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Enhancing cellular behavior in repaired tissue via silk fibroin-integrated triboelectric nanogenerators

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Microsystems & Nanoengineering 2024年第3期10卷 137-147页

作者： Zhelin Li shuxing Xu Zijie Xu sheng shu Guanlin Liu Jianda Zhou Ding Lin Wei Tang Changsha Aier Eye Hospital Aier School of OphthalmologyCentral South UniversityChangshaHunanChina The Xiangya Hospital Central South UniversityChangshaHunanChina Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 101400China Center on Nanoenergy Research School of Physical Science&TechnologyGuangxi UniversityNanning 530004China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Plastic Surgery the Third Xiangya HospitalChangshaHunanChina

Triboelectric nanogenerators(TENGs)have emerged as a promising approach for generating electricity and providing electrical stimuli in medical electronic *** their potential benefits,the clinical implementation of TENGs faces challenges such as skin compliance and a lack of comprehensive assessment regarding their biosafety and ***,further research is imperative to overcome these limitations and unlock the full potential of TENGs in various biomedical *** this study,we present a flexible silk fibroin-based triboelectric nanogenerator(SFB-TENG)that features an on-skin substrate and is characterized by excellent skin compliance and air/water *** range of electrical output generated by the SFB-TENG was shown to facilitate the migration and proliferation of Hy926,NIH-3T3 and RSC96 ***,apoptosis of fibroblast NIH-3T3 cells was observed when the output voltage increased to more than 20 V at a frequency of 2 *** addition,the moderate electrical stimulation provided by the SFB-TENG promoted the cell proliferation cycle in Hy926 *** research highlights the efficacy of a TENG system featuring a flexible and skin-friendly design,as well as its safe operating conditions for use in biomedical *** findings position TENGs as highly promising candidates for practical applications in the field of tissue regeneration.

关键词： overcome spite generating

Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Behavior:Synthesis,Characterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming Yin Li-Li Wu shu-sheng Li Xiao-Na Pan Xiao-Li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Shandong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled phase change,have garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and phase transition remains *** this study,we synthesized a series of catalyst-free aza-Michael addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively characterized,and demonstrated dual-phase transition behavior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

Fe/S oxidation-coupled arsenic speciation transformation mediated by AMD enrichment culture under different pH conditions

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Journal of Environmental Sciences 2024年第3期137卷 681-700页

作者： Yu-hang Zhou Wei-xi Huang Zhen-yuan Nie Hong-chang Liu Yue Liu Can Wang Jin-lan Xia Wen-sheng shu Key Lab of Biometallurgy of Ministry of Education of China School of Minerals Processing and BioengineeringCentral South UniversityChangsha 410083China School of Life Sciences South China Normal UniversityGuangzhou 510631China

Arsenic(As)speciation transformation in acid mine drainage(AMD)is comprehensively affected by biological and abiotic factors,such as microbially mediated Fe/S redox reactions and changes in environmental conditions(pH and oxidation-reduction potential).However,their combined impacts on arsenic speciation transformation remain poorly ***,we explored arsenic transformation and immobilization during pyrite dissolution mediated by AMD enrichment culture under different acidic pH *** results for incubation and mineralogical transformation of solid residues show that in the presence of AMD enrichment culture,pH 2.0,2.5,and 3.0 are more conducive to the formation of jarosites and ferric arsenate,which could immobilize high quantities of dissolved arsenic by adsorption and *** pH conditions significantly affect the initial adsorption of microbial cells to the minerals and the evolution of microbial community structure,further infuencing the biodissolution of pyrite and the release and oxidation process of Fe/*** results of Fe/S/As speciation transformation of the solid residues show that the transformation of Fe,S,and As in solution is mainly regulated by pH and potential values,which imposed significantly different effects on the formation of secondary minerals and thus arsenic oxidation and *** above results indicated that arsenic transformation is closely related to the Fe/S oxidation associated with pyrite bio-oxidation,and this correlation is critically regulated by the pH conditions of the system.

关键词： Acid mine drainage(AMD) pH conditions Fe/S/As speciation transformation Microbial community structure

Immunoglobulin G-mediated food intolerance and metabolic syndrome influence the occurrence of reflux esophagitis in Helicobacter pylori-infected patients

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World Journal of Gastroenterology 2024年第8期30卷 855-862页

作者： Li-Hui Wang Bin-Bin Su sheng-shu Wang Guan-Chao Sun Kun-Ming Lv Yi Li Hui Shi Qian-Qian Chen College Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology Second Medical Center of Chinese PLA General HospitalBeijing 100853China Institute of Geriatrics The 2nd Medical CenterBeijing Key Laboratory of Aging and GeriatricsNational Clinical Research Center for Geriatrics DiseasesSecond Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China

BACKGROUND Reflux esophagitis has an increasing prevalence and complex and diverse *** its risk factors is crucial to understanding the etiology,prevention,and management of the *** occurrence of reflux esophagitis may be associated with food reactions,Helicobacter pylori(***)infection,and metabolic *** To investigate the risk factors for reflux esophagitis and analyze the effects of immunoglobulin(Ig)G-mediated food intolerance,*** infection,and metabolic syndrome on reflux *** Outpatients attending the Second Medical Center of the PLA General Hospital between 2017 and 2021 were retrospectively *** patients’basic information,test results,gastroscopy results,*** test results,and IgG-mediated food intolerance results were *** logistic regression analysis was used to analyze risk factors for reflux *** mediation analysis was used to evaluate the effects of IgG-mediated food intolerance and metabolic syndrome on *** infection affecting reflux *** A total of 7954 outpatients were included;the prevalence of reflux esophagitis,IgG-mediated food intolerance,*** infection,and metabolic syndrome were 20.84%,61.77%,35.91%,and 60.15%,*** analysis showed that the independent risk factors for reflux esophagitis included IgG-mediated food intolerance(OR=1.688,95%CI:1.497-1.903,P<0.00001)and metabolic syndrome(OR=1.165,95%CI:1.030-1.317,P=0.01484),and the independent protective factor for reflux esophagitis was *** infection(OR=0.400,95%CI:0.351-0.456,P<0.00001).IgG-mediated food intolerance had a partially positive mediating effect on *** infection as it was associated with reduced occurrence of reflux esophagitis(P=0.0200).Metabolic syndrome had a partially negative mediating effect on *** infection and reduced the occurrence of reflux esophagitis(P=0.0220).CONCLUSION Patients with IgG-mediated food intol

关键词： Gastroesophageal reflux Esophagitis Food intolerance Metabolic syndrome Helicobacter pylori Chemokines

Hepatitis B surface antigen-negative but hepatitis B envelope antigen-positive false occult hepatitis B virus infection:A case report

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World Journal of Hepatology 2024年第10期16卷 1199-1207页

作者： shu-sheng Yang Fei Fu Qian-Kun Xuan Zhou-Xiang Zhang Zhi-Jun Li Guang-Bo Li Xiao-Yu Yu Department of Laboratory Medicine Shanghai East HospitalTongji University School of MedicineShanghai 200123China Department of Obstetrics and Gynecology Shanghai East HospitalTongji University School of MedicineShanghai 200123China

BACKGROUND Occult hepatitis B infection(OBI)is characterized by the detection of hepatitis B virus(HBV)DNA in serum(usually HBV DNA<200 IU/mL)or the liver but negativity for hepatitis B surface antigen(HBsAg).The diagnosis of OBI relies on the sensitivity of assays used in the detection of HBV DNA and *** assays with inadequate sensitivity or inability to detect HBV S variants may lead to misdiagnosis of OBI in people with overt HBV *** SUMMARY We report a HBsAg-negative but hepatitis B envelope antigen-positive patient who had a significant HBV DNA *** patient was initially diagnosed as having ***,sequence analysis revealed a unique insertion of amino acid residues at positions 120-124 in the S protein,which affects the formation of a disulfide bond that is associated with the formation of a *** is well known that there is an overlap between the S protein and Pol *** found that this new insertion site occurred in polymerase/reverse transcriptase domain,indi-cating that this insertion might be involved in HBV *** patient was finally diagnosed with a false *** An insertion of amino acid residues at positions 120-124 of the S protein affects the formation of immunodominant epitopes and results in negative HBsAg levels.

关键词： Occult hepatitis B infection Hepatitis B virus Hepatitis B surface antigen Hepatitis B envelope antigen Immunodominant epitopes Case report

《生化分析》专辑序言——助力疾病的临床诊断

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应用化学 2024年第1期41卷 1-2页

作者：张书圣临沂大学医学院山东省肿瘤标志物检测技术重点实验室临沂276000

疾病的发生、发展与患者体内不正常生理活动产生的生化分子异常表达密切相关,例如,正常人体内三磷酸腺苷(ATP)浓度通常小于0.4 mmol/L,而恶性肿瘤细胞的ATP浓度可达1.5~15 mmol/L;又如血浆中组氨酸水平异常可能与癫痫、精神分裂症和肝... 详细信息

疾病的发生、发展与患者体内不正常生理活动产生的生化分子异常表达密切相关,例如,正常人体内三磷酸腺苷(ATP)浓度通常小于0.4 mmol/L,而恶性肿瘤细胞的ATP浓度可达1.5~15 mmol/L;又如血浆中组氨酸水平异常可能与癫痫、精神分裂症和肝硬化等多种疾病相关。多种疾病相关的生化分子已成为临床诊断的理想生物标志物,为疾病的早期诊断和及时治疗提供有力工具。然而,某些生化分子相对较低的丰度以及高度的相似性为其准确定量带来了巨大挑战,因此,发展出更快速、更灵敏和特异性高的生化分析方法,将疾病相关分子以光、电等多种信号形式呈现出来具有重要意义。

关键词：生化分析临床诊断正常生理活动生物标志物 ATP浓度精神分裂症准确定量早期诊断

基于语义本体的在线健康信息行为与情感交互关系及情感画像分析

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情报科学 2024年第2期42卷 119-129页

作者：盛姝李娜黄奇董晔烟台大学经济管理学院山东烟台264005 南京大学信息管理学院江苏南京210023 烟台大学文学与新闻传播学院山东烟台264005

【目的/意义】探寻在线健康社区健康信息行为与情感之间交互关系,帮助社区疏导与关怀用户情绪,发挥社区情感支持作用。【方法/过程】研究以“方面词-情感”关系三元组抽取方式挖掘社区“行为-情感”之间的语义结构关系,进而建立“行为-... 详细信息

【目的/意义】探寻在线健康社区健康信息行为与情感之间交互关系,帮助社区疏导与关怀用户情绪,发挥社区情感支持作用。【方法/过程】研究以“方面词-情感”关系三元组抽取方式挖掘社区“行为-情感”之间的语义结构关系,进而建立“行为-情感”本体。在此基础上从多个视角及路径揭示行为与情感之间交互关联。【结果/结论】研究发现,在线健康信息行为与情感之间存在交互关系,且不同健康信息行为下与情感交互关系也具有明显差异。健康分享行为下,个体的情感显著影响个体行为。健康分享行为与积极情感的组合一定程度上促进知识的信任及接纳程度;健康信息搜寻行为下,个体的消极情感显著影响个体不同行为;积极情感通过健康信息分享行为作为中介对健康信息偶遇行为产生积极影响;情感对健康信息规避行为起到调节作用。【创新/局限】语义本体技术丰富了健康信息行为与情感之间交互关系及路径的方法研究,为社区监控舆情及疏散用户情绪提供了建议参考。研究有待于进一步探索多情境下行为与情感相互作用机制。

关键词：健康信息行为情感交互关系情感画像本体

场域理论视角下中国参与全球体育治理的困境、成因与路径

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广州体育学院学报 2024年第1期44卷 64-71,119页

作者：白银龙舒盛芳湖南师范大学体育学院湖南长沙410012 玉溪师范学院体育学院云南玉溪653100 上海体育大学体育教育学院上海200438

中国参与全球体育治理是维护国家体育利益、提高国际影响力的重要举措,也是为全球体育发展贡献中国方案、中国智慧的必然路径。基于布迪厄场域理论系统探讨我国参与全球体育治理这一实践活动,明晰我国在全球体育治理中的角色地位和现实... 详细信息

中国参与全球体育治理是维护国家体育利益、提高国际影响力的重要举措,也是为全球体育发展贡献中国方案、中国智慧的必然路径。基于布迪厄场域理论系统探讨我国参与全球体育治理这一实践活动,明晰我国在全球体育治理中的角色地位和现实样态及其成因。研究认为:我国参与全球体育治理正从半边缘走向中心位置,表现出明显的治理主体、平台、话语和效能困境。其主要成因是场域位置失衡和固化制约主导地位的获得、资本差距限制场域位置的跃升以及惯习束缚导致主体自觉的缺失。未来,需通过营造有利于我国深度参与的场域环境、加强资本积累获得更高的场域位置和培养参与主体积极进取的良好惯习,促进我国参与全球体育治理效能持续提升。

关键词：中国全球体育治理体育对外交往场域理论

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燃气轮机中心分级旋流燃烧器的几何模化研究

热能动力工程 2024年第1期39卷 119-126页

作者：刘占南葛冰姜海燕臧述升上海交通大学机械与动力工程学院上海200240 中国船舶第七○三研究所黑龙江哈尔滨150078

针对燃气轮机原尺寸燃烧试验不易开展的问题,基于特征速度、雷诺数与达姆科勒数等特征参量,对燃气轮机中心分级旋流器开展模化试验研究。本研究通过火焰自发光拍摄、气体组分分析等方法,在相同分层比下,对比等速度、等雷诺数和等达姆科... 详细信息

针对燃气轮机原尺寸燃烧试验不易开展的问题,基于特征速度、雷诺数与达姆科勒数等特征参量,对燃气轮机中心分级旋流器开展模化试验研究。本研究通过火焰自发光拍摄、气体组分分析等方法,在相同分层比下,对比等速度、等雷诺数和等达姆科勒数3种不同模化准则的试验结果在火焰结构、出口温度、污染物排放等方面的一致性,确定不同模化准则的模化特性;并在不同分层比下,研究分层比对达姆科勒准则模化效果的影响。结果表明:应用等达姆科勒数准则进行模化,模化燃烧器与原型的试验结果差异度最小;等雷诺数准则在各项特征的模化中,均与原型燃烧室存在较大差异。改变分层比,选择等达姆科勒数准则模化方法时,火焰结构的模化差异随分层比升高而减小,NO排放量在分层比取值为1时差异度最小。

关键词：中心分级相似准则变分层比