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Analysis of post-operative endophthalmitis after pars plana vitrectomy： a 10-year experience at a single center

Chinese Medical Journal 2013年第15期126卷 2890-2893页

作者： SHI Xiang-yu ZHAO Hong-shu wei wen-bin Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Laboratory Beijing 100730 China

Background Endophthalmitis can be a devastating complication after pars plana vitrectomy. The incidence of post- vitrectomy endophthalmitis is significantly lower than that of endophthalmitis occurring after other intraocular operations. However, normal post-operative pain and inflammation may mask endophthalmitis and lead to delayed diagnosis and grave visual consequences. This study aimed to summarize the outcomes of cases that underwent pars plana vitrectomy over a 10-year period and to analyze the characteristics of post-vitrectomy endophthalmitis. Methods A retrospective observational case study was conducted on all the cases who underwent pars plana vitrectomy in the Beijing Tongren Hospital between January 1, 2002 and March 31, 2012. All cases of endophthalmitis that occurred during a period of 10 years and 3 months were reviewed, and the possible risk factors, clinical findings, causative organism（s）, and the sources of infection were analyzed. Results Within the 10-year observational period, 14 patients developed endophthalmitis after pars plana vitrectomy. The incidence of post-vitrectomy endophthalmitis （0.05%） was lower than that reported previously from the same center （0.12%）. Staphylococcus epidermidis （five patients, 35.71%） was the most common organism identified in aqueous or vitreous cultures. Eight patients （57.14%） had diabetes mellitus. There was no statistically significant difference （P 〉0.05） in the incidence of endophthalmitis between period 1 （with antibiotic pretreatment） and period 2 （without antibiotic pretreatment）. Surgical procedures for the treatment of endophthalmitis were performed in 10 patients （71.43%）. Conclusions This series of cases showed that the incidence of endophthalmitis after pars plana vitrectomy is lower than what was previously reported in our hospital. A variable degree of corneal edema with relatively normal or mildly increased intraocular pressure was one of the commonly observed characteristics of post-vitrecto

关键词： pars plana vitrectomy endophthalmitis post-operative complication

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NEW DISTENIID BEETLES FROM CHINA(Coleoptera:Disteniidae)

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昆虫分类学报 1987年第1期 25-28页

作者： Chiang shu-nan Wu wei-wen(Southwest Agricultural University)

Eight new species of disteniid beetles from south and southw-estern China are described. All the type specimens are deposited in theEntomological Laboratory, Southwest Agricultural University.

关键词： Coleoptera ventral basal Southwest margin struts slightly outer nodules groove

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Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)

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Signal Transduction and Targeted Therapy 2023年第3期8卷 1198-1207页

作者： Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang wei-Zhu Yang Guo-wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge wen-Bin Ding wen-Hui Li Jin-Hua Huang wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao shu-wei wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan wei-Dong Wang Ming Huang wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han wei-Xin Ren Zai-Ming Lu wen-Ge Xing Yong Fan Hai-Lan Lin Zi-shu Zhang Guo-Hui Xu wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng Center of Interventional Radiology&Vascular Surgery Department of RadiologyZhongda HospitalMedical SchoolSoutheast UniversityNanjing 210009China Department of Minimally invasive Intervention The Affiliated Cancer Hospital of Zhengzhou UniversityZhengzhou 450008China Department of Interventional Radiology the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhou 510630China Department of Interventional Radiology Union Hospital of Fujian Medical UniversityFuzhou 350001China Department of Interventional Radiology Jiangsu Cancer Hospital&Jiangsu Institute of Cancer Research&The Affiliated Cancer Hospital of Nanjing Medical UniversityNanjing 210009China Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySoochow UniversitySuzhou 215006China Hepatobiliary and Pancreatic Interventional Treatment Center Division of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Interventional Radiology Eastern Hospital of Hepatobiliary SurgeryNavy Medical University(Second Military Medical University)Shanghai 200438China Department of Interventional Radiology Nantong First People’s HospitalNantong 226001China Department of Interventional Radiology Yancheng Third People’s HospitalYancheng 224008China Department of Minimally Invasive Interventional Therapy Sun YatSen University Cancer CenterGuangzhou 510060China Department of Vascular Surgery Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China. Department of Interventional Radiology Hunan Cancer HospitalChangsha 410031China Department of Interventional Oncology The First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080China Department of Interventional Radiology The Hospital of Nantong UniversityNantong 226001China Department of Interventional Therapy Shanxi Tumor HospitalTaiyuan 030001China Department of Interventional Radiology Tibet Autonomous Region People’s

There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world *** this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May *** primary endpoint was progression-free survival(PFS)according to modified *** secondary outcomes included overall survival(OS),objective response rate(ORR),and *** performed propensity score matching approaches to reduce bias between two *** matching,228 pairs were included with a predominantly advanced disease *** PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,*** results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile.

关键词： hepatocellular targeted matching

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空时分组码的联合信道估计和符号检测算法

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上海交通大学学报 2004年第2期38卷 207-210,214页

作者：单淑伟罗汉文宋文涛上海交通大学电子信息与电气工程学院上海200030

提出了假设信道仅在p个符号持续时间内(p为空时分组码传输矩阵的行数)是不变的慢衰落条件下,适用于空时分组码发射分集系统的联合信道估计和符号检测的EM(Expectation-Maximization)算法.利用空时分组码的正交结构,该算法保持了空时分... 详细信息

提出了假设信道仅在p个符号持续时间内(p为空时分组码传输矩阵的行数)是不变的慢衰落条件下,适用于空时分组码发射分集系统的联合信道估计和符号检测的EM(Expectation-Maximization)算法.利用空时分组码的正交结构,该算法保持了空时分组码线性译码的优点,具有较低的复杂度和较小的计算量.仿真结果表明,在不同信噪比条件下,该算法可得到较好的误帧率性能.

关键词：空时分组码信道估计符号检测慢衰落

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魏书文作品

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经济师 2020年第11期 F0003-F0004页

作者：魏书文中国包装技术学会中国工艺美术学会中国收藏家协会中央工艺美术学院(清华大学美术学院)师友画院

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魏书文作品

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经济师 2023年第7期 F0002-F0002,F0004页

作者：魏书文清华大学美术学院

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过滤机在我国铀水冶工艺中的应用

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过滤与分离 2007年第4期17卷 34-36,41页

作者：方伟舒伟文江西核工业金建机械有限公司江西南昌330101

简要介绍了铀水冶中固液分离的主要方法、阐述了各种固液分离设备在我国铀水冶工艺中的应用概况;分析了主要固液分离设备的优缺点。

关键词：水冶工艺铀水冶应用过滤机固液分离设备

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基于奥马哈系统的延续性护理模式对乳腺癌患者术后生活质量的影响研究

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中国当代医药 2018年第5期25卷 166-168页

作者：危淑文江西省抚州市第一人民医院心胸外科江西抚州344000

目的探讨乳腺癌患者经奥马哈系统的延续性护理模式对术后生活质量的影响情况。方法选取2015年4月~2017年6月我院接收的30例行乳腺癌手术治疗的患者为研究对象,依照均等、随机的方式分为常规组和研究组,每组各15例。常规组患者给予常规... 详细信息

目的探讨乳腺癌患者经奥马哈系统的延续性护理模式对术后生活质量的影响情况。方法选取2015年4月~2017年6月我院接收的30例行乳腺癌手术治疗的患者为研究对象,依照均等、随机的方式分为常规组和研究组,每组各15例。常规组患者给予常规方法护理,在常规护理基础上,予以研究组患者奥马哈系统的延续性护理,观察两组患者护理干预后生活质量的改善情况。结果干预后,研究组患者的生活质量、对病症认知情况及护理满意度率均高于对照组,差异均有统计学意义(P<0.05)。结论将奥马哈系统延续性护理干预应用到乳腺癌手术患者临床治疗中,不仅能使患者的护理满意度提升,而且对术后患者生活质量的提升有一定的推动作用。

关键词：乳腺癌延续性护理生活质量奥马哈系统

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Identification of a dual functional betulinic acid analog for the treatment of osteoarthritis by phenotypic screening

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Science China Life Sciences 2025年第1期 300-302页

作者： Ze-Min Lin Mai Xiang wen-Hui wei shu-Hui Fan Li Chen Jie Wang Xiao-Qian Yang Chun-Hao Yang Shi-Jun He Jian-Ping Zuo Laboratory of Immunopharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences School of Pharmacy University of Chinese Academy of Sciences School of Pharmacy Nanjing University of Chinese Medicine State Key Laboratory of Drug Research Department of Medicinal ChemistryShanghai Institute of Materia MedicaChinese Academy of Sciences Innovation Research Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Experiment Center for Science and Technology Shanghai University of Traditional Chinese Medicine

Dear Editor, Phenotypic drug discovery, which observes compound effects on physiology,has given way to targeting specific molecules, but has revived by using modern methods to find drugs based on therapeutic outcomes in disease models(Vincent et al., 2022). Osteoarthritis(OA) is a prevalent chronic joint disorder, primarily affecting knee joints, with osteoclast activation due to low-grade inflammation resulting in increased bone resorption and structural changes in the joint(Katz et al.,2021).

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PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou wei Chen Aidong wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

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