coordination polymers based on 4-nitropyrazole by solid-melt crystallization in non-ionization condition

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Defence Technology（防务技术） 2023年第10期28卷 13-22页

作者： Ting-wei Wang shu Bu Kun Wang Lu zhang Zhen-xin Yi shun-guan Zhu Jian-guo zhang State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing100081China School of Chemical Engineering Nanjing University of Science and Technology200 Xiaolingwei StreetXuanwuNanjing210094China Department of Chemistry Laboratory of Structure and Functional Regulation of Hybrid MaterialsAnhui UniversityMinistry of EducationHefei230601China

Based on the theory of crystallization,a solvent-free solid-liquid phase crystallization method called solid-melt crystallization was designed to prepare energetic coordination *** target compounds[Cu(NPyz)_(4)NO_(3)]·NO_(3)(ECPs-1)and Cu(NPyz)_(4)(ClO_(4))_(2)(ECCs-2)were prepared through programmed heating and cooling by using 4-nitropyrazole(NPyz),(Cu(NO_(3))_(2)·5H_(2)O and Cu(ClO_(4))_(2)·5H_(2)O) as raw *** addition,crystallization pre-experiments and annealing experiments also verified the feasibility of the *** structures were confirmed by IR,elemental analysis,single-crystal X-ray diffraction and powder X-ray *** physicochemical properties and sensitivity test results showed that ECCs-2 has better thermal stability(T_(d)=221℃),while ECPs-1 is less sensitive to mechanical stimuli(IS=12 J,FS=240 N).Calculations based on EXPLO5 and the Kamlet-Jacobs equation showed that ECCs-2 has more considerable detonation performance(P=25.2 GPa,D=7.5 km/s).In comparison,the more intuitive results from the HN test,flame test,thermal resistance test and lead plate explosion test revealed that ECCs-2 has an“acceptable”detonation *** laser detonation test also showed that ECCs-2 is a promising excellent laser detonation material(E=408 mJ,P=24 W,τ=17 ms).

关键词： 4-Amino-1,2,5-oxadiazole-3-carbohydrazide Crystallization Coordination polymers Laser Primary explosives

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Evaluation of the production-living-ecology space function suitability of Pingshan County in the Taihang mountainous area,China

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Journal of Mountain Science 2020年第10期17卷 2562-2576页

作者： YU shu-hui DENG Wei XU You-xin zhang Xia XIANG Hao-lin Institute of Mountain Hazards and Environment Chinese Academy of SciencesChengdu610041China College of Geography Resource Sciences Sichuan Normal UniversityChengdu610101China Hebei GEO University Shijiazhuang050031China Weifang University of Science and Technology Weifang262700China

A rational utilization of land is a matter of importance in sustainable development of mountainous *** land function in mountainous areas has a close connection with space structure of ecology,production and *** promote a harmonious development of the relationship between people and nature in mountainous areas,it is necessary to coordinate their relationships of space *** evaluation of basic unit function associated with multi-scale space analysis is a prerequisite to a reasonable optimization of land function *** this study,an optimized evaluation index system of combination functions was introduced into the assessment of ecological spatial functional suitability in ecological fragile regions by adding three indicators,namely,soil erosion sensitivity,landscape ecological risk and ecological *** principle of"taking high"(referred to a function with high suitability to be regarded as the main function of an evaluation unit)and ecological priority(referred to the case,supposing the suitability of a unit’s three functions is consistent,the main function is determined to be the ecological function)were used to determine the main function of an evaluation *** County,China,located at the eastern foot of the Taihang Mountain,was targeted in this case *** production-livingecology space(PLES)function in Pingshan was identified by applying our improved valuation ***,the functional suitability distribution of the combination of elements was obtained by using overlapping comprehensive analysis method,considering the tradeoff of the functional suitability of combination *** regions suitable for production/living were distributed in relatively flat piedmont plains,whereas the regions suitable for ecology were distributed in the mountain areas of middle and low ***,to maintain a sustainable development in mountainous areas,an improved scheme of development for Pingshan should be

关键词： Taihang Mountain Area Space of production-living-ecology Functional tradeoff Suitability evaluation

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Microstructural evolution during the progressive transformation-induced plasticity effect in a Fe-0.1C-5Mnmedium manganese steel

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 369-379页

作者： Mei zhang Wenhao Li Yangfei Chen Yang Jiang Xiaofei Guo Han Dong School of Materials Science and Engineering Shanghai UniversityShanghai 200444China State Key Laboratory of Advanced Special Steel Shanghai UniversityShanghai 200444China

The microstructural evolution of a cold-rolled and intercritical annealed medium-Mn steel(Fe-0.10C-5Mn)was investigated during uniaxial tensile ***-situ observations under scanning electron microscopy,transmission electron microscopy,and X-ray diffraction analysis were conducted to characterize the progressive transformation-induced plasticity process and associated fracture initiation *** findings were discussed with the local strain measurements via digital image *** results indicated that Lüders band formation in the steel was limited to 1.5%strain,which was mainly due to the early-stage martensitic phase transformation of a very small amount of the less stable large-sized retained austenite(RA),which led to localized stress concentrations and strain hardening and further retardation of *** small-sized RA exhibited high stability and progressively transformed into martensite and contributed to a stably extended Portevin-Le Chatelier *** volume fraction of RA gradually decreased from 26.8%to 8.2%prior to *** the late deformation stage,fracture initiation primarily occurred at the austenite/martensite and ferrite/martensite interfaces and the ferrite phase.

关键词： medium-Mn steel retained austenite progressive transformation-induced plasticity effect local strain fracture initiation

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Research progress on the mechanism of improving peanut yield by single-seed precision sowing

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Journal of Integrative Agriculture 2020年第8期19卷 1919-1927页

作者： zhang Jia-lei GENG Yun GUO Feng LI xin-guo WAN shu-bo Biotechnology Research Center Shandong Academy of Agricultural Sciences/Shandong Provincial Key Laboratory of Crop Genetic ImprovementEcology and PhysiologyJinan 250100P.R.China

The contradiction between the supply and demand of edible vegetable oil in China is prominent,and the self-sufficiency rate is less than 35%.Peanut has a very outstanding status in ensuring the security of edible oil and *** emphasis of increasing peanut yield should be the improvement of pod yield per unit area,because the total yield of peanut has not increased as *** is attributed to mainly two factors-low increase in the crop productivity and the competition for land for grain and cotton *** traditional double-seed sowing pattern,it is difficult to further increase the peanut yield due to the serious contradiction between populations and individuals and the declining population quality under high-yield ***-seed precision sowing was proven to be a new way to increase the economic coefficient(economic yield/biological yield)with the basic stability of the total biomass,which could make plants distribute evenly,reduce the competition among individuals and attain the full production potential of single *** order to reveal the mechanism of increasing peanut yield by single-seed precision sowing,the effects on the ontogenetic development(plant character,physiological characteristic and nutrient utilization)and population structure(population uniformity and photosynthesis,source-sink relationship and yield composition)were systematically *** study reports establishment of the high-yield cultivation technology system with the key technology of single-seed precision sowing and the supporting technology of fertilizing and *** anticipate its wider application for the improvement of peanut yield.

关键词： peanut single-seed precision sowing ontogenetic development population structure yield-increasing mechanism key technology

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Zhikang Capsule Ameliorates Inflammation, Drives Polarization to M2 Macrophages, and Inhibits Apoptosis in Lipopolysaccharide-induced RAW264.7 Cells

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Current Medical Science 2021年第6期41卷 1214-1224页

作者： Sheng-liang xin Xia YANG Yu-ping zhang Ke-shu XU Department of Infectious Diseases Peking University First HospitalBeijing 100034China Department of Gastroenterology Wuhan Asia General HospitalWuhan 430056China Department of Gastroenterology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China

Objective:To explore the anti-inflammatory effect of the traditional Chinese medicine Zhikang capsule(ZKC)on lipopolysaccharide(LPS)-induced RAW264.7 ***:Safe concentrations of ZKC(0.175,0.35,and 0.7 mg/mL)were used after the half-maximal inhibitory concentration(IC_(50))of RAW264.7 cells was calculated through the CCK-8 *** addition,the optimal intervention duration of ZKC(0.7 mg/mL)on RAW264.7 cells was determined to be 6 h,since all proinflammatory mediators[tumor necrosis factor-alpha(TNF-α),interleukin-1 beta(IL-1β),inteleukin-6(IL-6),cyclooxygenase-2(COX-2),inducible nitric oxide synthase(iNOS),and monocyte chemotactic protein-1(MCP-1)]had a decreasing tendency and relatively down-regulated mRNA expression levels as compared with other durations(4,8,and 12 h).RAW264.7 cells were pretreated with ZKC at various concentrations(0.175,0.35 and 0.7 mg/mL)for 6 h and then stimulated with LPS(1 μg/mL)for an additional 12 ***:In terms of inflammation,ZKC could reverse LPS-induced upregulation of TNF-α,IL-1β,IL-6,COX-2,iNOS,and MCP-1 at both the mRNA and protein levels in RAW264.7 cells in a dose-dependent *** terms of the NF-κB signaling pathway,ZKC could reduce phosphorylated p65 and promote M2 polarization of RAW264.7 cells under LPS stimulation in a dose-dependent ***,ZKC exhibited a protective effect on macrophages from ***:ZKC exhibited obvious antiinflammatory and anti-apoptotic effects on LPS-induced RAW264.7 cells at the cellular level,and a weakened NF-κB signaling pathway may be a potential significant target.

关键词： Zhikang capsule macrophage RAW 264.7 inflammation apoptosis nuclear factor kappa B

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Ammonia pyrolysis oxidation excited by nanosecond pulsed discharge:Global/fluid models hybrid solution

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Journal of Energy Chemistry 2025年第1期100卷 385-396页

作者： Mingming zhang Hanyu Wu Qi Chen Jiaxin Yang Bonan Liu School of Mechanical Electronic and Control Engineering Beijing Jiaotong University China University of Petroleum

The kinetic characteristics of plasma-assisted oxidative pyrolysis of ammonia are studied by using the global/fluid models hybrid solution ***,the stable products of plasma-assisted oxidative pyrolysis of ammonia are *** results show that the consumption of NH3/O2and the production of N2/H2change linearly with the increase of voltage,which indicates the decoupling of nonequilibrium molecular excitation and oxidative pyrolysis of ammonia at low ***,the detailed reaction kinetics mechanism of ammonia oxidative pyrolysis stimulated by a nanosecond pulse voltage at low pressure and room temperature is *** on the reaction path analysis,the simplified mechanism is *** detailed and simplified mechanism simulation results are compared with experimental data to verify the accuracy of the simplified ***,based on the simplified mechanism,the fluid model of ammonia oxidative pyrolysis stimulated by the nanosecond pulse plasma is established to study the pre-sheath/sheath behavior and the resultant consumption and formation of key *** results show that the generation,development,and propagation of the pre-sheath have a great influence on the formation and consumption of *** consumption of NH3by the cathode pre-sheath is greater than that by the anode pre-sheath,but the opposite is true for OH and O（1S）.However,within the sheath,almost all reactions do not ***,by changing the parameters of nanosecond pulse power supply voltage,it is found that the electron number density,electron current density,and applied peak voltages are not the direct reasons for the structural changes of the sheath and ***,the discharge interval has little effect on the sheath structure and gas mixture *** research results of this paper not only help to understand the kinetic promotion of non-equilibrium excitation in the process of oxidative pyrolysis but also help to explore th

关键词： Nanosecond pulsed discharge Ammonia Oxidative pyrolysis Fluid model Global model

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Co/Co_(7)Fe_(3)heterostructures with controllable alloying degree on carbon spheres as bifunctional electrocatalyst forrechargeable zinc-air batteries

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 476-487页

作者： Junkang Chen Yongyue Zhuang Yanxin Qiao Yu zhang Aihua Yuan Hu Zhou School of Materials Science and Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China School of Environmental and Chemical Engineering Jiangsu University of Science and TechnologyZhenjiang 212003China

Exploring efficient and nonprecious metal electrocatalysts of oxygen reduction reaction(ORR)and oxygen evolution reaction(OER)is crucial for developing rechargeable zinc-air batteries(ZABs).Herein,an alloying-degree control strategy was employed to fabricate nitrogen-doped carbon sphere(NCS)decorated with dual-phase Co/Co_(7)Fe_(3)heterojunctions(CoFe@NCS).The phase composition of materials has been adjusted by controlling the alloying *** optimal CoFe_(0.08)@NCS electrocatalyst displays a half-wave potential of 0.80 V for ORR and an overpotential of 283 mV at 10 mA·cm^(-2)for OER in an alkaline *** intriguing bifunctional electrocatalytic activity and durability is attributed to the hierarchically porous structure and interfacial electron coupling of highly-active Co_(7)Fe_(3)alloy and metallic Co *** the CoFe_(0.08)@NCS material is used as air-cathode catalyst of rechargeable liquid-state zinc-air battery(ZAB),the device shows a high peak power-density(157 mW·cm^(-2))and maintains a stable voltage gap over 150 h,outperforming those of the benchmark(Pt/C+RuO_(2))-based *** particular,the as-fabricated solid-state flexible ZAB delivers a reliable compatibility under different bending *** work provides a promising strategy to develop metal/alloy-based electrocatalysts for the application in renewable energy conversion technologies.

关键词： bifunctional electrocatalysts oxygen reduction reaction oxygen evolution reaction zinc-air battery metal/alloy carbon sphere

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