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Cerebrospinal fluid liver pseudocyst:A bizarre long-term complication of ventriculoperitoneal shunt:A case report

World Journal of Hepatology 2023年第5期15卷 715-724页

作者： Muhammad Nadeem Yousaf Haider A Naqvi shriya kane Fizah S Chaudhary Jason Hawksworth Vikram V Nayar Thomas W Faust Division of Gastroenterology and Hepatology Department of MedicineUniversity of MissouriColumbiaMO 65212United States Department of Medicine MedStar Union Memorial HospitalBaltimoreMD 21218United States Department of Surgery University Iowa School of MedicineIowa CityIA 52242United States Department of Medicine University of MissouriColumbiaMO 65212United States Department of Surgery Transplant HepatologyMedStar Georgetown University HospitalWashingtonDC 20007United States Department of Neurosurgery MedStar Georgetown University HospitalWashingtonDC 20007United States Department of Medicine Transplant HepatologyJames D.Eason Transplant InstituteMethodist Le Bonheur HealthcareMemphisTN 38104United States

BACKGROUND Ventriculoperitoneal(VP)shunt placement has become a standard of care procedure in managing hydrocephalus for drainage and absorption of cerebrospinal fluid(CSF)into the *** pseudocysts containing CSF are the common long-term complication of this frequently performed procedure,mainly because VP shunts have significantly prolonged *** these,liver CSF pseudocysts are rare entities that may cause shunt dysfunction,affect normal organ function,and therefore pose therapeutic *** SUMMARY A 49-year-old man with history of congenital hydrocephalus status post bilateral VP shunt placement presented with progressively worsening dyspnea on exertion,abdominal discomfort/*** computed tomography(CT)scan revealed a large CSF pseudocyst in the right hepatic lobe with the tip of VP shunt catheter into the hepatic cyst *** underwent robotic laparoscopic cyst fenestration with a partial hepatectomy,and repositioning of VP shunt catheter to the right lower quadrant of the ***-up CT demonstrated a significant reduction in hepatic CSF *** A high index of clinical suspicion is required for early detection of liver CSF pseudocysts since their presentation is often asymptomatic and cunning early in the ***-stage liver CSF pseudocysts could have adverse outcomes on the treatment course of hydrocephalus as well as on hepatobiliary *** is paucity of data to define the management of liver CSF pseudocyst in current guidelines due to rare nature of this *** reported occurrences have been managed by laparotomy with debridement,paracentesis,radiological imaging guided fluid aspiration and laparoscopic-associated cyst *** surgery is an additional minimally invasive option in the management of hepatic CSF pseudocyst;however,its use is limited by lack of widespread availability and cost of surgery.

关键词： shunt fluid peritoneal

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Transient decrease in sound tolerance levels following hearing deprivation in normal-hearing subjects

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Journal of Otology 2022年第4期17卷 232-238页

作者： Eleazar Grateron Tricia Scaglione shriya Airen Stefania Goncalves Sinay A.Ceballos David Baguley Juan A.Chiossone Fundacion Venezolana de Otología Clinical Research GroupVenezuela University of Miami Department of OtolaryngologyUSA University of Nottingham Hearing ScienceUK

Objective:To determine the circadian influence on sound sensitivity produced by temporal hearing deprivation in healthy normal human ***:Participants underwent bilateral earplugging before completion of anthropometry,the author's developed questionnaire,the Hamilton Anxiety and Depression Inventory,pure tone audiometry(PTA),stapedial reflex thresholds(SRT),distortion products otoacoustic emissions input/output(DPOAE-I/O),and uncomfortable loudness levels(ULLs).Afterward,the participants were randomly divided into group A,starting at 8:00 *** finishing at 8:00 p.m.,and group B,starting at 4:00 *** ending at 4:00 *** cortisol levels and audiological test results were obtained at the beginning and end of the session and 24-h free urinary cortisol levels were *** sample:Thirty healthy ***:PTA was 2.68 and 3.33 dB HL in groups A and B,respectively,with no statistical difference between *** were significantly lower in group A compared to group B,with an average of 8.1 dB SPL in group A and 3.3 dB SPL in group B(p<0.0001).A SRT shift was observed in group A,with no difference in group B,and a night shift in DPOAE-I/O in group ***:Reduced loudness tolerance is demonstrated during daytime hearing deprivation in contrast to nighttime;this may be due to increased central gain in the awake cortex.

关键词： Hyperacusis Central gain Hearing deprivation

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Acclimatization of microalgae Arthrospira platensis for treatment of heavy metals in Yamuna River

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Water Science and Engineering 2020年第3期13卷 214-222页

作者： Nilesh Kumar shriya Hans Ritu Verma Aradhana Srivastava University School of Chemical Technology Guru Gobind Singh Indraprastha UniversityNew Delhi 110078India

Bioaccumulation and biosorption in microalgae are effective approaches for the removal of heavy metals(HMs)from river *** objective of this study was to investigate the potential for use of acclimatized microalgae in the removal of HMs from the Yamuna River water as an acclimatizing *** active culture of Arthrospira platensis(***)was acclimatized to HMs up to a concentration of 100 mg/*** was gradually exposed to increasing concentrations of HMs in five subsequent batches with a step increase of 20 mg/L to acclimatize live cells in the simulated Yamuna River *** presence of high levels of HMs in the Yamuna River water caused growth *** empirical growth inhibition model was developed,and it predicted high threshold concentrations of HMs(210.7e424.5 mg/L),producing a positive specific growth rate of *** also showed high average removal efficiencies of HMs,including 74.0%for Cu,77.0%for Cd,50.5%for Ni,76.0%for Cr,76.5%for Pb,and 63.5%for Co,from HMs-enriched Yamuna River *** findings demonstrated that the maximum specific removal amounts of Cu,Cd,Ni,Cr,Pb,and Co were 54.0,58.0,39.0,62.8,58.9,and 45.3 mg/g,*** maximum yields of the value-added products chlorophyll and phycocyanin were 2.5 mg/g(in a batch of 40 mg/L for Cd)and 1054 mg/g(in a batch of 20 mg/L for Cu),***,acclimatized *** was proven to be a potential microalga not only for sequestration of HMs but also for production of valuable pigments.

关键词： Yamuna River A.platensis Heavy metals Acclimatization Biosorption Pigments

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General-motors diet: A quick fix for steatotic live liver donors

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iLIVER 2023年第3期2卷 151-155页

作者： Anish Gupta Abhideep Chaudhary Gaurav Sood Niteen Kumar Imtiakum Jamir Aditya shriya Vipin Pal Singh Rekha Subramaniyam Hitesh Soni Milind Mandwar Department of Hepato-Pancreato-Biliary Surgery and Liver Transplantation BLK MAX Super Specialty HospitalNew DelhiIndia

Background and aims:GM(General-Motors)diet is a low-calorie 7-day diet plan using complex carbohydrates used for quick weight *** optimisation is known to decrease steatosis and improve outcomes in liver *** evaluated the efficacy and feasibility of using GM diet in steatotic live liver donors(LLD).Methods:LLDs who either had BMI>30 kg/m^(2),Computerised tomography liver attenuation index(CT-LAI)10%were started on GM diet for 1 *** of these LLDs and their recipients were retrieved retrospectively and ***,liver function tests(LFT),MR fat-frac-tion,CT-LAI,hospital-stay and complications were analysed in LLDs while early graft dysfunction(EGD)and complications were assessed in ***:A total of 51 LLDs with mean age of 34.6?9.5 years with baseline mean weight of 80.6±10.8 kg and BMI of 29.1±2.78 kg/m^(2) were started on GM *** a week of following the GM diet,there was an average weight loss of 3.46±2.1 kg,a decrease in fat-fraction by 3.8%±2.7,and an improvement in CT-LAI by 6.7?3.7 *** patients could successfully undergo donor hepatectomy with an average postoperative ICU stay of 2.86±0.8 days and hospital stay of 6.82?0.81 *** donor had steatosis>10% on intraoperative Tru-cut biopsy and their post-operative outcomes were similar to normal liver *** were intra-abdominal collections in 2 donors requiring drainage and one required re-exploration for intestinal *** was EGD in 8 recipients(15.6%)and mortality in 1(1.9%)***:GM diet is safe and effective regimen to reduce steatosis and increase healthy LLD pool without compromising donor or recipient safety.

关键词： Steatosis GM diet weight loss donor optimization LDLT donor hepatectomy donor outcomes

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尼泊尔消费者电子商务购买行为研究

尼泊尔消费者电子商务购买行为研究

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作者：甘丽（Kapali shriya）西南科技大学

学位级别：硕士

本论文的目的是确定尼泊尔电子商务行业的现状,以及影响尼泊尔客户购买行为的因素。尼泊尔电子商务发展缓慢,多种因素影响着该国电子商务。研究和数据收集的结果突出了影响客户购买行为的重要方面。收集到的信息可用于确定阻碍尼泊尔改... 详细信息

本论文的目的是确定尼泊尔电子商务行业的现状,以及影响尼泊尔客户购买行为的因素。尼泊尔电子商务发展缓慢,多种因素影响着该国电子商务。研究和数据收集的结果突出了影响客户购买行为的重要方面。收集到的信息可用于确定阻碍尼泊尔改善其电子商务的障碍,这些因素可以在客户和研究人员自己的建议的帮助下得到解决。由于研究人员现在正在中国攻读学位,尼泊尔的电子商务行业可以从中国的经验中学到很多东西。该研究还提到了尼泊尔电子商务可以从中受益的一些策略和经验,并且年轻有抱负的创业者可以获得一些指导和方法来开始他们的电子商务之旅。研究表明,电子商务业务的现有消费者是年轻人。大多数女性消费者对在线购买商品感兴趣,因此与女性消费者相关的商品是电子商务平台上最好的销售,便利性是最重要的因素,影响着大多数消费者的购买行为。通过客户的建议可以知道,他们期望产品与网站描述的一样,以及顺畅的客户和售后服务。朋友和家人的意见以及公司的评级直接影响他们的购买行为。客户也非常期待灵活的支付系统。此外,人们正在寻找组织良好的物流和及时的货物交付。

关键词：电子商务消费者购买行为电子商务平台尼泊尔

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Mechanically induced stiffening, thermally driven softening,and brittle nature of SiC

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Journal of Advanced Ceramics 2016年第1期5卷 13-34页

作者： Dinesh VARSHNEY Swarna shriya Sanjay JAIN Meenu VARSHNEY R.KHENATA School of Physics Vigyan Bhavan Devi Ahilya University Khandwa Road Campus Indore 452001 India Department of Physics M.B.Khalsa College Indore 452002 India Laboratoire de Physique Quantique et de Modélisation Mathématique(LPQ3M) Département de TechnologieUniversité de Mascara Mascara 29000 Algeria

An effective interionic potential calculation with long range Coulomb, charge transfer interaction, covalency effect, short range overlap repulsion extended, van der Waals interaction, and zero point energy effect is implemented to investigate the pressure dependent structural phase transition (ZnS-type (B3) to NaCl-type (B1) structure), and mechanical, elastic, and thermodynamic properties of silicon carbide (SiC). Both charge transfer interaction and covalency effect are important in revealing the pressure induced structural stability, Cauchy discrepancy, anisotropy factor, melting temperature, shear modulus, Young’s modulus, and Grüneisen parameter. We also present the results for the temperature dependent behaviors of normalized volume, hardness, heat capacity, and thermal expansion coefficient. SiC is mechanically stiffened and thermally softened as inferred from pressure (temperature) dependent elastic constant’s behavior. The Pugh’s ratio ∅ = B T / G H, the Poisson’s ratio v, and the Cauchy’s pressure C 12–C 44 for SiC ceramic confirm its brittle nature.

关键词： carbide computational techniques phase transition equation of state

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Analyzing the Prebiotic Potential of Glucosamine for Targeting the Gut Microbiome Health

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Food and Nutrition Sciences 2023年第2期14卷 119-134页

作者： Pranav Pancham Divya Jindal Archita Gupta Deepshikha Yadav shriya Agarwal Saurabh Jha Manisha Singh Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida India Neuroimmunology Laboratory School of Medicine Western Sydney University Campbelltown Australia Birla Institute of Technology Mesra India Indian Institute of Technology-Kanpur Kanpur India Bhartiya Nirdeshak Dravya Division CSIR-National Physical Laboratory New Delhi India Physico-Mechanical Metrology Division CSIR-National Physical Laboratory New Delhi India Academy of Scientific and Innovation Research (AcSIR) Ghaziabad India School of Natural Sciences Macquarie University Sydney Australia Department of Biotechnology School of Engineering and Technology Sharda University Greater Noida India

Recognizing the composition and modulation of the microbiome, a viable therapeutic tool for multi-targeted therapy is a new strategy that has recently been explored. Glucosamine (GS) is being studied for its prebiotic potential in addition to being the most abundant and naturally occurring amino monosaccharide. The current study focuses on glucosamine’s prebiotic potential by assessing the stability of various GS concentrations (1% - 5%) in the gastrointestinal tract (GIT) and its ability to be fermented by the gut microbiota. The results showed that GS stimulated the most growth in L. acidophilus even after a longer incubation time than B. bifidum and L. acidophilus growth was concentration-dependent, with maximum growth at 3% with a simultaneous decrease in pH (5.6 - 1.7). The decrease in GS concentration with time also represented the growth of bacterial species, demonstrating the species’ utilization of GS. Furthermore, at 3%, GS also represented the prebiotic index of 1.9. In addition, the concentration of GS in various simulated GIT fluids was estimated in both fast and fed conditions to examine GS stability at various levels in the gut. The results showed that GS remained unaffected and non-digestible in all of the simulated GIT fluids (salivary, gastric, intestinal, and colonic), but there was a slight decrease in GS concentration (2.8%) in the fasted state of gastric fluid due to low pH levels (1.6). As a result, the findings are conclusive and suggest that GS possesses prebiotic properties.

关键词： Microbiome Enteric Nervous System (ENS) Prebiotic Index Hexosamine Biosynthetic Pathway (HBP) Vagal Afferents Phosphotransferase System

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Nutritional and medical food therapies for diabetic retinopathy

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Eye and Vision 2020年第6期7卷 312-327页

作者： Ce Shi Peng Wang shriya Airen Craig Brown Zhiping Liu Justin H.Townsend Jianhua Wang Hong Jiang Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Department of Ophthalmology Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghaiChina College of Arts and Sciences University of MiamiMiamiFLUSA Department of Ophthalmology College of Medicinethe University of Arkansas for Medical SciencesFayettevilleARUSA Ophthalmic Center the Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdongChina Department of Neurology University of Miami Miller School of MedicineMiamiFLUSA

Diabetic retinopathy(DR)is a form of *** oxidative stress in the mitochondria and cell membranes decreases ischemic injury and end-organ damage to the *** approaches are needed,which reduce the risk and improve the outcomes of DR while complementing current therapeutic ***(Hcy)elevation and oxidative stress are potential therapeutic targets in *** genetic polymorphisms such as those of methylenetetrahydrofolate reductase(MTHFR),increase Hcy and DR risk and *** with DR have high incidences of deficiencies of crucial vitamins,minerals,and related compounds,which also lead to elevation of Hcy and oxidative *** the effects of the MTHFR polymorphism and addressing comorbid deficiencies and insufficiencies reduce the impact and severity of the *** approach provides safe and simple strategies that support conventional care and improve *** vitamin co-factor availability also impairs the release of neurotrophic and neuroprotective growth ***,this accounts for variability in presentation and response of DR to conventional ***,there are straightforward recommendations for addressing these issues and supporting traditional treatment *** have reviewed the literature for nutritional interventions that support conventional therapies to reduce disease risk and *** combinations of vitamins B1,B2,B6,L-methylfolate,methylcobalamin(B12),C,D,natural vitamin E complex,lutein,zeaxanthin,alpha-lipoic acid,and n-acetylcysteine are identified for protecting the retina and *** medical foods have been successfully used as therapy for *** based on this review and our clinical experience are developed for clinicians to use to support conventional therapy for *** from both type 1 diabetes mellitus(T1DM)and type 2 diabetes mellitus(T2DM)have similar retinal findings and responses to nutritional therapies.

关键词： Diabetic retinopathy Homocysteine Lutein N-acetyl cysteine Vitamins L-methylfolate

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Synthesis and Characterization of <i>Citrus limonum</i>Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Journal of Biomaterials and Nanobiotechnology 2020年第4期11卷 215-236页

作者： Harleen Kaur Pranav Pancham Ramneek Kaur shriya Agarwal Manisha Singh Amity Institute of Biotechnology Amity University Noida U.P. India Department of Biotechnology Jaypee Institute of Information Technology (JIIT) Noida U.P. India School of Medicine Western Sydney University Campbelltown New South Wales Australia

Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (Smix). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 - 104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi’s model in comparison to burst release of LO alone. Lastly, the stability analysis of the optimised formulation (LO-NE) and LO was estimated through antioxidant assay and subjecting them for thermodynamic stability after 6 months. The results attained, showed higher stability and anti-oxidant capability of LO-NE than LO alo

关键词： Lemon Oil Surfactants Particle Size Analysis Ternary Phase Diagrams Release Kinetics Thermodynamic Stability

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Current status and future challenges with Coronavirus(COVID-19):an update on vaccines

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Life Research 2023年第1期6卷 1-10页

作者： Kumar Rakesh shriya Gupta Anant Gupta Department of Pharmaceutical Sciences Vaish Institute of Pharmaceutical Education and ResearchRohtak 124001India Department of Medicine and Surgery GurugramHaryana 122505India Department of Medicine and Surgery Jaipur National University of Medical Sciences and Research Centre JagatpuraJaipurRajasthan 302017India

SARS-COV-2 coronavirus causes COVID-19,which is a respiratory ***-19,the common cold,seasonal allergies,and the flu have many similar ***-19 is caused by SARS-CoV-2,while rhinoviruses most often cause the common *** World Health Organization issued notifications on December 30,2019,and January 30,2020,classifying this viral disease as a Public Health Emergency of International ***-CoV-2 was detected in humans and animals in *** investigations are underway to cure COVID-19 and develop a vaccine to prevent infection with *** COVID-19 vaccines have now been approved or licensed for human use(SII/Covishield,AstraZeneca/AZD1222,Janssen/*** 2.S,Sinopharm,Moderna,Sinovac-CoronaVac,Covaxin).Four issues arise in the research and manufacture of the COVID-19 vaccine:production,affordability,allocation and *** adenovirus-vectored and mRNA-based vaccines for COVID-19 showed the highest efficacy after the first and second doses,*** mRNA-based vaccines had higher side *** few experienced extreme adverse effects and all stimulated robust immune responses.

关键词： COVID-19 viral life cycle pathophysiology COVID-19 vaccines

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