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Life's essential 8 and risk of subclinical atherosclerosis progression: a prospective cohort study

Journal of Geriatric Cardiology 2024年第7期21卷 751-759页

作者： Shi-Yu ZHOU Fang-Chao LIU shu-feng chen Jian-Xin LI Jie CAO Ke-Yong HUANG Zheng-Hao TANG feng-Chao LIANG Dong-Sheng HU Lian-cheng ZHAO Ying LI Jian-feng HUANG Xiang-feng LU Bin LU Dong-feng GU Department of Epidemiology&Key Laboratory of Cardiovascular Epidemiology State Key Laboratory of Cardiovas-cular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina School of Public Health and Emergency Management School of Medi-cineSouthern University of Science and TechnologyShenzhenChina Department of Epidemiology and Health Stat-istics School of Public HealthZhengzhou UniversityZhengzhouChina Department of Biostatistics and Epidemi-ology School of Public HealthShenzhen University Health Science CenterShenzhenChina Department of Radi-ology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijingChina

BACKGROUND Previous studies have demonstrated the benefits of ideal cardiovascular health(CVH) in reducing cardiovascular ***,its role in subclinical atherosclerosis(SA) progression remains *** aim to examine the association of CVH,estimated by the American Heart Association's new Life's Essential 8(LE8),with the progression of *** This prospective cohort study was conducted among 972 asymptomatic Chinese participants and followed up for5.7 *** LE8 score(range,0–100) consisted of blood pressure,lipids,glucose,body mass index,smoking status,diet health,physical activity and sleep health was evaluated in 1998 and 2008–*** of SA was determined by carotid plaque and coronary artery calcification(CAC) in 2008–2009 and 2013–***-binomial regression model was used to estimate the association of LE8 score with SA *** Each 10 points increment in LE8 score was associated with 15.2%(RR:0.848,95% CI:0.797–0.902),17.7%(RR:0.823,95% CI:0.766–0.884) and 12.0%(RR:0.880,95% CI:0.845–0.916) lower risks of carotid plaque,CAC and overall SA progression,*** with participants with non-ideal CVH at both visits,the participants with ideal CVH at both visits had39.1%(RR:0.609,95% CI:0.494–0.752),41.0%(RR:0.590,95% CI:0.456–0.764) and 29.7%(RR:0.703,95% CI:0.598–0.825) lower risks of carotid plaque,CAC and overall SA progression,*** Higher LE8 scores were associated with lower risks of SA ***,long-term maintenance of optimal CVH was more beneficial to prevent SA progression.

关键词： atherosclerosis prospective cardiovascular

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Stiff-stilbene derivatives as new bright fluorophores with aggregation-induced emission

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Science China Chemistry 2019年第9期62卷 1194-1197页

作者： Ya-Hang Wu Kun Huang shu-feng chen Yu-Zhe chen chen-Ho Tung Li-Zhu Wu Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 China University of the Chinese Academy of Sciences Beijing 100049 China College of Chemistry and Chemical Engineering Inner Mongolia University Hohhot 010021 China

Stiff-stilbene derivatives have been widely explored as molecular rotors, molecular force probes and optical switches with excellent performance. However, their function as fluorophores is poorly understood. In the present work, we design three stiffstilbene derivatives and study their photophysical properties. These compounds exhibit very weak emission in solution but significantly enhanced monomer emission in viscous solvent, bright excimer emission in aggregates and at solid state. Detailed spectroscopic studies, single crystal structural analysis, powder X-ray diffraction(XRD) as well as effects of substituents have been carefully examined. They provide direct evidence that intermolecular interactions and molecular packing, which can restrict bond vibration and rotation, are responsible for the bright aggregation-induced emission.

关键词： stiff-stilbene derivatives intermolecular interactions molecular packing aggregation-induced emission

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Calculations of the 3-D neutronics for CH HCSB TBM with 3×3 sub-modules

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核聚变与等离子体物理 2006年第3期26卷 170-175页

作者： ZHANG Guo-shu feng Kai-ming chen Rong-guang YUAN Tao LI Zeng-qiang Southwestern Institute of Physics Chengdu 610041

Using three dimension MCNP code and FENDL2.0 data library, neutronics calculation for a HCSB (helium cooling solid breeder ) TBM ( test blanket module ) with 3×3 sub-modules has been performed. Local tritium breeding ratio (TBR) of 0.907, total tritium generation rate of 0.0175 g· d-1, peak power density of 9.27MW· m-3 and total power deposit of 0.422MW·m-3 are obtained under neutron wall loading of 0.78MW·m-2 and duty factor of 22%.

关键词：融化覆盖中子物理 TBR 再生区

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Concise Synthesis of(±)-epi-Chrysotricine

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Chinese Chemical Letters 2001年第3期12卷 199-202页

作者： Guang Xing WANG Jing Xin ZHANG shu feng chen Xiao Tian LIANG Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

epi-Chrysotricine 6 was synthesized by a cascade stereoselective oxidative cyclization of 5-hydroxyalkene 3 using tert-butyl hydroperoxide(TBHP) catalyzed by VO(acac)2.

关键词： (±)-epi-chrysotricine dilithium salt of harman VO(acac)2 TBHP oxidation

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Common SNPs of APM1 Gene Are Not Associated With Hypertension or Obesity in Chinese Population

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Biomedical and Environmental Sciences 2006年第3期19卷 179-184页

作者： WEI-LI YAN shu-feng chen JIAN-feng HUANG YAN SHENA BO-QIN QIANG DONG-HAI LIU DONG-feng GU Division of Population Genetics and Prevention Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College 167 Beilishi Road Beijing 100037 China National Human Genome Center North Yongchang Rd 3-707 Beijing 100176 China

Objective To investigate whether the common variants 45T/G and 276G/T in APM1 gene were associated with hypertension combined with obesity （HO） and related clinical features in Chinese Han population. Methods A case-control study design was applied. Common polymorphisms of 45T/G and 276G/T were genotyped by PCR product sequencing in 484 cases with HO and 502 controls with normal blood presure and BMI 〈 25. Results The genotype and allele frequencies of 45T/G, 276G/T, and haplotype defined by the two variants in cases did not differ from those in controls. The means of blood pressure, BMI and waist-hip ratio did not differ among genotypes of the two polymorphisms and haplotypes. Among lipid profiles, only serum high-density lipoprotein cholesterol （HDL-C） levels were significantly lower in T allele carders than that in non-T carriers after adjusting possible confounding factors （1.21 vs 1.32 mmol/L, P=0.0001）. Condusion Polymorphisms of 45T/G and 276G/T in APM1 gene are not associated with hypertension or obesity, or their clinical features in Chinese Han population. Common polymorphism of 45T/G might be associated with serum HDL-C levels in Chinese.

关键词： Adiponectin HDL-C Hypertension Obesity

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Association of the Apolipoprotein B Gene Polymorphisms With Essential Hypertension in Northern Chinese Han Population

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Biomedical and Environmental Sciences 2007年第3期20卷 260-264页

作者： WEI-YAN ZHAO JIAN-feng HUANG LAI-YUAN WANG HONG-FAN LI PENG-HUA ZHANG QI ZHAO shu-feng chen DONG-feng GU Department of Evidence Based Medicine and Division of Population Genetics Cardiovascular Institute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China National Human Genome Center Beijing 100176 China

Objective To study the association of the apolipoprotein B gene polymorphisms with essential hypertension in Northern Chinese Han population. Methods XbaI and EcoRl polymorphisms of the apolipoprotein B （APOB） gene were genotyped by polymerase chain reaction （PCR） and restriction fragment-length polymorphism （RFLP） method in 503 unrelated hypertensive patients and 490 healthy controls recruited from international collaborative study of cardiovascular disease in Asia （InterAsia）. Results The difference in the genotypic distributions could be neglected across the groups. The prevalence of X＋ allele in healthy controls （4.8%） was less frequent in Chinese, and there was no significant difference in the frequency of the X＋ allele between cases （5.7%） and controls （P=0.38）. The observed E- allele frequencies were closely similar among groups （5.9% in cases vs 5.0% in controls, P=0.39）. Logitstic regression analyses revealed that the lack of association still persisted after adjustment of other environmental factors. Haplotype analysis showed that X-E＋ was most frequent and no haplotype could significantly contribute to essential hypertension. Conclusion The APOB gene XbaI and EcoRI polymorphisms are not associated with essential hypertension in the Northern Chinese Han population. Future studies on single nucleotide polymorphisms in larger samples are needed to further investigate the possible contribution of the APOB gene to essential hypertension.

关键词： Essential hypertension APOB gene Polymorphisms Case-control study

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The Effect of Total Cholesterol on Myocardial Infarction in Chinese Male Hypertension Population

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Biomedical and Environmental Sciences 2010年第1期23卷 37-41页

作者： JIAN-XIN LI JIE CAO XIANG-feng LU shu-feng chen DA-HAI YU XIU-FANG DUAN XI-GUI WU DONG-feng GU Department of Evidence Based Medicine Cardiovascular lnstitute and Fuwai Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beo'ing 100037 China

Objective Total cholesterol （TC） is an important risk factor for myocardial infarction （M1）, but the effect of TC on MI in Chinese male hypertension population has not been well documented. We conducted a prospective cohort study to determine the incidence and relative risk for M1 across a wide range of TC levels in Chinese male hypertension population. Methods A cohort of 5 298 male employees aged 18-74 years recruited from Capital Steel and Iron Company in Beijing of China in 1974-1980 was followed up for an average of 20.84 years. A total of 122 incident M1 cases were identified during the period of follow-up. Results The incidence of MI among participants with elevated TC and those with desirable TC in male non-hypertension population was 137.20 and 63.81 per 100 000 person-years, respectively; and the corresponding incidence in male hypertension population was 279.80 and 130.96 per 100 000 person-years, respectively. After adjustment for important covariables, 10.38%, 16.71%, and 23.80% of M1 cases were attributable to hypertension, elevated TC, and hypertension plus elevated TC, respectively. In male hypertension population, the multivariate adjusted hazard ratios of MI were 1.21, 2.39, 3.38, and 3.95 for participants with TC level of 5.17-5.68, 5.69-6.20, 6.21-6.71, and ≥6.72 mmol/L, compared with those with TC〈5.17 mmol/L. The corresponding population attributable risks were 2.92%, 9.20%, 8.87%, and 9.84%, respectively. Conclusion Elevated TC is an important independent risk factor of M1 both in male non-hypertension and hypertension populations. There is a linear association between TC level and M1 incidence in Chinese male hypertension population.

关键词： Hypertension Cholesterol Myocardial infarction Cohort studies

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Towards complex scenes: A deep learning-based camouflaged people detection method for snapshot multispectral images

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Defence Technology（防务技术） 2024年第4期34卷 269-281页

作者： shu Wang Dawei Zeng Yixuan Xu Gonghan Yang feng Huang Liqiong chen School of Mechanical Engineering and Automation Fuzhou UniversityFuzhou 350108China

Camouflaged people are extremely expert in actively concealing themselves by effectively utilizing cover and the surrounding environment. Despite advancements in optical detection capabilities through imaging systems, including spectral, polarization, and infrared technologies, there is still a lack of effective real-time method for accurately detecting small-size and high-efficient camouflaged people in complex real-world scenes. Here, this study proposes a snapshot multispectral image-based camouflaged detection model, multispectral YOLO(MS-YOLO), which utilizes the SPD-Conv and Sim AM modules to effectively represent targets and suppress background interference by exploiting the spatial-spectral target information. Besides, the study constructs the first real-shot multispectral camouflaged people dataset(MSCPD), which encompasses diverse scenes, target scales, and attitudes. To minimize information redundancy, MS-YOLO selects an optimal subset of 12 bands with strong feature representation and minimal inter-band correlation as input. Through experiments on the MSCPD, MS-YOLO achieves a mean Average Precision of 94.31% and real-time detection at 65 frames per second, which confirms the effectiveness and efficiency of our method in detecting camouflaged people in various typical desert and forest scenes. Our approach offers valuable support to improve the perception capabilities of unmanned aerial vehicles in detecting enemy forces and rescuing personnel in battlefield.

关键词： Camouflaged people detection Snapshot multispectral imaging Optimal band selection MS-YOLO Complex remote sensing scenes

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Associations of tea consumption with blood pressure progression and hypertension incidence

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Journal of Geriatric Cardiology 2021年第8期18卷 645-653页

作者： Xiao-Ge NIU Can CAI Fang-Chao LIU Jian-Xin LI Ke-Yong HUANG Xue-Li YANG Jie CAO shu-feng chen Hong-Fan LI Chong SHEN Ying-Xin ZHAO Dong-Sheng HU shu-Jun GU Jian-feng HUANG Xiang-feng LU Dong-feng GU Department of Epidemiology State Key Laboratory of Cardiovascular DiseaseFuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Tianjin Key Laboratory of Environment Nutrition and Public HealthDepartment of Occupational and Environmental HealthSchool of Public HealthTianjin Medical UniversityTianjinChina Department of Epidemiology and Biostatistics School of Public HealthNanjing Medical UniversityNanjingChina Cardio-Cerebrovascular Control and Research Center Institute of Basic MedicineShandong First Medical University(Shandong Academy of Medical Sciences)JinanChina Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityHenanChina Department of Biostatistics and Epidemiology School of Public HealthShenzhen University Health Science CentreShenzhenChina Changshu Center for Disease Control and Prevention JiangsuChina School of Medicine Southern University of Science and TechnologyShenzhenChina

BACKGROUND Association between tea consumption and incident hypertension remains *** study conducted to examine the health effects of tea consumption on blood pressure progression and hypertension *** A population-based cohort of 38,913 Chinese participants without hypertension at baseline were included in the current *** on tea consumption was collected through standardized *** of tea consump-tion with blood pressure progression and incident hypertension were analyzed using logistic regression models and Cox propor-tional hazards regression models,*** During a median follow-up of 5.9 years,17,657 individuals had experienced progression to a higher blood pressure stage and 5,935 individuals had developed *** multivariate analyses,habitual tea drinkers(≥3 times/week for at least six months)had a 17%lower risk for blood pressure progression[odds ratio(OR)=0.83,95%CI:0.79-0.88]and a 14%de-creased risk for incident hypertension[hazard ratio(HR)=0.86,95%CI:0.80-0.91]compared with non-habitual tea ***-dividuals in different baseline blood pressure groups could obtain similar benefit from habitual tea *** terms of tea con-sumption amount,an inverse,linear dose-response relation between monthly consumption of tea leaves and risk of blood pres-sure progression was observed,while the risk of incident hypertension did not reduce further after consuming around 100 g of tea leaves per *** Our study demonstrated that habitual tea consumption could provide preventive effect against blood pres-sure progression and hypertension incidence.

关键词： hypertension progression consuming

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Near-zero-adhesion-enabled intact wafer-scale resist-transfer printing for high-fidelity nanofabrication on arbitrary substrates

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International Journal of Extreme Manufacturing 2024年第1期6卷 313-326页

作者： Zhiwen shu Bo feng Peng Liu Lei chen Huikang Liang Yiqin chen Jianwu Yu Huigao Duan College of Mechanical and Vehicle Engineering National Engineering Research Centre for High Efficiency GrindingHunan UniversityChangsha 410082People’s Republic of China Greater Bay Area Institute for Innovation Hunan UniversityGuangzhou 511300People’s Republic of China School of Mechanical Engineering Hunan University of Science and TechnologyXiangtan 411201People’s Republic of China Shenzhen Research Institute Hunan UniversityShenzhen 518000People’s Republic of China

There is an urgent need for novel processes that can integrate different functional nanostructures onto specific substrates,so as to meet the fast-growing need for broad applications in nanoelectronics,nanophotonics,and fexible *** direct-lithography methods are difficult to use on fexible,nonplanar,and biocompatible ***,this fabrication is usually accomplished by nanotransfer ***,large-scale integration of multiscale nanostructures with unconventional substrates remains challenging because fabrication yields and quality are often limited by the resolution,uniformity,adhesivity,and integrity of the nanostructures formed by direct ***,we proposed a resist-based transfer strategy enabled by near-zero adhesion,which was achieved by molecular modification to attain a critical surface energy *** approach enabled the intact transfer of wafer-scale,ultrathin-resist nanofilms onto arbitrary substrates with mitigated cracking and wrinkling,thereby facilitating the in situ fabrication of nanostructures for functional *** this approach,fabrication of three-dimensional-stacked multilayer structures with enhanced functionalities,nanoplasmonic structures with~10 nm resolution,and MoS2-based devices with excellent performance was demonstrated on specific *** results collectively demonstrated the high stability,reliability,and throughput of our strategy for optical and electronic device applications.

关键词： resist-based transfer printing near-zero adhesion critical surface energy wafer-scale nanofabrication in situ fabrication optoelectronic devices

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