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Defence Technology（防务技术） 2023年第2期20卷 72-83页

作者： shu-sen yuan Wen-Xiang Deng Jian-Yong Yao Guo-Lai Yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjingChina

Backlash nonlinearity inevitably exists in the actuator of tank horizontal stabilizer and has adverse effect on the system control performance,however,how to effectively eliminate its effect remains a pending *** solve this problem,a robust adaptive precision motion controller is presented in this paper to address uncertainties and unknown actuator backlash of tank horizontal *** controller handles the modeling uncertainties including parameter uncertainties and unmodeled disturbances by integrating adaptive feedforward compensation and continuous nonlinear robust *** on the backstepping method,a smooth backlash inverse model is constructed by combining the adaptive ***,the unknown backlash parameters of the system can be approximated through the parameter adaptation,and the impact of the actuator backlash nonlinearity is effectively compensated via the inverse operation,which can availably improve the tracking ***,the adaptive law can update the disturbance ranges of tank horizontal stabilizer online in real time,which enhances the feasibility in practical engineering ***,the stability analysis based on Lyapunov function shows that with the existence of unmodeled disturbances and unknown actuator backlash,the designed controller guarantees excellent asymptotic output tracking *** comparative results verify the effectiveness of the proposed control strategy.

关键词： Tank Horizontal stabilizer Adaptive control Robust control Backlash inverse

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Studies on organophosphorus compounds ***-reactivity studies of organophosphorus compounds by MNDO calculations

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Chinese Journal of Chemistry 1992年第2期10卷 161-170页

作者： LI,shu-sen yuan,Cheng-Ye Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032 Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032

MNDO and MM2(85)methods were used to study the conformation and the structure- reactivity relationship of neutral and acidic phosphorus *** calculation results indicate that for the most stable conformation,the charge density of phosphoryl oxygen(q_O)is determined not only by the electronegativity of the substituents,but also by the conformation of the alkoxyl groups on the phosphorus ***,the conformation of the alkoxyl group provides,as a rule, more important influence on the charge density of the phosphoryl ***,the energy of the highest occupied molecular orbital(EHOMO)is basically dependent on the eletronegativity of the substituents,while the donating ability or the withdrawing ability of the neutral phosphorus com- pounds is mainly governed by the EHOMO but not the q_*** is also true for other kinds of the neutral oxygen-containing compounds.

关键词： Studies on organophosphorus compounds 52.Structure-reactivity studies of organophosphorus compounds by MNDO calculations

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Photolithographic Microfabrication of Microbatteries for On-Chip Energy Storage

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Nano-Micro Letters 2025年第5期17卷 117-144页

作者： yuan Ma sen Wang Zhong-shuai Wu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023People’s Republic of China School of Transportation Engineering Dalian Jiaotong UniversityDalian 116028People’s Republic of China University of Chinese Academy of Sciences Beijing 100049People’s Republic of China Dalian National Laboratory for Clean Energy Chinese Academy of SciencesDalian 116023People’s Republic of China

Microbatteries(MBs)are crucial to power miniaturized devices for the Internet of *** the evolutionary journey of MBs,fabrication technology emerges as the cornerstone,guiding the intricacies of their configuration designs,ensuring precision,and facilitating scalability for mass *** stands out as an ideal technology,leveraging its unparalleled resolution,exceptional design flexibility,and entrenched position within the mature semiconductor ***,comprehensive reviews on its application in MB development remain *** review aims to bridge that gap by thoroughly assessing the recent status and promising prospects of photolithographic microfabrication for ***,we delve into the fundamental principles and step-by-step procedures of photolithography,offering a nuanced understanding of its operational mechanisms and the criteria for photoresist ***,we highlighted the specific roles of photolithography in the fabrication of MBs,including its utilization as a template for creating miniaturized micropatterns,a protective layer during the etching process,a mold for soft lithography,a constituent of MB active component,and a sacrificial layer in the construction of micro-Swiss-roll ***,the review concludes with a summary of the key challenges and future perspectives of MBs fabricated by photolithography,providing comprehensive insights and sparking research inspiration in this field.

关键词： Microbatteries Photolithography Internet of Things Micropatterns On-chip energy storage

Understanding and probing progression of localized corrosion on inner walls of steel pipelines:an overview

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Journal of Iron and Steel Research International 2025年第1期32卷 1-18页

作者： Ming-yu Wang Hai-yuan Yao Yong-fei Liu Ye-sen Zhu Wan-bin Chen Yun-ze Xu Yi Huang School of Naval Architecture and Ocean Engineering Dalian University of TechnologyDalian 116024LiaoningChina China National Offshore Oil Corporation Research Institute Co. Ltd.Beijing 100028China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial EquipmentDalian University of TechnologyDalian 116024LiaoningChina

Corrosion poses a major threat to the safety of transportation ***,it is crucial to have an in-depth understanding of corrosion mechanisms in pipeline steels for the effective management of pipeline *** research on corrosion mechanisms relies on the use of efficient and reliable corrosion monitoring and analysis *** advancements in corrosion monitoring techniques specifically designed for the localized corrosion monitoring were aimed to be introduced,and a comprehensive overview of recent progress in understanding the localized corrosion mechanisms in pipeline steels was *** on the different corrosive environments encountered,the localized corrosion issues inside pipelines are classified into two categories:localized corrosion primarily influenced by electrochemical processes and localized corrosion controlled by both electrochemical and mechanical ***,a thorough analysis of the synergistic effects between micro-cell and macro-cell currents,as well as the interplay of mechanics and electrochemistry is ***,recommendations for future research on the mechanisms of internal localized corrosion in pipelines are provided.

关键词： Pipeline steel Localized corrosion Corrosion type Corrosion monitoring Corrosion mechanism

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming yuan Guo-Da Zhang Chao Wang shu-Juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Mapping the landscape of gastric cancer immunotherapy:Bibliometric insights into advances and hotspots

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World Journal of Gastrointestinal Oncology 2025年第3期17卷 349-370页

作者： Zhen yuan Jing-Hang Wang Hao Cui shu-yuan Wang Bo Wei Jian-Xin Cui School of Medicine Nankai UniversityTianjin 300071China Department of General Surgery The First Medical CenterChinese PLA General HospitalBeijing 100853China

BACKGROUND Immunotherapy has surfaced as a promising therapeutic modality for gastric cancer(GC).A comprehensive review of advancements,current status,and research trends in GC immunotherapy is essential to inform future investigative *** To delineate the trends,advancements,and focal points in immunotherapy for *** We performed a bibliometric analysis of 2906 articles in English concerning GC immunotherapy published from 2000 to December 20,2023,indexed in the Web of Science Core *** analysis and visualization were facilitated by CiteSpace(6.1.6R),VOSviewer v.1.6.17,and GraphPad Prism *** There has been an increase in the annual publication rate of GC immunotherapy *** leads in publication volume,while the United States demonstrates the highest citation *** University is notable for its citation frequency and publication ***-citation analysis and keyword frequency revealed and highlighted a focus on GC prognosis,the tumor microenvironment(TME),and integrative immunotherapy with targeted *** research areas include gastroesophageal junction cancer,adoptive immunotherapy,and the role of Treg cell in *** GC immunotherapy research is an expanding field attracting considerable scientific *** the clinical adoption of immunotherapy in GC,the primary goals are to enhance treatment efficacy and patient *** hematological malignancies,GC's solid TME presents distinct immunological challenges that may attenuate the cytotoxic effects of immune cells on cancer *** instance,although CAR-T therapy is effective in hematological malignancies,it has underperformed in GC *** research is centered on overcoming immunosuppression within the TME,with a focus on combinations of targeted therapy,adoptive immunotherapy,Treg cell dynamics,and precise prognosis prediction in ***,immunotherapy's role in treating gastroesophageal junctio

关键词： Bibliometrics Gastric cancer Immunotherapy Immune checkpoint inhibitor Tumor microenvironment

Valence electron matching law for MXene-based single-atom catalysts

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Journal of Energy Chemistry 2025年第2期101卷 641-650页

作者： Pei Song Yuhang Zhou Zishan Luo Hang Zhang Xi Sun sen Lu Zepeng Jia Hong Cui Weizhi Tian Rong Feng Lingxia Jin Hongkuan yuan School of Mechanical Engineering Shaanxi University of Technology Shaanxi Key Laboratory of Industrial Automation Shaanxi University of Technology Shaanxi Key Laboratory of Catalysis College of Chemical & Environment Science Shaanxi University of Technology School of Physical Science and Technology Southwest University

Single-atom catalysts（SACs） have attracted considerable interest in the fields of energy and environmental science due to their adjustable catalytic *** this study,we investigated the matching of valence electron numbers between single atoms and adsorbed intermediates（O,N,C,and H） in MXene-anchored SACs（M-Ti2C/M-Ti2CO2）.The density functional theory results demonstrated that the sum of the valence electron number（VM） of the interface-doped metal and the valence electron number（VA） of the adsorbed intermediates in M-Ti2C followed the 10-valence electron matching ***,based on the 10-valence electron matching law,we deduced that the sum of the valence electron number（k） and VMfor the molecular adsorption intermediate interactions in M-Ti2CO2adhered to the 11-valence electron matching *** repulsion between the interface electrons in M-Ti2CO2and H2O weakened the adsorption of intermediates,Furthermore,we applied the 11-valence electron matching law to guide the design of catalysts for nitrogen reduction reaction,specifically for N2→ NNH conversion,in the *** sure independence screening and sparsifying operator algorithm was used to fit a simple three-dimensional descriptor of the adsorbate（R2up to 0.970） for catalyst *** study introduced a valence electron matching principle between doped metals（single atoms） and adsorbed intermediates（atomic and molecular） for MXene-based catalysts,providing new insights into the design of high-performance SACs.

关键词： Density functional theory Nitrogen reduction reaction Sure independence screening and sparsifying operator Valence electron matching law

Heat transfer prediction modeling method combining threedimensional high-precision and one-dimensional real-time dynamic simulations

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Science China Technological Sciences 2025年第3期68卷 86-100页

作者： Xuanang ZHANG Ping yuan Gequn shu Xuan WANG Hua TIAN State Key Laboratory of Engines Tianjin University Department of Thermal Science and Energy Engineering University of Science and Technology of China

Heat exchangers are the core components of energy transfer and conversion and are widely used in the energy,chemical, and other fields. In an actual operational process, load changes lead to variations in the operating conditions of the heat exchanger. Evaluating the heat-transfer performance is crucial for the safe and efficient operation of the system. To realize high-precision heat transfer prediction through simulations, instead of using traditional solid equipment, this study proposed a heat transfer prediction modeling method that combines three-dimensional high-precision and one-dimensional real-time dynamic simulations. This method combines the high-precision advantage of three-dimensional simulation with the real-time advantage of one-dimensional simulation. To verify the feasibility of the modeling method, a heat transfer prediction model was constructed based on the heat transfer channel structure of a CO2mixture heat transfer characteristic experimental test *** steady-state and dynamic heat transfer characteristics of CO2/R32 mixtures were simulated and experimentally ***, the real-time operational capability of the heat transfer prediction model was verified using a real-time simulator. The results showed that the heat transfer prediction model modeling method proposed in this study could improve the accuracy by 1.75–4.64 times compared with the conventional one-dimensional dynamic model. The established heat transfer prediction model exhibited good accuracy for both dynamic and steady-state processes. The average relative errors with the experimental results were in the range of 0.91%–2.83% under six sets of experimental tests. Thus, the proposed heat transfer prediction model can predict the heat transfer process in real-time under all experimental heat source conditions.

关键词： heat transfer prediction model CO2 mixture heat exchanger real-time simulation

Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation

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Journal of Animal Science and Biotechnology 2025年第1期16卷 193-205页

作者： Lei Jia Wenying Zhang Tao Luo Yongtao Li Jianhong shu Julie Strand yuan Yue Stig Purup Jianxin Liu Hengbo Shi Zhejiang Key Laboratory of Cow Genetic Improvement&Milk Quality Research Institute of Dairy ScienceCollege of Animal SciencesZhejiang UniversityHangzhou 310058China College of Life Sciences and Medicine Zhejiang Sci-Tech UniversityHangzhou 310018China Department of Animal and Veterinary Sciences Aarhus UniversityTjele DK‑8830Denmark Ministry of Education Key Laboratory of Molecular Animal Nutrition Zhejiang UniversityHangzhou 310058China

Background Although several cell culture systems have been developed to investigate the function of the mam-mary gland in dairy livestock,they have potential limitations,such as the loss of alveolar structure or genetic and phe-notypic differences from their native *** these challenges is crucial for lactation *** of protocols to establish lactating organoid of livestock represents a promising goal for the *** this study,we developed a protocol to establish a culture system for mammary organoids in dairy goats to model the mammary gland development and lactation *** The organoids cultured within an extracellular matrix gel maintained a bilayer structure that closely resem-bled the native architecture of mammary *** expansion of mammary organoids was significantly promoted by growth factors containing epidermal growth factor and fibroblast growth factor 2 whereas the proliferative index of the organoids was significantly inhibited by the treatment with WNT *** stimulation with a lactogenic medium containing prolactin,the mammary organoids exhibited efficient lactation,characterized by the accumu-lation of lipid droplets in the lumen *** lactation could be sustained for more than 3 ***,the expression patterns of genes related to fatty acid synthesis and milk proteins in lactating organoids closely mirrored those observed in mammary *** observations were confirmed by data from proteomic analysis that the bulk of milk proteins was produced in the lactating *** This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in *** efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.

关键词： Cell-based milk production Lactation Mammary gland Organoid

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Enantioselective synthesis of indenols via rhodium(III)-catalyze C–H activation/annulation of ketones with alkynes

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Science China Chemistry 2025年

作者： Bo-Bo Gou Wen-Jie Shen yuan-Jun Gao Qing Gu shu-Li You New Cornerstone Science Laboratory State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of Sciences

Molecular chirality is a cornerstone of modern chemistry and it has a profound impact on biological activity, chemical reactivity and physical property. Developing asymmetric synthesis methods to efficiently and precisely produce chiral molecules remains a challenging issue in organic chemistry. In recent years, transition-metal-catalyzed enantioselective C–H activation has emerged as an efficient strategy for the rapid access to valuable chiral compounds from readily available feedstocks in an atom-and step-economic manner. Here we report a rhodium(III)-catalyzed C–H activation/annulation of ketones with alkynes. This method features mild conditions, wide substrate scope, and perfect atom economy, affording a series of chiral tertiary indenols in excellent yields and enantioselectivity(up to 98% yield and 99% ee). Combined experimental and computational studies revealed the turnover-limiting step of the reaction and the origins of enantioselectivity and regioselectivity.

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