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基于两样本孟德尔随机化研究血脂水平和子宫内膜异位症之间的关系

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成都医学院学报 2024年第3期19卷 424-427页

作者：李永红何家楠许俊晖张圆青郑群何跃东四川大学华西第二医院妇产科 610041 成都市温江区人民医院妇产科 611130 成都医学院临床医学院 610500

目的采用两样本孟德尔随机化研究,探索血脂水平和子宫内膜异位症之间的因果关系。方法利用大样本全基因组关联研究(GWAS)汇总数据,选择与各类血脂水平密切相关的遗传位点为工具变量,采用逆方差加权法进行两样本孟德尔随机化分析,以OR... 详细信息

目的采用两样本孟德尔随机化研究,探索血脂水平和子宫内膜异位症之间的因果关系。方法利用大样本全基因组关联研究(GWAS)汇总数据,选择与各类血脂水平密切相关的遗传位点为工具变量,采用逆方差加权法进行两样本孟德尔随机化分析,以OR值评价各类血脂水平与子宫内膜异位症间的因果关系。结果除了极小极低密度脂蛋白(VLDL)胆固醇外,其余与VLDL有关的血脂水平升高会增加子宫内膜异位症的发病风险(OR>1)。高密度脂蛋白(HDL)中与胆固醇有关的血脂类型、小低密度脂蛋白(LDL)中总胆固醇水平升高可减少子宫内膜异位症的发病风险(OR1)。结论多种类型的血脂水平会影响子宫内膜异位症的发生,HDL中与胆固醇或甘油三酯相关的血脂水平可作筛查子宫内膜异位症的生物指标。

关键词：孟德尔随机化研究子宫内膜异位症血脂水平因果关系

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中医妇科学硕士研究生学位论文现状浅析

新疆中医药 2024年第1期42卷 65-68页

作者：于明玥张丽娟朱书萌李雪梅张旭山东中医药大学中医学院山东济南250014 山东中医药大学第一临床医学院山东济南250014

通过统计综合实力突出的10所中医院校2015~2022年中医妇科学硕士研究生学位论文选题方向、课题设计、研究方法等相关数据并利用Excel、Word软件进行数据分析,剖析近年来中医妇科学硕士研究生学位论文的特色与不足,挖掘新时代教育背景下... 详细信息

通过统计综合实力突出的10所中医院校2015~2022年中医妇科学硕士研究生学位论文选题方向、课题设计、研究方法等相关数据并利用Excel、Word软件进行数据分析,剖析近年来中医妇科学硕士研究生学位论文的特色与不足,挖掘新时代教育背景下中医类别硕士研究生教育培养存在的潜在问题,为进一步深化中医妇科学教育改革、提高中医妇科研究生培养质量提供借鉴和指导。

关键词：中医妇科学研究生教育学位论文

杭州运河亚运公园体育馆智能化系统工程的应用与实践(一)

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智能建筑与智慧城市 2024年第1期 137-140页

作者：吴哲昊陈永福张群力周鹏飞徐羿浙江省建筑设计研究院浙江新盛建设集团有限公司

杭州运河亚运公园体育馆是建筑艺术和科学技术完美的结晶,场馆流线流面卵石造型,光顺润滑、自然流畅。场馆设计采用了数字技术、绿色建筑技术与智能化技术取得了良好效果。实现了场馆建筑功能空间与体育工艺空间、建筑智能化系统与体育... 详细信息

杭州运河亚运公园体育馆是建筑艺术和科学技术完美的结晶,场馆流线流面卵石造型,光顺润滑、自然流畅。场馆设计采用了数字技术、绿色建筑技术与智能化技术取得了良好效果。实现了场馆建筑功能空间与体育工艺空间、建筑智能化系统与体育工艺智能化系统、建筑绿色生态与体育智慧生态完美结合。

关键词：体育场馆工艺智能化系统智能监控系统场馆专用系统

Assessment of Coronary Stents by 64-slice Computed Tomography: In-stent Lumen Visibility and Patency

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Chinese Medical Sciences Journal 2009年第3期24卷 156-160页

作者： Ling-yan Kong Zheng-yu Jin shu-yang zhang Zhu-hua zhang Yi-ning Wang Lan Song Xiao-na zhang Yun-qing zhang Department of Radiology Department of Cardiology Peking Union Medical College Hospital Chinese Academy of Medical Sciences ＆ Peking Union Medical College Beijing 100730 China

Objective To assess lumen visibility of coronary stents by 64-slice computed tomography （CT） coronary angiography, and determine the value of 64-slice CT in non-invasive detecting of in-stent restenosis after coronary artery stent implantation. Methods Totally, 60 patients （54 males, aged 57.0±12.7 years） and /05 stents were investigated by 64-slice CT at a mean interval of 20.0±16.6 months after coronary stents implantation. Axial multi-planar reconstruction images of the stents and curved-planar reconstruction images through the median of the stents were reconstructed for evaluating stent image quality on a 5-point scale （1=excellent, 5=nonassessable）, and stent lumen diameter was detected. Conventional coronary angiography was performed in 18 patients, and 32 stents were evaluated. Results Image quality was good to excellent on average （score 1.71±0.76）. Stent image quality score was correlated to heart rate （r=0. 281, P〈0.01） and stent diameter （r=-0.480, P〈0.001）. All the stents were assessable in lumen visibility with an average visible lumen diameter percentage of 60.7%±13.6%. Visible lumen diameter percentage was correlated to heart rate （r=-0.193, P〈0.05）, stent diameter （r=0.403, P〈0.001）, and stent image quality score （r=-0.500, P〈0.001）. Visible lumen diameter percentage also varied depending on the stent type. In comparison with the conventional coronary angiography, 4 of 6 in-stent stenoses were correctly detected. The sensitivity and specificity for the detection of in-stent stenosis were 66.7% and 84.6%, respectively. Conclusions Using a 64-slice CT, the stent lumen is partly visible in most of the stents. And 64-slice CT may be useful in the assessment of stent patency.

关键词： coronary artery in-stent restenosis computed tomography

Temperature change between neighboring days and hospital admissions in China

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Advances in Climate Change Research 2023年第6期14卷 847-855页

作者： Yu-shu HUANG He-Jia SONG Yi-Bin CHENG Shilu TONG Rui zhang Xiao-Yuan YAO Yong-Hong LI China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Deparment of Big Data in Health Science School of Public Health and Centerof Clinical Big Data and Analytics of the Second Affiliated HospialZhejiang University School of MedicineHangzhou 310058China Jiaxing Center for Disease Control and Prevention Jiaxing 314050China Instinurte of Environmenr and Population Health School of Public HealrhAnhui Medical UniversityHefei 230032China School of Public Health and Social Work Queensland University of TechnologyBrisbane 4006Australia Information Center Chinese Center for Disease Control and PreventionBeiing 102206China

The short-term temperature fluctuation caused by global climate change is one of the risk factors affecting public *** the association between temperature fluctuation and diseases,which has received relatively limited research attention,can contribute to enhancing awareness of health risks and taking timely measures for health risk alert and ***,this study aims to investigate the relationship between temperature change between neighboring days(TCN)and hospitalizations,identify diseases sensitive to extreme TCN,and evaluate the related disease *** collected meteorological and hospitalization data from 2014 to 2019 in 23 sites of China to explore the impact of TCN on *** first quantified site-specific associations between TCN and hospitalizations and then conducted meta-analysis to pool the results,to assess the relative risk of extreme TCN for susceptible diseases,and to estimate the related disease burden attributed to *** analyses were undertaken by age,sex,and disease *** showed that all-cause hospital admission was significantly linked to TCN.A negative TCN(below-1.9℃)in the cool season and a positive TCN(above 1.0℃)in the warm season increased the risk of *** aged 15-64 years,men,and patients with musculoskeletal system or connective tissue diseases were more sensitive to extremely negative TCN during the cool *** aged over 65 years,men,and patients with respiratory diseases were more sensitive to extremely positive TCN during the warm *** attributable fraction to all-cause hospitalization from negative TCN in the cool season was 2.05%(95%CI:-0.90%,4.53%)and from positive TCN in the warm season was 5.79%(95%CI:2.98%,8.31%).Circulatory diseases in the cool season and respiratory diseases in the warm season had the highest disease *** findings indicate that awareness of TCN and its health risks should be promoted and evidence-informed policies are nee

关键词： Temperature change between neighboring days Morbidity Hospital admissions Sensitive diseases Vulnerable populations Disease burden

髓过氧化物酶在结直肠腺瘤组织的表达及临床意义

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川北医学院学报 2024年第5期39卷 589-592页

作者：曹丽群李一然张平梁海清李洪雷山东大学齐鲁医院德州医院病理科山东德州253014 山东大学齐鲁医院德州医院老年医学科山东德州253014 德州市德城区妇幼保健院病理科山东德州253017

目的:通过测定结直肠腺瘤组织中髓过氧化物酶(MPO)的水平,探讨其在结直肠腺瘤发生发展及“腺瘤-癌”转变过程中的作用。方法:收集80例结直肠腺瘤患者的组织学标本,常规HE染色,采用免疫组织化学方法检测MPO表达。根据HE染色结果分为低级... 详细信息

目的:通过测定结直肠腺瘤组织中髓过氧化物酶(MPO)的水平,探讨其在结直肠腺瘤发生发展及“腺瘤-癌”转变过程中的作用。方法:收集80例结直肠腺瘤患者的组织学标本,常规HE染色,采用免疫组织化学方法检测MPO表达。根据HE染色结果分为低级别管状腺瘤(A)组、管状绒毛状腺瘤(B)组、高级别上皮内瘤变和/或粘膜内癌(C)组;根据结肠镜检查腺瘤最大直径分为直径<10 mm(D)组、直径≥10mm(E)组。比较不同结直肠腺瘤癌变风险及不同结肠镜镜检腺瘤大小间MPO的表达水平。结果:腺瘤组织MPO阳性表达率为81.2%。A组呈弱阳性表达,阳性率66.0%;B组弱阳性表达率45.5%,中等强度阳性表达率45.5%;C组中等阳性表达率45.5%,强阳性表达率36.4%,各组两两比较,差异均有统计学意义(P<0.05)。E组MPO阳性表达率及表达强度均高于D组(P<0.05)。结论:MPO在结直肠腺瘤组织阳性表达,MPO可作为监测疾病病程和严重程度评估的组织学指标。

关键词：结直肠腺瘤髓过氧化物酶癌变风险

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A diagnosis model of parental care:How parents optimize their provisioning strategy in brood reduction?

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Current Zoology 2023年第4期69卷 385-392页

作者： Zhen-Qin Zhu shu-Mei Zi Li-Fang Gao Xiao-Dan zhang Fang-Yuan Liu Qian Wang Bo Du School of Life Sciences Lanzhou UniversityLanzhou CityGansu Province 730000China College of Ecology Lanzhou UniversityLanzhou CityGansu Province 730000China

Altricial birds often display biased preferences in providing parental care for their dependent offspring,especially during food *** this process,such inflexible rules may result in provisioning *** demonstrate how parents optimize their provisioning strategies,we proposed a“diagnosis model”of parental care to posit that parents will undergo a diagnosis procedure to test whether selecting against some particular offspring based on phenotype is an optimal *** tested this model in an asynchronous hatching bird,the Azure-winged Magpie Cyanopica cyanus,based on 10 years of data about demography and parental provisioning *** their higher daily survival rates,core offspring(those hatched on the first day)merits an investment priority compared with their marginal brood mates(those hatched on later days).However,a marginal offspring also merited a priority if it displayed greater weight gain than the expected value at the early post-hatching *** could detect such a marginal offspring via a diagnosis strategy,in which they provisioned the brood at the diagnosis stage by delivering food to every nestling that begged,then biased food toward high-value nestlings at the subsequent decision stage by making a negative response to the begging of low-value *** this provisioning strategy,the growth performance of a nestling became a more reliable indicator of its investment value than its hatching order or competitive *** findings provide evidence for this“diagnosis model of parental care”wherein parents use a diagnosis method to optimize their provisioning strategy in brood reduction.

关键词： brood reduction parental care provisioning strategy weight gain

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间变性多发性骨髓瘤3例临床病理学分析

诊断病理学杂志 2024年第3期31卷 226-230页

作者：曾麟舒赵媛张之钰贾俊梅陈红首都医科大学附属北京朝阳医院石景山院区病理科北京100043 首都医科大学附属北京朝阳医院石景山院区检验科北京100043

目的探讨间变性多发性骨髓瘤(AMM)的临床病理学特征。方法收集首都医科大学附属北京朝阳医院石景山院区2017—2022年诊断的3例AMM,对其病理学形态、免疫表型及分子病理特征进行回顾性分析。结果男性2例、女性1例,其中2例表现为多发性骨... 详细信息

目的探讨间变性多发性骨髓瘤(AMM)的临床病理学特征。方法收集首都医科大学附属北京朝阳医院石景山院区2017—2022年诊断的3例AMM,对其病理学形态、免疫表型及分子病理特征进行回顾性分析。结果男性2例、女性1例,其中2例表现为多发性骨质破坏;1例以髓外病变引发的压迫症状就诊。镜下:由异型性明显的幼稚浆细胞构成,可见多形性核、奇异形核和多核细胞。免疫组化显示肿瘤细胞CD38、CD138和MUM1均弥漫阳性,CD20、CD79α均阴性。免疫球蛋白均为Lambda链限制性表达。分子检测均为高危细胞遗传学异常,主要出现1q21基因扩增。结论AMM较为罕见,组织学形态多形性明显,需与多种肿瘤进行鉴别,具有高危细胞遗传学异常和侵袭性病程,需要引起临床和病理医师的高度重视。

关键词：多发性骨髓瘤间变性临床病理特征免疫组化鉴别诊断

Wavelet chaotic neural networks and their application to continuous function optimization

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Natural Science 2009年第3期1卷 204-209页

作者： Jia-Hai zhang Yao-qun Xu 不详

Neural networks have been shown to be pow-erful tools for solving optimization problems. In this paper, we first retrospect Chen’s chaotic neural network and then propose several novel chaotic neural networks. Second, we plot the figures of the state bifurcation and the time evolution of most positive Lyapunov exponent. Third, we apply all of them to search global minima of continuous functions, and respec-tively plot their time evolution figures of most positive Lyapunov exponent and energy func-tion. At last, we make an analysis of the per-formance of these chaotic neural networks.

关键词： Wavelet Chaotic Neural Networks Wavelet Optimization