检索结果-南通市图书馆

Gut microbiota dysbiosis contributes toα-synuclein-related pathology associated with C/EBPβ/AEP signaling activation in a mouse model of Parkinson’s disease

引用

Neural Regeneration Research 2024年第9期19卷 2081-2088页

作者： Xiaoli Fang Sha Liu Bilal Muhammad Mingxuan Zheng Xing Ge Yan Xu shu kan Yang Zhang Yinghua Yu Kuiyang Zheng Deqin Geng Chun-Feng Liu Department of Neurology and Clinical Research Center of Neurological Disease The Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Department of Neurology Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogen Biology and ImmunologyXuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Neurology Xuzhou Central HospitalXuzhouJiangsu ProvinceChina Jiangsu Key Laboratory of Neuropsychiatric Disease and Institute of Neuroscience Soochow UniversitySuzhouJiangsu ProvinceChina

Parkinson’s disease is a neurodegenerative disease characterized by motor and gastrointestinal *** dysfunction can precede the onset of motor symptoms by several *** microbiota dysbiosis is involved in the pathogenesis of Parkinson’s disease,whether it plays a causal role in motor dysfunction,and the mechanism underlying this potential effect,remain ***/enhancer binding proteinβ/asparagine endopeptidase(C/EBPβ/AEP)signaling,activated by bacterial endotoxin,can promoteα-synuclein transcription,thereby contributing to Parkinson’s disease *** this study,we aimed to investigate the role of the gut microbiota in C/EBPβ/AEP signaling,α-synuclein-related pathology,and motor symptoms using a rotenone-induced mouse model of Parkinson’s disease combined with antibiotic-induced microbiome depletion and fecal microbiota *** found that rotenone administration resulted in gut microbiota dysbiosis and perturbation of the intestinal barrier,as well as activation of the C/EBP/AEP pathway,α-synuclein aggregation,and tyrosine hydroxylase-positive neuron loss in the substantia nigra in mice with motor ***,treatment with rotenone did not have any of these adverse effects in mice whose gut microbiota was depleted by pretreatment with ***,we found that transplanting gut microbiota derived from mice treated with rotenone induced motor deficits,intestinal inflammation,and *** of fecal microbiota from healthy control mice alleviated rotenone-induced motor deficits,intestinal inflammation,endotoxemia,and intestinal barrier *** results highlight the vital role that gut microbiota dysbiosis plays in inducing motor deficits,C/EBPβ/AEP signaling activation,andα-synuclein-related pathology in a rotenone-induced mouse model of Parkinson’s ***,our findings suggest that supplementing with healthy microbiota may be a safe and effective treatment that c

关键词： C/EBP/AEP signaling pathway endotoxemia fecal microbiota transplantation intestinal barrier intestinal inflammation microbiota-gut-brain axis Parkinson’s disease

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Integrated color defect detection method for polysilicon wafers using machine vision

引用

Advances in Manufacturing 2014年第4期2卷 318-326页

作者： Zai-Fang Zhang Yuan Liu Xiao-Song Wu shu-Lin kan School of Mechatronic and Automation Engineering Shanghai University School of Mechanical and Power Engineering Shanghai JiaoTong University

For the typical color detects of polysilicon wafers, i.e., edge discoloration, color inaccuracy and color non-uniformity, a new integrated machine vision detection method is proposed based on an HSV color model. By transforming RGB image into three-channel HSV images, the HSV model can efficiently reduce the disturbances of complex wafer textures. A fuzzy color clustering method is used to detect edge discoloration by defining membership function for each channel image. The mean-value classi- fying method and region growing method are used to identify the other two defects, respectively. A vision detection system is developed and applied in the produc- tion of polysilicon wafers.

关键词： Polysilicon wafers Color defect detection Machine vision Fuzzy color clustering Region growingmethod

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Coupling Analysis of Multiple Machine Learning Models for Human Activity Recognition

引用

Computers, Materials & Continua 2024年第6期79卷 3783-3803页

作者： Yi-Chun Lai shu-Yin Chiang Yao-Chiang kan Hsueh-Chun Lin Department of Public Health China Medical UniversityTaichung406040Taiwan Department of Information and Telecommunications Engineering Ming Chuan UniversityGui-ShanTaoyuan333Taiwan Department of Electrical Engineering Yuan Ze UniversityChung-Li32003Taiwan Department and Institute of Health Service Administrations China Medical UniversityTaichung406040Taiwan

Artificial intelligence(AI)technology has become integral in the realm of medicine and healthcare,particularly in human activity recognition(HAR)applications such as fitness and rehabilitation *** study introduces a robust coupling analysis framework that integrates four AI-enabled models,combining both machine learning(ML)and deep learning(DL)approaches to evaluate their effectiveness in *** analytical dataset comprises 561 features sourced from the UCI-HAR database,forming the foundation for training the ***,the MHEALTH database is employed to replicate the modeling process for comparative purposes,while inclusion of the WISDM database,renowned for its challenging features,supports the framework’s resilience and *** ML-based models employ the methodologies including adaptive neuro-fuzzy inference system(ANFIS),support vector machine(SVM),and random forest(RF),for data *** contrast,a DL-based model utilizes one-dimensional convolution neural network(1dCNN)to automate feature ***,the recursive feature elimination(RFE)algorithm,which drives an ML-based estimator to eliminate low-participation features,helps identify the optimal features for enhancing model *** best accuracies of the ANFIS,SVM,RF,and 1dCNN models with meticulous featuring process achieve around 90%,96%,91%,and 93%,*** analysis using the MHEALTH dataset showcases the 1dCNN model’s remarkable perfect accuracy(100%),while the RF,SVM,and ANFIS models equipped with selected features achieve accuracies of 99.8%,99.7%,and 96.5%,***,when applied to the WISDM dataset,the DL-based and ML-based models attain accuracies of 91.4%and 87.3%,respectively,aligning with prior research *** conclusion,the proposed framework yields HAR models with commendable performance metrics,exhibiting its suitability for integration into the healthcare services system through AI-driven applications.

关键词： Human activity recognition artificial intelligence support vector machine random forest adaptive neuro-fuzzy inference system convolution neural network recursive feature elimination

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evaluation of pharmacokinetics and pharmacodynamics relationships for Salvianolic Acid B micro-porous osmotic pump pellets in angina pectoris rabbit

引用

Asian Journal of Pharmaceutical Sciences 2014年第3期9卷 137-145页

作者： shu-Ling kan Jin Li Jian-Ping Liu Hong-Liang He Wen-Jing Zhang Department of Pharmaceutics China Pharmaceutical UniversityNanjingPR China Department of Pharmacy Xuzhou Medical CollegeXuzhouPR China

The work aims to investigate the in vitro release,pharmacokinetics(PK),pharmacodynamics(PD)and PK-PD relationships of Salvianolic Acid B micro-porous osmotic pump pellets(SalB-MPOPs)in angina pectoris New Zealand White(NZW)rabbits,compared with those of SalB immediate-release pellets(SalB-IRPs).The SalB plasma concentrations and Superoxide dismutase levels(PD index)were recorded continuously at predetermined time interval after administration,and the related parameters were calculated by using Win-Nonlin *** release profile of MPOPs was more sustained than that of *** results indicated that the mean C_(max) was significantly lower,the SalB plasma concentrations were steadier,both area under concentration-time curve from 0 to 24 h(AUC_(0-24 h))and from 0 to infinity(AUC_(0-∞))were presented larger,and both the peak concentration time(T_(max))and mean residence time(MRT)were prolonged for MPOPs,as compared with those of *** results suggested that peak drug effect(E_(max))was lower and the equilibration rate constant(k_(e0))between the central compartment and the effect compartment was higher of MPOPs *** of *** relationships demonstrated that the effectconcentration-time(ECT)course of MPOPs was clockwise hysteresis loop,and that of IRPs was counter-clockwise hysteresis ***,those results demonstrated that MPOPs were potential formulations in treating angina pectoris induced by atherosclerosis.

关键词： Salvianolic Acid B Pharmacokinetics Pharmacodynamics SalB micro-porous osmotic pump pellets PKePD relationships

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

带航路规划的反舰导弹新“纯方位”攻击方法

引用

系统工程与电子技术 2013年第10期35卷 2110-2114页

作者：卢发兴刘树衎海军工程大学电子工程学院湖北武汉430033

针对反舰导弹对海攻击中传统"纯方位"攻击方法存在的末制导雷达开机早、易被干扰的不足,提出一种新的"纯方位"攻击方法。所提方法利用导弹航路规划能力,将传统方法中朝目标散布区长轴方向攻击改变为朝短轴方向迂回攻击,推迟了末制导雷... 详细信息

针对反舰导弹对海攻击中传统"纯方位"攻击方法存在的末制导雷达开机早、易被干扰的不足,提出一种新的"纯方位"攻击方法。所提方法利用导弹航路规划能力,将传统方法中朝目标散布区长轴方向攻击改变为朝短轴方向迂回攻击,推迟了末制导雷达的开机时间,可有效避免导弹被敌方电子干扰设施提前发现,增强了导弹的隐蔽性和末端突防能力。对所提方法中由于航路规划所带来的导弹可攻击范围的改变进行了建模和评估,从而为采用新方法的反舰导弹作战能力和需求的匹配提供依据。

关键词：反舰导弹攻击方法纯方位航路规划可攻击范围

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Verifying hierarchical network nonlocality in general quantum networks

引用

Chinese Physics B 2024年第7期33卷 199-208页

作者：杨舒媛侯晋川贺衎 College of Mathematics Taiyuan University of TechnologyTaiyuan 030024China

Recently, a class of innovative notions on quantum network nonlocality(QNN), called full quantum network nonlocality(FQNN), have been proposed in Phys. Rev. Lett. 128 010403(2022). As the generalization of full network nonlocality(FNN), l-level quantum network nonlocality(l-QNN) was defined in arxiv. 2306.15717 quant-ph(2024). FQNN is a NN that can be generated only from a network with all sources being non-classical. This is beyond the existing standard network nonlocality, which may be generated from a network with only a non-classical source. One of the challenging tasks is to establish corresponding Bell-like inequalities to demonstrate the FQNN or l-QNN. Up to now, the inequality criteria for FQNN and l-QNN have only been established for star and chain networks. In this paper, we devote ourselves to establishing Bell-like inequalities for networks with more complex structures. Note that star and chain networks are special kinds of tree-shaped networks. We first establish the Bell-like inequalities for verifying l-QNN in k-forked tree-shaped networks. Such results generalize the existing inequalities for star and chain networks. Furthermore, we find the Bell-like inequality criteria for l-QNN for general acyclic and cyclic networks. Finally, we discuss the demonstration of l-QNN in the well-known butterfly networks.

关键词： full network nonlocality hierarchical network nonlocality tree network

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantitative effect of kerogen type on the hydrocarbon generation potential of Paleogene lacustrine source rocks,Liaohe Western Depression,China

引用

Petroleum Science 2024年第1期21卷 14-30页

作者： Sha-Sha Hui Xiong-Qi Pang Fu-Jie Jiang Chen-Xi Wang shu-Xing Mei Tao Hu Hong Pang Min Li Xiao-Long Zhou kan-Yuan Shi State Key Laboratory of Petroleum Resources and Prospecting China University of Petroleum(Beijing)Beijing102249China College of Geosciences China University of Petroleum(Beijing)Beijing102249China Exploration and Development Research Institute PetroChina Liaohe Oilfield CompanyPanjin 124010LiaoningChina

Kerogen types exert a decisive effect on the onset and capacity of hydrocarbon generation of source *** source rocks in the Liaohe Western Depression are characterized by thick deposition,high total organic carbon(TOC)content,various kerogen types,and a wide range of thermal ***,their hydrocarbon generation potential and resource estimation can be *** this study,geochemical tests,numerical analysis,hydrocarbon generation kinetics,and basin modeling were integrated to investigate the differential effects of kerogen types on the hydrocarbon generation potential of lacustrine source *** hydrocarbon generation and expulsion(HGE)models of different kerogen types were established quantitatively upon abundant Rock-Eval/TOC/vitrinite reflectance(R_(o))*** sets of good-excellent source rocks deposited in the fourth(Es4),third(Es3),and first(Es1)members of Paleogene Shahejie Formation,are predominantly types I-II_(1),II_(1)-II_(2),and II-III,*** activation energy of types I-II_(2)kerogen is concentrated(180-230 kcal/mol),whereas that of type III kerogen is widely distributed(150-280 kcal/mol).The original hydrocarbon generation potentials of types I,II_(1),II_(2),and III kerogens are 790,510,270,and 85 mg/g TOC,*** Ro values of the hydrocarbon generation threshold for type I-III source rocks gradually increase from 0.42%to 0.74%,and Ro values of the hydrocarbon expulsion threshold increase from 0.49%to 0.87%.Types I and II_(1)source rocks are characterized by earlier hydrocarbon generation,more rapid hydrocarbon expulsion,and narrower hydrocarbon generation windows than types II_(2)and III source *** kerogen types also affect the HGE history and resource *** types(conventional,tight,and shale oil/gas)and three levels(realistic,expected,and prospective)of hydrocarbon resources of different members in the Liaohe Western Depression are *** suggest that t

关键词： Kerogen type Hydrocarbon generation potential Lacustrine source rocks Liaohe western depression

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

焦化区土壤苯并(a)芘的污染状况

引用

光谱实验室 2011年第1期28卷 314-316页

作者：阚术铖山西省环境保护技术评估中心太原市漪汾街望景路9号030024

采用同步荧光光谱法对焦化厂附近不同距离采集的土壤样品中苯并(a)芘含量进行了检测。结果表明,苯并(a)芘的含量在距离焦化厂200m左右处出现最大值,检测结果与当地风向具有相关性。采用大气污染扩散模型对焦化厂焦炉无组织烟气中苯并(a... 详细信息

采用同步荧光光谱法对焦化厂附近不同距离采集的土壤样品中苯并(a)芘含量进行了检测。结果表明,苯并(a)芘的含量在距离焦化厂200m左右处出现最大值,检测结果与当地风向具有相关性。采用大气污染扩散模型对焦化厂焦炉无组织烟气中苯并(a)芘扩散浓度和距离进行了计算,结果与土壤中苯并(a)芘的检出规律具有一致性。

关键词：焦化区土壤苯并(a)芘污染

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

论教辅出版的精细化管理

引用

现代出版 2019年第3期 64-65页

作者：舒刊倪明华东师范大学出版社教辅分社

本文论述了教辅出版中精细化管理的重要性,阐述了精细化在进度管理、成本核算、印数决策、营销工作等方面的一些具体体现,以及对品牌形成的影响;进而探讨了精细化管理对任务分解到位、部门业绩提升、企业文化建设的重要作用。

关键词：精细化管理教辅出版图书市场

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The impact of female sex hormones on cardiovascular disease:from mechanisms to hormone therapy

引用

Journal of Geriatric Cardiology 2024年第6期21卷 669-681页

作者： Yi kan Yu-Lu PENG Ze-Hao ZHAO shu-Tong DONG Yin-Xiao XU Xiao-Teng MA Xiao-Li LIU Yu-Yang LIU Yu-Jie ZHOU Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina

Cardiovascular disease remains the leading cause of mortality in women,yet it has not raised the awareness from the *** pathogenesis of cardiovascular disease differs significantly between females and males concerning the effect of sex *** and progestogen impact cardiovascular system through genomic and non-genomic *** menopause,cardiovascular protective effects of estrogens have been well *** were often used in combination with estrogens in hormone *** in sex hormone levels,particularly estrogen deficiency,were considered the specific risk factor in women’s cardiovascular ***,considerable heterogeneity in the impact of hormone therapy was observed in clinical *** heterogeneity is likely closely associated with factors such as the initial time,administration route,dosage,and formulation of hormone *** review will delve into the pathogenesis and hormone therapy,summarizing the effect of female sex hormones on hypertension,pre-eclampsia,coronary heart disease,heart failure with preserved ejection fraction,and cardiovascular risk factors specific to women.

关键词： impact dosage protective

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：