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Reversible Li plating regulation on graphite anode through a barium sulfate nanofibers-based dielectric separator for fast charging and high-safety lithium-ion battery

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Journal of Energy Chemistry 2025年第2期101卷 511-523页

作者： Yaxin Zhang long Cheng Ying-Jie Zhu Jin Wu Han-Ping Yu Sida Xie Dandan Li Zhaohui Wang Heng Li State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences College of Materials Science and Engineering Hunan University Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Poor Li plating reversibility and high thermal runaway risks are key challenges for fast charging lithiumion batteries with graphite ***,a dielectric and fire-resistant separator based on hybrid nanofibers of barium sulfate（BS） and bacterial cellulose（BC） is developed to synchronously enhance the battery's fast charging and thermal-safety *** regulation mechanism of the dielectric BS/BC separator in enhancing the Li+ion transport and Li plating reversibility is revealed.（1） The Max-Wagner polarization electric field of the dielectric BS/BC separator can accelerate the desolvation of solvated Li+ions,enhancing their transport kinetics.（2） Moreover,due to the charge balancing effect,the dielectric BS/BC separator homogenizes the electric field/Li+ion flux at the graphite anode-separator interface,facilitating uniform Li plating and suppressing Li dendrite ***,the fast-charge graphite anode with the BS/BC separator shows higher Coulombic efficiency（99.0% vs.96.9%） and longer cycling lifespan（100 cycles vs.59 cycles） than that with the polypropylene（PP） separator in the constantlithiation cycling test at 2 mA *** high-loading LiFePO4(15.5 mg cm-2)//graphite(7.5 mg cm-2) full cell with the BS/BC separator exhibits excellent fast charging performance,retaining 70% of its capacity after 500 cycles at a high rate of 2C,which is significantly better than that of the cell with the PP separator（retaining only 27% of its capacity after 500 cycles）.More importantly,the thermally stable BS/BC separator effectively elevates the critical temperature and reduces the heat release rate during thermal runaway,thereby significantly enhancing the battery's safety.

关键词： Fast charging Graphite anode Ion transport Lithium-ion battery Separator

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Metallized polymer current collector as “stress acceptor” for stable micron-sized silicon anodes

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Journal of Energy Chemistry 2025年第2期101卷 786-794页

作者： Ziyi Cao Haoteng Sun Yi Zhang Lixia Yuan Yaqi Liao Haijin Ji shuaipeng Hao Zhen Li long Qie Yunhui Huang State Key Laboratory of Material Processing and Die & Mold Technology School of Materials Science and Engineering Huazhong University of Science and Technology department of Chemistry Brown University

Micron-sized silicon（μSi） is a promising anode material for next-generation lithium-ion batteries due to its high specific capacity,low cost,and abundant ***,the volume expansion that occurs during cycling leads to the accumulation of undesirable stresses,resulting in pulverization of silicon microparticles and shortened lifespan of the ***,a composite film of Cu-PET-Cu is proposed as the current collector（CC） for μSi anodes to replace the conventional Cu ***-PET-Cu CC is prepared by depositing Cu on both sides of a polyethylene terephthalate（PET） *** PET layer promises good ductility of the film,permitting the Cu-PET-Cu CC to accommodate the volumetric changes of silicon microparticles and facilitates the stress release through ductile *** a result,the μSi electrode with Cu-PET-Cu CC retains a high specific capacity of 2181 mA h g-1,whereas the μSi electrode with Cu CC（μSi/Cu） exhibits a specific capacity of 1285 mA h g-1after 80 *** stress relieving effect of CuPET-Cu was demonstrated by in-situ fiber optic stress monitoring and multi-physics *** work proposes an effective stress relief strategy at the electrode level for the practical implementation of μSi anodes.

关键词： Electrode design Metallized polymer current collector Micron-sized Si anodes Stress relieving

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Tandem asymmetric dearomatized functionalization reaction of phenols with Evans-ynamides enabled by divergent electrophiles

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Science China Chemistry 2025年第2期68卷 649-660页

作者： Ying-Qi Zhang Gan-Lu Qian Yun Liu Jia-Hui Li Xin Hong Zhou Xu Bo Zhou long-Wu Ye State Key Laboratory of Physical Chemistry of Solid Surfaces Key Laboratory of Chemical Biology of Fujian Provinceand College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Center of Chemistry for Frontier Technologies Department of ChemistryState Key Laboratory of Clean Energy UtilizationZhejiang UniversityHangzhou 310027China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy School of PharmacyXuzhou Medical UniversityXuzhou 221004China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China State Key Laboratory of Organometallic Chemistry Chinese Academy of SciencesShanghai 200032China

Herein,we disclose a highly regio-/chemoselective tandem asymmetric dearomatized halofunctionalization reaction of phenoltethered ynamides with diverse electrophilic halogenation sources in a catalyst-free manner for the practical and rapid assembly of a series of halogenated spirocyclic ***,the related dearomatized selenation and protonation are also achieved,affording the corresponding selenated and protonated spirocycles in high ***,the enantioselectivities of these products can be perfectly induced by Evans auxiliaries(99%ees).Significantly,this protocol not only represents the first tandem asymmetric halofunctionalization reaction of phenol derivatives,but also constitutes the first asymmetric halogenation/selenation of *** calculations indicate a remote induction model of Evans chiral auxiliary-attached keteniminium.

关键词： alkynes cyclization dearomatization Evans chiral auxiliary spirocycles

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Enhanced autophagic clearance of amyloid-βvia histone deacetylase 6-mediated V-ATPase assembly and lysosomal acidification protects against Alzheimer's disease in vitro and in vivo

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Neural Regeneration Research 2025年第9期20卷 2633-2644页

作者： Zhimin long Chuanhua Ge Yueyang Zhao Yuanjie Liu Qinghua Zeng Qing Tang Zhifang Dong Guiqiong He Institute of Neuroscience School of Basic Medical SciencesChongqing Medical UniversityChongqingChina department of Anatomy Chongqing Medical UniversityChongqingChina department of Physiology Chongqing Medical UniversityChongqingChina Pediatric Research Institute Children’s Hospital of Chongqing Medical UniversityChongqingChina Ministry of Education Key Laboratory of Child development and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina National Clinical Research Center for Child Health and Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders Children’s Hospital of Chongqing Medical UniversityChongqingChina

Recent studies have suggested that abnormal acidification of lysosomes induces autophagic accumulation of amyloid-βin neurons,which is a key step in senile plaque ***,resto ring normal lysosomal function and rebalancing lysosomal acidification in neurons in the brain may be a new treatment strategy for Alzheimer's *** acetylation/deacetylation plays a central role in lysosomal ***,we show that inhibiting the classic microtubule deacetylase histone deacetylase 6 with an histone deacetylase 6 shRNA or thehistone deacetylase 6 inhibitor valproic acid promoted lysosomal reacidification by modulating V-ATPase assembly in Alzheimer's *** rthermore,we found that treatment with valproic acid markedly enhanced *** clearance of amyloid-βaggregates,and ameliorated cognitive deficits in a mouse model of Alzheimer's *** findings demonstrate a previously unknown neuroprotective mechanism in Alzheimer's disease,in which histone deacetylase 6 inhibition by valproic acid increases V-ATPase assembly and lysosomal acidification.

关键词： Alzheimer's disease amyloid-β APP/PS1 mice autophagy cognitive impairment histone deacetylase 6 lysosomal acidification microtubule acetylation valproic acid V-ATPase

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Optimization of production well patterns for natural gas hydrate reservoir: Referring to the results from production tests and numerical simulations

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China Geology 2025年第1期8卷 39-57页

作者： Lang-feng Mu Hao-tian Liu Chi Zhang Yi Zhang Hai-long Lu School of Earth and Space Sciences Peking UniversityBeijing 100871China Beijing International Center for Gas Hydrate School of Earth and Space SciencesPeking UniversityBeijing 100871China Chinese Academy of Geological Sciences China Geological SurveyMinistry of Natural Resources Beijing 100037China College of Engineering Peking UniversityBeijing 100871China National Engineering Research Center of Natural Gas Hydrate Exploration and development Guangzhou 511458China China National Oil and Gas Exploration and development LTD Corporation Petro-ChinaBeijing 100034China

Natural gas hydrate is a clean energy source with substantial resource *** contrast to conventional oil and gas,natural gas hydrate exists as a multi-phase system consisting of solids,liquids,and gases,which presents unique challenges and complicates the mechanisms of seepage and *** domestic and international natural gas hydrate production tests typically employ a single-well production *** this approach has seen some success,it continues to be hindered by low production rates and short production ***,there is an urgent need to explore a new well network to significantly increase the production of a single *** paper provides a comprehensive review of the latest advancements in natural gas hydrate research,including both laboratory studies and field *** further examines the gas production processes and development outcomes for single wells,dual wells,multi-branch wells,and multi-well systems under conditions of depressurization,thermal injection,and CO_(2) *** this basis,well types and well networks suitable for commercial exploitation of natural gas hydrate were explored,and the technical direction of natural gas hydrate development was *** study shows that fully exploiting the flexibility of complex structural wells and designing a well network compatible with the reservoir is the key to improving production from a single ***,multi-well joint exploitation is identified as an effective strategy for achieving large-scale,efficient development of natural gas hydrate.

关键词： Gas Hydrate Production depressurization Heat Injection Replacement Multi-Branch Well Well patterns Hydrate exploration engineering

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肝门部胆管癌经皮经肝胆道引流与内镜下逆行胆管引流胆汁中肿瘤细胞成瘤性对比与分析

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中国生物化学与分子生物学报 2025年第1期41卷 112-124页

作者：祝凯华张德祥陶颖张舒龙范坤刘厚宝上海市徐汇区中心医院普外科上海200031 复旦大学附属中山医院胆道外科上海200032

肝门部胆管癌发病隐匿,常因胆汁淤积引起梗阻性黄疸,导致肝功能受损。对肿瘤合并恶性梗阻性黄疸,临床通常在手术前行胆汁引流。目前,胆汁引流方式主要是经皮经肝胆道引流(percutaneous transhepatic biliary drainage,PTBD)和内镜下逆... 详细信息

肝门部胆管癌发病隐匿,常因胆汁淤积引起梗阻性黄疸,导致肝功能受损。对肿瘤合并恶性梗阻性黄疸,临床通常在手术前行胆汁引流。目前,胆汁引流方式主要是经皮经肝胆道引流(percutaneous transhepatic biliary drainage,PTBD)和内镜下逆行胆管引流(endoscopic retrograde biliary drainage,ERBD),2种引流方式各有优劣。PTBD引流易引起肿瘤种植转移,但机制不清楚。本文分析肝门部胆管癌PTBD及ERBD引流胆汁,从中分离获得肿瘤细胞,通过体外肿瘤球形成及体内移植瘤模型对PTBD与ERBD胆汁中肿瘤细胞的致瘤性及机制进行研究。以胆结石组作为阴性对照,分为良性结石组(30例),ERBD减黄组(13例),PTBD减黄组(14例),其中良性结石30例的胆汁中无肿瘤细胞,未形成肿瘤球,ERBD减黄13例胆汁中有3例形成肿瘤球(23%),PTBD减黄14例胆汁有6例形成肿瘤球(42%),PTBD组细胞的肿瘤球形成能力显著高于ERBD组。皮下移植瘤检测表明,PTBD组移植瘤生长能力显著高于ERBD组,PTBD胆汁中的肿瘤细胞具有更强的致瘤能力。在机制研究中,RT-PCR检测表明,PTBD组肿瘤球干细胞转录因子Nanog的mRNA水平显著高于ERBD组。在3例PTBD组细胞中敲低Nanog,肿瘤球形成,皮下移植瘤生长均被降低,Nanog在PTBD肿瘤细胞强的致瘤能力中发挥重要作用。PTBD细胞中Nanog的mRNA半衰期长于ERBD组,Nanog的mRNA受转录后修饰潜在调控。本文发现,PTBD肿瘤细胞中Nanog的m 6A水平高于ERBD组。对RNA修饰的甲基转移酶及去甲基化酶进行检测表明,ALKBH5(α-ketoglutarate dependent dioxygenase alkb homolog 5)的mRNA表达水平在PTBD组低于ERBD组,且与Nanog的m 6A水平显著相关。敲低ALKBH 5,Nanog的m 6A水平升高,而过表达ALKBH 5则下调Nanog的m 6A水平。双荧光素酶活性检测表明,ALKBH 5敲低显著增强荧光素酶活性,而ALKBH 5过表达则降低荧光素酶活性。进一步研究证实,敲低ALKBH 5,Nanog的mRNA和蛋白质水平均被上调,相反过表达ALKBH 5,Nanog的mRNA和蛋白质水平被下调。ALKBH5介导Nanog去甲基化修饰,PTBD组低的ALKBH5水平促进其Nanog的m 6A修饰上调。过表达ALKBH 5降低肿瘤球生长;敲低ALKBH 5肿瘤球生长被上调,但同时敲低Nanog,升高的肿瘤球生长被抑制。综上,肝门部胆管癌经PTBD与ERBD减黄胆汁中的肿瘤细胞可形成肿瘤球,具有致瘤性。相比于ERBD组,PTBD胆汁中肿瘤细胞ALKBH5的表达水平低,增强了Nanog的m 6A修饰,上调Nanog表达水平,具有更强的致瘤性,对揭示PTBD引流易引起肿瘤种植转移具有重要意义。

关键词：经皮经肝胆道引流内镜下逆行胆管引流肝门部胆管癌 α-酮戊二酸依赖的双加氧酶alkb家族同系物5 Nanog

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Zinc finger transcription factors BnaSTOP2s regulate sulfur metabolism and confer Sclerotinia sclerotiorum resistance in Brassica napus

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Journal of Integrative Plant Biology 2025年第1期67卷 101-116页

作者： Lihong Dai Zhaoqi Xie Tianxu Ai Yushun Jiao Xiaoyi Lian Angchen long Jinyun Zhang Guangsheng Yang dengfeng Hong National Key Laboratory of Crop Genetic Improvement College of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070China Lushan Botanical Garden Chinese Academy of SciencesJiujiang 332900China Hubei Hongshan Laboratory Wuhan 430070China Yazhouwan National Laboratory Sanya 572024China

Rapeseed(Brassica napus L.)exhibits high-sulfur requirements to achieve optimal growth,development,and pathogen *** the importance of sulfur,the mechanisms regulating its metabolism and disease resistance are not fully *** this study,we found that the zinc finger transcription factors BnaSTOP2s play a pivotal role in sulfur metabolism and Sclerotinia sclerotiorum *** findings indicate that BnaSTOP2s are involved in sulfur metabolism,as evidenced by extensive protein interaction ***2s knockout reduced the content of essential sulfurcontaining metabolites,including glucosinolate and glutathione,which is consistent with the significantly lowered transcriptional levels of BnaMYB28s and BnaGTR2s,key factors involved in glucosinolate synthesis and transportation,*** RNA-seq analysis revealed the substantial effect of BnaSTOP2s on sulfur metabolism from roots to siliques,which serve as pivotal sources and sinks for sulfur metabolism,***,we found that leaf lesion size significantly decreased and increased in the BnaSTOP2-OE and Bnastop2 mutants,respectively,compared with the wild-type during *** infection,suggesting a vital role of BnaSTOP2s in plant defense *** conclusion,BnaSTOP2s act as global regulators of sulfur metabolism and confer resistance to *** infection in ***,they have potential implications for improving crop resilience.

关键词： BnaSTOP2 Brassica napus CRISPR/Cas9 glucosinolate Sclerotinia sclerotiorum sulfur metabolism

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Bowel preparation before colonoscopy: Consequences, mechanisms, and treatment of intestinal dysbiosis

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World Journal of Gastroenterology 2025年第2期31卷 13-26页

作者： Ze-long Zheng Qing-Fan Zheng Li-Qiang Wang Yi Liu department of Gastroenterology(Endoscopy Center) China-Japan Union Hospital of Jilin UniversityChangchun 130033Jilin ProvinceChina

The term“gut microbiota”primarily refers to the ecological community of various microorganisms in the gut,which constitutes the largest microbial community in the human *** adequate bowel preparation can improve the results of colonoscopy,it may interfere with the gut *** preparation for colonoscopy can lead to transient changes in the gut microbiota,potentially affecting an individual’s health,especially in vulnerable populations,such as patients with inflammatory bowel ***,measures such as oral pro-biotics may ameliorate these adverse *** focused on the bowel prepa-ration-induced changes in the gut microbiota and host health status,hypothesized the factors influencing these changes,and attempted to identify measures that may reduce dysbiosis,thereby providing more information for individualized bowel preparation for colonoscopy in the future.

关键词： Bowel preparation Colonoscopy Microbiota Inflammatory bowel disease Probiotics

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When Embodied AI Meets Industry 5.0:Human-Centered Smart Manufacturing

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IEEE/CAA Journal of Automatica Sinica 2025年第3期12卷 485-501页

作者： Jing Xu Qiyu Sun Qing-long Han Yang Tang IEEE the Key Laboratory of Smart Manufacturing in Energy Chemical Process Ministry of Education East China University of Science and Technology the School of Science Computing and Engineering Technologies Swinburne University of Technology

As embodied intelligence(EI), large language models(LLMs), and cloud computing continue to advance, Industry5.0 facilitates the development of industrial artificial intelligence(Ind AI) through cyber-physical-social systems(CPSSs) with a human-centric focus. These technologies are organized by the system-wide approach of Industry 5.0, in order to empower the manufacturing industry to achieve broader societal goals of job creation, economic growth, and green production. This survey first provides a general framework of smart manufacturing in the context of Industry 5.0. Wherein, the embodied agents, like robots, sensors, and actuators, are the carriers for Ind AI, facilitating the development of the self-learning intelligence in individual entities, the collaborative intelligence in production lines and factories(smart systems), and the swarm intelligence within industrial clusters(systems of smart systems). Through the framework of CPSSs, the key technologies and their possible applications for supporting the single-agent, multi-agent and swarm-agent embodied Ind AI have been reviewed, such as the embodied perception, interaction, scheduling, multi-mode large language models, and collaborative training. Finally, to stimulate future research in this area, the open challenges and opportunities of applying Industry 5.0 to smart manufacturing are identified and discussed. The perspective of Industry 5.0-driven manufacturing industry aims to enhance operational productivity and efficiency by seamlessly integrating the virtual and physical worlds in a human-centered manner, thereby fostering an intelligent, sustainable, and resilient industrial landscape.

关键词： Embodied AI human-centered manufacturing Industry 5.0 internet of things large multi-mode language models

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Photo-controllable multiple and orthogonal regulation of gene expression by chemically modified oligonucleotides

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Science China Chemistry 2025年第2期68卷 694-704页

作者： Yang Wang Qiu-long Zhang Yan Liu Liang-Liang Wang Chao-Qun Wu Ming Shao Xiwen Xing Juan Du Liang Xu Key Laboratory of Tropical Biological Resources of Ministry of Education and One Health Institute School of Pharmaceutical SciencesHainan UniversityHaikou 570228China Central Laboratory department of The Second Affiliated Hospital School of MedicineThe Chinese University of Hong KongShenzhen&Longgang District People’s Hospital of ShenzhenShenzhen 518172China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry School of ChemistrySun Yat-sen UniversityGuangzhou 510275China department of Biotechnology College of Life Science and TechnologyJinan University InstitutionGuangzhou 510632China School of Pharmacy and Medical Technology Putian UniversityPutian 351100China

Gene expression must be precisely regulated in cells and functional nucleic acids are the most widely utilized tools for gene *** of how these nucleic acid tools work in the cellular environment can precisely manipulate gene expression through a non-invasive *** we report a methodology on multiplex photocontrol of functional nucleic acids to achieve totally temporal and orthogonal regulation of gene expression in living *** select two functional nucleic acid systems as examples,DNAzyme and CRISPR/Cas9,and demonstrate the power of light control for precise gene manipulation by rational design of chemically modified oligonucleotides through introduction of two photocleavable *** the previous modulation of functional nucleic acids by simply activating or deactivating,we successfully achieve versatile controlling patterns using light as the governing *** design represents a generalized pathway towards the photo-controllable functional nucleic acids,which greatly enriches the toolbox for optogenetic studies.

关键词： functional nucleic acids optogenetics modified oligonucleotides gene technology

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