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Prediction of gastric cancer risk by a polygenic risk score of Helicobacter pylori

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World Journal of Gastrointestinal Oncology 2022年第9期14卷 1844-1855页

作者： Xiao-Yu Wang Li-Li Wang shu-zhen liang Chao Yang Lin Xu Meng-Chao Yu Yi-Xuan Wang Quan-Jiang Dong Central Laboratories and Department of Gastroenterology Qingdao Municipal HospitalQingdao UniversityQingdao 266071Shandong ProvinceChina The Center for Microbes Development and HealthCAS Key Laboratory of Molecular Virology and ImmunologyInstitute Pasteur of ShanghaiChinese Academy of SciencesShanghai 200000China

BACKGROUND Genetic variants of Helicobacter pylori(H. pylori) are involved in gastric cancer occurrence. Single nucleotide polymorphisms(SNPs) of H. pylori that are associated with gastric cancer have been reported. The combined effect of H. pylori SNPs on the risk of gastric cancer remains *** To assess the performance of a polygenic risk score(PRS) based on H. pylori SNPs in predicting the risk of gastric *** A total of 15 gastric cancer-associated H. pylori SNPs were selected. The associations between these SNPs and gastric cancer were further validated in 1022 global strains with publicly available genome sequences. The PRS model was established based on the validated SNPs. The performance of the PRS for predicting the risk of gastric cancer was assessed in global strains using quintiles and random forest(RF) methods. The variation in the performance of the PRS among different populations of H. pylori was further *** Analyses of the association between selected SNPs and gastric cancer in the global dataset revealed that the risk allele frequencies of six SNPs were significantly higher in gastric cancer cases than non-gastric cancer cases. The PRS model constructed subsequently with these validated SNPs produced significantly higher scores in gastric cancer. The odds ratio(OR) value for gastric cancer gradually increased from the first to the fifth quintile of PRS, with the fifth quintile having an OR value as high as 9.76(95% confidence interval: 5.84-16.29). The results of RF analyses indicated that the area under the curve(AUC) value for classifying gastric cancer and non-gastric cancer was 0.75, suggesting that the PRS based on H. pylori SNPs was capable of predicting the risk of gastric cancer. Assessing the performance of the PRS among different H. pylori populations demonstrated that it had good predictive power for cancer risk for hp Europe strains, with an AUC value of *** The PRS model based on H. pylori SNPs

关键词： Polygenic risk scores Helicobacter pylori Gastric cancer Single nucleotide polymorphism

The prognosis and survival of integrated traditional Chinese and western medicine on glioma: a meta-analysis

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TMR Integrative Medicine 2021年第9期5卷 1-11页

作者： Bo Yu shu-zhen liang Ming Hu Special Medicine School of Basic MedicineQingdao UniversityQingdaoChina Department of Oncology Qingdao Municipal HospitalQingdaoChina

Objective:To systematically access the effects of integrated traditional Chinese and western medicine treatment versus western medicine treatment alone in ***:Published randomized controlled trials were included from electronic databases(Cochrane Library,Pubmed,Embase,Chinese National Knowledge Infrastructure,Wanfang database,Chinese Scientific Journal Database,Chinese Biomedical Literature *** on January 30,2020).The Cochrane handbook was referred to evaluate the methodological *** efficacy,gastrointestinal side effects,bone marrow suppression,survival time and quality of life(Karnofsky)were compared between the two ***-analysis was conducted using Reveman 5.3 and Stata 14.0 ***:Twelve randomized controlled trials involved 886 cases were selected,including 446 cases in the trial group and 440 cases in the control *** meta-analysis indicated that the overall efficacy of integrated traditional Chinese and western medicine showed significant improvement compared with western medicine *** effects included reduced tumor size(RR=1.32,95%CI(1.18,1.49),P<0.05),gastrointestinal adverse reactions(RR=0.42,95%CI(0.30,0.60),P<0.05),bone marrow suppression(RR=0.437,95%CI(0.282,0.677),P<0.05),and improved KPS score(SMD=0.632,95%CI(0.312,0.952),P<0.05).Conclusion:For patients with glioma,integrated traditional Chinese and western medicine treatment can be one of the options for a better treatment.

关键词： Glioma Integrated traditional Chinese and western medicine Gastrointestinal reactions Suppressing bone marrow Meta-analysis

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He zhen Wang Yuchen Wang Mengjie Zhu Zhile liang Kanghong Zhang Yuge Xu Gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

A promising approach for quantifying focal stroke modeling and assessing stroke progression:optical resolution photoacoustic microscopy photothrombosis

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Neural Regeneration Research 2025年第7期20卷 2029-2037页

作者： Xiao liang Xingping Quan Xiaorui Geng Yujing Huang Yonghua Zhao Lei Xi zhen Yuan Ping Wang Bin Liu Faculty of Health Sciences University of MacaoMacao Special Administrative RegionChina Center for Cognitive and Brain Sciences University of MacaoMacao Special Administrative RegionChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhenGuangdong ProvinceChina State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical SciencesUniversity of MacaoTaipaMacao Special Administrative RegionChina Department of Emergency Zhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

To investigate the mechanisms underlying the onset and progression of ischemic stroke,some methods have been proposed that can simultaneously monitor and create embolisms in the animal cerebral ***,these methods often require complex systems and the effect of age on cerebral embolism has not been adequately studied,although ischemic stroke is strongly *** this study,we propose an optical-resolution photoacoustic microscopy-based visualized photothrombosis methodology to create and monitor ischemic stroke in mice simultaneously using a 532 nm pulsed *** observed the molding process in mice of different ages and presented age-dependent vascular embolism ***,we integrated optical coherence tomography angiography to investigate age-associated trends in cerebrovascular variability following a *** imaging data and quantitative analyses underscore the differential cerebrovascular responses to stroke in mice of different ages,thereby highlighting the technique's potential for evaluating cerebrovascular health and unraveling age-related mechanisms involved in ischemic strokes.

关键词： age-dependent cerebral cortex ischemic stroke mouse model optical coherence tomography angiography photoacoustic microscopy photothrombosis vascular imaging

妊娠期高血压综合征治疗中眼底观察的临床意义

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国际眼科杂志 2010年第5期10卷 1021-1022页

作者：郭建玲余凤慈梁淑贞中国广东省佛山市妇幼保健院眼科 528000

目的:探讨妊娠期高血压综合征患者眼底观察的临床意义。方法:对妊娠期高血压疾病患者产前、产后的眼底观察情况进行分析。结果:患者599例中眼底正常152例(25.4%),眼底改变447例(74.6%),其中妊娠期高血压眼底改变率为63.9%,子痫前期轻度... 详细信息

目的:探讨妊娠期高血压综合征患者眼底观察的临床意义。方法:对妊娠期高血压疾病患者产前、产后的眼底观察情况进行分析。结果:患者599例中眼底正常152例(25.4%),眼底改变447例(74.6%),其中妊娠期高血压眼底改变率为63.9%,子痫前期轻度眼底改变率为80.4%,子痫前期重度眼底变率为98.8%,子痫眼底改变率为100%,视网膜病变III期69例中12例合并视网膜脱离。视网膜病变发病率及严重程度与妊娠期高血压综合征疾病程度成正比,血压越高,蛋白尿越高,红细胞压积越高,视网膜病变发生率越高。产后子痫,与重度妊娠期高血压合并视网膜病变有关。结论:眼底观察对判断妊娠期高血压综合征病情程度,制订治疗方案,对防止产后子痫及防止严重视网膜病变都具有重要意义。

关键词：妊娠期高血压综合征眼底观察视网膜病变期预后

Constructing 2D bismuth-based heterostructure for highly efficient photocatalytic CO2 reduction

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Tungsten 2025年第1期7卷 71-79页

作者： Ruo-Hang Xu Hao-Yu Jiang Dan-Dan Cui Kun-Rong Du Hong-Run Zhang Sheng-Jie Xu Ya-Qi Li Zhi-zhen Ren liang Wang Wei-Chang Hao Yi Du School of Physics and BUAA-UOW Joint Research Centre Beihang University Shenzhen Institute of Beihang University Centre for Catalysis and Clean Energy School of Environment and Science Griffith University

Reforming carbon dioxide（CO2） into fuels and valuable chemicals using solar energy holds significant potential for emission reduction and addressing energy supply *** recombination of photocarriers remains a major obstacle,however,to enhancing solar energy conversion efficiency in the photocatalytic reaction *** two-dimensional materials,constructing heterogeneous structures has emerged as an effective strategy to enhance the separation of photoexcited carriers by leveraging the internal electric field at the heterogeneous ***,we present a facile strategy for preparing Bi4NbO8Br/Bi2WO6plate-on-plate Z-scheme junctions with a strong internal electric field by in situ *** unique heterostructure facilitates efficient separation and transport of photoexcited charges by harnessing the internal electric field induced by chemical bonding at the lateral ***,the Bi4NbO8Br/Bi2WO6heterostructure exhibits enhanced CO2photoreduction properties,along with a CO yield rate of approximately 35 μmol·g-1·h-1under full light *** work offers novel insights into the synthesis of unique hetero structures intended to enhance the efficiency of photocatalytic CO2reduction.

关键词： Bi4NbO8Br/Bi2WO6 CO2 reduction Heterostructures Photocatalysts

Metastable seed-crystals: epitaxial growth of branched-array organic heterostructure nanowires

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Science China Chemistry 2025年

作者： Jin Feng zhen-Yu Geng Ting-Yao Song Ying-Xin Ma Chuan-Zeng Wang Wei Zhang Hong-Tao Lin Jin Zhou shu-Ping Zhuo shu-Hai Chen Xue-Dong Wang School of Chemistry and Chemical Engineering Shandong University of Technology Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & DevicesSoochow University College of Chemistry and Chemical Engineering Hunan Normal University

Tunable light–matter interactions are exhibited by organic low-dimensional crystals, making these crystals a promising platform for organic photonics. However, the precise synthesis of organic low-dimensional crystals remains challenging due to the stochastic nature of molecular nucleation processes. Herein, the directed nucleation process is driven by the introduction of metastable seed-crystals as the trunk, which ultimately leads to branched-array organic heterostructures. The successful formation of organic heterostructures with high-density branched arrays is attributed to the highest attachment energy (Eatt（023）=-104.25 kcal mol-1) of the exposed （023） crystal plane during the seed-crystal growth route. Significantly, these as-prepared heterostructures inherently have an ultralow lattice mismatch ratio η of 0.7%between trunk and branch, which contributes to the multi-channel photon transportation. Therefore, this work provides valuable insights into a versatile synthetic strategy for accessing low-dimensional heterostructures for integrated optoelectronics.

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Ⅲ期妊娠高血压综合征视网膜病变105例临床分析

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国际眼科杂志 2014年第9期14卷 1699-1701页

作者：邱晓云郭建玲余凤慈梁淑贞李振安何清泉中国广东省佛山市妇幼保健院眼科 528000

目的:探讨妊娠高血压患者并发Ⅲ期视网膜病变的相关发病因素及结局。方法:收集我院2012-01/2013-12Ⅲ期妊娠高血压综合征视网膜病变患者105例的临床资料。结果:Ⅲ期妊娠高血压综合征视网膜病变的发生与妊娠高血压综合征病程、血压、蛋... 详细信息

目的:探讨妊娠高血压患者并发Ⅲ期视网膜病变的相关发病因素及结局。方法:收集我院2012-01/2013-12Ⅲ期妊娠高血压综合征视网膜病变患者105例的临床资料。结果:Ⅲ期妊娠高血压综合征视网膜病变的发生与妊娠高血压综合征病程、血压、蛋白尿呈正相关,在冬春寒冷季节发病率高,及时终止妊娠及适当用激素治疗可促进孕妇视力恢复,改善孕产妇及围产儿预后。结论:Ⅲ期妊娠高血压综合征视网膜病变与冬春季节、妊高征病情严重程度相关,及时治疗可恢复正常视力,改善母子预后,眼底检查应作为妊娠高血压综合征的常规检查。

关键词：妊娠高血压综合征视网膜病变发病因素结局

佛山市学龄前儿童近视眼流行病学调查及相关因素分析

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国际眼科杂志 2010年第6期10卷 1191-1192页

作者：郭建玲黄学林余凤慈梁淑贞赖婷婷中国广东省佛山市妇幼保健院眼科 528000 广东省妇幼保健院五官科中国广东省广州市510010 中国广东省佛山市三水区妇幼保健院保健科 528100

目的：调查学龄前儿童近视眼的流行病学状况、分析相关因素,为早期预防近视提供一定依据。方法：随机选取佛山市五区属下幼儿园5182例3~6岁学龄前儿童作为调查对象。使用尼德克AR-20快速电脑验光仪对所选儿童进行屈光筛查。可疑近视者... 详细信息

目的：调查学龄前儿童近视眼的流行病学状况、分析相关因素,为早期预防近视提供一定依据。方法：随机选取佛山市五区属下幼儿园5182例3~6岁学龄前儿童作为调查对象。使用尼德克AR-20快速电脑验光仪对所选儿童进行屈光筛查。可疑近视者和屈光度≤＋2.00D者予10g/L阿托品眼膏涂双眼3d,由专人进行视网膜检影。确诊为近视及屈光度≤＋2.00D的儿童由专人进行近视相关因素调查。确诊为近视者经适当的屈光矫正后,每6mo进行1次屈光复查,按要求进行为期1a的随访。结果：学龄前儿童近视眼患病率为1.95%,城区2.10%,农村1.80%;其中3~〈4岁占0.98%,4~〈5岁占1.96%,5~6岁占2.45%。相关因素分析：学龄前儿童近视眼发生与近亲近视史密切相关。城区与农村学龄前儿童近视眼发病情况无显著性差异。结论：学龄前儿童近视在临床上并不少见,不容忽视。

关键词：近视流行病学调查学龄前儿童