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Role of endogenous Schwann cells in tissue repair after spinal cord injury

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Neural Regeneration Research 2013年第2期8卷 177-185页

作者： shu-xin zhang Fengfa Huang Mary Gates Eric G. Holmberg Spinal Cord Society Research Center Department of Chemistry University of Alaska

Schwann cells are glial cells of peripheral nervous system, responsible for axonal myelination and ensheathing, as well as tissue repair following a peripheral nervous system injury. They are one of several cell types that are widely studied and most commonly used for cell transplantation to treat spinal cord injury, due to their intrinsic characteristics including the ability to secrete a variety of neurotrophic factors. This mini review summarizes the recent findings of endogenous Schwann cells after spinal cord injury and discusses their role in tissue repair and axonal regeneration. After spinal cord injury, numerous endogenous Schwann cells migrate into the lesion site from the nerve roots, involving in the construction of newly formed repaired tissue and axonal myelination. These invading Schwann cells also can move a long distance away from the injury site both rostrally and caudally. In addition, Schwann cells can be induced to migrate by minimal insults （such as scar ablation） within the spinal cord and integrate with astrocytes under certain circumstances. More importantly, the host Schwann cells can be induced to migrate into spinal cord by transplantation of different cell types, such as exogenous Schwann cells, olfactory ensheathing cells, and bone marrow-derived stromal stem cells. Migration of endogenous Schwann cells following spinal cord injury is a common natural phenomenon found both in animal and human, and the myelination by Schwann cells has been examined effective in signal conduction electrophysiologically. Therefore, if the inherent properties of endogenous Schwann cells could be developed and utilized, it would offer a new avenue for the restoration of injured spinal cord.

关键词： neural regeneration spinal cord injury Schwann cells spinal cord injury tissue repair axonalregeneration myelination rat scar ablation astrocytes cell transplantation rose Bengal olfactoryensheathing cells bone marrow stromal cell grant-supported paper neuroregeneration

Synthesis and cytotoxicity studies of quinoline-3-carbonitrile derivatives

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Chinese Chemical Letters 2010年第8期21卷 939-942页

作者： shu Lan zhang xin Zhai Shi Jiao zhang Hong Hao Yu Ping Gong Key Laboratary of Original New Drugs Design and Discovery of Ministry of Education School of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang 110016China

A series of quinoline-3-carbonitrile derivatives were designed and *** cytotoxicity in vitro against four cancer cell lines（A549,HT-29,MDA-MB-231 and SMMC-7721） were evaluated by standard MTT *** pharmacological results showed that most of the prepared compounds displayed excellent selective cytotoxicity toward SMMC-7721 cell *** them, compounds 7c,7e,11b,11f and 11g were more active than Gefitinb against SMMC-7721 cell line.

关键词： Quinoline-3-carbonitrile Synthesis Cytotoxicity

Asymmetric Hydrogenation of Tetrapyridine-Type N-Heteroarenes Using Phosphine-Free Ruthenium Diamine Catalysts

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Chinese Journal of Chemistry 2023年第24期41卷 3573-3578页

作者： Chenghao Li shu-xin zhang Yu Feng Yan-Mei He Qing-Hua Fan Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and FunctionInstitute of Chemistry Chinese Academy of SciencesBeijing100190 China University of Chinese Academy of Sciences Beijing100049 China

Chiral ruthenium-catalyzed enantioselective hydrogenation of tetrapyridine-type N-heteroarenes was firstly *** partial reduction of adjacent tetraheteroaromatic substrates proceeded smoothly in the presence of phosphine-free chiral cationic ruthenium diamine complexes,affording unprecedented high reactivity,enantioselecitivity and diastereoselectivity(up to 93%yield,>99%ee and 92:8 dr).The potential application of chiral tetradentate pyridine-amine products as chiral ligands has been demonstrated in the Cu-catalyzed asymmetric Friedel–Crafts alkylation reaction between indoles and nitroalkenes.

关键词： Asymmetric catalysis Chiral nitrogen ligands N-Heteroarenes Hydrogenation Ruthenium

Microstructure and magnetostrictive properties of Tb doped Fe–Ga bulk alloys prepared by melt quenching

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Rare Metals 2014年第3期33卷 309-312页

作者： shu-xin zhang Wei Wu Xiao-Xi Zhu Jing-Hua Liu Cheng-Bao Jiang School of Materials Science and Engineering Beijing University of Aeronautics and Astronautics

The microstructure and magnetostrictive properties were investigated in the Tb doped Fe83Ga17-xTbx（x = 0.05, 0.10, 0.20, 0.30, 0.40, 0.50） bulk rods prepared by melt rapidly quenching. The partial solid solubility of Tb in the Fe-Ga matrix was preliminary detected by the lattice parameters and SEM observation. The matrix keeps A2 structure and the second phase appears surround the grain boundary as x C 0.1. h100 i preferred orientation is also observed for x = 0.1 sample along the axis of the quenched rod. The saturation magnetostriction first increases and maximum value reaches at x = 0.1, and then decreases with Tb addition increasing. The initial increase of the magnetostriction should be associated with the partial solution of Tb in the matrix, the maximum value at x = 0.1 should be attributed to the h100 i preferred orientation, and the decrease of the magnetostriction is correlated with the appearance of the second phase along the grain boundary.

关键词： Fe-Ga alloys Magnetostriction Microstructure Melt quenching

Neural metabolic activity in idiopathic tinnitus patients after repetitive transcranial magnetic stimulation

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World Journal of Clinical Cases 2019年第13期7卷 1582-1590页

作者： Ying Kan Wei Wang shu-xin zhang Huan Ma Zhen-Chang Wang Ji-Gang Yang Department of Nuclear Medicine Beijing Friendship Hospital Capital Medical University Beijing 100050 China Department of Radiology Beijing Friendship Hospital Capital Medical University Beijing 100050 China

BACKGROUND The central mechanism of idiopathic tinnitus is related to hyperactivity of cortical and subcortical auditory and non-auditory *** transcranial magnetic stimulation(rTMS)is a well-tolerated,non-invasive potential treatment option for *** To investigate the changes of neural metabolic activity after rTMS in chronic idiopathic tinnitus(IT)*** THODS Eleven patients underwent rTMS(1 Hz,90%motor threshold,1000 stimuli/day for consecutive 10 d)on the left temporoparietal region *** handicap inventory(THI)and visual analogue score(VAS)were assessed at baseline and *** patients underwent 18 F-fluorodeoxyglucose(FDG)positron emission tomography to evaluate the neural metabolic *** were preprocessed using statistical parametric mapping and Gretna software to extract the regions of interest(ROls).The correlation between brain areas involved and THI scores was *** Baseline and posttreatment parameters showed no significant difference regarding THI score(t=1.019,P=0.342>0.05)and VAS(t=0.00,P=1.0>0.05).Regions with the highest FDG uptake were the right inferior temporal gyrus(ITG),right parahippocampa gyrus(PHG),right hippocampus,rectus gyrus,left middle frontal gyrus,and right inferior frontal gyrus in IT *** rTMS treatment,IT patients showed increased activities in the right PHG,right superior temporal gyrus,right superior frontal gyrus,anterior insula,left inferior parietal lobule,and left precentral gyrus,and decreased activities in the left postcentral gyrus and left *** ROIs in the right parahippocampa gyrus and right superior frontal gyrus were positively correlated with THI scores(r=0.737,P=0.037<0.05;r=0.735,P=0.038<0.05).CONCLUSION Our study showed that 1-Hz rTMS directed to the left temporo-parietal junction resulted no statistically significant symptom *** treatment,brain areas of the limbic and prefrontal system showed high neutral metabolic activity

关键词： Tinnitus Brain imaging Metabolism Positron emission tomography

Association of β-cell function and insulin resistance with pediatric type 2 diabetes among Chinese children

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World Journal of Diabetes 2021年第8期12卷 1292-1303页

作者： Zhen-Ran Xu Hong-Wei Du Lan-Wei Cui Rong-Xiu Zheng Gui-Mei Li Hai-Yan Wei Fei-Yu Lu Li-Li Chen Chu-Shan Wu shu-xin zhang shu-Le zhang Fang Liu Miao-Ying zhang Zhou Pei Cheng-Jun Sun Jing Wu Fei-Hong Luo Department of Pediatric Endocrinology and Inherited Metabolic Diseases National Children’s Medical CenterChildren’s Hospital of Fudan UniversityShanghai 201102China Department of Pediatric Endocrinology and Inherited Metabolic Diseases The First Bethune Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of Pediatrics The First Affiliated Hospital of Harbin Medical UniversityHarbin 150001Heilongjiang ProvinceChina Department of Pediatrics Tianjin Medical University General HospitalTianjin 300052China Department of Pediatric Endocrinology and Inherited Metabolic Diseases Shandong Provincial Hospital Affiliated to Shandong UniversityJinan 250021Shandong ProvinceChina Department of Endocrinology Henan Children's HospitalZhengzhou 450052Henan ProvinceChina

BACKGROUND In addition to insulin resistance,impaired insulin secretion has recently been identified as a crucial factor in the pathogenesis of type 2 diabetes mellitus(T2DM).Scarce clinical data exist for pediatric *** To investigate the association ofβ-cell function and insulin resistance with pediatric T2DM in the first Chinese multicenter *** This multicenter cross-sectional study included 161 newly diagnosed T2DM children and adolescents between January 2017 and October *** with normal glycemic levels(n=1935)were included as healthy control *** homeostasis models(HOMAs)were used to assess theβ-cell function(HOMA2-%B)and insulin resistance(HOMA2-IR)*** HOMA index was standardized by sex and *** performed logistic regression analysis to obtain odds ratios(ORs)for T2DM risk using the standardized HOMA index,adjusted for confounding factors including sex,Tanner stage,T2DM family history,body mass index z-score,and lipid *** The male-female ratio of newly diagnosed T2DM patients was 1.37:1(OR=2.20,P=0.011),and the mean ages of onset for boys and girls were 12.5±1.9 years and 12.3±1.7 years,*** prevalence of related comorbidities including obesity,elevated blood pressure,and dyslipidemia was 58.2%,53.2%,and 80.0%,*** T2DM group had lower HOMA2-%B levels(P<0.001)and higher HOMA2-IR levels(P<0.001)than the control *** the decrease in HOMA2-%B z-score(OR=8.40,95%CI:6.40-11.02,P<0.001)and the increase in HOMA2-IR z-score(OR=1.79,95%CI:1.60-2.02,P<0.001)were associated with a higher risk of T2DM,and the decrease in HOMA2-%B z-score always had higher ORs than the increase in HOMA2-IR z-score after adjusting for confounding *** Besides insulin resistance,β-cell function impairment is also strongly associated with Chinese pediatric *** difference in susceptibility and high comorbidities warrant specific T2DM screening and prevention strategies in Chinese children.

关键词： Diabetes mellitus Type 2 β-cell dysfunction Insulin resistance Adolescent Homeostasis models

Molecular mechanism underlying actin-dependent primary neurite initiation

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Molecular mechanism underlying actin-dependent primary neuri...

Target-induced Programmed Assembly of DNA Branched Junctions and Its Application for In Situ Cell Imaging

中国神经科学学会第十届全国学术会议

作者： shu-xin zhang Li-Hui DUAN Xiang YU Institute of Neuroscience and State Key Laboratory of Neuroscience Shanghai Institutes for Biological SciencesChinese Academy of Sciences University of Chinese Academy of Sciences

Objective The morphology of different types of neurons varies *** differences form an important basis for neural circuit *** studies have shown that the process of dendritic morphogenesis is regulated by a combination of intrinsic genetic programming and extracellular *** found that,at least for some cell types,such as hippocampal pyramidal neurons,basic dendrite patterning（such as neurite number,dendritic field,dendritic segment length） is determined *** initiation,the first step of neurite patterning,is the process by which the nascent neurite springs out from the symmetric post-mitotic neuronal somata and starts *** till now,little is known about the molecular mechanism mediating neurite *** Here we address this question using dissociated hippocampal neuronal cultures as a model system.A combination of live-imaging,immunocytochemistry and molecular manipulations were used to determine if the sub-cellular localization of specific proteins correlated with the sites of neurite *** manipulations were used to determine if these identified molecules were required for mediating the process of neurite *** We found that reorganization of the actin cortex initiates the cascades of neurite *** live-imaging,we showed that the layer of thick cortical actin directly underneath the entire cell membrane becomes reorganized to form actin ***,neurites initiate from these sites of actin ***,the globular to filamentous actin ratio was kept constant during this *** further demonstrated mat the formation of actin aggregation is necessary and sufficient for neurite initiation,and that protein synthesis is not *** currently have evidence suggesting that a membrane phospholipid may act as a cue for actin *** Based on these results,we propose that the process of neurite initiation depends on the

关键词： Dendrite patterning neurite initiation actin cortex actin aggregation

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Target-induced Programmed Assembly of DNA Branched Junctions...

中国化学会第十三届全国分析化学年会

作者： Chang Xue shu-xin zhang Chang-He Ouyang ZaiSheng Wu Cancer Metastasis Alert and Prevention Center Pharmaceutical Photocatalysis of State Key Laboratory of Photocatalysis on Energy and Environment and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy College of Chemistry Fuzhou University

DNA branched junctions with a unique molecular configuration existed naturally and function in specific biological processes.[1-3] The unique branched structures have been built in some works [4-6], exhibiting the slower electrophoretic mobility due to their extended arms [7-8]. In a confined environment such as cells, DNA branched junctions were conjectured to process the similar physical property. Herein we designed a target-induced catalytic assembly of DNA branched junctions and its application for in situ imaging of microRNAs. The precursors were delivered into cells, followed by in situ growth of DNA branched junctions. Their extended arms significantly impact their freedom of movement in cells, contributing to the in situ imaging of targets. Compare to the traditional fluorescence in situ hybridization（FISH） method, the proposed imaging technique is more sensitive. To our knowledge, DNA branched junctions were for the first time exploited for chemical biology applications, leading to an impressive method for in situ imaging of biomolecules within cells.

关键词： DNA branched junctions in situ microRNAs

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带月池的同轴双立柱垂荡运动特性研究

水动力学研究与进展（A辑） 2022年第4期37卷 501-511页

作者：支鹏飞张新曙上海交通大学海洋工程国家重点实验室上海200240 高新船舶与深海开发装备协同创新中心上海200240

该文基于线性势流理论,研究了带月池的同轴双立柱垂荡运动的水动力特性。利用半解析方法特征函数匹配法建立矩阵方程,对立柱辐射问题进行求解,同时使用WAMIT进行了计算验证。并对同轴立柱的垂荡运动水动力特性进行了一系列参数分析,研... 详细信息

该文基于线性势流理论,研究了带月池的同轴双立柱垂荡运动的水动力特性。利用半解析方法特征函数匹配法建立矩阵方程,对立柱辐射问题进行求解,同时使用WAMIT进行了计算验证。并对同轴立柱的垂荡运动水动力特性进行了一系列参数分析,研究了月池直径、外柱外径、内柱和外柱吃水等参数对内柱的水动力特性及月池中心点波高的影响。研究表明:内柱的附加质量和阻尼系数及其所受到的波浪激励力、月池活塞共振频率及共振频率附近的月池中心点波高会随月池直径的增大、内柱吃水的增大以及外柱吃水的减小而减小;内柱的水动力学系数及其所受到的波浪激励力则随外柱外径与月池直径之比a2/a0的增大而减小;而月池活塞共振频率与共振频率附近的月池中心点波高随a2/a0的增大而增大。对同轴立柱的运动响应分析得出,两立柱之间的水动力干扰能够获得相对于单柱更大的运动响应,利用两立柱之间的相对运动,有望可以获得可观的波浪量转换效率。

关键词：水动力特性半解析方法特征函数月池