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Traditional Chinese medicine in the treatment of idiopathic pulmonary fibrosis based on syndrome differentiation:Study protocol of an exploratory trial

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Journal of Integrative Medicine 2020年第2期18卷 163-168页

作者： Xue-qing Yu shu-guang yang yang Xie Jian-sheng Li Department of Respiratory Diseases The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouHenan Province 450000China Co-construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases by Henan&Education Ministry of P.R.China Henan University of Chinese MedicineZhengzhouHenan Province 450046China Henan Key Laboratory of Chinese Medicine for Respiratory Diseases Henan University of Chinese MedicineZhengzhouHenan Province 450046China

Background: Idiopathic pulmonary fibrosis(IPF) has a poor prognosis and is often a kind of heavy financial burden to patients. Currently, few treatments are available for IPF. Clinical practice of traditional Chinese medicine(TCM), using a syndrome differentiation approach, offers some treatment success in IPF. However, there is no sufficient evidence-based study of the role of TCM in IPF management to make strong conclusions. This study evaluates the efficacy and safety of TCM in the treatment of *** and design: A multicenter, exploratory, randomized, double-blind and placebo-controlled trial is planned. A total of 80 patients will be enrolled in the study, which will include 26 weeks of *** will be randomly assigned into TCM group or control group in a 1:1 ratio. The TCM group will be given TCM granules based on syndrome differentiation. Formulae include Bao-fei Hua-xian granule for lung qi deficiency, Jin-shui Huan-xian granule for lung-kidney qi deficiency and yang-qing Kang-xian granule for yin deficiency and inner heat. The control group will be given a corresponding TCM granule placebo. The efficacy and safety of interventions will be evaluated by the outcome variables,including frequencies of acute exacerbations, pulmonary function, clinical symptoms, dyspnea, healthrelated quality of life(HRQo L), 6-minute walk distance and safety ***: It is hypothesized that TCM will decrease the frequency of adverse events, improve pulmonary function and HRQo L, based on our clinical experience. This trial is the first study of TCM treatment in IPF that is based on syndrome differentiation and will evaluate the efficacy and safety of TCM in IPF.

关键词： Idiopathic pulmonary fibrosis Traditional Chinese medicine Syndrome differentiation Protocol

Dewetting Behavior of Hydrogen Bonded Polymer Complex Film under Hydrothermal Condition

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Chinese Journal of Polymer Science 2018年第9期36卷 1036-1042页

作者： Chao Su Song-Mei Ma Geng-Xin Liu shu-guang yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension Materials College of Material Science and Engineering Donghua University Department of Polymer Science The University of Akron

Hydrogen-bonded polymer complex films with the thickness ranging from 50 nm to 2400 nm were prepared by layer-by-layer （LbL） assembly of poly（2-ethyl-2-oxazoline）（PEOX） and poly（acrylic acid）（PAA）. The dewetting behavior of PEOX/PAA films under hydrothermal condition was investigated. It was found that the dewetting occurred at solid-liquid interface, and the typical morphologies such as holes, irregular cellular structure, and droplets were observed. Atomic force microscopy （AFM） revealed the initial rupture of the film. Microscopic Raman and infrared （IR） imaging demonstrated that the PEOX and PAA chains remained association during the dewetting process.

关键词： Hydrogen-bonding Polymer complex Dewetting

Fibers Make a Better Life

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Chinese Journal of Polymer Science 2022年第4期40卷 331-332页

作者： Li-Ping Zhu shu-guang yang Mei-Fang Zhu State Key Laboratory for Modification of Chemical Fibers&Polymer Materials College of Materials Science&EngineeringDonghua UniversityShanghai 201620China

Naturally occurring fibers,such as cotton,flax,silk,and wool have been utilized by mankind for *** silk gauze gown of Han-dynasty found in 1972 by archaeological discovery in Mawangdui Han Tomb weighs only 49 *** demonstrates the advanced silkworm cultivation,harvesting and weaving techniques in the early Han Dynasty in *** today,we are not able to replicate this silk gown with such light *** a long time.

关键词： wool harvesting silk

Langmuir-Blodgett Films of C_(60)-end-capped Poly(ethylene oxide)

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Chinese Journal of Polymer Science 2019年第6期37卷 604-608页

作者： Ke Ou Xian Xu Yu Shao Wei-Jie Wang Wen-Bin Zhang shu-guang yang Center for Advanced Low-dimension Materials State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Material Science and Engineering Donghua University Key Laboratory of Polymer Chemistry&Physics of Ministry of Education Center for Soft Matter Science and Engineering College of Chemistry and Molecular Engineering Peking University

Buckyballs(C_(60)) are linked to one end and two ends of linear poly(ethylene oxide)(PEO) chains through highly efficient click chemistry to obtain giant amphiphilic molecules C_(60)-PEO and C_(60)-PEO-C_(60), respectively. C_(60)-PEO and C_(60)-PEO-C_(60) molecules are spread on water surface and then transferred to solid substrates with Langmuir-Blodgett(LB) film deposition approach. C_(60)-PEO and C_(60)-PEO-C_(60) exhibit fractal growth behavior on the solid substrate under certain conditions owing to the crystallization ability of PEO segment. PEO chain length and the end capped mode both affect the fractal growth pattern.

关键词： LB film Giant amphiphilic molecule Fractal growth

Stabilize and Reinforce Hydrogen-Bonded Polymer Complex Elastic Fiber by Catechol Chemistry and Coordination

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Chinese Journal of Polymer Science 2023年第12期41卷 1846-1855,I0006页

作者： Ze-Xin Liu De-Zhong Liu Cai-Hong Zhang Wei-Jie Wang Hao Huang shu-guang yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-Dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China

Hydrogen-bonded polymer complex fiber of poly(ethylene oxide)(PEO)and poly(acrylic acid)(PAA)shows rubber elasticity in ambient environment,but the fiber has relatively low strength and weak *** apply the catechol chemistry and metal coordination to stabilize and strengthen the PEO/PAA *** is grafted with dopamine(Dopa),and then combines with PEO to prepare ***-Dopa in the fiber is crosslinked through oxidation induced dismutation and the metal ions are introduced through *** cross-linking and coordination greatly improve the stability of the fiber against the erosion of alkaline *** four different metal coordination fibers,PEO/PAA-Dopa/Cu fiber keeps the excellent extensibility(~1000%)and presents much higher initial modulus(~7 MPa),ultimate strength(~20 MPa),and toughness(~60 MJ/m^(3))than its precursor PEO/PAA *** addition,PEO/PAA-Dopa/Cu fiber shows quick recovery and large energy dissipation ratio compared with the PEO/PAA *** distinct mechanical properties enhancement of the hydrogen-bonded complex fiber is attributed to the synergy of hydrogen bonds,coordination and covalent bond cross-linking.

关键词： Elastic fiber Hydrogen-bonded complexation Catechol chemistry Coordination Elastomer

Fractal Growth of Giant Amphiphiles in Langmuir-Blodgett Films

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Chinese Journal of Polymer Science 2022年第6期40卷 556-566页

作者： Wei-Jie Wang Xian Xu Yu Shao Jian-Wen Liao Han-Xin Jian Bing Xue shu-guang yang State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Center for Advanced Low-dimension MaterialsCollege of Materials Science and EngineeringDonghua UniversityShanghai 201620China Beijing National Laboratory for Molecular Sciences Key Laboratory of Polymer Chemistry and Physics of Ministry of EducationCenter for Soft Matter Science and EngineeringCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Fractal structures have attracted considerable scientific interest,and fractal geometry is an effective tool to study the complicated structure and dynamic processes,such as dilation symmetry of disorder structure,percolation,gelation,and metal-insulator ***,we summarized our findings of fractal growth of giant amphiphiles in Langmuir-Blodgett(LB)*** amphiphiles composed of polyhedral oligomeric silsesquioxanes(POSS)derivatives and poly(ethylene oxide)(PEO),with structural diversities of POSS head modification,POSS head number,PEO chain length,are precisely *** effect of molecular structures and operation parameters on the fractal growth patterns are discussed,in addition,other fractal growth patterns in LB films and in Langmuir films are included,aiming to understand the basic molecular principle of fractal growth in LB system.

关键词： Fractal growth Langmuir-Blodgett(LB)film Langmuir film Giant amphiphiles Poly(ethylene oxide)(PEO)crystallization

Time course analysis of sensory axon regeneration in vivo by directly tracing regenerating axons

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Neural Regeneration Research 2020年第6期15卷 1160-1165页

作者： Yan Gao Yi-Wen Hu Run-Shan Duan shu-guang yang Feng-Quan Zhou Rui-Ying Wang Guilin Medical University GuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedic Surgery Affiliated Hospital of Guilin Medical UniversityGuilinGuangxi Zhuang Autonomous RegionChina Department of Orthopedics Henan Provincial People’s HospitalPeople’s Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Orthopedic Surgery Johns Hopkins University School of MedicineBaltimoreMDUSA

Most current studies quantify axon regeneration by immunostaining regeneration-associated proteins,representing indirect measurement of axon lengths from both sensory neurons in the dorsal root ganglia and motor neurons in the spinal *** recently developed method of in vivo electroporation of plasmid DNA encoding for enhanced green fluorescent protein into adult sensory neurons in the dorsal root ganglia provides a way to directly and specifically measure regenerating sensory axon lengths in whole-mount nerves.A mouse model of sciatic nerve compression was established by squeezing the sciatic nerve with *** DNA carrying enhanced green fluorescent protein was transfected by ipsilateral dorsal root ganglion electroporation 2 or 3 days before *** distribution of dorsal root or sciatic nerve was observed by confocal *** 12 and 18 hours,and 1,2,3,4,5,and 6 days of injury,lengths of regenerated axons after sciatic nerve compression were measured using green fluorescence ***-related protein caspase-3 expression in dorsal root ganglia was determined by western blot *** found that in vivo electroporation did not affect caspase-3 expression in dorsal root *** root ganglia and sciatic nerves were successfully removed and subjected to a rapid tissue clearing *** soma in dorsal root ganglia expressing enhanced green fluorescent protein or fluorescent dye-labeled microRNAs were imaged after tissue *** results facilitate direct time course analysis of peripheral nerve axon *** study was approved by the Institutional Animal Care and Use Committee of Guilin Medical University,China(approval ***201503010)on March 7,2014.

关键词： axon regeneration cell apoptosis dorsal root ganglion in vivo electroporation micro RNAs peripheral nervous system sciatic nerve tissue clearing

Metamorphic P-T conditions and ages of garnet-biotite schists in the Dahongshan Group from the southwestern yangtze Block

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Acta Geochimica 2024年第4期43卷 707-718页

作者： Jun-xiao Ma guang-shu yang Yong-feng Yan Xiao-Fei Xu Yun-hua Ren Hui Zhao Xiao-jun Zheng Yuan Qin Faculty of Land Resources Engineering Kunming University of Science and TechnologyKunming 650093China Geological Team 306 of Yunnan Non-Ferrous Metals Geological Bureau Kunming 650217China Yunnan Provincial Bureau of Non-Ferrous Geology Kunming 650051China

The Dahongshan Group,situated at the southwestern margin of the yangtze Block,represents a geological unit characterized by relatively high-grade metamorphism in the *** paper investigates the garnet-biotite schist from the Laochanghe Formation of the Dahongshan Group,employing an integrated approach that includes petrological analysis,phase equilibrium modeling,and zircon U-Pb *** schist is mainly composed of garnet,biotite,plagioclase,quartz,rutile,and *** equilibrium modeling revealed the peak metamorphic conditions of 8-9 kbar and 635-675°*** further integrating the prograde metamorphic profile of garnet and geothermobarometric results,a clockwise P-T metamorphic evolution path is constructed,which includes an increase in temperature and pressure during the prograde ***-ICP-MS zircon U-Pb dating and zircon Ti thermometry constrains the post-peak metamorphic age of 831.2±7.2 *** with previously reported results,it is revealed that the southwestern margin of the yangtze Block experienced a large-scale regional metamorphism during the Neoproterozoic(890-750 Ma),which is related to the collisional orogenic *** may be associated with the late-stage assembly of the Rodinia supercontinent or with local compression and subduction processes during the breakup of the Rodinia supercontinent.

关键词： Southwestern yangtze Block Dahongshan Group Phase equilibrium modeling Zircon U-Pb dating Neoproterozoic metamorphism

链间氢键调控对聚丙烯酸-聚氧化乙烯复合物薄膜力学性能的影响

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高分子学报 2019年第8期50卷 857-862页

作者：李皆富杨曙光纤维材料改性国家重点实验室东华大学材料科学与工程学院先进低维材料中心

采用可调节式涂膜器制备了聚丙烯酸(PAA)和聚氧化乙烯(PEO)复合物薄膜.通过改变薄膜组分和酸处理调控PAA与PEO间氢键相互作用.利用傅里叶红外光谱、示差扫描量热仪、X射线衍射仪和力学拉伸仪对氢键相互作用、薄膜聚集态结构和力学性能... 详细信息

采用可调节式涂膜器制备了聚丙烯酸(PAA)和聚氧化乙烯(PEO)复合物薄膜.通过改变薄膜组分和酸处理调控PAA与PEO间氢键相互作用.利用傅里叶红外光谱、示差扫描量热仪、X射线衍射仪和力学拉伸仪对氢键相互作用、薄膜聚集态结构和力学性能进行表征.研究结果表明,氢键相互作用的强弱影响着材料的聚集态结构和力学性能,当PAA与PEO分子间相互作用较弱时,PEO结晶,薄膜呈现塑形材料的性质,当PAA与PEO分子间相互作用较强时,氢键能完全抑制PEO结晶,薄膜呈现高弹性.

关键词：高弹性氢键高分子复合物