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Chinese Physics B 2020年第2期29卷 100-106页

作者： shu-jing zhang Chen Xiao Chun Zhou Xiang Wang Jian-shu Yao Hai-Long zhang Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography PLA SSF IEUZhengzhou 450001China PLA SSF IEU Zhengzhou 450001China Fujian Chengyi College of Jimei University Xiamen 361021China

The effects of weather conditions are ubiquitous in practical wireless quantum communication *** in this work,the performances of atmospheric continuous-variable measurement-device-independent quantum key distribution(CV-MDI-QKD)under diverse weather conditions are analyzed *** to the Mie scattering theory and atmospheric CV-MDI-QKD model,we numerically simulate the relationship between performance of CV-MDI-QKD and the rainy and foggy conditions,aiming to get close to the actual combat environment in the *** results show that both rain and fog will degrade the performance of the CV-MDI-QKD *** the rainy condition,the larger the raindrop diameter,the more obvious the extinction effect is and the lower the secret key rate *** addition,we find that the secret key rate decreases with the increase of spot deflection distance and the fluctuation of *** the foggy condition,the results illustrate that the transmittance decreases with the increase of droplet radius or deflection distance,which eventually yields the decrease in the secret key ***,in both weather conditions,the increase of transmission distance also leads the secret key rate to *** work can provide a foundation for evaluating the performance evaluation and successfully implementing the atmospheric CV-MDI-QKD in the future field operation environment under different weather conditions.

关键词： weather conditions atmospheric continuous-variable measurement-device-independent quantum key distribution(CV-MDI-QKD) performance

Temperature effects on atmospheric continuous-variable quantum key distribution

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Chinese Physics B 2019年第8期28卷 56-61页

作者： shu-jing zhang Hong-Xin Ma Xiang Wang Chun Zhou Wan-Su Bao Hai-Long zhang Henan Key Laboratory of Quantum Information and Cryptography Zhengzhou Information Science and Technology Institute

Compared with the fiber channel,the atmospheric channel offers the possibility of a broader geographical coverage and more flexible transmission for continuous-variable quantum key distribution(CVQKD).However,the fluctuation of atmospheric conditions will lead to the loss of performance in atmospheric quantum *** this paper,we study how temperature affects atmospheric *** mainly consider the temperature effects on the transmittance and interruption *** the numerical simulation analysis,it can be shown that the performance of atmospheric CVQKD is improved as temperature increases,with the other factors ***,the results in this work can be used to evaluate the feasibility of the experimental implementation of the atmospheric CVQKD protocols.

关键词： atmospheric continuous-variable quantum key distribution temperature effects performance secret key rate

Identification of novel PKD1 mutations in two Chinese families with autosomal dominant polycystic kidney disease by targeted next generation sequencing

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Chinese Medical Journal 2020年第6期133卷 738-740页

作者： Qun Liu Jun-Xia Ruan jing-shu zhang Lu-Lu zhang Guang-Rong Qiu Department of Medical Genetics School of Life SciencesChina Medical UniversityShenyangLiaoning 110122China Dalian Municipal Women and Children's Medical Center DalianLiaoning 116037China

To the Editor:Autosomal dominant polycystic kidney disease(ADPKD)is a common inherited kidney disease with an estimated incidence of 1 in 400 to 1 in 1000.[1] It is a late-onset systemic disorder characterized by the development and progressive enlargement of cysts in the kidney,eventually leading to end-stage renal disease.[2] Previous studies have shown that ADPKD is a heterogeneous monogenic disorder resulting from mutations in two genes:PKD1 and *** data showed that PKD1 and PKD2 mutations account for 85% and 15% of ADPKD cases,respectively.[3]

关键词： PKD1 kidney Clinical

Regulatory effect of a Chinese herbal medicine formula on nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2019年第34期25卷 5105-5119页

作者： Jia-Min Yang Yan Sun Min Wang Xin-Lei zhang shu-jing zhang Yu-Shan Gao Lin Chen Meng-Yao Wu Lu Zhou Yu-Mei Zhou Yue Wang Feng-Jie Zheng Yu-Hang Li School of Traditional Chinese Medicine Beijing University of Chinese Medicine

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)has become a major cause of chronic liver *** Chinese herbal medicine(CHM)Dachaihu decoction(DCHD)has been proved to treat NAFLD with good efficacy in previous *** on the TCM principle of formula formation,we divided DCHD into soothing liver part,invigorating spleen part,and dredging intestine *** officially proposed the concept of“intestinal-hepatic axis”,which systematically explains the interactions between the intestine and *** hypothesized that the effect of CHM on NAFLD is achieved by regulating the liver and ***,we aimed to investigate the possible effect of a CHM formula on NAFLD in a rat *** To investigate the effects of a CHM formula(a decoction of Chinese thorowax root,scutellaria root,and white peony root)on NAFLD and its regulatory effect on the“intestinal-liver”*** Sixty rats were randomly divided into control,model,pioglitazone hydrochloride(PH),and CHM(a decoction of Chinese thorowax root,scutellaria root,and white peony root)*** NAFLD rat model was established using a high-fat highfructose diet for 16 *** the 13th week,rats were administered with PH or a decoction of Chinese thorowax,scutellaria,and white peony root(CHM group)for 4 *** in the control group and model group were administered with an equal volume of distilled *** the end of the study,blood was collected via the abdominal *** tissues were harvested and any morphological changes were observed by hematoxylin-eosin(HE)staining,Oil red O staining,and Masson *** addition,blood lipids,liver function markers,and triglyceride(TG)in liver tissues were *** levels of transforming growth factor-β1(TGF-β1),tumor necrosis factor-α(TNF-α),Toll-like receptor-4(TLR4),and nuclear factor-kappa B(NF-кB)in liver tissues and secreted immunoglobulin A(sIgA)in intestinal tissues were analyzed by ELISA,and protein and mRNA expression of occludin and zonula occ

关键词： Non-alcoholic fatty liver disease Chinese herbal medicine Liver function Intestinal-hepatic axis

Overcoming chemoresistance in non-angiogenic colorectal cancer by metformin via inhibiting endothelial apoptosis and vascular immaturity

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Journal of Pharmaceutical Analysis 2023年第3期13卷 262-275页

作者： Guang-Yue Li shu-jing zhang Dong Xue Yue-Qi Feng Yan Li Xun Huang Qiang Cui Bo Wang Jun Feng Tao Bao Pei-Jun Liu Shao-Ying Lu Ji-Chang Wang Department of Science and Technology The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Vascular Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of General Surgery The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Center for Translational Medicine The First Affiliated Hospital of Xi'an Jiaotong UniversityXi'an710061China Department of Pharmacy Xi'an Jiaotong University Health Science CenterXi'an710061China

The development of chemoresistance which results in a poor prognosis often renders current treatments for colorectal cancer(CRC).In this study,we identified reduced microvessel density(MVD)and vascular immaturity resulting from endothelial apoptosis as therapeutic targets for overcoming *** focused on the effect of metformin on MVD,vascular maturity,and endothelial apoptosis of CRCs with a non-angiogenic phenotype,and further investigated its effect in overcoming *** situ transplanted cancer models were established to compare MVD,endothelial apoptosis and vascular maturity,and function in tumors from metformin-and vehicle-treated *** in vitro co-culture system was used to observe the effects of metformin on tumor cell-induced endothelial *** sequencing was performed for genetic ***-angiogenic CRC developed independently of angiogenesis and was characterized by vascular leakage,immaturity,reduced MVD,and *** phenomenon had also been observed in human ***,non-angiogenic CRCs showed a worse response to chemotherapeutic drugs in vivo than in *** suppressing endothelial apoptosis,metformin sensitized non-angiogenic CRCs to chemo-drugs via elevation of MVD and improvement of vascular *** results showed that endothelial apoptosis was induced by tumor cells via activation of caspase signaling,which was abrogated by metformin *** findings provide pre-clinical evidence for the involvement of endothelial apoptosis and subsequent vascular immaturity in the chemoresistance of non-angiogenic *** suppressing endothelial apoptosis,metformin restores vascular maturity and function and sensitizes CRC to chemotherapeutic drugs via a vascular mechanism.

关键词： Metformin Colorectal cancer Non-angiogenic Endothelial apoptosis Vascular immaturity

Effects of Dachaihu Decoction and Its “Prescription Elements” on Intestinal Flora of Nonalcoholic Fatty Liver Disease Model Rats

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World Journal of Traditional Chinese Medicine 2020年第1期6卷 97-105页

作者： Yan Sun Min Wang shu-jing zhang Yu-Shan Gao Lin Chen Meng-Yao Wu Xin-Lei zhang Lu Zhou Hui-Min Yuan Feng-Jie Zheng Jian Cui Yu-Hang Li School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijingChina Department of Medicine Columbia University Medical CenterNYUSA

Objective:The study objective was to observe the effect of Dachaihu decoction and its "prescription elements" on intestinal flora of model rats with nonalcoholic fatty liver disease (NAFLD). Materials and Methods:Healthy male Sprague-Dawley rats were randomly divided into the following seven groups (n=105):normal, model, pioglitazone hydrochloride (PH), shuganlidan, Jianpihuatan, Tongfuxiezhuo, and dachaihu decoction (DD). 16SrRNA high-throughput IIlumina sequencing platform was used for sequencing, and bioinformatics analysis of rat intestinal flora was done. Results:Compared with the normal group, rats in the model, PH, shuganlidan, Jianpihuatan, Tongfuxiezhuo,and DD groups showed significant differences in the intestinal microflora structure. The microorganisms that play an important role in the normal group are Ruminococcaceae, Oscillospira, Lactobacillales, Lactobacillaceae, Lactobacillus, bacilli, Ruminococcus, TM7, Spirochaetes,Clostridium, Elusimicrobia, Elusimicrobiaceae, Elusimicrobiales, Lactobacillus helveticus, Lactobacillus reuteri, Elusimicrobium, RF39, and Christensenellaceae;in the model group are Ruminococcus gnavus;in the PH group are Prevotella, Paraprevotellaceae, and Blautia;in the Jianpihuatan group are Bacteroidetes, Bacteroidia, Bacteroidales, Roseburia, Rikenellaceae, and?Stridium methylpentosum;in the TongfuXiezhuo group are Bacteroidaceae, Bacteroides, Porphyromonadaceae, Parabacteroide, 4C0d2, Cyanobacteria, YS2, Parabacteroides distasonis,Bacteroides uniformis, Verrucomicrobiaceae, Verrucomicrobiae, Verrucomicrobiales, Akkermansia, Akkermansia muciniphila, Coprobacillus,Parabacteroides gordonii, Blautia producta, and Ruminococcus torques;and in the DD group are Erysipelotrichales, Erysipelotrichi, and Erysipelothrichaceae. Conclusion:The Tongfuxiezhuo prescription elements of the DD significantly improved the intestinal flora of rats with NAFLD, improving the relative abundance of beneficial bacteria in the intestinal flora of NAFLD rat

关键词： Dachaihu decoction intestinal flora nonalcoholic fatty liver disease prescription elements

Equation Method for DOA Estimation of Complete Coherent Sources

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Equation Method for DOA Estimation of Complete Coherent Sour...

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

1996 3rd International Conference on Signal Processing(ICSP’96)

作者： Zhong Ding Lei Xiu Kun Huang shu jing zhang Institute of Information Science Northern Jiaotong University

ISBN: (纸本)0780329120

＜正＞An Equation Method for high-resolution direction-of-arrival（DOA） estimation of complete coherent sources is *** method,which has superhigh resolution,is based on resolving equations about received data and estimated unknown parameters of DOA. Algorithm of the method to uniform linear array（ULA） is given and simulation results demonstrate its superior performance.

关键词： direction-of-arrival estimation signal resolution linear antenna arrays array signal processing covariance matrices equation method DOA estimation complete coherent sources direction-of-arrival estimation superhigh resolution uniform linear array simulation results array processing

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing zhang Lanfang Li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang Liu Youming Lu Xinyan Li Kai shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu jing zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant LiCoO2/Li5.4PS4.4Cl1.4I0.2/Li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LiCoO2/Li5.4PS4.4Cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

Suspended moxibustion relieves chronic visceral hyperalgesia and decreases hypothalamic corticotropin-releasing hormone levels

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World Journal of Gastroenterology 2011年第5期17卷 662-665页

作者： En-Hua Zhou Xiao-Mei Wang Guang-Hong Ding Huan-Gan Wu Li Qi Hui-Rong Liu shu-jing zhang Department of Mechanicsand Engineering Science Fudan University Shanghai 200433China Key Laboratory of Acupuncture-Moxibustion and Immunological Effects Shanghai Universityof Traditional Chinese Medicine Shanghai 201203 China Shanghai Research Center of Acupunctureand Meridians Shanghai 200433 China

AIM:To evaluate the effect of suspended moxibustion(SM) on rectal sensory thresholds and to analyze the possible mechanisms involved in SM treatment of chronic visceral hypersensitivity(CVH) in ***:SM was administered once daily to 37-dold CVH rats for 7 *** two pairs of acupoints(ST25 and ST37,bilateral) were simultaneously treated with *** treatment lasted for 30 *** undergoing treatment with SM were not *** CVH rats and normal rats were used as *** abdominal withdrawal reflex was determined 30-90 min after the seven *** hypothalamic corticotropin-releasing hormone(CRH) mRNA level was measured using real-time quantitative reverse transcriptionpolymerase chain ***:We found that SM treatment significantly decreased visceral sensitivity to colorectal distention in this rat *** treated animals,SM also decreased the relative hypothalamic CRH mRNA expression level to control ***:Lower hypothalamic CRH levels may mediate the beneficial effects of SM in this rat irritable bowel syndrome model.

关键词： Chronic visceral hypersensitivity Corticotro-pin-releasing hormone Irritable bowel syndrome Rat Suspended moxibustion