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Impact of the COVID-19 pandemic on lung cancer treatment and research

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Genes & Diseases 2023年第4期10卷 1217-1219页

作者： shreya Kailas Lovlekar Yihua Wang Biological Sciences Faculty of Environmental and Life SciencesUniversity of SouthamptonSouthampton SO171BJUK

Despite recent advances in immunotherapy and targeted therapy,the mortality rate seen in lung cancer(LC)is the highest of all cancer *** recent topical coronavirus disease 19(COVID-19)and its subsequent pandemic have resulted in over 505 million confirmed cases and approxi-mately 6.2 million fatalities as of April 2022,1 with a stag-gering 30%e50%mortality rate seen in LC patients with COVID-19.2 Cancer patients,in particular,are highly vulnerable to COVID-19 infection due to immunosuppression.

关键词： mortality cancer lung

Potential therapeutic activities and novel delivery systems of chrysin-a nature’s boon

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Food Bioscience 2022年第1期45卷 52-64页

作者： shreya Chitrakant Adangale Sarika Wairkar Shobhaben Pratapbhai Patel School of Pharmacy&Technology Management SVKMs NMIMSV.L.Mehta RoadVile Parle(W)Mumbai.Maharashtra400056India

Flavonoids are a diverse group of phytonutrients that have gained attention as dietary supplements due to their broad spectrum of therapeutic properties and negligible side ***,a 5,7-dihydroxyflavone,has been explored for various pharmacological effects in the last few *** vast biological activities,the use of this polyphenol seems to be compromised due to low solubility,extensive pre-systemic metabolism and thus very poor oral *** present review elucidates various pharmacological actions of chrysin such as cardioprotective,antioxidant,neuroprotective,hepatoprotective,anti-inflammatory,anticancer and antidiabetic activities with the help of reported scientific ***,it focuses on different formulations developed for chrysin to increase its absorption and subsequent *** review thus analyses the beneficial effects of chrysin and gives an overview of possible techniques adopted to increase its systemic bioavailability.

关键词： Chrysin Flavonoids Poor bioavailability Delivery systems Improved therapeutic activity

Production, purification, characterization, immobilization, and application of Serrapeptase： a review

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Frontiers in Biology 2017年第5期12卷 333-348页

作者： Selvarajan Ethiraj shreya Gopinath Department of Genetic Engineering School of Bioengineering SRM University Kattankulathur Tamil Nadu India

BACKGROUND： Serrapeptase is a proteolytic enzyme with many favorable biological properties like anti-inflammatory, analgesic, anti-bacterial, fibrinolytic properties and hence, is widely used in clinical practice for the treatment of many diseases. Although Serrapeptase is widely used, there are very few published papers and the information available about the enzyme is very meagre. Hence this review article compiles all the information about this important enzyme Serrapeptase. METHODS： A literature search against various databases and search engines like PubMed, SpringerLink, Scopus etc. was performed. RESULTS： We gathered and highlight all the published information regarding the molecular aspects, properties, sources, production, purification, detection, optimizing yield, immobilization, clinical studies, pharmacology, interaction studies, formulation, dosage and safety of the enzyme Serrapeptase. CONCLUSION： Serrapeptase is used in many clinical studies against various diseases for its anti-inflammatory, fibrinolytic and analgesic effects. There is insufficient data regarding the safety of the enzyme as a health supplement. Data about the anti- atherosclerotic activity, safety, tolerability, efficacy and mechanism of action of the Serrapeptase are still required.

关键词： Serrapeptase proteolytic enzyme anti-inflammatory fibrinolytic

A Context Sensitive Multilevel Thresholding Using Swarm Based Algorithms

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IEEE/CAA Journal of Automatica Sinica 2019年第6期6卷 1471-1486页

作者： shreya Pare Anil Kumar Varun Bajaj Girish Kumar Singh PDPM Indian Institute of Information Technology Design and Manufacturing Jabalpur 482005MPIndia Institute of Technology Roorkee Uttarakhand 247667India

In this paper, a comprehensive energy function is used to formulate the three most popular objective functions:Kapur's, Otsu and Tsalli's functions for performing effective multilevel color image thresholding. These new energy based objective criterions are further combined with the proficient search capability of swarm based algorithms to improve the efficiency and robustness. The proposed multilevel thresholding approach accurately determines the optimal threshold values by using generated energy curve, and acutely distinguishes different objects within the multi-channel complex images. The performance evaluation indices and experiments on different test images illustrate that Kapur's entropy aided with differential evolution and bacterial foraging optimization algorithm generates the most accurate and visually pleasing segmented images.

关键词： Color image segmentation Kapur's entropy multilevel thresholding Otsu method swarm based optimization algorithms Tsalli's entropy

Parenteral nanosuspensions:a brief review from solubility enhancement to more novel and specific applications

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Acta Pharmaceutica Sinica B 2018年第5期8卷 733-755页

作者： Eknath Ahire shreya Thakkar Mahesh Darshanwad Manju Misra Department of Pharmaceutics National Institute of Pharmaceutical Education and Research (NIPER)

Advancements in in silico techniques of lead molecule selection have resulted in the failure of around 70% of new chemical entities(NCEs). Some of these molecules are getting rejected at final developmental stage resulting in wastage of money and resources. Unfavourable physicochemical properties affect ADME profile of any efficacious and potent molecule, which may ultimately lead to killing of NCE at final stage. Numerous techniques are being explored including nanocrystals for solubility enhancement purposes. Nanocrystals are the most successful and the ones which had a shorter gap between invention and subsequent commercialization of the first marketed product. Several nanocrystal-based products are commercially available and there is a paradigm shift in using approach from simply being solubility enhancement technique to more novel and specific applications. Some other aspects in relation to parenteral nanosuspensions are concentrations of surfactant to be used, scalability and in vivo fate. At present, there exists a wide gap due to poor understanding of these critical factors,which we have tried to address in this review. This review will focus on parenteral nanosuspensions,covering varied aspects especially stabilizers used, GRAS(Generally Recognized as Safe) status of stabilizers, scalability challenges, issues of physical and chemical stability, solidification techniques to combat stability problems and in vivo fate.

关键词： Parenteral Nanosuspension Stabilizer In vivo fate Solidification Scalability

A solution to stochastic unit commitment problem for a wind-thermal system coordination

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Frontiers in Energy 2014年第2期8卷 192-200页

作者： B. SARAVANAN shreya MISHRA Debrupa NAG School of Electrical Engineering VIT University Vellore 632014 India

Unit commitment （UC） problem is one of the most important decision making problems in power system. In this paper the UC problem is solved by considering it as a real time problem by adding stochasticity in the generation side because of wind-thermal co-ordination system as well as stochasticity in the load side by incorporating the randomness of the load. The most important issue that needs to be addressed is the achievement of an economic unit commitment solution after solving UC as a real time problem. This paper proposes a hybrid approach to solve the stochastic UC problem considering the volatile nature of wind and formulating the UC problem as a chance constrained problem in which the load is met with high probability over the entire time period.

关键词： unit commitment (UC) randomness wind generation univariate chance constrained

Current trends in health-promoting potential and biomaterial applications of edible mushrooms for human wellness

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Food Bioscience 2023年第1期51卷 30-44页

作者： Arman Hamza shreya Ghanekar Devarai Santhosh Kumar Department of Chemical Engineering Indian Institute of Technology HyderabadTelanganaIndia

Edible mushrooms are ubiquitous around the world due to their enormous health *** have been used as folk medicine and healthy food from ancient times but their health-promoting effects have not been *** a superfood,mushroom powder is an essential component of the human diet for improving health and *** components present in them such as proteins,polysaccharides,terpenes,and lipids have recently sparked much attention to exhibit therapeutic properties such as anti-cancer,immunomodulatory,antihypercholesterolemia,antiviral,antidiabetic,and anti-inflammatory ***,these isolated compounds have the potentiality to be used in dietary supplements and *** addition,numerous bioactive compounds such as ergosterol,gallic acid,and cordycepin proved to be essential in preventing or reducing the severity of *** review unveils a comprehensive understanding of the nutraceutical as well as the medicinal potential of mushrooms and their applications in food products for human wellness.

关键词： Edible mushrooms Medicinal properties Mycelium-based biomaterials Anti-Covid-19 Nutrition

Correlation Analysis of the Morphological Diversity of the Left Coronary Artery and the Formation of Atherosclerotic Plaques

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Correlation Analysis of the Morphological Diversity of the L...

作者： shreya Shrestha 吉林大学

学位级别：硕士

PurposeThe main aim of our study was to measure the length,the dimensions and areas at different points including ostium,midportion and distal,the bifurcation angles and the types of the left main coronary artery（LM）,on 320-slice spiral CT,and research the differences between men and women without left coronary atherosclerotic *** also studied the relationship between the anatomical diversity of LM and the localization and formation of the atherosclerotic *** and MethodsA total of 199 consecutive patients who underwent 320-slice spiral CT coronary angiography in our hospital between September 2017 and March 2018 were selected,including 98 females and 101 males,age 55 to 65 years *** to the presence and severity of the plaques in the left coronary artery,the patients were divided into three groups,including 69 cases of the normal group,74 cases of the mild stenosis group,and 56 cases of the moderate-severe stenosis *** the basis of the plaque positions,the coronary lesion group was further divided into proximal and distal *** multiple lesions were coexist in any of the major branches,the most severe one was taken into *** to the 3D volume rendering technology,the LM can be divided into four types: type I（biconcave-shaped pattern）,type II（tapering pattern）,type III（combined pattern,cone-shaped at the ostium and then tubular-shaped in the other parts of the vessel）,and type IV（funnel-shaped pattern）We adopted the Japan Toshiba 320-row spiral CT scanner,the retrospective ECG gating and the 75% R-R intervals *** Vitrea Workstation software and reconstruction technologies such as the volume rendering,the maximum intensity projection,the multi-planar reformatting and the curved multi-planar reformation,the length of the LM,the dimensions and areas（at the ostium,midportion and distal of the LM）,angle 1,2,and 3,the angles between LAD and LCX,LM and LAD,LM and LCX were *** diameter stenos

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Insulin resistance and adipose tissue interactions as the cornerstone of metabolic(dysfunction)-associated fatty liver disease pathogenesis

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World Journal of Gastroenterology 2023年第25期29卷 3999-4008页

作者： shreya C Pal Nahum Méndez-Sánchez Faculty of Medicine National Autonomous University of MexicoMexico City 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationMexico City 04510Mexico

The relationship between metabolic derangements and fatty liver development are undeniable,since more than 75% of patients with type 2 diabetes mellitus present with fatty *** is also significant epidemiological association between insulin resistance(IR)and metabolic(dysfunction)-associated fatty liver disease(MAFLD).For little more than 2 years,the nomenclature of fatty liver of non-alcoholic origin has been intended to change to MAFLD by multiple *** a myriad of reasons for which MAFLD is thought to be of metabolic origin could be exposed,the bottom line relies on the role of IR as an initiator and perpetuator of this *** is a reciprocal role in MAFLD development and IR as well as serum glucose concentrations,where increased circulating glucose and insulin result in increased de novo lipogenesis by sterol regulatory elementbinding protein-1c induced lipogenic enzyme stimulation;therefore,increased endogenous production of *** same effect is achieved through impaired suppression of adipose tissue(AT)lipolysis in insulin-resistant states,increasing fatty acid influx into the *** complementary reciprocal situation occurs when liver steatosis alters hepatokine secretion,modifying fatty acid metabolism as well as IR in a variety of tissues,including skeletal muscle,AT,and the *** aim of this review is to discuss the importance of IR and AT interactions in metabolic altered states as perhaps the most important factor in MAFLD pathogenesis.

关键词： Metabolic(dysfunction)-associated fatty liver disease Insulin resistance Adipose tissue Fatty liver Metabolic syndrome Adipokine