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Hepatobiliary & Pancreatic Diseases International 2024年第4期23卷 438-440页

作者： Bing-Yi Lin Qi-Jun Zhang Zhe Yang shu-sen zheng Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Thyroid Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Division of Hepatobiliary Pancreatic Surgery Shulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310000China

To the Editor:Hepatocellular carcinoma(HCC)is one of the main causes of cancer related death worldwide,and new cases are expected to continue to increase in future[1].Surgical resection is still the best way to remove the tumor and improve patient’s ***,resection of caudate lobe often presents a technical challenge,even to accomplished hepatic *** lobe is located anterior to the inferior vena cava(IVC)and posterior to the bifurcation of the portal vein(PV),generally consists of three regions:the paracaval portion,the left Spiegel lobe and the process portion[2].The anatomy of the paracaval portion includes the liver parenchyma ventral to the hepatic IVC and the area between the Spiegel lobe and the right lobe adjacent to the middle hepatic vein(MHV)ventrally,which was classified by Couinaud as segment IX[3].Here,we presented a case of HCC with successful downstaging therapy,as well as variation of MHV,which provides a safe path for anterior transection of segment IX.

关键词： hepatic anatomy Middle

Comment on“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”

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Hepatobiliary & Pancreatic Diseases International 2024年第1期23卷 109-110页

作者： Xiang-Yan Liu Yun-Yang Xu Ze Xiang shu-sen zheng shulan(Hangzhou)Hospital Affiliated to Zhejiang shuren University shulan International Medical College Hangzhou 310015China Zhejiang University School of Medicine Hangzhou 310009China

To the Editor:We read with great interest the article by Schulze et ***“Robotic surgery and liver transplantation:A single-center experience of 501 robotic donor hepatectomies”[1].It is the first single-center report including over 500 fully robotic donor *** the donors,the overall complication rate was 6.4%(n=32).Postoperative self-limiting bleeding(0.4%)and bile leakage from the resection plane(1.8%)were rare.

关键词： robotic Robotic center

Diagnosis and treatment of biliary mucinous cystic neoplasms: A single-center experience

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 495-501页

作者： Jun-Jun Jia Ya-Fen Cheng Mei-Bao Feng Li Liu Ming-Qi shuai Xiao-Dong Shen Xiao-Feng Tang shu-sen zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of International Healthcare Center the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Pathology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Library the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Background: Biliary mucinous cystic neoplasms(BMCNs) are rare hepatobiliary cystic tumors, which can be divided into noninvasive and invasive types. This study aimed to investigate the diagnosis, treatment, and prognosis of BMCNs in a large single center. Methods: We analyzed 49 patients with BMCNs confirmed by postoperative pathology at the First Afflliated Hospital, Zhejiang University School of Medicine between January 2007 and December 2021. Results: Among the 49 patients, 37 were female(75.5%), and the average age was 57.04 years. Common symptoms included abdominal discomfort, jaundice and fever, while 22 patients(44.9%) had no symptoms. Serum carbohydrate antigen(CA) 19-9 and CA125 concentrations were elevated in 34.8% and 19.6% of patients, respectively. Forty-eight patients had tumors in the intrahepatic bile ducts and only one had a tumor in the extrahepatic bile duct. Forty-eight patients with noninvasive intrahepatic BMCNs were further analyzed in terms of pathological features: 34(70.8%) had low-grade intraepithelial neoplasms(LGINs), and 14(29.2%) had high-grade intraepithelial neoplasms(HGINs). The potential immunohistochemical markers of BMCNs were cytokeratin(CK) 19, CK7, estrogen receptor and progesterone receptor. Follow-up data for 37 patients with intrahepatic BMCNs were obtained. The median overall survival(OS) of BMCNs was not reached. The longest survival time was 137 *** 5-and 10-year OS rates were 100% and 85.4%, respectively. The 5-and 10-year recurrence-free survival(RFS) rates were 93.9% and 80.2%, respectively. Conclusions: BMCNs are rare cystic neoplasms that commonly occur in middle-aged females. BMCNs can only be diagnosed and classified by postoperative pathology, as there are no specific clinical presentations, serological indicators or imaging modalities for preoperative diagnosis. Complete surgical resection is necessary for BMCNs, and the postoperative prognosis is favorable.

关键词： Biliary mucinous cystic neoplasms Low-grade intraepithelial neoplasms High-grade intraepithelial neoplasms Overall survival Recurrence-free survival

The journal in its fourth five-year publication

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 10-11页

作者： shu-sen zheng Editorial Office of Hepatobiliary & Pancreatic Diseases International First Affiliated HospitalZhejiang University School of Medicine

As 2016 begins, Hepatobiliary 8： Pancreatic Diseases~ International enters its fourth five-year publicat tion. It is also an occasion on which to look back the things we have done.

关键词：杂志出版工作期刊编辑工作

Postoperative outcomes after open splenectomy versus laparoscopic splenectomy in cirrhotic patients:a meta-analysis

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Hepatobiliary & Pancreatic Diseases International 2016年第1期15卷 14-20页

作者： Khaled Al-raimi shu-sen zheng Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of Medicine

BACKGROUND： Laparoscopic splenectomy is considered the gold standard for resecting normal-to-moderately bigger spleens in benign conditions, and in addition could be tried for patients with malignant splenic disorders. However, the safety of laparoscopic splenectomy in patients with hyper- splenism is not well-known. This study aimed to investigate the efficacy and safety of laparoscopic splenectomy for pa- tients with hypersplenism secondary to liver cirrhosis by com- paring with the open splenectomy.

关键词： open splenectomy laparoscopic splenectomy cirrhosis

Glucagonoma syndrome with necrolytic migratory erythema as initial manifestation

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Hepatobiliary & Pancreatic Diseases International 2021年第6期20卷 598-600页

作者： Wei-Fang Zhu shu-sen zheng Department of Dermatology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

To the Editor:Necrolytic migratory erythema(NME)is a group of cutaneous lesions characterized by periodic episodes of annular or figurative dark red plaques,which are typically accompanied by blisters,erosions,and *** is often associated with *** is an extremely rare neuroendocrine tumor that arises from pancreatic isletαcells and manifests as elevated glucagon,with an incidence of about 1 in 20 million per year[1,2].

关键词： erythema elevated islet

Current strategies for preventing the recurrence of hepatocellular carcinoma after liver transplantation

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Hepatobiliary & Pancreatic Diseases International 2015年第2期14卷 145-149页

作者： Zhuo-Yi Wang Lei Geng shu-sen zheng Key Laboratory of Combined Multi-organ Transplantation Ministry of Public Health Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine Division of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital Zhejiang University School of Medicine

BACKGROUND：Liver transplantation is the optimal treatment for a selected group of patients with moderate to severe cirrhosis and hepatocellular carcinoma（HCC）.Despite the strict selection of candidates,post-transplant recurrence often occurs and markedly reduces the long-term survival of patients with *** present review focuses on the current strategies on preventing the recurrence of HCC after liver *** SOURCES： Relevant articles were identified by exten- sive searching of PubMed using the keywords ＂hepatocellular carcinoma＂, ＂recurrence＂ and ＂liver transplantation＂ between January 1996 and January 2014. Additional papers were searched manually from the references in key articles. RESULTS： The current theories of HCC recurrence after liver transplantation are：（i） the growth of pre-transplant occult metastases; （ii） the engraftment of circulating tumor cells released at the time of transplantation. Pre-transplant treatment aims to control local tumor by radiofrequency ablation, transarterial embolization and transarterial chemoembolization. The main objective during the operation is to prevent tumor cell dissemination. Post-transplant treatment includes systemic anticancer therapy, antiviral therapy, and most recently, immunotherapy. These strategies concentrate on the control of the tumor when the patients are waiting for transplant, to reduce the release of HCC cells during surgical procedures and to dear the occult HCC cells after ***： Much can be done to prevent HCC recurrence after liver transplantation. In future, effort is likely to be di- rected towards combining multidisciplinary approaches and various treatment modalities.

关键词： hepatocellular carcinoma recurrence liver transplantation

Narrative medicine principles and organ donation communications

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Hepatobiliary & Pancreatic Diseases International 2023年第3期22卷 323-325页

作者： Jun-Jun Jia Jia Luo Jing shu shu-sen zheng Division of Hepatobiliary and Pancreatic Surgery Department of Surgerythe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHC Key Laboratory of Combined Multi-organ Transplantation Zhejiang UniversityHangzhou 310003China Division of ICU Department Zhejiang Sian International HospitalJiaxing 314000China

Dawei was in intensive care unit on a *** was declared brain death after a traffic *** visiting time,his younger brother Dayong told me their final decision to give up the subsequent treatment.“We don’t have enough ... 详细信息

关键词： enough younger money

Liver transplantation for intrahepatic and perihilar cholangiocarcinoma: Current and future

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Hepatobiliary & Pancreatic Diseases International 2020年第2期19卷 101-102页

作者： shu-sen zheng Zhe Yang Yi-Chao Wu Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China National Clinical Research Center of Infectious Diseases Hangzhou 310003China Division of Hepatobiliary Pancreatic Surgery First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Cholangiocarcinomas are categorized as intrahepatic cholangio- carcinoma (iCCA), perihilar cholangiocarcinoma (pCCA), and dis- tal cholangiocarcinoma (dCCA) [1] . iCCA and pCCA are the second most common primary hepatobiliary malignant neoplasms [ 1 , 2 ]. Most patients with iCCA and pCCA have asymptomatic clinical course, highly aggressive nature and dismal prognosis [3] . Com- plete surgical resection offers the best possibility of long-term sur- vival but only a minority of patients are amenable to R0 resec- tion [4] . Tumor involvement of segmental bilateral intrahepatic bile duct, inadequate remnant liver volume or hepatic functional reserve due to underlying chronic liver disease, are key factors limiting the resectability of iCCA and pCCA. Liver transplantation (LT) provides an option for patients with unresectable iCCA and pCCA [4] .

关键词： intrahepatic neoplasms Liver

Laparoscopic pancreaticoduodenectomy: From “standard” to “extended”

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Hepatobiliary & Pancreatic Diseases International 2023年第2期22卷 113-114页

作者： Zhe Yang Ze-Kuan Li shu-sen zheng Department of Hepatobiliary and Pancreatic Surgery Department of Liver TransplantationShulan(Hangzhou)HospitalZhejiang Shuren University School of MedicineHangzhou 310022China Zhejiang University School of Medicine Hangzhou 310000China

Pancreatic cancer is one of the most desperate malignances worldwide with approximately 470 0 0 0 deaths per year, and the 5-year survival rate is only 11% [1]. Pancreaticoduodenectomy(PD) is the standard treatment for pancreatic head and periampullary lesions [2]. PD is often either described as “standard PD” or “extended PD”(e.g., “PD with portal vein resection, additional organ resection or arterial resection”) [3].

关键词： Laparoscopic arterial lesions