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Advances in the research of plant-derived natural products against retinoblastoma

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International Journal of Ophthalmology(English edition) 2022年第8期15卷 1391-1400页

作者： Jing-Chen Liu Chun-Li Zhang Kai-Ye Dong Ming-Jun Li shu-guang sun Cai-Rui Li Department of Ophthalmology Jiangxi Provincial Hospital of Integrated Traditional Chinese and Western Medicinethe Fourth Affiliated Hospital of Jiangxi University of Traditional Chinese MedicineNanchang 330003Jiangxi ProvinceChina School of Clinical Medicine Dali UniversityDali 671000Yunnan ProvinceChina School of Clinical Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330006Jiangxi ProvinceChina Department of Ophthalmology General Hospital of Southern Theatre CommandGuangzhou 510010Guangdong ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina Department of Endocrinology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina

Retinoblastoma(RB)is a highly aggressive ocular tumor,and due to socioeconomic and medical constraints,many children receive treatment only in the metaphase and advanced clinical stages,resulting in high rates of blindness and *** several approaches exist in the treatment of RB,some children with the disease do not have satisfactory results because of various *** natural products have shown definite therapeutic effects in the treatment of various tumors and are also widely used in the study of *** review plant-derived natural products used in the study of anti-RB to provide ideas for the clinical application of these drugs and the development of new therapeutic drugs.

关键词： plant-derived retinoblastoma apoptosis cell cycle drug resistance

Anti-proliferation and apoptosis-inducing effects of sodium aescinate on retinoblastoma Y79 cells

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International Journal of Ophthalmology(English edition) 2020年第10期13卷 1546-1553页

作者： Lei Li Bing Xu Cai-Rui Li Miao-Miao Zhang Sheng-Jun Wu Wen-Jun Dang Jing-Chen Liu shu-guang sun Wei Zhao College of Clinical Medicine Dali UniversityDali 671000Yunnan ProvinceChina Department of Ophthalmology Fuling Central Hospital of Chongqing CityFuling 408000Chongqing ProvinceChina Department of Ophthalmology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina Department of Endocrinology the First Affiliated Hospital of Dali UniversityDali 671000Yunnan ProvinceChina

AIM:To investigate the anti-proliferation and apoptosisinducing effects of sodium aescinate(SA)on retinoblastoma Y79 cells and its ***:Y79 cells were cultured at different drug concentrations for different periods of time(24,48,and 72 h).The inhibitory effect of SA on proliferation of Y79 cells was detected by the cell counting kit-8(CCK-8)assay,and the morphology of Y79 cells in each group was observed under an inverted *** IC50 of 48 h was selected for subsequent *** pretreatment with SA for 24 and 48 h,cellular DNA distribution and apoptosis were detected by flow ***-time qunatitative polymerase chain reaction(RT-qPCR)and Western blot were used to assess changes in related genes(CDK1,CyclinB1,Bax,Bcl-2,caspase-9,caspase-8,and caspase-3).RESULTS:SA inhibited proliferation and induced apoptosis of Y79 cells in a time-dependent and concentrationdependent *** its intervention in the cell cycle pathway,SA can inhibit the expression of CDK1 and Cyclin B1 at the mRNA and protein levels,and block cells in the G2/M *** caspase-related apoptotic pathways,up-regulation of Bax and down-regulation of Bcl-2 caused caspase-9 to self-cleave and further activate ***’s more,the caspase-8-mediated extrinsic apoptosis pathway was activated,and the activated caspase-8 was released into the cytoplasm to activate caspase-3,which as a member of the downstream apoptotic effect group,initiates a caspase-cascade reaction that induces cell ***:SA inhibits the proliferation of Y79 cells by arresting the cell cycle at the G2/M phase,and induces apoptosis via the caspase-related apoptosis pathway,indicating that SA may have promising potential as a chemotherapeutic drug.

关键词： sodium aescinate retinoblastoma intrinsic apoptosis pathway extrinsic apoptosis pathway cell cycle arrest

A Mn-porphyrinic metal–organic framework immobilizing glucose oxidase for combined photodynamic/chemodynamic/starvation therapy

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Tungsten 2025年第1期7卷 183-194页

作者： Xin-Ran sun Hao-Ming Yuan Guo-Da Zhang Chao Wang shu-Juan sun Peng-Fei Shi Shandong Provincial Key Laboratory of Detection Technology for Tumor Markers School of Chemistry and Chemical Engineering Linyi University

The combination of photodynamic therapy（PDT） and chemodynamic therapy（CDT） in tumor treatment has attracted considerable ***,tumor hypoxia and glutathione（GSH） overproduction in the tumor tissue restricted the progress of their ***,a Mn-porphyrinic metal-organic framework（Mn-TCPP） was constructed by the one-pot method and further used for immobilizing glucose oxidase（GOx） to obtain GOx@*** would rapidly exhaust endogenous glucose into hydrogen peroxide（H2O2） and gluconic acid,thus shutting off the energy supply of tumor cells for starvation ***-TCPP catalyzed H2O2to produce oxygen,regulating the hypoxic tumor microenvironment and in turn improving1O2generation under laser ***,Mn-TCPP can reduce reactive oxygen species consumption owing to the redox reaction between Mn3+and GSH,thus greatly enhancing ***,benefiting from GOx-mediated starvation therapy,Mn2+produced by Mn3+reduction can react with sufficient intracellular H2O2to generate ·OH with high cytotoxicity through a Fenton-like *** treatment by GOx@Mn-TCPP under laser irradiation in vitro,the cell viability of 4T1 and A549 tumor cells reached to 20%,reflecting GOx@Mn-TCPP could give full play to the advantages of PDT/CDT/starvation *** results in vivo demonstrated that GOx@Mn-TCPP mediated synergistic cascade therapy could significantly inhibit tumor growth and improve the therapeutic effect.

关键词： Chemodynamic therapy Immobilizing enzyme Metal–organic frameworks Photodynamic therapy Starvation therapy

糖尿病和糖尿病视网膜病变相关的自然发病啮齿动物模型(英文)

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国际眼科杂志 2010年第3期10卷 417-420页

作者：李才锐孙曙光澳大利亚狮子眼科研究所分子眼科中心云南大理学院附属医院眼科中国云南省大理市2671000

糖尿病是一种复杂的异质性疾病,目前世界各地有超过一亿人感染此病,造成极其严重社会和经济问题。自然发病的糖尿病啮齿动物模型对于糖尿病发病机制,糖尿病并发症和增加糖尿病危险性的遗传或环境影响等的研究有着无可比拟的重要作用。... 详细信息

糖尿病是一种复杂的异质性疾病,目前世界各地有超过一亿人感染此病,造成极其严重社会和经济问题。自然发病的糖尿病啮齿动物模型对于糖尿病发病机制,糖尿病并发症和增加糖尿病危险性的遗传或环境影响等的研究有着无可比拟的重要作用。我们综述了与糖尿病视网膜病变相关的自然发病啮齿动物模型的发生发展和其特性特点。

关键词：啮齿模型糖尿病糖尿病视网膜病变

NOD小鼠视网膜VEGF表达和视网膜细胞凋亡(英文)

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国际眼科杂志 2010年第8期10卷 1459-1462页

作者：李才锐孙曙光云南大理学院附属医院眼科中国云南省大理市671000

目的:研究NOD小鼠早期糖尿病视网膜VEGF表达和视网膜细胞凋亡情况,以及二者间的关系。方法:NOD小鼠分为对照组(非糖尿病小鼠)(2,4,6,8,12wk组,n=30)和糖尿病组(2,4,6,8,12wk组,n=30)。每组小鼠在规定时间处死,提取血液标本,摘除眼球,分... 详细信息

目的:研究NOD小鼠早期糖尿病视网膜VEGF表达和视网膜细胞凋亡情况,以及二者间的关系。方法:NOD小鼠分为对照组(非糖尿病小鼠)(2,4,6,8,12wk组,n=30)和糖尿病组(2,4,6,8,12wk组,n=30)。每组小鼠在规定时间处死,提取血液标本,摘除眼球,分离视网膜备用。ELISA法检测视网膜VEGF和血液VEGF。透射电子显微镜检测小鼠视网膜细胞凋亡情况。结果:糖尿病组血液和视网膜VEGF表达与对照组相比明显增高(12wk,血液标本:4.9±0.4μg/gvs0.19±0.1μg/g,P<0.01;视网膜,165.0±9.0μg/gvs18.0±4.0μg/g,P<0.01)。NOD小鼠早期糖尿病视网膜VEGF表达和血液VEGF表达呈正相关(γ=0.9902,P=0.001)。糖尿病组视网膜神经节细胞和血管内皮细胞凋亡明显增加P<0.01。结论:视网膜VEGF表达增加可能与视网膜凋亡增多有关。早期糖尿病NOD小鼠视网膜VEGF表达增加是多因素的。

关键词：视网膜凋亡血管内皮细胞 NOD小鼠

Control Law Design of Aircraft Super-maneuverable Flight Based on Dynamic Surface Backstepping Control

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Control Law Design of Aircraft Super-maneuverable Flight Bas...

玻璃体腔内注射贝伐单抗对增生性糖尿病视网膜病变玻璃体手术的影响(英文)

2009中国控制与决策会议

作者： LIU shu-guang,sun Xiu-xia,DONG Wen-han,SONG Hong-fei Engineering Institute,Air Force Engineering University,Xi''an 710038

＜正＞It proposed a dynamic surface backstepping control for super-maneuverable *** contrast to the basic backstepping method,our scheme abandons the adaptive laws,and introduces sliding surfaces and reaching conditions to design the virtual control signal and the final control ***,instead of involving model differentiation,a low pass dynamic filter is used in the two steps backstepping design,which provides a more simplified control algorithm. The simulation results show that the new scheme achieves a simple design procedure and a satisfying tracking performance.

关键词： Adaptive Control Super-maneuver Flight Flight Control Dynamic Surface Control Backstepping

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国际眼科杂志 2010年第9期10卷 1654-1656页

作者：李才锐孙曙光洪卫云南大理学院附属医院眼科中国云南省大理市671000

目的:评估术前1wk玻璃体腔内注射贝伐单抗对增生性糖尿病视网膜病变(PDR)玻璃体手术(PPV)的效果。方法:对46例PDR患者进行回顾性研究,46例患者随机分为玻璃体手术(PPV)组(n=28)和IVB组(n=18,PPV术前注射贝伐单抗)。玻璃体术前1wk注射贝... 详细信息

目的:评估术前1wk玻璃体腔内注射贝伐单抗对增生性糖尿病视网膜病变(PDR)玻璃体手术(PPV)的效果。方法:对46例PDR患者进行回顾性研究,46例患者随机分为玻璃体手术(PPV)组(n=28)和IVB组(n=18,PPV术前注射贝伐单抗)。玻璃体术前1wk注射贝伐单抗,比较两组间视力,医源性视网膜裂孔发生率,术中和术后出血情况。结果:术后1mo,PPV组和IVB组视力都明显提高(82.1%对88.9%)(P<0.01),两组间并无明显差异。医源性视网膜裂孔发生率PPV组18例,IVB组4例(64.3%对22.2%)(P<0.05)。术中出血PPV组28例,IVB组7例(100%对39%)(P<0.01),术后出血PPV组9例,IVB组0例(32.1%对0)(P<0.01)。结论:术前注射贝伐单抗可以减少增生性糖尿病视网膜病变玻璃体手术中医源性视网膜裂孔、术中出血和术后出血发生率。

关键词：贝伐单抗血管内皮细胞生长因子增生性糖尿病视网膜病变玻璃体切除手术

Trimetallic mesoporous PdCuRu for efficient formate electrosynthesis from polyethylene terephthalate recycling

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Science China Chemistry 2025年

作者： Yuting Li Huiqin Yao Lizhi sun shu Han Xiaoxiang Xu guangyin Fan Ben Liu College of Chemistry and Materials Science Sichuan Normal University Key Laboratory of Green Chemistry and Technology of Ministry of Education College of Chemistry Sichuan University School of Basic Medical Sciences Ningxia Medical University Department of Otorhinolaryngology-Head and Neck Surgery Zhongnan Hospital of Wuhan University

Electrochemical recycling of waste polyethylene terephthalate（PET） plastics represents a green and sustainable route to produce valuable fuels and address serious environmental issues. Despite some encouraged achievements, their progress is still slower because of the lack of highly active and selective electrocatalysts. Here, we reported an efficient PET recycling route with trimetallic PdCuRu mesoporous nanospheres（MSs） as a high-performance electrocatalyst that achieved selective electrosynthesis of valuable formate from PET hydrolysate（PETH） electrooxidation. Penetrated metal mesopores and trimetallic compositions of PdCuRu MSs synergistically optimized electronic structures of Pd sites and changed chemisorption properties of intermediates, which disclosed a high formate Faradic efficiency of 97% and impressive yield rate of 0.49 mmol h-1cm-2in an alkaline solution. Meanwhile, this electrocatalyst held good electrocatalytic stability, retaining high formate Faradic efficiency and yield rate even being performed for 10 cycles, which highlighted its potential applications for practical PET recycling. Our study provides a powerful strategy for designing high-performance electrocatalysts toward selective electro-synthesis of valuable fuels from various waste plastics.

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醛糖还原酶在糖尿病视网膜病变中作用的研究进展

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国际眼科杂志 2015年第7期15卷 1176-1178页

作者：李宏哲李才锐孙曙光大理大学附属医院眼科中国云南省大理市671000 大理大学附属医院内分泌科中国云南省大理市671000

醛糖还原酶(aldose reductase,AR)属于烟酰胺腺嘌呤二核苷酸(nicotinamide-adenine dinudeotide phosphate,NADPH)依赖性的醛-酮还原酶超家族,是多元醇代谢通路中的关键限速酶,在机体高糖代谢中发挥重要作用。AR广泛存在于肾脏、血管、... 详细信息

醛糖还原酶(aldose reductase,AR)属于烟酰胺腺嘌呤二核苷酸(nicotinamide-adenine dinudeotide phosphate,NADPH)依赖性的醛-酮还原酶超家族,是多元醇代谢通路中的关键限速酶,在机体高糖代谢中发挥重要作用。AR广泛存在于肾脏、血管、晶状体、视网膜、心脏、骨骼肌等组织器官中,催化葡萄糖转化为不易通透细胞膜的山梨醇,使细胞肿胀、变性、坏死,与糖尿病慢性并发症的发生发展有密切关系。糖尿病视网膜病变(diabetic retinopathy,DR)为多因素疾病,目前确切的病因尚不清楚,但多元醇代谢通路被证实在DR发病机制中发挥重要作用。临床工作中控制血糖、血压等危险因素的治疗方案对于DR的病情缓解仅有部分疗效或无效,如果能明确与DR病情相关的基因,将有助于更好地理解其病理机制,有助于新治疗方法及药物的研制。本文就目前AR及其基因多态性在DR中的作用和AR抑制剂的临床应用进行综述。

关键词：醛糖还原酶醛糖还原酶抑制剂糖尿病视网膜病变多元醇代谢通路基因多态性