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Dielectric-ion-conductive ZnNb2O6 layer enabling rapid desolvation and diffusion for dendrite-free Zn metal batteries

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Journal of Energy Chemistry 2025年第1期100卷 693-701页

作者： Haifeng Yang Jian Wang Panpan zhang Xiaomin Cheng Qinghua Guan jing Dong Bixian Chen Lujie Jia jing zhang Yongzheng zhang Yunjian Liu Hongzhen Lin School of Materials Science and Engineering Jiangsu University i-Lab & CAS Key Laboratory of Nanophotonic Materials and Devices Suzhou Institute of Nano-Tech and Nano-Bionics Chinese Academy of Sciences Helmholtz Institute Ulm (HIU) Karlsruhe Institute of Technology (KIT) School of Materials Science and Engineering Xi'an University of Technology State Key Laboratory of Chemical Engineering East China University of Science and Technology

Rechargeable aqueous zinc-metal batteries （AZMBs） are promising candidates for large-scale energy storage systems due to their low cost and high ***,their performance and sustainability are significantly hindered by the sluggish desolvation kinetics at the electrode/electrolyte interface and the corresponding hydrogen evolution reaction where active water molecules tightly participate in the Zn（H2O）62+solvation ***,learnt from self-generated solid electrolyte interphase （SEI） in anodes,the dielectric but ion-conductive zinc niobate nanoparticles artificial layer is constructed on metallic Zn surface （ZNB@Zn）,acting as a rapid desolvation *** zincophilic and dielectric-conductive properties of ZNB layer accelerate interfacial desolvation/diffusion and suppress surface corrosion or dendrite formation,achieving uniform Zn plating/stripping behavior,as confirmed by electronic/optical microscopies and interface spectroscopical measurements together with theoretical ***,the as-prepared ZNB@Zn electrode exhibits excellent cycling stability of over 2000 h and robust reversibility （99.54%） even under high current density and depth of discharge ***,the assembled ZNB@Zn-based full cell displays high capacity-retention rate of 80.21%after 3000 cycles at 5 A g-1and outstanding rate performance up to 10 A *** large-areal pouch cell is stabilized for hundreds of cycles,highlighting the bright prospects of the dielectric but ion-conductive layer in further application of AZMBs.

关键词： Zn metal battery Dielectric artificial layer Rapid ion diffusion Zincophilic diffusion Active water inhibition

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An Improved CNN Search Algorithm

An Improved CNN Search Algorithm

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2005年全国理论计算机科学学术年会

作者： CAI shu-Lan YU jing zhang Zhong-Ping (Department of Computer Science, Yanshan University, Hebei Qinhuangdao 066004)

＜正＞ This paper discusses how to find all split points covered by a new data point, we propose a direct comparison method, which is applied to search single nearest neighbor （NN）of moving objects. Its computation is fewer than the method taken by the continuous NN （CNN） search algorithm. And we also propose a dynamic comparison method, which is applied to search multiple NN of moving objects.

关键词： Moving objects Nearest neighbor CNN search

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糖尿病性黄斑水肿的临床研究进展

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国际眼科杂志 2010年第3期10卷 510-512页

作者：马惠凤张淑静中国天津市蓟县医院眼科 301900

糖尿病黄斑水肿（diabetic macular edema，DME）是指南于糖尿病引起的黄斑中心1D以内的视网膜增厚或硬性渗出。是造成糖尿病性视网膜病变（diabetic retinopathy，DR）视力下降的主要原因之一。其发病机制推测是视网膜内、外屏障的破... 详细信息

糖尿病黄斑水肿（diabetic macular edema，DME）是指南于糖尿病引起的黄斑中心1D以内的视网膜增厚或硬性渗出。是造成糖尿病性视网膜病变（diabetic retinopathy，DR）视力下降的主要原因之一。其发病机制推测是视网膜内、外屏障的破坏以及细胞因子的作用。有多种检查可以对黄斑水肿做出诊断，包括眼底血管荧光造影（FFA）、视网膜断层摄影仪（HRT）、光学相干断层扫描（OCT）等。激光治疗仍然是目前最广泛使用的治疗方法，临床上一直探索其更有效的治疗方法，玻璃体腔注射糖皮质激素等药物的应用，以及玻璃体切除联合视网膜内界膜剥离术等治疗措施联合应用，目前取得了较好的效果，在治疗糖尿病黄斑水肿方面尽管已有巨大进展，但显然尚需有效、副作用更小的治疗措施。

关键词：糖尿病性黄斑水肿光学相干断层扫描仪曲安奈德激光光凝治疗玻璃体视网膜手术

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Exploring the mechanism of action of DHI on myeloproliferative neoplasms based on network pharmacology

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TMR Pharmacology Research 2023年第2期3卷 16-24页

作者： Ming-Jie Liu YuanLi Qian Zhou shu-jing zhang Tao Shen Chun-Hua Lu Rui-Fen Dong Pu Wang Zhi-Da Shi Bao-Bing Zhao Key Lab of Chemical Biology(MOE) School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China NMPA Key Laboratory for Technology Research and Evaluation of Drug Products School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Department of Pharmacology School of Pharmaceutical SciencesCheeloo College of MedicineShandong UniversityJinan 250012China Department of Obstetrics and Gynecology Qilu HospitalShandong UniversityJinan 250012China Department of Urology Heze municipal HospitalHeze 274031China Center for Reproductive Medicine Maternal and Child Health Care Hospital of Shandong ProvinceJinan 250011China

Objective:The aim of this study is to explore the active ingredients and mechanism of action of danhong injection(DHI)in treating myeloproliferative neoplasms using network ***:The TCMSP platform and relevant literature were used to search for the active ingredients and targets of Radix Salviae and Carthami Flos in *** targets related to myeloproliferative neoplasms were obtained from the GEO database,GeneCards,and DisGeNET *** queried component targets were normalized using the UniProt *** targets were identified by constructing protein-protein interactions networks using STRING 11.5 and visualized and analyzed using Cytoscape *** and KEGG analysis were performed using the Metascape platform,and visualization was done using the built-in plug-in CluoGO or SangerBox platforms with Cytoscape ***:The active ingredients of DHI for treating myeloproliferative neoplasms mainly consist of flavonoids and o-benzoquinones,including quercetin,luteolin,kaempferol,stigmasterol,tanshinone iia,cryptotanshinone,beta-carotene,2-isopropyl-8-methylphenanthrene-3,4-dione,and neocryptotanshinone *** potential targets are JUN,TP53,STAT3,AKT1,MAPK1,RELA,TNF,MAPK14,IL6,and *** relevant signaling pathways involved are mainly TNFαsignaling pathway,PI3K-Akt signaling pathway,apoptosis,IL-17 signaling pathway,cellular senescence,MAPK signaling pathway,p53 signaling pathway,JAK-STAT signaling pathway,and NF-kappa B ***:DHI acts mainly through flavonoids and o-benzoquinones to treat myeloproliferative neoplasms in a multi-targeted and multi-pathway manner.

关键词： danhong injection myeloproliferative neoplasms network pharmacology effective material basis molecular mechanism

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Neuroprotective Effect of Da-Bu-Yin-Wan and Qian-Zheng-San on Mitochondrial quality in Parkin overexpression SHSY5Y Cells of Parkinson's Disease

Neuroprotective Effect of Da-Bu-Yin-Wan and Qian-Zheng-San o...

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中国神经科学学会第十二届全国学术会议

作者： Tian-yao Qiang Cong Gai Wan-di Feng Hao-jie Ma Yuan Chai shu-jing zhang jing-Hong Hu Hong-Mei Sun Zhen-Yu Guo Yuan-yuan Wang School of Preclinical Medicine Beijing University of Chinese Medicine

Objective To investigate the protective effect and possible mechanism of DaBu-Yin-Wan and Qian-Zheng-San(DBYW&QZS)on mitochondrial quality in a cell model of Parkinson’s disease(PD) associated with Parkin overexpression. Methods: Human neuroblastoma SH-SY5 Y cells were transfected with EGFP–Parkin, expressions of Parkin m RNA and protein evaluated by Quantitative RT-PCR and Western blotting, and then treated with neurotoxin MPP and Chinese medicine prescription DBYW&QZS. The cell viability was measured by the CCK-8 assay. Mitochondrial Morphology Probed by Staining with Mito Tracker-Red CMXRos and mitochondria membrane potential(ΔΨm) Probed with TMRM was observed by laser scanning confocal microscope. The cellular ATP content were also measured with ATP assay Kit. The protein expressions of mitochondrial fusion(mitofusin1, Mfn1, mitofusin2) and fission(dynamic related protein1, drp1 and mitochondrial fission protein1, Fis1) were detected by Western blotting. In addition, Triple immunofluorescence imaging with Laser Scanning Confocal Microscopy was applicated for the colocalization of Parkin, PINK1 and TOM20. Results: After EGFP–Parkin transfection, the m RNA and protein expression of Parkin were significantly increased, while no significant change in the control group and negative control group. After MPP+ treatment,the cell survival rate, the form-factor, the ATP production, ΔΨm and the protein expression of mitochondrial fission and fusion were reduced apparently. However, the Pearson’s Coefficient of Parkin, PINK1 and TOM20 remained unchanged. DBYW&QZS decreased the MPP+-induced toxicity by increasing the cell survival rate, the form-factor, ΔΨm, ATP content markedly. Overexpression of Parkin combined with DBYW&QZS enhanced the augment of ΔΨm, ATP content;moreover, the colocalization coefficient of Parkin and PINK1 and the expression of Mfn1 ascended while the expression of Fis1 descended observably. Conclusion: These results highlight a protective effect of DBYW

关键词： Parkinson’s disease Qian-Zhen-San Da-Bu-Yin-Wan Parkin mitochondria

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Unraveling brain aging through the lens of oral microbiota

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Neural Regeneration Research 2025年第7期20卷 1930-1943页

作者： Qinchao Hu Si Wang Weiqi zhang jing Qu Guang-Hui Liu State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Hospital of Stomatology Guanghua School of StomatologyGuangdong Provincial Key Laboratory of StomatologySun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Advanced Innovation Center for Human Brain Protection and National Clinical Research Center for Geriatric Disorders Xuanwu HospitalCapital Medical UniversityBeijingChina Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijingChina CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijingChina University of Chinese Academy of Sciences BeijingChina Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijingChina Aging Biomarker Consortium BeijingChina State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijingChina Beijing Institute for Stem Cell and Regenerative Medicine BeijingChina

The oral cavity is a complex physiological community encompassing a wide range of *** of oral microbiota can lead to various oral infectious diseases,such as periodontitis and tooth decay,and even affect systemic health,including brain aging and neurodegenerative *** studies have highlighted how oral microbes might be involved in brain aging and neurodegeneration,indicating potential avenues for intervention *** this review,we summarize clinical evidence demonstrating a link between oral microbes/oral infectious diseases and brain aging/neurodegenerative diseases,and dissect potential mechanisms by which oral microbes contribute to brain aging and *** also highlight advances in therapeutic development grounded in the realm of oral microbes,with the goal of advancing brain health and promoting healthy aging.

关键词： Alzheimer's disease brain aging multiple sclerosis neurodegeneration neurodegenerative diseases oral microbiota Parkinson's disease periodontitis bacteria Porphyromonas gingivalis

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公交车用细水雾灭火系统性能试验研究

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消防科学与技术 2017年第8期36卷 1093-1096页

作者：郝卿儒许淑惠张京安北京建筑大学建筑能源高效综合利用工程技术研究中心北京100044 中瑞华特(北京)高新技术开发有限公司北京100036

对公交车全尺寸压力罐细水雾灭火系统的性能进行试验研究。试验采用汽油油盘火,进行了4种工况的灭火性能试验,测试了车门关闭、车门开启、人员影响、座椅遮挡等状况下灭火时间、车厢中的温度分布以及灭火前后的烟气成分等。分析结果表明... 详细信息

对公交车全尺寸压力罐细水雾灭火系统的性能进行试验研究。试验采用汽油油盘火,进行了4种工况的灭火性能试验,测试了车门关闭、车门开启、人员影响、座椅遮挡等状况下灭火时间、车厢中的温度分布以及灭火前后的烟气成分等。分析结果表明,该压力罐细水雾灭火系统能够在较短时间内灭火;灭火前后的车厢内温度和烟气对乘车人员的危害较小;火灾时棉质衣料不易烧损,化纤衣料极易引燃。

关键词：公交车细水雾灭火系统温度分布烟气成分灭火时间

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Effects of the extrusion parameters on microstructure,texture and room temperature mechanical properties of extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy

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International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 136-146页

作者： Chenjin zhang Guangyu Yang Lei Xiao Zhiyong Kan jing Guo Qiang Li Wanqi Jie State Key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi’an 710072China College of Materials Science and Engineering Fuzhou UniversityFuzhou 350108China College of Chemistry and Environmental Science Qujing Normal UniversityQujing 655011China

Microstructure,texture,and mechanical properties of the extruded Mg-2.49Nd-1.82Gd-0.2Zn-0.2Zr alloy were investigated at different extrusion temperatures(260 and 320℃),extrusion ratios(10:1,15:1,and 30:1),and extrusion speeds(3 and 6 mm/s).The experimental results exhibited that the grain sizes after extrusion were much finer than that of the homogenized alloy,and the second phase showed streamline distribution along the extrusion direction(ED).With extrusion temperature increased from 260 to 320℃,the microstructure,texture,and mechanical properties of alloys changed *** dynamic recrystallization(DRX)degree and grain sizes enhanced as the extrusion ratio increased from 10:1 to 30:1,and the strength gradually decreased but elongation(EL)*** the extrusion speed increased from 3 to 6 mm/s,the grain sizes and DRX degree increased significantly,and the samples presented the typical-rare-earth(RE)*** alloy extruded at 260℃ with extrusion ratio of 10:1 and extrusion speed of 3 mm/s showed the tensile yield strength(TYS)of 213 MPa and EL of 30.6%.After quantitatively analyzing the contribution of strengthening mechanisms,it was found that the grain boundary strengthening and dislocation strengthening played major roles among strengthening *** results provide some guidelines for enlarging the industrial application of extruded Mg-RE alloy.

关键词： Mg-rare earth alloys extrusion temperature extrusion ratio extrusion speed strengthening mechanisms

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AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

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Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing Yang shuo zhang Mengjie Li Chunyan Zuo Chengyuan Mao Zhongxian zhang Mibo Tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

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微波辐射原位聚合法合成蒙脱土(MMT)/淀粉改性高吸水性树脂的研究

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化工科技 2017年第3期25卷 30-35页

作者：舒静张卿源赵大飙东北石油大学化学化工学院石油与天然气化工省重点实验室黑龙江大庆163318 大庆油田储运销售分公司黑龙江大庆163455

通过微波辐射采用原位聚合法制备了蒙脱土(MMT)改性淀粉基高吸水性复合树脂。考察了各种工艺条件对树脂吸水量的影响及树脂在60℃下的保水性,采用FTIR对树脂结构进行了表征。结果表明,在210W的微波功率下仅需反应150s就可获得最大吸水量... 详细信息

通过微波辐射采用原位聚合法制备了蒙脱土(MMT)改性淀粉基高吸水性复合树脂。考察了各种工艺条件对树脂吸水量的影响及树脂在60℃下的保水性,采用FTIR对树脂结构进行了表征。结果表明,在210W的微波功率下仅需反应150s就可获得最大吸水量为1 350g/g的树脂,MMT的加入使树脂吸水量和保水率分别提高了22%和33%。FTIR表征结果显示MMT和淀粉及丙烯酸发生了接枝共聚反应,蒙脱土和淀粉基丙烯酸之间形成了氢键。

关键词：微波辐射高吸水性复合树脂(SAPCs) 原位聚合丙烯酸(AA) 蒙脱土(MMT) 淀粉

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