检索结果-南通市图书馆

Medial prefrontal cortex-pontine nuclei projections modulate associative motor learning

在线全文

学校读者我要写书评

暂无评论

Medial prefrontal cortex-pontine nuclei projections modulate...

Blockades of angiotensin and aldosterone reduce osteopontin expression and interstitial fibrosis infiltration in rats with myocardial infarction

中国生理学会张锡钧基金会第十四届全国青年优秀生理学学术论文交流及评奖会议、中国生理学会第十二届全国青年生理学工作者学术会议

作者： Guang-Yan Wu shu-lei Liu Jian-Feng Sui Department of Physiology College of Basic Medical SciencesThird Military Medical University

Diverse and powerful mechanisms have evolved to enable organisms to modulate learning and memory under a variety of survival *** evidence has shown that the medial prefrontal cortex(PFC) is closely involved in many higher-order cognitive ***,we have found that optogenetic activation of the mPFC pyramidal neurons as a conditioned stimulus(CS)is sufficient to support the acquisition of delay eyeblink conditioning(DEC).Interestingly,the associative memory was not stably expressed during the initial period of daily conditioning session even after the DEC acquisition reached the asymptotic *** intensity and consistency of the CS were found to be crucial factors in regulating the retrieval of the associative memory(i.e.,high encoding specificity).In addition,it is well established that the brainstem-cerebellar circuit is essential and sufficient for DEC under optimal learning conditions,and that several forebrain structures,such as the mPFC and hippcampus are required for trace eyeblink conditioning(TEC),but not for DEC under optimal learning ***,when and how the mPFC modulates associative motor learning remains largely ***,we show that the DEC with the weak CS(wCS) but not the strong CS(sCS) elicited a significant increase in the levels of c-Fos expression in *** optogenetic inhibition and activation of the mPFC,or its axon terminals at the pontine nucleus(PN) significantly impaired the acquisition,recent and remote retrieval of DEC with the wCS,but not the ***,direct optogenetic activation of the PN had no significant effect on the acquisition,recent and remote retrieval of ***,we also show that optogenetic inhibition of the mPFC or its axon terminals at the pontine nuclei(PN) during trace intervals or whole trial period significantly impaired TEC,but had no significant effects on TEC during the CS or intertrial interval ***,the nature of the roles of mPFC in TEC and DEC may be

关键词： Medial prefrontal cortex-pontine nuclei projections modulate associative motor learning

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Medical Journal 2008年第21期121卷 2192-2196页

作者： ZHANG Yu-ling ZHOU shu-xian lei Juan YUAN Gui-yi WANG Jing-feng Department of Cardiology Second Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510120 China

Background It has been reported that osteopontin has an important role in cardiac fibrosis and remodeling. However, its direct mechanisms remain unclear. The purpose of this study was to investigate the role of angiotensin and aldosterone blockades in cardiac osteopontin expression associated with cardiac remodeling in myocardial infarcted （MI） rats. Methods Fifty SD rats that survived 24 hours after ligating left anterior descending coronary artery were randomly divided into three groups： MI-saline group （n=15, 5 ml/d）, MI-perindopril group （n=18, perindopril 2 mg·kg^-1·d^-1） and MI-spironolacton （n=-17, spironolacton 20 mg·kg^-1·d^-1）. A sham operation group （n=15） was selected as non-infarcted control. At 6 weeks after treatment, hemodynamic pararmeters and left ventricular function were measured with catheterization, interstitial fibrosis infiltration and cardiomyocyte diameters were evaluated histologically. Myocardium osteopontin protein expression level in the non-infarcted myocardium was detected by Western blotting. Results No osteopontin protein was detected in the myocardium of sham-operation rats. High levels of osteopontin protein expression were detected in the MI-saline rats, but the levels were suppressed in the MI-perindopril and MI-spironolacton rats at 6 weeks following MI （P 〈0.01, respectively）. Compared with the sham operation group, all rats in the MI group showed marked interstitial fibrosis infiltration in the non-infarction area, higher ventricular weight/body weight ratio, significantly increased cardiomyocyte diameter （P 〈0.01, respectively）, and developed significant systolic and diastolic dysfunction as indicated by decreased left ventricular systolic pressure （LVSP） and ±dp/dt, as well as increased left ventricular end-diastolic pressure （LVEDP）（P 〈0.01, respectively）. Angiotensin and aldosterone blockades partly prevented cardiac fibrosis and systolic and diastolic dysfunction （P 〈0.01, respectively）. Conclusion Treatment with an

关键词： osteopontin myocardial infarction renin-angiotensin system

Systemic air embolism in a fungal pneumonia patient with lung cavities formation and review of literature

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Traumatology 2019年第5期22卷 308-310页

作者： Hai-Jun Huang shu lei Lin Yang Li-Ming Jin First Affiliated Hospital Zhejiang University of Traditional Chinese MedicineHangzhou 310006China Zhejiang Provincial People's Hospital Hangzhou 310014China Affiliated People's Hospital of Hangzhou Medical College Hangzhou 310014China

Systemic air embolism is a rare but potentially fatal complication related to many *** purpose of this article is to alert clinicians once patients occurs an abnormal neurological and cardiovascular status,following minor traumatic treatment,air embolism should be considered.A 20-year-old man who presented with fungal pneumonia with lung cavities formation was adm让ted to an intensive care unit(ICU)and received positive airway pressure *** days later,the fun gal pneumonia was improved,but the patient's blood pressure and arterial oxygen saturation deteriorated,so computed tomography(CT)scans were preformed to reevaluate *** scans detected air embolism in the left atrium and ventricle,ascending aorta,aortic arch and its branches(right brachiocephalic,bilateral common carotid and right subclavian arteries),descending aorta and right coronary artery.A CT scan of the abdomen revealed air in the spleen,cauda pancreatic,superior mesenteric artery and right external iliac *** patient died two days later from multiple organ *** suggest that vascular air embolism should be considered under mechanical ventilation when patients'neurologic and cardiovascular status deteriorates,and hyperbaric oxygen therapy should be conducted immediately.

关键词： Air embolism Fungal pneumonia Positive end-expiratory pressure

在线全文

学校读者我要写书评

暂无评论

高效耗能黏弹性阻尼框架结构减震性能研究

计算力学学报 2024年第3期41卷 437-444,505页

作者：张敏舒磊兴江西科技师范大学建筑工程学院南昌330038 华东交通大学土木建筑学院南昌330038

提出了高效耗能黏弹性阻尼器,研究了该阻尼器对框架结构的减震机理。首先给出了高效耗能黏弹性阻尼器的结构构造,推导了小震、大震与巨震作用下的阻尼放大系数计算公式,由此分析了该放大系数的变化规律。此外,还推导了设置高效耗能黏弹... 详细信息

提出了高效耗能黏弹性阻尼器,研究了该阻尼器对框架结构的减震机理。首先给出了高效耗能黏弹性阻尼器的结构构造,推导了小震、大震与巨震作用下的阻尼放大系数计算公式,由此分析了该放大系数的变化规律。此外,还推导了设置高效耗能黏弹性阻尼框架结构的等效阻尼比。分析表明,框架结构设置高效耗能黏弹性阻尼器在阻尼等效前后顶部位移反应时程曲线相差不超过10%。

关键词：框架阻尼高效减震黏弹性等效放大

维普期刊数据库博看期刊

在线全文

学校读者我要写书评

暂无评论

中条山野生观赏树种资源的多样性研究

林业科学研究 2016年第6期29卷 861-868页

作者：裴淑兰王凯雷淑慧山西林业职业技术学院山西太原030009

[目的]观赏树种资源的多样性是植物多样性的组成部分,研究野生观赏树种资源的组成、分布特点和开发利用策略有重要的科学价值和社会意义。[方法]采用线路调查法,对中条山野生观赏树种及其生长环境、生长状况、分布特点、观赏特性等进行... 详细信息

[目的]观赏树种资源的多样性是植物多样性的组成部分,研究野生观赏树种资源的组成、分布特点和开发利用策略有重要的科学价值和社会意义。[方法]采用线路调查法,对中条山野生观赏树种及其生长环境、生长状况、分布特点、观赏特性等进行实地调查,经专家初选后采用层次分析法对其进行定量评价。[结果]表明:中条山有野生观赏树种380种(包括亚种、变种及变型),隶属63科128属,种类、生活型、分布、观赏及应用多样性丰富;专家初步评定筛选出90种重要观赏树种,并分乔木、灌木、藤本进行综合定量评级,结果分别划分为3个等级:分值>4.5为Ⅰ级,乔木9种、灌木6种、藤本4种;3.5<分值≤4.5为Ⅱ级,乔木9种、灌木11种、藤本6种;分值≤3.5为Ⅲ级,乔木20种、灌木20种、藤本5种。[结论]Ⅰ级树种可以在适生范围内优先大量开发利用;Ⅱ级树种可以在适生范围内适度开发利用;Ⅲ级树种可以在适生范围内选择性地开发利用。

关键词：中条山野生观赏树种多样性综合评价开发利用

转移支付分配如何影响地方基本公共服务供给——基于政府间财政竞争的视角

在线全文

学校读者我要写书评

暂无评论

当代财经 2021年第12期 28-40页

作者：束磊梁倩上海商学院商务经济学院上海201400 贵州财经大学大数据应用与经济学院贵州贵阳550025

转移支付是保障地方基本公共服务供给的重要制度安排。利用2003—2019年中国省级面板数据,实证分析了政府间财政竞争机制下,转移支付分配对地方基本公共服务供给产生的影响。研究发现,政府间转移支付分配与地方基本公共服务供给表现为... 详细信息

转移支付是保障地方基本公共服务供给的重要制度安排。利用2003—2019年中国省级面板数据,实证分析了政府间财政竞争机制下,转移支付分配对地方基本公共服务供给产生的影响。研究发现,政府间转移支付分配与地方基本公共服务供给表现为显著的竞争性策略互动关系。竞争性地区分配的转移支付资金越多,本地政府越倾向于减少基本公共服务供给;这种竞争性的策略互动关系,抑制了转移支付对地方基本公共服务供给的激励保障作用。分转移支付类型来看,这种竞争性策略互动关系对地方基本公共服务供给的抑制作用在专项转移支付上表现更加突出;分地区来看,竞争性策略互动关系对地方基本公共服务供给的抑制作用在经济发达地区表现更加明显。因此,规范地区间财政竞争秩序,构建更加科学透明的转移支付资金分配制度,进一步优化转移支付资金分配结构,有利于发挥转移支付制度保障地方基本公共服务供给的激励作用。

关键词：转移支付地方基本公共服务政府间财政竞争策略互动关系

在线全文

学校读者我要写书评

暂无评论

稀见戏曲《仙合曲谱》考述

中国典籍与文化 2011年第1期 92-96页

作者：孙书磊南京师范大学文学院

何兆瀛《仙合曲谱》杂剧为稀见的古典戏曲之一。作者创作该剧旨在纪念其两位亡妻蔡耆和管鞠。该剧本事源自现实生活,显示中国古代戏曲题材处理的新动向;其艺术形式的创新体现古典戏曲体制的变异与交融,代表文人南杂剧发展的新形式;而其... 详细信息

何兆瀛《仙合曲谱》杂剧为稀见的古典戏曲之一。作者创作该剧旨在纪念其两位亡妻蔡耆和管鞠。该剧本事源自现实生活,显示中国古代戏曲题材处理的新动向;其艺术形式的创新体现古典戏曲体制的变异与交融,代表文人南杂剧发展的新形式;而其凸显的自娱功能与"去舞台化"现象,则表明古典戏曲从艺术层面向文学层面的回归。

关键词：仙合曲谱何兆瀛杂剧

在线全文

学校读者我要写书评

暂无评论

从《龙舟会》杂剧看王夫之的历史观与戏剧观

东南大学学报（哲学社会科学版） 2007年第1期9卷 105-109页

作者：孙书磊南京师范大学文学院江苏南京210097

王夫之《龙舟会》杂剧的创作,体现了作者肯定政治中兴的历史观念、忠君怀国的历史评价标准、进步的妇女问题史观,显示了作者对明清鼎革历史的独有认识。剧作对民族戏剧的艺术创作原则有创造性的发挥,对南北曲的通融处理体现了作者与时... 详细信息

王夫之《龙舟会》杂剧的创作,体现了作者肯定政治中兴的历史观念、忠君怀国的历史评价标准、进步的妇女问题史观,显示了作者对明清鼎革历史的独有认识。剧作对民族戏剧的艺术创作原则有创造性的发挥,对南北曲的通融处理体现了作者与时俱进的戏剧观,同时,剧作还明显地受其诗景诗歌理论的影响。王夫之的历史观和戏剧观在当时具有明显的进步性和独创性。

关键词：王夫之《龙舟会》杂剧历史观戏剧观

在线全文

学校读者我要写书评

暂无评论

一种文物微环境专用调湿剂的回烘方法初探

文博 2020年第3期 101-106,78页

作者：雷淑四川博物院四川成都610071

文物微环境调湿剂的重复利用,不但能充分发挥其湿度调控作用,还能降低成本投入,是环境湿度调控中既经济实用又安全便携的方法之一。本文通过对比分析调湿剂在不同回烘时间、不同回烘方式下的吸放湿效果,并测定其回烘后的单位吸湿能力、... 详细信息

文物微环境调湿剂的重复利用,不但能充分发挥其湿度调控作用,还能降低成本投入,是环境湿度调控中既经济实用又安全便携的方法之一。本文通过对比分析调湿剂在不同回烘时间、不同回烘方式下的吸放湿效果,并测定其回烘后的单位吸湿能力、单位放湿能力、单位目标湿容量等相关调湿性能,探索出一种有效的回烘方法。实验结果表明,回烘时间、回烘方式和包装材料对调湿剂的吸放湿效果均有一定影响,采用烘干至恒重后再恒湿的方式,吸湿效果更好,采用直接恒湿的方式,放湿效果更好,且等温吸放湿曲线表明,该调湿剂的吸湿量明显大于放湿量。研究结果对不同文物保存环境的调控需求具有一定的实践指导意义。

关键词：调湿剂回烘时间回烘方式吸放湿效果调湿性能