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Chinese Physics B 2024年第12期33卷 258-263页

作者： Xin-Yu Hao shu-juan yan Ying Guo Jing Guo Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

By numerically solving the two-dimensional(2D)time-dependent Schrödinger equation(TDSE),we present photoelectron momentum distributions(PMDs)and photoelectron angular distributions(PADs)of symmetric(H_(2)^(+))and asymmetric(HeH^(2+))molecular ions in circularly polarized(CP)laser *** adjusting the laser wavelength,two circumstances of resonance excitation and direct ionization were *** ionization mechanism of the resonance excitation was mainly *** results show that the PMDs of H_(2)^(+)and HeH^(2+)in the y-direction gradually increase with increasing intensity,and the number of PMDs lobes is in good agreement with the results predicted by the ultrafast ionization *** the resonance excitation scenario,the PMDs of are dominated by two-photon ionization,whereas the PMDs of HeH_(2)^(+)are dominated by three-photon ***,the PMDs of HeH^(2+)are stronger in the resonance excitation scenario than those of H_(2)^(+),which can be explained by the time-dependent population of *** addition,the molecular structure is clearly imprinted onto the PMDs.

关键词： resonance excitation time-dependent Schrödinger equation ultrafast ionization model photoelectron momentum distributions

The momentum distributions of triatomic molecular ion H_(3)^(2+) by intense laser pulses

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Communications in Theoretical Physics 2023年第6期75卷 112-119页

作者： Zhi-Xian Lei shu-juan yan Xin-Yu Hao Pan Ma Sheng-Peng Zhou Jing Guo Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

We investigate theoretically the photoionization of triatomic molecular ion H_(3)^(2+) by numerically solving the two-dimensional time-dependent Schrödinger equations under Bohn-Oppenheimer *** results show that the photoelectron momentum distributions(PMDs)of H_(3)^(2+) with different initial states are strongly dependent on the laser ellipticities and molecular orbital symmetry,and the PMDs of degenerate electronic states E^(±)are mirror ***,for degenerate electronic states E^(±),vortex structures appear in the PMDs by the counter-rotating circularly polarized laser pulses as the time delay between the two pulses increases,which can be explained by multicenter ionization and ultrafast photoionization model.

关键词： momentum distribution ringlike molecules intense laser fields

Mixed Self-adapting GA Optimal Scheduling Algorithm for a Multiple Resource Job-shop

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International Journal of Plant Engineering and Management 2007年第3期12卷 160-170页

作者： LI shu-juan LI yan LIU Zhi-gang School of Mechanical and Instrumental Engineering Xi＇an Universityof Technology Xi＇an 710048 P. R. China

With an aim at the job-shop scheduling problem of multiple resource constraints, this paper presents mixed self-adapting Genetic Algorithm （ GA ） , and establishes a job-shop optimal scheduling model of multiple resource constraints based on the effect of priority scheduling rules in the heuristic algorithm upon the scheduling target. New coding regulations or rules are designed. The sinusoidal function is adopted as the self-adapting factor, thus making cross probability and variable probability automatically change with group adaptability in such a way as to overcome the shortcoming in the heuristic algorithm and common GA, so that the operation efficiency is improved. The results from real example simulation and comparison with other algorithms indicate that the mixed self-adapting GA algorithm can well solve the job-shop optimal scheduling problem under the constraints of various kinds of production resources such as machine-tools and cutting tools.

关键词： heuristic rule mixed self-adapting GA multiple resource constraint optimal scheduling

Multi-agent-based Approach for Determination of Time-quota in Integrated Environment

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厦门大学学报（自然科学版） 2002年第S1期41卷 156-157页

作者： LI shu-juan, LI yan, ZHENG Jian-ming, XIAO Ji-ming, HONG Wei (The Mechanical and Instrument Engineering School, Xi’an University of Technology, Xi’an 710048, China)

Time-quota is one of important factors in producti on system. It is affected by various factors. time-quota is studied in CAPP and p roduction schedule integration environment in this paper. An agent-based time- quota method is put forward and the structure model is established by means of i ntelligent agent in integrated environment. The method can map the influencing t ime-quota factors into part agent related to process state and machine method a gent, resorting to the function of agent rule-based reasoning, the agents can t ransform these factors into data mode that artificial neural network (ANN) can a ccept and recognize. As a tool, ANN agent can calculate time-quota quickly. A b lackboard method is used as the means of communication and collaborative control between agents. The experiments show that precise process time-quota can be obtained rapidly with proper samples selected, continuous self-study and self -organization in system, and multi-agent approach is an effective method for d etermination of time-quota.

关键词： multi-agent artificial neural network (ANN) ti me-quota integrated environment

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran Sun Hao-Ming Yuan Guo-Da Zhang Chao Wang shu-juan Sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

Quantum control of ultrafast magnetic field in H_(3)^(2+)molecules by tricircular polarized laser pulses

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Chinese Physics B 2023年第3期32卷 212-218页

作者：徐清芸何永林杨志杰雷志仙闫淑娟刘学深郭静 Institute of Atomic and Molecular Physics Jilin UniversityChangchun 130012China

We present a scheme to control the generated ultrafast magnetic field in H_(3)^(2+)molecules using multi-frequency tricircular pulses composed of co-and counter-rotating bicircular *** show that the field amplitude and the wavelength are two significant factors for magnetic field generation by tricircular ***,the strength of the magnetic field is linearly related to the field amplitude atλ_(0)=50 nm,while atλ_(0)=70 nm,the strength first increases and then decreases with the amplitude,this can be attributed to the resonance between the ground and excited ***,the phase and helicity of bicircular pulses are shown to have important effects on the magnetic *** dependence of the magnetic field on the phase arises from the interference effect between multiple ionization *** findings illustrate a guiding principle for controlling the magnetic field in molecular systems for future research in ultrafast magneto-optics.

关键词： magnetic field tricircular pulses field amplitude phase helicity

Endotoxin tolerance of adrenal gland:attenuation of corticosterone production in response to lipopolysaccharide and adrenocorticotropin hormone

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Endotoxin tolerance of adrenal gland:attenuation of corticos...

白菜叶形发育相关基因BrLOM2的克隆与表达分析

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： shu-juan LIU,Xiao-yan ZHU,Shan WANG,Xiao-Lu TANG,Xin NI Department of Physiology,the Second Military Medical University,Shanghai 200433,China

＜正＞Objectives:Reversible adrenal insufficiency has been frequently diagnosed in critically ill patients with sepsis who have either low basal Cortisol levels or low Cortisol responses to adrenocorticotrophic hormone（ACTH） *** is generally accepted that a phenomenon called"endotoxin tolerance"’ contributes to immunosuppression during *** present study was to investigate whether endotoxin tolerance occurs in the adrenal gland,leading to hyporesponsiveness of adrenal gland during ***:Controlled laboratory experiment. Setting:University research ***:Primary isolated adrenal fasciculata-reticularis（F/R） cells. Interventions:The F/R cells were pretreated with purified lipopolysaccharide（LPS） at 0.1-100 ng/mL for 24 h, and then challenged,in fresh media,with 1μg/mL LPS for another 24 h or 10 ng/mL ACTH for 6 *** and Main Results:Toll-like receptor 4（TLR4） and P450 11β-hydroxylase（CYP11B1） were co-localized in adrenal gland and primary F/R *** pretreatment caused a significant decrease in corticosterone production in response to subsequent LPS or ACTH stimulation in primary F/R *** pretreatment inhibited LPS-induced expression of steroidogenic acute regulatory protein（StAR） and CYP11B1,as well as ACTH-induced expression of cholesterol side-chain cleavage cytochrome P450（CYP11A1）,3-hydroxysteroid dehydrogenase（HSD3B） and cytochrome P450 21-hydroxylase（CYP21）.LPS significantly decreased TLR4 and ACTH receptor（ACTH-R） ***:LPS pretreatment impaired corticosterone production of F/R cells in response to LPS and ACTH,which was associated with decreased expression of synthetic enzymes required for corticosterone production and down-regulation of TLR4 and *** results indicate that endotoxin tolerance of adrenal gland during sepsis is one of mechanisms for adrenocortical insufficiency,and activation of synthetic enzymes can be a promising treatment strategy.

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园艺学报 2016年第10期43卷 2029-2038页

作者：张淑娟闫芳芳鱼昭君张明科惠麦侠西北农林科技大学园艺学院农业部西北地区园艺作物生物学与种质资源创新重点实验室陕西杨凌712100

为了揭示白菜(Brassica rapa ***)BrLOM2基因在叶发育中的调控机制,以白菜圆叶、裂叶近等基因系为材料,同源克隆得到BrLOM2基因,分析其时空表达特性及对激素的响应。结果显示,BrLOM2的ORF全长为549 bp,编码182个氨基酸,含有GRAS家族保... 详细信息

为了揭示白菜(Brassica rapa ***)BrLOM2基因在叶发育中的调控机制,以白菜圆叶、裂叶近等基因系为材料,同源克隆得到BrLOM2基因,分析其时空表达特性及对激素的响应。结果显示,BrLOM2的ORF全长为549 bp,编码182个氨基酸,含有GRAS家族保守结构域,定位于细胞核,两种材料中的氨基酸序列在保守结构域存在两处突变。进化分析表明,BrLOM2属于十字花科LOM2分支,与大白菜(XP_009138823.1)亲缘关系最近。RT-PCR结果显示,BrLOM2在圆叶白菜中的表达量高于同期裂叶白菜,两种材料茎尖、第1片叶中表达量最高;裂叶中的表达量与叶缘裂刻数呈现同步增加的趋势,6-BA和GA_3分别抑制和促进叶片中的表达,说明BrLOM2低表达可能是裂叶表型产生的主要原因。

关键词：白菜 LOM2 裂叶基因克隆表达特性

清开灵对LPS诱导仔猪发热相关调节因子动态变化的影响

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中国兽医学报 2017年第7期37卷 1348-1352,1371页

作者：袁丽花刘付国树刘娟闫志强杨婷婷西南大学荣昌校区动物医学系重庆荣昌402460

采用LPS人工复制仔猪发热模型,攻毒5h后按要求给于清开灵。监测各时间段的体温以及在0,5,30,72h各时段采血用ELISA法检测PGE2、cAMP、α-MSH和AVP的含量。结果显示:在注射LPS时,各组PGE2、cAMP、AVP、α-MSH的含量无显著性差异(P>0.05)... 详细信息

采用LPS人工复制仔猪发热模型,攻毒5h后按要求给于清开灵。监测各时间段的体温以及在0,5,30,72h各时段采血用ELISA法检测PGE2、cAMP、α-MSH和AVP的含量。结果显示:在注射LPS时,各组PGE2、cAMP、AVP、α-MSH的含量无显著性差异(P>0.05);在注射LPS 5h后,与空白组相比,模型组PGE2、cAMP、AVP和α-MSH的含量升高;在30h时,与模型组相比,清开灵各组PGE2、cAMP含量降低,AVP含量升高,且差异显著(P0.05)。体温与上述相关因子存在显著相关性。结果表明:清开灵有明显的解热作用,其机制可能是通过诸多调节因子共同调节的作用。

关键词：清开灵 LPS PGE2 cAMP α-MSH

Enhanced subacute ischemic stroke treatment via multistage drug delivery system design for combination therapy

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Science China Chemistry 2025年

作者： Xihan Xu juan-juan Li Jiamin Li Hui-yan Zhang Yilin Qi Bing-Sen Shi Tianqi Li Shan-Shan Su Weitao Zhao Chang Chen Zhongying Gong Huiyu Liu Ke-Rang Wang Dong-Sheng Guo Xue Xue State Key Laboratory of Medicinal Chemical Biology College of Pharmacy Nankai University College of Chemistry State Key Laboratory of Elemento-Organic Chemistry Key Laboratory of Functional Polymer Materials (Ministry of Education) Frontiers Science Center for New Organic Matter Collaborative Innovation Center of Chemical Science and EngineeringNankai University College of Chemistry and Materials Science State Key Laboratory of New Pharmaceutical Preparations and Excipients Key Laboratory of Medicinal Chemistry and Molecular Diagnosis (Ministry of Education) Key Laboratory of Chemical Biology of Hebei Province Hebei Research Center of the Basic Discipline of Synthetic Chemistry Hebei University Department of Neurology Tianjin First Central Hospital School of Medicine Nankai University Beijing Advanced Innovation Center for Soft Matter Science and Engineering State Key Laboratory of Organic-Inorganic Composites Beijing Laboratory of Biomedical Materials Bionanomaterials & Translational Engineering Laboratory Beijing Key Laboratory of BioprocessBeijing University of Chemical Technology

The management of acute ischemic stroke remains challenging due to its abrupt onset and the narrow treatment window,resulting in high rates of disability and *** therapy for neuroprotection and neurorepair strategies provided new hopes for subacute stroke *** we designed a multistage nanodelivery system that matches the unique microenvironment of the subacute phase of stroke,which utilizes calixarene as a building block to effectively load the neuroprotective drug *** calixarene is designed with glycosidic linkages targeting the glucose transporter 1 (GLUT1)on the blood-brain barrier (BBB) and azo bonds that are responsive to hypoxic ***,the decomposed calixarene molecules themselves possess intrinsic bio-activation to modulate inflammatory responses,achieving a multistage therapeutic approach that transitions from targeting to release and finally to *** approach combines anti-inflammation and neuroprotection,providing a multi-level treatment *** system was validated in a rat model of permanent middle cerebral artery occlusion (pMCAO),demonstrating that intravenous administration of the nanodelivery system repairs brain damage and improves motor function 24 h post-pMCAO *** work offers a precise and integrative strategy for stroke patients missing the acute therapy window to improve functional recovery and enhance the effect of comprehensive treatment.

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