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Preparation and structure of microarc oxidation ceramic coatings containing ZrO2 grown on LY12 Al alloy

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Rare Metals 2008年第1期27卷 55-58页

作者： WU Zhendong YAO Zhongping jiang Zhaohua Department of Applied Chemistry Harbin Instinute of Technology Harbin 150001 China Department of Applied Chemistry Baicheng Normal College Baicheng 137000 China

Ceramic coatings containing ZrO2 were prepared in situ on LY12 aluminum alloy by microarc oxidation（MAO） in the mixed solution of zirconate and phosphate *** phase composition and morphology of the coatings were studied by XRD and SEM,*** growing mechanism of ceramic coatings was discussed in a preliminary *** results show that with an increase in MAO time,the compactness of the coating improved and the thickness *** the inner layer to the coating surface,the content of Zr increased,while the content of Al *** addition,the coating was composed of m-ZrO2,t-ZrO2,and a little amount of γ-*** an increase in reaction time,the relative content of t-ZrO2 within the coating sharply decreased while the relative content of m-ZrO2 sharply increased,and then both generally kept at a constant level after 60 min.

关键词： microarc oxidation aluminium alloy ceramic coating zirconium dioxide

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高温高压对三元预混燃料爆炸特性的影响

高压物理学报 2025年第1期39卷 64-78页

作者：朱源姜根柱王筱蓉郭宏展苏傲成江苏科技大学机械工程学院江苏镇江212003

乙醇/甲烷/氢气(C_(2)H_(5)OH/CH_(4)/H_(2))作为一种新型的替代燃料,研究其爆炸特性对于我国新能源的可持续发展具有重要意义。在不同的当量比(0.8~1.4)、初始压力(0.1、0.2和0.4 MPa)和初始温度(370、400和450 K)下,从实验和化学动力... 详细信息

乙醇/甲烷/氢气(C_(2)H_(5)OH/CH_(4)/H_(2))作为一种新型的替代燃料,研究其爆炸特性对于我国新能源的可持续发展具有重要意义。在不同的当量比(0.8~1.4)、初始压力(0.1、0.2和0.4 MPa)和初始温度(370、400和450 K)下,从实验和化学动力学角度分析了其对关键爆炸特性参数,如峰值爆炸压力、峰值爆炸压力上升速率、爆炸时间以及爆燃指数的影响。结果表明,爆炸特性参数在当量比为1.2~1.3之间时出现极值。峰值爆炸压力与初始压力呈线性正相关,而与初始温度呈线性负相关。增大初始压力,火焰锋面裂纹、胞化程度加深,峰值爆炸压力增大。此外,实验工况下评估的最大爆燃指数为20.83 MPa·m/s,表明预混燃料的燃烧处于相对安全水平。基元反应敏感性分析表明:爆燃反应与H和OH自由基密切相关,而R1、R8、R24、R96是影响爆炸反应强度最重要的4个基元反应。研究成果可为C_(2)H_(5)OH/CH_(4)/H_(2)三元混合燃料在实际燃烧装置中的应用、燃料安全性评估以及爆炸事故预防提供参考。

关键词：乙醇/甲烷/氢气爆炸特性线性相关 H和OH自由基

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The MdWRKY31 transcription factor binds to the MdRAV1 promoter to mediate ABA sensitivity

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Horticulture Research 2019年第1期6卷 918-933页

作者： Xian-yan Zhao Chen-Hui Qi Han jiang Chun-Xiang You Qing-Mei Guan Feng-Wang Ma Yuan-Yuan Li Yu-Jin Hao State Key Laboratory of Crop Stress Biology for Arid Areas/Shaanxi Key Laboratory of Apple College of HorticultureNorthwest A&F UniversityYangling 712100 ShaanxiChina National Key Laboratory of Crop Biology College of Horticulture Science and EngineeringShandong Agricultural UniversityTai-AnShandong 271018China

The phytohormone abscisic acid(ABA)is a major element involved in apple(Malus domestica)production because of its role in seed germination and early seedling *** WRKY family,which is one of the largest families of transcription factors,plays an important role in ABA signaling in ***,the underlying molecular mechanisms of WRKY-mediated ABA sensitivity in apple are poorly understood.A genome-wide transcriptome analysis indicated that MdWRKY31 is a key factor induced by *** real-time PCR showed that MdWRKY31 is induced by ABA in response to PEG4000,which is used to simulate *** a transcription factor,MdWRKY31 is localized in the *** expression of MdWRKY31 in Arabidopsis and Nicotiana benthamiana enhanced plant sensitivity to *** of MdWRKY31 in apple roots and apple calli increased sensitivity to ABA,whereas repression of MdWRKY31 reduced sensitivity to ABA in the roots of‘Royal Gala’.Electrophoretic mobility shift assays,chromatin immunoprecipitation PCR,and yeast one-hybrid assays indicated that MdWRKY31 directly binds to the promoter of *** analyses of transgenic apple calli containing MdWRKY31 and pMdRAV1::GUS implied that MdWRKY31 represses the expression of *** also found that MdRAV1 binds directly to the promoters of MdABI3 and MdABI4 and repressed their *** findings reveal a new important regulatory mechanism of MdWRKY31-MdRAV1-MdABIs in the ABA signaling pathway in apple.

关键词： expression roots media

Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-yan yang Shan-Shan Hu Ye jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density Colorectal adenoma Colorectal cancer Targeted therapy

Long-term follow-up of cumulative incidence of hepatocellular carcinoma in hepatitis B virus patients without antiviral therapy

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World Journal of Gastroenterology 2021年第11期27卷 1101-1116页

作者： Xiao-yan jiang Bing Huang Dan-Ping Huang Chun-Shan Wei Wei-Chao Zhong De-Ti Peng Fu-Rong Huang Guang-Dong Tong Department of Gastroenterology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina Department of Hepatology Shenzhen Traditional Chinese Medicine HospitalThe Fourth Clinical Medical College of Guangzhou University of Chinese MedicineShenzhen 518033Guangdong ProvinceChina

BACKGROUND China has a high prevalence of hepatitis B virus(HBV),but most chronic hepatitis B(CHB)patients do not receive standardized antiviral *** are few relevant reports addressing the outcomes of the large number of CHB patients who do not receive antiviral *** To observe the outcomes of long-term follow-up of patients with CHB without antiviral *** This study included 362 patients with CHB and 96 with hepatitis B cirrhosis without antiviral treatment and with only liver protection and anti-inflammatory treatment from 1993 to *** median follow-up times were 10 and 7 years,respectively.A total of 203 CHB and 129 hepatitis B cirrhosis patients receiving antiviral therapy were selected as the control *** median follow-up times were 8 and 7 years,***-Meier curves were used to analyze the cumulative incidence of hepatocellular carcinoma(HCC),and the Cox regression model was used to analyze the risk factors for *** Among the patients in the non-antiviral group,16.9%had spontaneous decreases(HBeAg)*** the antiviral group,87.2%of patients had undetectable HBV DNA,and 52%showed HBeAg *** CHB and hepatitis B cirrhosis patients,the cumulative incidence rates of HCC were 14.9%and 53.1%,respectively,in the non-antiviral group and were 10.7%and 31.9%,respectively,in the antiviral *** was no difference between the two groups regarding the CHB patients(P=0.842),but there was a difference between the groups regarding the hepatitis B cirrhosis patients(P=0.026).The cumulative incidence rates of HCC were 1.6%and 22.3%(P=0.022)in the groups with and without spontaneous HBeAg seroconversion,*** incidence rates of HCC among patients with and without spontaneous declines in HBV DNA to undetectable levels were 1.6%and 19.1%,respectively(P=0.051).There was no difference in the cumulative incidence of HCC between the two groups regarding the patients with drug-resistan

关键词： Chronic hepatitis B Anti-inflammatory therapy Hepatoprotective therapy Cumulative incidence Hepatocellular carcinoma Antiviral therapy

Tauroursodeoxycholic acid(TUDCA)improves intestinal barrier function associated with TGR5-MLCK pathway and the alteration of serum metabolites and gut bacteria in weaned piglets

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Journal of Animal Science and Biotechnology 2022年第6期13卷 1917-1931页

作者： Min Song Fenglin Zhang Yiming Fu Xin Yi Shengchun Feng Zhichang Liu Dun Deng Qiang yang Miao Yu Canjun Zhu Xiaotong Zhu Lina Wang Ping Gao Gang shu Xianyong Ma Qingyan jiang Songbo Wang Guangdong Provincial Key Laboratory of Animal Nutrition Control ALLT ECH-SCAU Animal Nutrition Control Research Allianceand National Engineering Research Center for Breeding Swine IndustryCollege of Animal ScienceSouth China Agricultural UniversityGuangzhou 510642P.R.China Institute of Animal Science Guangdong Academy of Agricultural SciencesState Key Laboratory of Livestock and Poultry BreedingKey Laboratory of Animal Nutrition and Feed Science in South ChinaMinistry of Agriculture and Rural AffairsGuangdong Key Laboratory of Animal Breeding and NutritionGuangdong Engineering Technology Research Center of Animal Meat Quality and Safety Control and EvaluationGuangzhou 510640P.R.China Maoming Branch Guangdong Laboratory for Lingnan Modern Agricultural Science and TechnologyMaoming 525000P.R.China

Background:Tauroursodeoxycholic acid(TUDCA),a hydrophilic bile acid,is the main medicinal component of bear bile and is commonly used to treat a variety of hepatobiliary ***,TUDCA has been shown to modulate the intestinal barrier function and alleviate DSS-induced colitis in ***,the effect of TUDCA on the intestinal barrier of weaned piglets remains largely ***:The weaned piglets and porcine IPEC-J2 intestinal epithelial cells were used to investigate the effects of TUDCA on intestinal barrier function in weaned piglets and explore the possible underlying *** vivo,72 healthy weaned piglets were randomly allocated into 2 groups according to their gender and body weight,and piglets were fed the basal diet with 0(control,CON)and 200 mg/kg TUDCA for 30 d,*** female and three male piglets reflecting the average bodyweight were slaughtered in each group and samples were *** vitro,IPEC-J2 cells were subjected to 100μmol/L TUDCA to explore the possible underlying ***:Our results demonstrated that dietary TUDCA supplementation significantly reduced the diarrhea incidence of weaned piglets,possibly attributing to the TUDCA-enhanced intestinal barrier function and *** addition,TUDCA supplementation altered serum metabolites and the relative abundance of certain gut bacteria,which might contribute to the improved intestinal barrier ***,the in-vitro results showed that TUDCA improved the ***-induced epithelial barrier impairment of IPEC-J2 cells and increased Takeda G-coupled protein receptor 5(TGR5)protein ***,knockdown of TGR5 and inhibition of myosin light chain kinase(MLCK)pathway abolished the TUDCA-improved epithelial barrier impairment in ***-treated IPEC-J2 cells,indicating the involvement of TGR5-MLCK in this ***:These findings showed that TUDCA improved intestinal barrier function associated with TGR5-MLCK pathway and the al

关键词： Gut bacteria Intestinal barrier function Serum metabolites Tauroursodeoxycholic acid(TUDCA) TGR5-MLCK pathway Weaned piglets

Cancer-associated fibroblasts derived fibronectin extra domain A promotes sorafenib resistance in hepatocellular carcinoma cells by activating SHMT1

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Genes & Diseases 2024年第6期11卷 510-524页

作者： yan Dong yanrong Chen Yijie Wang Xiang Zhao Ruiyang Zi Jie Hao Qiong Ding Haoran jiang Xuesong Wang Fanghao Lu Houjie Liang Zhihao Wei Jianjun Li Department of Oncology Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Brain Research Center and State Key Laboratory of Trauma Burnsand Combined InjuryThird Military Medical University(Army Medical University)Chongqing 400038China

Resistance to sorafenib,an effective first-line treatment for advanced hepatocellular carcinoma(HCC),greatly compromised the prognosis of *** extracellular matrix is one of the most abundant components of the tumor *** acting as a physical barrier,it remains unclear whether cell interactions and signal transduction mediated by the extracellular matrix contribute to sorafenib *** the analysis of primary HCC organoid RNA-seq data combined with in vivo and in vitro experiments validation,we discovered that fibronectin extra domain A(FN-EDA)derived from cancer-associated fibroblasts played a critical role in sorafenib ***,FN-EDA stimulates the up-regulation of the key one-carbon metabolism enzyme SHMT1 in HCC cells via the TLR4/NF-κB signaling pathway,thereby countering the oxidative stress induced by ***,we reinforced the clinical significance of our discoveries by conducting in vivo assays with an immunodeficiency subcutaneous xenograft tumor model,which was established using primary cancer-associated fibroblasts derived from clinical HCC tissues,and through the analysis of HCC samples obtained from The Cancer Genome Atlas(TCGA)*** findings suggest that targeting the FN-EDA/SHMT1 pathway could be a potential strategy to improve sorafenib responsiveness in HCC patients.

关键词： Cancer-associated fibroblasts Fibronectin extra domain A Hepatocellular carcinoma Serine hydroxymethyl transferase1 Sorafenib resistance

Structure, Optical Property and Thermal Stability of Copper Nitride Films Prepared by Reactive Radio Frequency Magnetron Sputtering

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Journal of Materials Science & Technology 2011年第5期27卷 403-407页

作者： Jianrong Xiao yanwei Li Aihua jiang College of Science Guilin University of Technology Guilin 541004 China College of Chemistry and Bioengineering Guilin University of Technology Guilin 541004 China

Copper nitride （Cu3N） films were prepared by reactive radio frequency magnetron sputtering at various nitrogen partial pressures, and the films were annealed at different temperatures. The crystal structure of the films was identified by X-ray diffraction technique. The Cu3N films have a cubic anti-ReO3 structure, and lattice constant is 0.3855 nm. With increasing nitrogen partial pressure, the Cu3N films are strongly textured with the crystal direction [100]. The atomic force microscope images show that the films presence a smooth and compact morphology with nanocrystallites of about 70 nm in size. The films were further characterized by UV-visible spectrometer, and the optical band gap of the films was calculated from the Tauc equation. The typical value of optical band gap of the films is about 1.75 eV, and it increases with increasing nitrogen partial pressure. The thermal property of the films was measured by thermogravimetry, and the decomposition temperature of the films was about 530 K.

关键词： Cu3N films X-ray diffraction Structure Optical property Decompositiontemperature

Thermoelectric Characterization of (Na_(1-y)M_y)_(1.6)Co_2O_4(M=K, Ca, Sr)

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Journal of Materials Science & Technology 2006年第4期22卷 526-528页

作者： Ying LI Guiying XU Maofa jiang School of Material and Metallurgy Northeastern University Shenyang 110004 China University of Science and Technology Beijing Beijing 100083 China

Oxide materials NaCo2O4 and （Na1-yMu）1.6Co2O4 （M=K, 0.05≤y≤0.35; M=Ca, St, 0.10≤y≤0.40） were prepared by a sol-gel method. Experimental resultS indicated that the Seebeck coefficient and the Powerfactor of NaCo2O4 were improved by doping Ca and Sr but not by K. The Power-factor of NaCo2O4 is in its maximum, 1.68×10^-4 W·m^-1·K^-2 and 11% bigger than that of the original one when the dopant fraction of Ca was 0.1. Doping Sr makes NaCo2O4 have the biggest Power-factor, 1.68×10^-4 W·m^-1·K^-2 that is 50% bigger than the non-doping oxide. The experimental results indicate that suitable dopants and addition amounts could improve the thermoelectric properties of NaCo2O4 greatly.

关键词： Thermoelectric materials Electric properties Sol-Gel method Doping