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Silicon detector array for radioactive beam experiments at HIRFL-RIBLL

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Nuclear Science and Techniques 2018年第11期29卷 271-278页

作者： Fang-Fang duan Yan-Yun Yang Bi-Tao Hu Jian-Song Wang Zhi-Hao Gao Xing-Quan Liu Dipikap Patel Peng Ma Jun-Bing Ma shu-Ya Jin Zhen Bai Qiang Hu Guo Yang Xin-Xin Sun Nan-Ru Ma Li-Jie Sun Hui-Ming Jia Xin-Xing Xu Cheng-Jian Lin School of Nuclear Science and Technology Lanzhou University Institute of Modern Physics Chinese Academy of Sciences Department of Nuclear Physics China Institute of Atomic Energy School of Physics and Astronomy Shanghai Jiao Tong University Department of Physics The University of Hong Kong

A new and innovative detector system based on a silicon strip detector dedicated to the study of the reaction induced by lighter radioactive beams is described *** detector system consists of five sets of three types of telescopes,which are successfully used to measure the angular distributions of both elastic scattering and breakup simultaneously, on the Radioactive Ion Beam Line in Lanzhou at Heavy Ion Research Facility in Lanzhou. This silicon detector array is used to measure the elastic scattering angular distributions of ^(11) Be on a ^(208) Pb target at E_(lab) = 140 and 209 MeV. A comparison of the Monte Carlo simulations with the experimental results shows a reasonable consistency.

关键词： Direct nuclear reactions Silicon detector array Radioactive ion beams Monte Carlo simulation

Rheological behavior and constitutive equations of heterogeneous titanium-bearing molten slag

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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 804-810页

作者： Tao Jiang De-ming Liao Mi Zhou Qiao-yi Zhang Hong-rui Yue Song-tao Yang Pei-ning duan Xiang-xin Xue School of Materials and Metallurgy Northeastern University Liaoning Key Laboratory for Recycling Science of Metallurgical Resources

Experimental studies on the rheological properties of a Ca O–Si O2–Al2O3–Mg O–Ti O2–(Ti C) blast furnace(BF) slag system were conducted using a high-temperature rheometer to reveal the non-Newtonian behavior of heterogeneous titanium-bearing molten slag. By measuring the relationships among the viscosity, the shear stress and the shear rate of molten slags with different Ti C contents at different temperatures, the rheological constitutive equations were established along with the rheological parameters; in addition, the non-Newtonian fluid types of the molten slags were determined. The results indicated that, with increasing Ti C content, the viscosity of the molten slag tended to increase. If the Ti C content was less than 2wt%, the molten slag exhibited the Newtonian fluid behavior when the temperature was higher than the critical viscosity temperature of the molten slag. In contrast, the molten slag exhibited the non-Newtonian pseudoplastic fluid characteristic and the shear thinning behavior when the temperature was less than the critical viscosity temperature. However, if the Ti C content exceeded 4wt%, the molten slag produced the yield stress and exhibited the Bingham and plastic pseudoplastic fluid behaviors when the temperature was higher and lower than the critical viscosity temperature, respectively. When the Ti C content increased further, the yield stress of the molten slag increased and the shear thinning phenomenon became more obvious.

关键词： molten slag rheological behavior constitutive equa

冲击绝热曲线上典型金属的激波速度与粒子速度

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现代应用物理 2013年第2期4卷 -页

作者：段耀勇西北核技术研究所西安710024

利用三项式高压状态方程和激波关系式,分析地下核爆中高压状态方程实验数据和强激光驱动的状态方程实验数据.Pb、Cu和Au样品中激波数据的理论预测与实验结果高度吻合,而Fe样品中的冲击波实验数据与相应的理论计算之间存在明显的偏差.多... 详细信息

利用三项式高压状态方程和激波关系式,分析地下核爆中高压状态方程实验数据和强激光驱动的状态方程实验数据.Pb、Cu和Au样品中激波数据的理论预测与实验结果高度吻合,而Fe样品中的冲击波实验数据与相应的理论计算之间存在明显的偏差.多种数据的比较暗示,这种偏差可能来自实测结果的误差而非理论计算.系列金属材料激波压缩的数值结果证实,在强激波条件下冲击压强或冲击温度与粒子速度之间渐近为抛物线关系,这与激波速度和粒子速度之间呈近似线性关系的实验结果形成了对比.所有这些在物理上都得到详细地阐明.

关键词：状态方程激波稠密等离子体

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空乘人员投诉性危机处理策略浅谈

中国民航飞行学院学报 2012年第6期23卷 34-35页

作者：段勇中国民航飞行学院四川广汉618307

投诉性危机是空乘人员遇到的最多的一类危机事件。处理此类危机总的原则是:大事化小,小事化了。本文主要以航班延误为例,具体阐述了空乘人员对投诉性危机的处理策略:平息怨气法;适当补偿法;欲擒故纵法。

关键词：空乘人员投诉性危机处理策略

Isolation and identification of sinapine-degrading bacteria from the intestinal tract of laying hens

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Animal Nutrition 2016年第1期2卷 57-62页

作者： Dan Yu Xiaoli Huang Chengyi Zou Bin Li Jing duan Qin Yin Feed Institute of Sichuan Animal Science Academy College of Animal Science and Technology Sichuan Agriculture University

This study was aimed to isolate sinapine-degrading bacteria from the intestinal tract of laying hens and to identify the predominant bacteria. Thirty-week old healthy laying hens were killed, and the chyme in the digestive tract was inoculated into modified Czapek medium containing sinapin and cultivated at 37 ℃for 10 days. The optical density(OD) values of the bacterial solutions at different cultivating times were detected by a spectrophotometric method. The predominant strains were identified by 16 S rRNA gene analysis. We extracted the extracellular products of the predominant strains to determine the total protein using the Coomassie brilliant blue method, and to determine the activities of some extracellular enzymes using the agar plate diffusion method. Nine strains were isolated from the lower intestinal tract of laying hens. Among the 9 strains, 5 were from the ileum, 2 were from the ceca and 2 were from the jejunum. We could not isolate any strains from the upper intestinal tract, such as the stomach and duodenum. Eight of those 9 isolated strains were gram negative and one was gram positive. Strains YD-1 and YD-2 were better than other strains in their abilities to degrade sinapine. Strains YD-1 and YD-2 were identified as Escherichia coli and Klebsiella spp., respectively, by the 16 S rRNA sequence *** total protein level of the extracellular products was 1.213 g/L for YD-1 and 1.990 g/L for YD-2. Both extracellular products of YD-1 and YD-2 had the activities of protease, amylase and urease. This study confirmed that the primary site of sinapine degradation is in the lower intestinal tract of laying hens. The sinapine-degrading strains are mainly gram negative. Strains YD-1 and YD-2 are predominant in degrading sinapine and they belong to E. coli and Klebsiella spp., respectively. Both extracellular products of YD-1 and YD-2 contain protease, amylase and urease. Strain YD-2 is better than strain YD-1 in its ability to degrade sinapine.

关键词： Laying hen Sinapine Bacteria Extracellular products Enzyme

Loss of O-GlcNAcylation on MeCP2 at Threonine 203 Leads to Neurodevelopmental Disorders

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Neuroscience Bulletin 2022年第2期38卷 113-134页

作者： Juanxian Cheng Zhe Zhao Liping Chen Ying Li Ruijing Du Yan Wu Qian Zhu Ming Fan Xiaotao duan Haitao Wu Department of Neurobiology Beijing Institute of Basic Medical SciencesBeijing 100850China Chinese Institute for Brain Research Beijing 102206China Key Laboratory of Neuroregeneration Co-innovation Center of NeuroregenerationNantong UniversityNantong 226019China State Key Laboratory of Toxicology and Medical Countermeasures Beijing Institute of Pharmacology and ToxicologyBeijing 100850China

Mutations of the X-linked methyl-CpG-binding protein 2(MECP2)gene in humans are responsible for most cases of Rett syndrome(RTT),an X-linked progressive neurological *** genome-wide screens in clinical trials have revealed several putative RTT-associ-ated mutations in MECP2,their causal relevance regarding the functional regulation of MeCP2 at the etiologic sites at the protein level requires more *** this study,we demonstrated that MeCP2 was dynamically modified by O-linked-P-N-acetylglucosamine(O-GlcNAc)at threonine 203(T203),an etiologic site in RTT *** of the O-GlcNAcylation of MeCP2 specifically at T203 impaired dendrite development and spine maturation in cultured hippocampal neurons,and disrupted neuronal migration,dendritic spine morphogenesis,and caused dysfunction of synaptic transmission in the developing and juvenile mouse cerebral ***,genetic disruption of O-GlcNAcylation at T203 on MeCP2 decreased the neuronal activity-induced induction of Bdnf *** study highlights the critical role of MeCP2 T203 O-GlcNAcylation in neural development and synaptic transmission potentially via brain-derived neurotrophic factor.

关键词： MeCP2 O-GlcNAcylation-Dendrite development Synaptic transmission Braiderived neurotrophic factor

不同B含量的Pb-Mg-Al-B合金在Cl^-中的腐蚀行为

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材料科学与工程学报 2014年第4期32卷 509-515页

作者：白苗孙勇段永华马国超昆明理工大学材料科学与工程学院云南昆明650093

采用模拟海水浸泡实验、析氢腐蚀、中性盐雾腐蚀试验、电化学法测试,并采用静态腐蚀失重法测定计算合金腐蚀速率,研究了具有核屏蔽性能的Pb-Mg-Al-B合金在3.5wt.%NaCl溶液中的腐蚀行为,并利用SEM、XRD以及XPS对腐蚀前后合金的表面形貌... 详细信息

采用模拟海水浸泡实验、析氢腐蚀、中性盐雾腐蚀试验、电化学法测试,并采用静态腐蚀失重法测定计算合金腐蚀速率,研究了具有核屏蔽性能的Pb-Mg-Al-B合金在3.5wt.%NaCl溶液中的腐蚀行为,并利用SEM、XRD以及XPS对腐蚀前后合金的表面形貌和腐蚀产物进行分析。结果表明:B含量为1.5%时合金的耐腐蚀性能最好;第二相Mg17Al12以网状形态分布于晶界时对合金腐蚀有明显的阻碍作用;XRD表明腐蚀产物主要为Mg2Pb、PbO、Pb、以及Al2O3、Mg17Al12和含B相AlB2,几乎没有Mg的衍射峰;造成耐蚀性差异的主要原因在于不同元素金属含量对合金微观组织结构的影响。

关键词：材料腐蚀与防护 Pb-Mg-Al合金 Cl离子耐腐蚀性能电化学

酮替芬联合沙丁胺醇片治疗支气管肺炎(喘息型)99例

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中国社区医师 2018年第27期34卷 19-20页

作者：段勇习水县人民医院儿科贵州564600

目的:探讨酮替芬联合沙丁胺醇片治疗支气管肺炎(喘息型)临床效果。方法:收治支气管肺炎(喘息型)患者198例,分为观察组与对照组,每组99例。对照组支气管肺炎(喘息型)患者采用常规药物治疗,观察组支气管肺炎(喘息型)患者在常规治疗基础上... 详细信息

目的:探讨酮替芬联合沙丁胺醇片治疗支气管肺炎(喘息型)临床效果。方法:收治支气管肺炎(喘息型)患者198例,分为观察组与对照组,每组99例。对照组支气管肺炎(喘息型)患者采用常规药物治疗,观察组支气管肺炎(喘息型)患者在常规治疗基础上加用富马酸酮替芬分散片联合沙丁胺醇片治疗,比较两组支气管肺炎(喘息型)患者治疗效果。结果:观察组支气管肺炎(喘息型)患者治疗有效率100%,对照组支气管肺炎(喘息型)患者治疗有效率96.97%。结论:酮替芬联合沙丁胺醇片治疗支气管肺炎(喘息型)临床效果显著。

关键词：富马酸酮替芬分散片沙丁胺醇片支气管肺炎(喘息型)

雷公藤红素通过调控ATF4/caspase-3/GSDME信号通路促进肝癌细胞焦亡

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中国药理学通报 2024年第2期40卷 299-307页

作者：李端王永辉周静张乐孔永红黄淮学院直属附属驻马店市中心医院药学部河南驻马店463000 苏州大学药学院药理学系江苏苏州215123 黄淮学院化学与制药工程学院河南驻马店463003

目的探究雷公藤红素(tripterine,TRI)抑制肝癌细胞(hepatocellular carcinoma,HCC)进展的新机制。方法利用不同浓度(0、0.5、2和8μmol·L-1)TRI作用于肝癌细胞,然后利用CCK-8、细胞克隆、Transwell和蛋白免疫印迹等实验方法评估细胞表... 详细信息

目的探究雷公藤红素(tripterine,TRI)抑制肝癌细胞(hepatocellular carcinoma,HCC)进展的新机制。方法利用不同浓度(0、0.5、2和8μmol·L-1)TRI作用于肝癌细胞,然后利用CCK-8、细胞克隆、Transwell和蛋白免疫印迹等实验方法评估细胞表型和可能机制;再利用siRNA将靶基因GSDME进行干扰,确定GSDME的作用;最后使用移植肿瘤模型验证TRI在体内抑制HCC细胞的生长的机制。结果TRI可抑制HCC细胞增殖、克隆和侵袭,促进细胞焦亡。免疫印迹结果显示,TRI处理后肝细胞癌HepG2或Hepa1-6中GSDME表达均上调,同时cleaved caspase-3和PARP也明显升高。敲除GSDME后可部分逆转TRI诱导的细胞焦亡。同时GSDME敲低后的细胞具有更强的克隆和迁移能力,且与单独的TRI治疗组相比,细胞凋亡率降低。在体内实验中,TRI抑制可HCC肿瘤生长,TRI+siGSDME组小鼠肿瘤生长速度比单独TRI治疗组快。此外,TRI刺激后HepG2和Hepa1-6细胞中p-eIF2a、ATF4均升高。免疫荧光结果显示,TRI刺激后HepG2和Hepa1-6细胞中ATF4阳性细胞数呈剂量依赖性增加。结论TRI抑制肝癌细胞生长和侵袭可能与其调控ATF4/caspase-3/GSDME信号通路促进肝癌细胞焦亡有关。

关键词：肝癌细胞细胞焦亡雷公藤红素 GSDME ATF4 caspase3