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Wireless sequential dual light delivery for programmed PDT in vivo

Light(Science & Applications) 2024年第6期13卷 1047-1061页

作者： Jiayi Liu Bowen Sun Wenkai Li Han-Joon Kim shu uin gan John S.Ho Juwita Norasmara Bte Rahmat Yong Zhang Department of Oncology The Second Xiangya HospitalCentral South UniversityChangshaHunan410011China Department of Biomedical Engineering College of Design and EngineeringNational University of SingaporeSingapore117585Singapore Department of Mechanical Engineering College of Design and EngineeringNational University of SingaporeSingapore117576Singapore Department of Electrical and Computer Engineering College of Design and EngineeringNational University of SingaporeSingapore117583Singapore Department of Medical IT Convergence Engineering Kumoh National Institute of TechnologyGumi39253Republic of Korea Department of Surgery Yong Loo Lin School of MedicineNational University of SingaporeSingapore119228Singapore The N.1 Institute for Health National University of SingaporeSingapore117456Singapore Institute for Health Innovation and Technology National University of SingaporeSingapore119276Singapore Department of Biomedical Engineering College of EngineeringCity University of Hong KongKowloonHong Kong SARChina

Using photodynamic therapy(PDT)to treat deep-seated cancers is limited due to inefficient delivery of photosensitizers and low tissue penetration of *** nanocarriers are widely used for photosensitizer delivery,while the self-quenching of the encapsulated photosensitizers would impair the PDT ***,the generated short-lived reactive oxygen spieces(ROS)can hardly diffuse out of nanocarriers,resulting in low PDT ***,a smart nanocarrier system which can be degraded by light,followed by photosensitizer activation can potentially overcome these limitations and enhance the PDT efficacy.A light-sensitive polymer nanocarrier encapsulating photosensitizer(RB-M)was *** implantable wireless dual wavelength microLED device which delivers the two light wavelengths sequentially was developed to programmatically control the release and activation of the loaded *** transmitter coils with matching resonant frequencies allow activation of the connected LEDs to emit different wavelengths *** irradiation time,dose,and RB-M concentration were determined using an agent-based digital simulation *** vitro and in vivo validation experiments in an orthotopic rat liver hepatocellular carcinoma disease model confirmed that the nanocarrier rupture and sequential low dose light irradiation strategy resulted in successful PDT at reduced photosensitizer and irradiation dose,which is a clinically significant event that enhances treatment safety.

关键词： PDT overcome hardly

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Upgrading of 6–0 mm low rank high sulfur lignite by a compound dry cascade separation bed

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International Journal of Mining Science and Technology 2025年第2期35卷 307-324页

作者： Yu, Xiaodong gan, Deqing College of Mining Engineering North China University of Science and Technology Tangshan 063210 China Mineral Processing Department Hebei Province Key Laboratory of Mining Exploitation and Security Technology Tangshan 063210 China

In this paper, the effect of vibration intensity on the spatial distribution of sulfur content in bed particles was studied. The effects of vibration and airflow on the mechanical characteristics of particles were studied, the collision behavior mode of particles was determined, the spatial saltation law of particles was investigated, the spatial functional axis of beds was determined, and the saltation separation period of particles was determined. The test results show that: When separation bed provides inlet airflow velocity (Uin) is 2.55 m/s, the airflow distribution interval of I, II and III areas were UI=2.55–2.57 m/s, UII=1.33–1.35 m/s, UIII=0.35–0.38 m/s, respectively;when separation bed vibration amplitude (A) A=2.4–2.5 mm, separation bed vibration frequency (f) f=23–24 Hz, the desulfurization effect is the best. When vibration intensity (Γ) Γ=1.22, Uin=1.05 m/s, the particles have disordered contact and collision behavior. When Γ=14.89, Uin=3.18 m/s, the particles have a transition cataclastic collision. When Γ=5.80, Uin=2.55 m/s, the particles have directional collision behavior. It is determined that the OX axis is the transverse stable diffusion axis of the material, the OY axis is the longitudinal gradient transport axis of the material, and the OZ axis is the vertical density cascade distribution axis of the material. When separation time (T) T=0–10 s was the period of disorderly diffusion and mixing of particles, T=10–20 s was the period of directional migration and stratification of particles, and T=20–30 s was the period of cascade distribution and separation of particles. Finally, separation experiments conducted under optimal operating parameters demonstrated that the clean coal yield was 72.02% with a sulfur content of 0.98%. © 2025

关键词： Compound dry cascade separation bed Desulfurization and ash reduction Low rank high sulphur lignite Particle space transition

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Upgrading of 6–0 mm low rank high sulfur lignite by a compound dry cascade separation bed

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International Journal of Mining Science and Technology 2025年第02期 307-324页

作者： Xiaodong Yu Deqing gan College of Mining Engineering North China University of Science and Technology Mineral Processing Department Hebei Province Key Laboratory of Mining Exploitation and Security Technology

In this paper,the effect of vibration intensity on the spatial distribution of sulfur content in bed particles was *** effects of vibration and airflow on the mechanical characteristics of particles were studied,the collision behavior mode of particles was determined,the spatial saltation law of particles was investigated,the spatial functional axis of beds was determined,and the saltation separation period of particles was *** test results show that:When separation bed provides inlet airflow velocity(uin) is 2.55 m/s,the airflow distribution interval of I,II and III areas were UI=2.55–2.57 m/s,UII=1.33–1.35 m/s,UIII=0.35–0.38 m/s,respectively;when separation bed vibration amplitude （A）A=2.4–2.5 mm,separation bed vibration frequency （f） f=23–24 Hz,the desulfurization effect is the *** vibration intensity （Γ）Γ=1.22,uin=1.05 m/s,the particles have disordered contact and collision ***Γ=14.89,uin=3.18 m/s,the particles have a transition cataclastic ***Γ=5.80,uin=2.55 m/s,the particles have directional collision *** is determined that the OX axis is the transverse stable diffusion axis of the material,the OY axis is the longitudinal gradient transport axis of the material,and the OZ axis is the vertical density cascade distribution axis of the *** separation time （T） T=0–10 s was the period of disorderly diffusion and mixing of particles,T=10–20 s was the period of directional migration and stratification of particles,and T=20–30 s was the period of cascade distribution and separation of ***,separation experiments conducted under optimal operating parameters demonstrated that the clean coal yield was 72.02%with a sulfur content of 0.98%.

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基于改进ORB算法的高原山区无人机影像特征匹配

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兰州大学学报(自然科学版) 2025年第1期61卷 43-49页

作者：唐迪甘淑袁希平昆明理工大学国土资源工程学院昆明650093 昆明理工大学云南省高校高原山地空间信息测绘技术应用工程研究中心昆明650093 滇西应用技术大学云南大理671006

针对高原山区地形条件下如何快速有效地进行无人机影像匹配的问题,提出一种适应高原山区地形条件的综合算法,其集成了方向性的高速特征检测(FAST)与旋转不变特征描述(ORB)算法、二进制鲁棒不变的可扩展关键点(BRISK)描述子、基于网格的... 详细信息

针对高原山区地形条件下如何快速有效地进行无人机影像匹配的问题,提出一种适应高原山区地形条件的综合算法,其集成了方向性的高速特征检测(FAST)与旋转不变特征描述(ORB)算法、二进制鲁棒不变的可扩展关键点(BRISK)描述子、基于网格的运动统计算法和随机抽样一致性算法(RANSAC)模型约束改进的方法.使用ORB算法中的FAST通过对像素灰度值的快速比较来检测特征点,使用BRISK描述子生成适合影像特征的描述子;采用集成暴力匹配算法和基于网格的运动统计算法,对特征点进行第一次约束优化提取;运用RANSAC对匹配点对进行第二次约束优化提取,以剔除不正确的匹配点对,提高影像匹配的准确性.结果显示,在以恐龙谷为例的高原山区复杂地形影像匹配中,改进算法在计算时间方面具有优势,且能够提取许多精确的特征点对.

关键词：无人机影像 ORB算法 BRISK描述子 GMS统计算法

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考虑震损的法兰板加强型梁柱边节点抗火性能

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兰州理工大学学报 2025年第1期51卷 129-137页

作者：许继祥甘晓书姜旺兰州理工大学土木工程学院甘肃兰州730050

为研究地震后法兰板加强梁翼缘型梁柱边节点的耐火性能,利用有限元软件ANSYS建立计算模型,将计算结果与已有试验结果进行对比验证计算模型的准确性和有效性.利用PUSHOVER方法,引入损伤变量D模拟不同地震等级下的震损.通过重启动分析法,... 详细信息

为研究地震后法兰板加强梁翼缘型梁柱边节点的耐火性能,利用有限元软件ANSYS建立计算模型,将计算结果与已有试验结果进行对比验证计算模型的准确性和有效性.利用PUSHOVER方法,引入损伤变量D模拟不同地震等级下的震损.通过重启动分析法,将地震作用产生的残余应力和残余变形全部传递给各个节点的升温加载中,并对不同参数和不同损伤变量下法兰板加强梁翼缘型梁柱边节点的耐火性能、极限位移和失效机理进行深入分析.结果表明:损伤变量对法兰板加强梁翼缘型梁柱边节点的耐火性能起着主要影响作用,随着损伤变量D的增加,各节点的临界温度大幅度降低.参数α和γ的增加均能提高法兰板加强梁翼缘型梁柱边节点的耐火性能.法兰板加强梁翼缘型梁柱边节点的耐火性能随着参数β的增加而降低.

关键词：震后火灾法兰板加强梁翼缘梁柱边节点损伤变量耐火性能

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多变分模态分解下的湿地植被高光谱识别特征波长优选与模型研究

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光谱学与光谱分析 2025年第3期45卷 601-607页

作者：李璇袁希平甘淑杨敏龚伟圳彭翔滇西应用技术大学/云南省高校山地实景点云数据处理及应用重点实验室云南大理671006 昆明理工大学国土资源工程学院云南昆明650093 云南省高校高原山区信息测绘技术应用工程研究中心云南昆明650093

高光谱数据以其高维度为特征,拥有更丰富的地物信息。在植被分类中,这种高维度数据为提升分类准确性和精度提供了更多机会。传统的特征波长建模往往因输入变量过多而导致分类精度不佳。为了克服这一问题并提高模型对湿地植被细微光谱差... 详细信息

高光谱数据以其高维度为特征,拥有更丰富的地物信息。在植被分类中,这种高维度数据为提升分类准确性和精度提供了更多机会。传统的特征波长建模往往因输入变量过多而导致分类精度不佳。为了克服这一问题并提高模型对湿地植被细微光谱差异的捕捉能力,以洱海东岸海滨作为研究区域展开探索,测取了3种典型湿地植被(菰、芦、槐叶蘋)的高光谱数据作为目标样本。对样本光谱曲线进行SG平滑后作为原始光谱(OS)、对原始光谱进行包络线去除变换(CR)、一阶微分(FD)并分析其光谱特征;再将原始光谱通过变分模态分解(VMD)为8个尺度。接着,用竞争性自适应重加权(CARS)算法选择出的波长作为特征波长。最后,利用寻找出的最佳参数组合放入经贝叶斯算法优化的支持向量机(Bayes-SVM)进行建模。结果表明:CARS算法提取的特征波长数量减少,且大都分布于植被的吸收特征区间内,降维效果显著;经过分解后的第4模态构建的模型(S_(4)-CARS-Bayes-SVM)分类效果最好,其精确率PR为0.9333,召回率RR为0.8889、F1分数为0.8963、AUC值为0.9286,即此模型具有很强的鲁棒性以及识别性能。

关键词：光谱学湿地植被变分模态分解特征波长支持向量机贝叶斯算法

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Contaminant removal from low-concentration polluted river water by the bio-rack wetlands

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Journal of Environmental Sciences 2012年第6期24卷 1006-1013页

作者： Ji Wang Lanying Zhang Shaoyong Lu Xiangcan Jint shu gan Key Laboratory of Groundwater Resources and Environment Ministry of EducationJilin UniversityChangchun 130021China State Environmental Protection Key Laboratory for Lake Pollution Control Engineering and Technology Center of LakeResearch Center of Lake EnvironmentChinese Research Academy of Environment SciencesBeijing 100012China College of Resources and Environment Hunan Agriculture UniversityChangsha 410128China

The bio-rack is a new approach for treating low-concentration polluted river water in wetland systems.A comparative study of the efficiency of contaminant removal between four plant species in bio-rack wetlands and between a bio-rack system and control system was conducted on a small-scale （500 mm length × 400 mm width × 400 mm height） to evaluate the decontamination effects of four different wetland *** was generally a significant difference in the removal of total nitrogen （TN）,ammonia nitrogen （NH 3-N） and total phosphorus （TP）,but no significant difference in the removal of permanganate index （COD Mn） between the bio-rack wetland and control ***-rack wetland planted with Thalia dealbata had higher nutrient removal rates than wetlands planted with other *** fine-root （root diameter 3 mm） biomass rather than total plant biomass was related to nutrient removal *** study suggested that the nutrient removal rates are influenced by plant species,and high fine-root biomass is an important factor in selecting highly effective wetland plants for a bio-rack *** to the mass balance,the TN and TP removal were in the range of 61.03-73.27 g/m^2 and 4.14-5.20 g/m^2 in four bio-rack wetlands during the whole operational *** N and P removal by plant uptake constituted 34.9%-43.81% of the mass N removal and 62.05%-74.81% of the mass P *** study showed that the nitrification/denitrification process and plant uptake process are major removal pathways for TN,while plant uptake is an effective removal pathway for TP.

关键词： bio-rack constructed wetland fine-root biomass low-concentration polluted river water plants uptake

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Low limit of detection of the Algan/gan-based sensor by the Kelvin connection detection technique

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Microsystems & Nanoengineering 2021年第4期7卷 35-44页

作者： Hanyuan Zhang Ying gan shu Yang Kuang Sheng Ping Wang College of Electrical Engineering Zhejiang University310027 HangzhouChina Biosensor National Special Laboratory Department of Biomedical EngineeringZhejiang University310027 HangzhouChina Hangzhou Global Scientific and Technological Innovation Center Zhejiang University310027 HangzhouChina

The Algan/gan-based sensor is a promising POCT(point-of-care-testing)device featuring miniaturization,low cost,and high *** is an effective protein biomarker for the early diagnosis of HF(heart failure).In this work,a novel Algan/gan device with the Kelvin connection structure and the corresponding detection technique was *** technique can effectively suppress the background noise and improve the SNR(signal-to-noise ratio).A BNP detection experiment was carried out to verify the effectiveness of this *** is shown that compared with that of the traditional detection method,the LOD(limit of detection)was improved from 0.47 ng/mL to 1.29 pg/*** BNP detection experiment was also carried out with a traditional electrochemical Au-electrode sensor with the same surface functionalization *** Algan/gan sensor showed a better LOD than the Au-electrode ***,the influence of Algan/gan sensor package on background noise was investigated with the mechanism of the noise source ***,based on the optimized package,the optimal SNR quiescent operating point of the Algan/gan sensor was *** biasing the sensor at the optimal quiescent operating point and immobilizing the magnetic beads with anti-BNP on the gate of the Algan/gan sensor,the LOD for BNP detection was further improved to 0.097 pg/mL.

关键词： Algan/gan limit noise

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Exploration of reaction rates of chlorine dioxide with tryptophan residue in oligopeptides and proteins

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Journal of Environmental Sciences 2020年第7期32卷 129-136页

作者： Yuexian Ge Yu Lei Xin Lei Wenhui gan Longfei shu Xin Yang School of Environmental Science and Engineering Guangdong Provincial Key Laboratory of Environmental Pollution Control and Remediation TechnologySun Yat-sen UniversityGuangzhou 510275China Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055China

Chlorine dioxide(ClO2),an alternative disinfectant to chlorine,has a superior ability to inactivate microorganisms,in which protein damage has been considered as the main inactivation ***,the reactivity of ClO2 with amino acid residues in oligopeptides and proteins remains poorly *** this research,we studied the reaction rate constants of ClO2 with tryptophan residues in five heptapeptides and four proteins using stopped-flow or competition kinetic *** heptapeptide and protein contain only one tryptophan residue and the reactivity of tryptophan residue with ClO2 was lower than that of free tryptophan(3.88×10^4(mol/L)^-1 sec^-1 at pH 7.0).The neighboring amino acid residues affected the reaction rates through promoting inter-peptide aggregation,changing electron density,shifting pKa values or inducing electron transfer via redox reactions.A single amino acid residue difference in oligopeptides can make the reaction rate constants differ by over 60%(e.g.3.01×10^4(mol/L)^-1 sec^-1 for DDDWNDD and 1.85×10^4(mol/L)^-1 sec^-1 for DDDWDDD at pH 7.0(D:aspartic acid,W:tryptophan,N:asparagine)).The reaction rates of tryptophan-containing oligopeptides were also highly pH-dependent with higher reactivity for deprotonated tryptophan than the neutral *** residues in proteins spanned a 4-fold range reactivity toward ClO2(i.e.0.84×10^4(mol/L)^-1 sec^-1 for ribonuclease T1 and 3.21×10^4(mol/L)^-1 sec^-1 for melittin at pH 7.0)with accessibility to the oxidant as the determinating *** local environment surrounding the tryptophan residue in proteins can also accelerate the reaction rates by increasing the electron density of the indole ring of tryptophan or inhibit the reaction rates by inducing electron transfer *** results are of significance in advancing understanding of ClO2 oxidative reactions with proteins and microbial inactivation mechanisms.

关键词： Chlorine dioxide(ClO2) Tryptophan Protein Disinfection Water treatment

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River basin landscape pattern and its modern earth surface process of the LRGR

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Chinese Science Bulletin 2006年第B11期51卷 33-38页

作者： gan shu HE Daming FENG Yan Asian International River Center of Yunnan University Kunming650091 China

Directing at the the longitudinal range-gorge region's special constituting condition of river basin geography landscape, the authors synthetically used the data analyses and spatial information treatment technique, selected corresponding measurable homology indicators, comparatively analyzed the characteristic difference of different river basin's landscape constitution patterns in the longitudinal range-gorge region, researched into different river net patterns and land cover conditions of each river basin landscape, and explored the river basin's landscape form and its spatial distributed chracters. Based on the analyses on river basin's landscape composition and its spatial distribution characters, this study researched into the main driving factor of modern earth surface process in the longitudinal range-gorge region, analyzed the relationship between the basin landscape changing and its modern earth surface process, finally completed a series of the potential ecological hydrology effect analyses.

关键词：江河流域风光现代地球表面作用生态水文学效数据分析

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