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Bcl-2 Interacts with Beclin 1 and Regulates Autophagy in 7,12- Dimethylbenz[a]anthracene-Induced Hamster Buccal-Pouch Squamous-Cell Tumorigenesis

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Current Medical Science 2021年第6期41卷 1198-1204页

作者： Qian liU Yang liU shu-e li Jin-huan GeNG Department of Stomatology Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430000China

Objective:Autophagy is a programmed cell death procedure,which has essential functions in ***,its temporal expression and function under different status are yet to be *** study aims to investigate the temporal expression of autophagy and its possible function in 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal-pouch cancer model(HBPCM).Methods:A total of 50 hamster buccal-pouch tumorigenesis models were established by painting DMBA for 4,8,10 and 13 *** expression and subcellular localization of LC3,Beclin 1 and Bcl-2 in buccal lesions were evaluated by immunohistochemical staining and Western *** damage was observed by immunohistochemical staining of *** relationship between Beclin 1 and Bcl-2 was analyzed by immunofluorescence ***:The expression levels of LC3 and Beclin 1 associated with autophagy in the experimental buccal pouch of HBPCM were significantly upregulated after 4 weeks(Pegulated after 13 weeks of HBPCM *** contrast,the expression level of Bcl-2 was significantly upregulated after 13 *** co-localized regions of Bcl-2 and Beclin 1 peaked after 4 weeks and then decreased *** DNA damage in epithelial cells increased slightly after 4 weeks,and then rapidly decreased over the next 2 ***:Autophagy is motivated by a tumor suppressor that diminishes carcinogen-induced DNA ***,autophagy is gradually suppressed,which may be attributed to the interaction between Bcl-2 and Beclin *** result indicates that the promotion of autophagy may suppress malignant transformation and provide new insights on future potential treatments of HBPCM.

关键词： tumorigenesis autophagy DNA damage Beclin 1 and Bcl-2

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A high li-ion diffusion kinetics in multidimensional and compact-structured electrodes via vacuum filtration casting

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Journal of energy Chemistry 2024年第6期93卷 368-376,I0010页

作者： Jieqiong li Ting Ouyang Lu liu shu Jiang Yongchao Huang M.-Sadeeq Balogun College of Materials Science and engineering Hunan Joint International Laboratory of Advanced Materials and Technology for Clean EnergyHunan UniversityChangsha 410082HunanChina Institute of environmental Research at Greater Bay Key Laboratory for Water Quality and Conservation of the Pearl River DeltaMinistry of EducationGuangzhou UniversityGuangzhou 510006GuangdongChina

Manufacturing process,diffusion co-efficient and areal capacity are the three main criteria for regulating thick electrodes for lithium-ion batteries(liBs).However,simultaneously regulating these criteria for liBs is desirable but remains a significant *** this work,niobium pentoxide(Nb_(2)O_(5))anode and lithium iron phosphate(liFePO_(4))cathode materials were chosen as the model materials and demonstrate that these three parameters can be simultaneously modulated by incorporation of micro-carbon fibers(MCF)and carbon nanotubes(CNT)with both Nb_(2)O_(5) and LFP via vacuum filtration *** as-prepared MNC-20 anode and MLC-20 cathode achieves high reversible areal capacity of≈5.4 m A h cm^(-2)@0.1 C and outstanding li-ion diffusion coefficients of≈10~(-8)cm~2 s~(-1)in the half-cell *** assembled MNC-20‖MLC-20 full cell liB delivers maximum energy and power densities of244.04 W h kg^(-1)and 108.86 W kg^(-1),*** excellent electrochemical properties of the asprepared thick electrodes can be attributed to the highly conductive,mechanical compactness and multidimensional mutual effects of the MCF,CNT and active materials that facilitates rapid li-ion diffusion ***,electrochemical impedance spectroscopy(eIS),symmetric cells analysis,and insitu Raman techniques clearly validates the enhanced li-ion diffusion kinetics in the present architecture.

关键词： Thick electrodes Carbon nanotubes li-ion diffusion co-efficient Vacuum filtration technique High areal capacity lithium-ion batteries

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Photosynthetic response dynamics in the invasive species Tithonia diversifolia and two co-occurring native shrub species under fluctuating light conditions

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Plant Diversity 2024年第2期46卷 265-273页

作者： Ju li shu-Bin Zhang Yang-Ping li CAS Key Laboratory of Tropical Forest ecology Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglunMengla 666303YunnanChina University of Chinese Academy of Sciences Beijing 100049China

To determine the invasiveness of invasive plants,many studies have compared photosynthetic traits or strategies between invasive and native ***,few studies have compared the photosynthetic dynamics between invasive and native species during light *** compared photosynthetic induction,relaxation dynamics and leaf traits between the invasive species,Tithonia diversifolia and two native species,Clerodendrum bungei and Blumea balsamifera,in full-sun and shady *** photosynthetic dynamics and leaf traits differed among *** showed a slower induction speed and stomatal opening response but had higher average intrinsic water-use efficiency than the two native species in full-sun ***,the slow induction response may be attributed to the longer stomatal length in *** had a significant effect on photosynthetic dynamics in *** and *** but not in *** shady habitat,*** had a faster photosynthetic induction response than in full-sun habitat,leading to a higher average stomatal conductance during photosynthetic induction in *** than in the two native *** contrast,*** had a larger stomatal length and slower photosynthetic induction and relaxation response in shady habitat than in full-sun habitat,resulting in higher carbon gain during photosynthetic ***,in both habitats,*** had an overall higher carbon gain during light fluctuations than the two native *** results indicated that *** can adopt more effective response strategies under fluctuating light environments to maximize carbon gain,which may contribute to its successful invasion.

关键词： Invasive plant Photosynthetic induction Photosynthetic relaxation Carbon gain Stomatal traits Tithonia diversifolia

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Machine Learning-based Identification of Contaminated Images in light Curve Data Preprocessing

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Research in Astronomy and Astrophysics 2024年第4期24卷 287-295页

作者： Hui li Rong-Wang li Peng shu Yu-Qiang li Yunnan Observatories Chinese Academy of SciencesKunming 650216China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Space Object and Debris Observation Chinese Academy of SciencesNanjing 210023China

Attitude is one of the crucial parameters for space objects and plays a vital role in collision prediction and debris *** light curves to determine attitude is the most commonly used *** photometric observations,outliers may exist in the obtained light curves due to various ***,preprocessing is required to remove these outliers to obtain high quality light *** statistical analysis,the reasons leading to outliers can be categorized into two main types:first,the brightness of the object significantly increases due to the passage of a star nearby,referred to as“stellar contamination,”and second,the brightness markedly decreases due to cloudy cover,referred to as“cloudy contamination.”The traditional approach of manually inspecting images for contamination is time-consuming and ***,we propose the utilization of machine learning methods as a *** Neural Networks and SVMs are employed to identify cases of stellar contamination and cloudy contamination,achieving F1 scores of 1.00 and 0.98 on a test set,*** also explore other machine learning methods such as ResNet-18 and light Gradient Boosting Machine,then conduct comparative analyses of the results.

关键词： techniques:image processing methods:data analysis light pollution

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Indian monsoon drove the dispersal of the thoracica group of Scytodes spitting spiders

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Zoological Research 2024年第1期45卷 152-159页

作者： Yu-Fa Luo shu-Qiang li School of life and environmental Sciences Shaoxing UniversityShaoxingZhejiang 312000China Key Laboratory of Zoological Systematics and evolution Institute of ZoologyChinese Academy of SciencesBeijing 100101China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

We examined the global biogeography of the Scytodes thoracica group of spitting spiders based on 23 years of sampling at the species level(61 species in the thoracica group and 84 species of Scytodes)using DNA data from six *** results indicated that the thoracica group initially dispersed from Southeast Asia to east Africa between 46.5 and 33.0 million years ago,and dispersal events intensified between Southeast/South Asia and east/South Africa from the early to late *** timing of these events indicates that Asian-African faunal exchange of the thoracica group was driven by the Indian monsoon,and the pattern of dispersal suggests that colonialization took root when the Indian monsoon shifted from a North-South direction to an east-West direction from the middle eocene.

关键词： Geological event Climate change Ballooning organism Faunal exchange Species distribution

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Influencing factors and risk prediction model for emergence agitation after general anesthesia for primary liver cancer

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World Journal of Gastrointestinal Surgery 2024年第7期16卷 2194-2201页

作者： shu-shu Song li lin li li Xiao-Dong Han Department of Anesthesia and Surgery Wenzhou Central HospitalWenzhou 325099Zhejiang ProvinceChina

BACKGROUND General anesthesia is commonly used in the surgical management of gastrointestinal tumors;however,it can lead to emergence agitation(eA).eA is a common complication associated with general anesthesia,often characterized by behaviors,such as crying,struggling,and involuntary limb movements in *** treatment is delayed,there is a risk of incision cracking and bleeding,which can significantly affect surgical ***,having a proper understanding of the factors influencing the occurrence of eA and implementing early preventive measures may reduce the incidence of agitation during the recovery phase from general anesthesia,which is beneficial for improving patient *** To analyze influencing factors and develop a risk prediction model for eA occurrence following general anesthesia for primary liver *** Retrospective analysis of clinical data from 200 patients who underwent hepatoma resection under general anesthesia at Wenzhou Central Hospital(January 2020 to December 2023)was ***-surgery,the Richmond Agitation-Sedation Scale was used to evaluate eA presence,noting eA incidence after general *** were categorized by eA presence postoperatively,and the influencing factors were analyzed using logistic regression.A nomogram-based risk prediction model was constructed and evaluated for differentiation and fit using receiver operating characteristics and calibration *** eA occurred in 51(25.5%)*** analysis identified advanced age,American Society of Anesthesiologists(ASA)grade Ⅲ,indwelling catheter use,and postoperative pain as risk factors for eA(Persely,postoperative analgesia was a protective factor against eA(Pe area under the curve of the nomogram was 0.972[95%confidence interval(CI):0.947-0.997]for the training set and 0.979(95%CI:0.951-1.000)for the test ***-Lemeshow test showed a good fit(χ^(2)=5.483,P=0.705),and calibration curves showed

关键词： Primary hepatocellular carcinoma resection General anesthesia emergence agitation Risk factors Forecast Nomograph

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A Semiparametric Additive-multiplicative Rates Model for the Weighted Composite endpoint of Recurrent and Terminal events

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Acta Mathematica Sinica,english Series 2024年第4期40卷 985-999页

作者： Yi DeNG Qiang XIONG shu Wei li School of economics and Statistics Guangzhou UniversityGuangzhou 510006P.R.China

Recurrent event data are commonly encountered in many scientific fields,including biomedical studies,clinical trials and epidemiological surveys,and many statistical methods have been proposed for their *** this paper,we consider to use a weighted composite endpoint of recurrent and terminal events,which is weighted by the severity of each event,to assess the overall effects of covariates on the two types of events.A flexible additive-multiplicative model incorporating both multiplicative and additive effects on the rate function is proposed to analyze such weighted composite event process,and more importantly,the dependence structure among the recurrent and terminal events is left *** the estimation,we construct the unbiased estimating equations by virtue of the inverse probability weighting technique,and the resulting estimators are shown to be consistent and asymptotically normal under some mild regularity *** evaluate the finite-sample performance of the proposed method via simulation studies and apply the proposed method to a set of real data arising from a bladder cancer study.

关键词： Additive-multiplicative rates model estimating equation recurrent events terminal event weighted composite endpoint

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OSMR is a potential driver of inflammation in amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第11期19卷 2513-2521页

作者： Wenzhi Chen Shishi Jiang shu li Cheng li Renshi Xu Department of Neurology Jiangxi Provincial People’s HospitalXiangya Hospital Jiangxi Hospital of Central South UniversityThe Clinical College of Nanchang Medical CollegeThe First Affiliated Hospital of Nanchang Medical CollegeNanchangJiangxi ProvinceChina

Amyotrophic lateral sclerosis is a neurodegenerative disease,and the molecular mechanism underlying its pathology remains poorly ***,inflammation is known to play an important role in the development of this *** identify driver genes that affect the inflammatory response in amyotrophic lateral sclerosis,as well as potential treatment targets,it is crucial to analyze brain tissue samples from patients with both sporadic amyotrophic lateral sclerosis and C9orf72-related amyotrophic lateral ***,in this study we used a network-driven gene analysis tool,NetBID2.0,which is based on SJARACNe,a scalable algorithm for the reconstruction of accurate cellular networks,to experimentally analyze sequencing data from patients with sporadic amyotrophic lateral *** results showed that the OSMR gene is pathogenic in amyotrophic lateral sclerosis and participates in the progression of amyotrophic lateral sclerosis by mediating the neuroinflammatory ***,there were differences in OSMR activity and expression between patients with sporadic amyotrophic lateral sclerosis and those with C9orf72-related amyotrophic lateral *** findings suggest that OSMR may be a diagnostic and prognostic marker for amyotrophic lateral sclerosis.

关键词： amyotrophic lateral sclerosis driver neuroinflammation OSMR C9ORF72 neurodegenerative disease pathogenesis oxidative stress protein misfolding mitochondrial dysfunction

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Unconventional Fluorescent and Multi-responsive Polysiloxane:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第5期42卷 579-590,I0006页

作者： Xiao-Di li shu-Sheng li Xu-Bao Jiang Xiao-li Zhu Xiang Zheng Kong College of Chemistry and Chemical engineering University of JinanJinan250022China College of Chemical engineering Tianjin UniversityTianjin300072China Foshan(Southern China)Institute for New Materials Foshan528200China

Owing to their high significance in fundamental study and diverse applications,stimuli-responsive and fluorescent polymers,particularly those with cluster-triggered emission(CTe)featured by non-conjugated chromophores,have drawn tremendous attention in recent *** this work,fluorescent and multi-responsive polysiloxane(FRPS)was synthesized by hydrolytic condensation polymerization of 3-aminopropyl methyl diethoxysilane(APMS)with 3-(N-isopropyl propionamide)iminopropyl methyl diethoxysilane(APMS-NIP),which was formed in situ through aza-Michael addition between APMS and N-isopropyl *** was not only highly sensitive to temperature,pH and CO_(2) in water,but also showed an enhanced and stimuli-adjustable fluorescence *** effects of monomer feeding,pH and CO_(2) on its lower critical solution temperature and fluorescent property were *** fluorescence emission was ascribed to CTe *** addition,FRPS was shown to be highly potential as physiological indicator for cell imaging,and for controlled release and trace detection of *** study provides therefore a type of stimuli-responsive and fluorescent material for potential applications in biomedical fields,and it is also of great significance for understanding of the fluorescence mechanism of polysiloxane-based stimuli-responsive polymers.

关键词： Polysiloxane Multi-responsiveness Cluster-triggered emission Cell imaging Controlled drug release

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Strong and tough chitin hydrogel constructed by dehydration and rehydration strategy

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Nano Research 2024年第9期17卷 8192-8199页

作者： Rui-Rui liu li-Bo Mao shu-Hong Yu Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the MicroscaleDepartment of ChemistryInstitute of Biomimetic Materials and ChemistryAnhui Engineering Laboratory of Biomimetic MaterialsUniversity of Science and Technology of ChinaHefei 230026China Institute of Innovative Materials Department of Materials Science and EngineeringDepartment of ChemistrySouthern University of Science and TechnologyShenzhen 518055China

As a renewable,biocompatible,biodegradable soft material,chitin hydrogels have better advantages in stability,antibacterial activity,antifouling,cost,immunogenicity,and so on than most polymer ***,compared with other widely used polymer hydrogels with high strength and toughness,the practical applications of chitin-based hydrogels have been limited by their weak mechanical properties,such as cartilage repair and meniscus ***,we present the design and fabrication of chitin hydrogels with excellent mechanical strength and toughness by a dehydration and rehydration *** sequential dehydration and rehydration processes,the crystalline domains in the chitin hydrogels can be properly *** optimized crystallinity,the elastic modulus of the chitin hydrogels exceeds all previously reported values,and the fracture toughness is even comparable to some synthetic polymer hydrogels,while maintaining a high-water-content of about 80 wt.%.At the same water content,the mechanical properties of the chitin hydrogels are positively correlated with the hydrogel crystallinity,which proves that the change of mechanical properties of hydrogels is not simply dependent on weight *** hydrogels can be further strengthened by incorporating other biopolymers that are intrinsically weak,which makes the hydrogels promising for applications in fields such as cartilage repair and meniscus ***,the hydrogels enable loading and release of water-soluble and poorly water-soluble *** highly extendable strengthening and toughening strategy of chitin and chitin-based biopolymer hydrogels paves the way for their widely applications.

关键词： chitin hydrogel crystallinity rehydration chemical transformation strong and tough

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