检索结果-南通市图书馆

Evaluation of erastin synergized cisplatin anti-nasopharyngeal carcinoma effect with a glutathione-activated near-infrared fluorescent probe

引用

Chinese Chemical Letters 2024年第2期35卷 311-316页

作者： Rong He Dandan Tang Ningge xu Heng Liu kun Dou xuejun Zhou Fabiao Yu Department of Otolaryngology Head and Neck SurgeryThe First Affiliated Hospital of Hainan Medical UniversityHaikou 570102China Key Laboratory of Hainan Trauma and Disaster Rescue Key Laboratory of Emergency and TraumaMinistry of EducationEngineering Research Center for Hainan Bio-Smart Materials and Bio-Medical DevicesCollege of Emergency and TraumaHainan Medical UniversityHaikou 571199China Sichuan Provincial General Hospital of Judicial Police Chengdu 610225China

Nasopharyngeal carcinoma(NPC),a malignant tumor originating from the nasopharynx,is one of the common malignant tumors of the head and *** are significant geographical differences in the incidence of nasopharyngeal carcinoma,with a high incidence in China and Southeast Asian ***,we designed and synthesized a novel near-infrared fluorescent(NIRF)probe to detect glutathione(GSH)in cellular and tumor environments using semi-naphthofluorescein(SNAFL)as the fluorescent molecular backbone and 2-fluoro-4-nitrobenzenesulfonate as the recognition *** reaction with GSH,SNAFL-GSH emitted a fluorescence signal,and its emission wavelength at 650 nm was remarkably *** results of selectivity experiments indicated that SNAFL-GSH was able to discriminate GSH from Cys,Hcy,and H_(2) ***,SNAFL-GSH could image both endogenous and exogenous GSH and distinguish normal and cancer cells by fluorescence signal *** the cellular level,cisplatin(DDP)-induced ferroptosis and inhibition of proliferation of various NPC cell lines(CNE2,CNE1,5-8F cells)by erastin combined with DDP were visualized with the help of *** a mouse tumor xenograft model,we successfully employed SNAFL-GSH for the evaluation of the efficacy of erastin combined with DDP in the treatment of *** importantly,the probe could image cancerous tissue sections from NPC patients with an imaging depth of approximately 80µ*** was foreseen that SNAFL-GSH offered great potential for application in the diagnosis and evaluation of the therapeutic efficacy of NPC,and these results would also provide new ideas for the clinical treatment of NPC.

关键词： Glutathione NIRF probe Ferroptosis Anti-tumor therapy evaluation Bioimaging

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A novel stiffness optimization model of space telescopic boom based on locking mechanism

引用

Frontiers of Mechanical Engineering 2024年第3期19卷 41-59页

作者： kun xu Xinghan ZHUANG Zhou SU Qiuhong LIN shouzhi REN Hang XIAO Xilun DING School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Beijing Institute of Spacecraft System Engineering Beijing 100094China

The deployable telescopic boom,whose mass and stiffness play crucial roles,is extensively used in the design of space-deployable ***,the most existing optimal design that neglects the influence of the locking mechanisms in boom joints cannot raise the whole stiffness while reducing the boom *** tackle this challenge,a novel optimization model,which utilizes the arrangement of the locking mechanisms to achieve synchronous improvement of the stiffness and mass,is *** proposed optimization model incorporates a novel joint stiffness model developed based on an equivalent parallel mechanism that enables the consideration of multiple internal stiffness factors of the locking mechanisms and tubes,resulting in more accurate representations of the joint stiffness *** analysis shows that the proposed stiffness model achieves more than at least 11% improved accuracy compared with existing ***,case verification shows that the proposed optimization model can improve stiffness while effectively reducing mass,and it is applied in boom optimization design.

关键词： deployable telescopic boom locking mechanism stiffness model clearance error optimization model

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Transfer-learning multi-input multi-output equalizer for mode-division multiplexing systems

引用

Chinese Optics Letters 2024年第7期22卷 12-18页

作者： Tianfeng Zhao Feng Wen Mingming Tan Baojian Wu Bo xu kun Qiu Key Laboratory of Optical Fiber Sensing and Communication Ministry of EducationUniversity of Electronic Science and Technology of ChinaChengdu 611731China Aston Institute of Photonics Technologies Aston UniversityBirmingham B47ETUK

We propose a transfer-learning multi-input multi-output(TL-MIMO)scheme to significantly reduce the required training complexity for converging the equalizers in mode-division multiplexing(MDM)*** on a built three-mode(LP01,LP11a,and LP11b)multiplexed experimental system,we thoughtfully investigate the TL-MIMO performances on the three-typed data,collecting from different sampling times,launching optical powers,and inputting optical signal-to-noise ratios(OSNRs).A dramatic reduction of approximately 40%–83.33%in the required training complexity is achieved in all three ***,the good stability of TL-MIMO in both the launched powers and OSNR test bands has also been proved.

关键词： mode division multiplexing multi-input multi-output transfer learning training complexity

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Structure regulating of metal clusters in carbonized metallic organic frameworks for high-efficient microwave absorption via tuning interaction strength between metals and ligands

引用

Nano Research 2024年第3期17卷 1699-1709页

作者： Chang Sun kun-Yan Zhao Ming-Lu Huang Cheng-Long Luo xu-Dong Chen Ming Wang School of Chemistry and Chemical Engineering Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function ManufacturingSouthwest UniversityChongqing 400715China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Carbonized metallic organic frameworks(CMOF)have been attracting attention in microwave absorption(MA)research area because of their diverse structures,tunable compositions,and rich ***,structure regulation on metal clusters in CMOF is achieved by tuning the interaction strength between metals and ligands to enhance microwave absorption *** to relatively weak interaction among copper cations and ligands,copper nanoclusters(CuNC)can be uniformly formed and embedded within the cobalt/zinc(Co/Zn)***,copper cations are added to the Co/Zn bimetallic zeolitic imidazolate frameworks(ZIFs).Secondly,the CMOF composite particles with CuNCs(CuNCs/CoZn-CMOF)were developed by a pyrolysis *** CuNCs/CoZn-CMOF with an appropriate amount of CuNCs can harmonize both dielectric and magnetic *** a result,the minimum reflection loss(RLmin)reaches–45.1 dB at a matching thickness of 2.30 mm and the effective absorption bandwidth(EAB)is 8.80 GHz at a thickness of 3.10 *** broadband response to electromagnetic waves is attributed to interfacial polarization at CuNCs surface and heterogeneous interfaces,impedance matching and multiple scattering of electromagnetic *** study provides a feasible method to develop CMOF microwave absorption materials with high EAB values.

关键词： heterogeneous interface carbonized metallic organic frameworks microwave absorption interfacial polarization

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Gel-Based Solidification Technology for Large Fracture Plugging

引用

Fluid Dynamics & Materials Processing 2024年第3期20卷 563-578页

作者： kunjian Wang Ruibin He Qianhua Liao kun xu Wen Wang Kan Chen Tianjin Branch of CNOOC(China)Co. Ltd.Tianjin300450China Jingzhou Jiahua Technology Co. Ltd.Jingzhou434001China

Fault fractures usually have large openings and considerable extension. Accordingly, cross-linked gel materials aregenerally considered more suitable plugging agents than water-based gels because the latter often undergo contaminationvia formation water, which prevents them from being effective over long times. Hence, in this study, aset of oil-based composite gels based on waste grease and epoxy resin has been developed. These materials havebeen observed to possess high compressive strength and resistance to the aforementioned contamination, therebyleading to notable increase in plugging success rate. The compressive strength, thickening time, and resistance toformation water pollution of these gels have been evaluated indoors. The results show that the compressivestrength of the gel can reach 11 MPa;additionally, the related gelation time can be controlled to be more than3 h, thereby providing a safe construction time;Invasion of formation water has a small effect on the gel strengthand does not shorten the thickening time. All considered performance indicators of the oil-based gel confirm itssuitability as a plugging agent for fault fractures.

关键词： Drilling loss fault fracture oil-based gel compressive strength gel plugging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

An improved analysis method for assessing the nuclear-heating impact on the stability of toroidal field magnets in fusion reactors

引用

Nuclear Science and Techniques 2024年第6期35卷 163-176页

作者： Yu-Dong Lu Jin-Xing Zheng xu-Feng Liu Huan Wu Jian Ge kun xu Ming Li Hai-Yang Liu Lei Zhu Fei Liu Institute of Plasma Physics Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China

The superconducting magnet system of a fusion reactor plays a vital role in plasma confinement,a process that can be dis-rupted by various operational factors.A critical parameter for evaluating the temperature margin of superconducting magnets during normal operation is the nuclear heating caused by D-T *** study investigates the impact of nuclear heat-ing on a superconducting magnet system by employing an improved analysis method that combines neutronics and thermal *** the magnet system,toroidal field(TF)magnets are positioned closest to the plasma and bear the highest nuclear-heat load,making them prime candidates for evaluating the influence of nuclear heating on *** enhance the modeling accuracy and facilitate design modifications,a parametric TF model that incorporates heterogeneity is established to expedite the optimization design process and enhance the accuracy of the computations.A comparative analysis with a homogeneous TF model reveals that the heterogeneous model improves accuracy by over 12%.Considering factors such as heat load,magnetic-field strength,and cooling conditions,the cooling circuit facing the most severe conditions is selected to calculate the temperature of the *** selection streamlines the workload associated with thermal-hydraulic *** approach enables a more efficient and precise evaluation of the temperature margin of TF ***,it offers insights that can guide the optimization of both the structure and cooling strategy of superconducting magnet systems.

关键词： Superconducting magnet Nuclear heating Neutronics Thermal hydraulics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Catalytic asymmetric dearomative azo-Diels–Alder reaction of 2-vinlyindoles

引用

Chinese Chemical Letters 2024年第4期35卷 357-362页

作者： Yu-Hang Miao Zheng-xu Zhang xu-Yi Huang Yuan-Zhao Hua Shi-kun Jia Xiao Xiao Min-Can Wang Li-Ping xu Guang-Jian Mei Green Catalysis Center and College of ChemistryZhengzhou UniversityZhengzhou 450052China School of Chemistry and Chemical Engineering Shandong University of TechnologyZibo 255000China Institute of Pharmaceutical Science and Technology Zhejiang University of TechnologyHangzhou 310014China

Due to the high electrophilic nature of azo-dienophiles, azo-Diels–Alder proceeds rapidly even without the need of a catalyst and is therefore regarded as the “click reaction”. This spontaneity causes strong background reaction and poses a daunting challenge to chemists for developing the catalytic asymmetric version. Reported herein is the first catalytic asymmetric dearomative azo-Diels–Alder reaction between2-vinylindoles and triazoledione. This protocol makes use of the high energy barrier of dearomatization to avert the strong background reaction of azo-Diels–Alder reaction, allowing the implementation of the projected reaction at ambient temperature. Density functional theory calculations have been performed to gain insights into the reaction mechanism and the origins of the enantioselectivity. By using this method,a variety of tetracyclic indole derivatives have been readily prepared in good to excellent yields and with excellent diastereo-and enantio–selectivities(33 examples, up to 97% yield and >99% ee, >20:1 dr).

关键词： Catalytic asymmetric dearomatization Azo-Diels–Alder reaction 2-Vinylindoles Chiral phosphoric acid Tetracyclic indole derivatives

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Bionic lightweight design of limb leg units for hydraulic quadruped robots by additive manufacturing and topology optimization

引用

Bio-Design and Manufacturing 2024年第1期7卷 1-13页

作者： Huaizhi Zong Junhui Zhang Lei Jiang kun Zhang Jun Shen Zhenyu Lu Ke Wang Yanli Wang Bing xu The State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang UniversityHangzhou 310058China Unmanned Vehicle Research and Development Center China North Vehicle Research InstituteBeijing 100072China School of Mechatronic Engineering Nanchang UniversityNanchang 330031China Auclean High-Tech Ltd. Wuxi 214108China

Galloping cheetahs,climbing mountain goats,and load hauling horses all show desirable locomotion capability,which motivates the development of quadruped *** various quadruped robots,hydraulically driven quadruped robots show great potential in unstructured environments due to their discrete landing positions and large *** the most critical movement unit of a quadruped robot,the limb leg unit(LLU)directly affects movement speed and reliability,and requires a compact and lightweight *** by the dexterous skeleton–muscle systems of cheetahs and humans,this paper proposes a highly integrated bionic actuator system for a better dynamic performance of an *** propose that a cylinder barrel with multiple element interfaces and internal smooth channels is realized using metal additive manufacturing,and hybrid lattice structures are introduced into the lightweight design of the piston *** addition,additive manufacturing and topology optimization are incorporated to reduce the redundant material of the structural parts of the *** mechanical properties of the actuator system are verified by numerical simulation and experiments,and the power density of the actuators is far greater than that of cheetah *** mass of the optimized LLU is reduced by 24.5%,and the optimized LLU shows better response time performance when given a step signal,and presents a good trajectory tracking ability with the increase in motion frequency.

关键词： Additive manufacturing Bionic lightweight design Limb leg unit Quadruped robot Trajectory tracking

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Human radiological safety assessment for petawatt laser-driven ion acceleration experiments in CLAPA-T

引用

Matter and Radiation at Extremes 2024年第4期9卷 8-15页

作者： Xiaopeng Zhang Jiarui Zhao Shengxuan xu xun Chen Ying Gao Shiyou Chen kun Zhu xueqing Yan Wenjun Ma State Key Laboratory of Nuclear Physics and Technology and Key Laboratory of HEDP of the Ministry of EducationCAPTPeking UniversityBeijing 100871China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsCASBeijing 100049China Beijing Laser Acceleration Innovation Center HuairouBeijing 101400China Institute of Guangdong Laser Plasma Technology BaiyunGuangzhou 510540China

The newly built Compact Laser Plasma Accelerator-Therapy facility at Peking University will deliver 60 J/1 Hz laser pulses with 30 fs *** by this petawatt laser facility,proton beams with energy up to 200 MeV are expected to be generated for tumor *** high-repetition operation,both prompt radiation and residual radiation may cause safety ***,human radiological safety assessment before commissioning is *** this paper,we simulate both prompt and residual radiation using the Geant4 and FLUKA Monte Carlo codes with reasonable proton and as-produced electron beam *** find that the prompt radiation can be shielded well by the concrete wall of the experimental hall,but the risk from residual radiation is nonnegligible and necessitates adequate radiation *** the basis of the simulation results,we discuss the constraints imposed by radiation safety considerations on the annual working time,and we propose radiation cooling strategies for different shooting modes.

关键词： laser prompt acceleration

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Technologies and studies of gas exchange in two-stroke aircraft piston engine:A review

引用

Chinese Journal of Aeronautics 2024年第1期37卷 24-50页

作者： Yu ZHOU xueyu LI Shuiting DING Shuai ZHAO kun ZHU Longtao SHAO Farong DU Gerui WANG Zheng xu Research Institute of Aero-Engine Beihang UniversityBeijing 100191China Aircraft/Engine Integrated System Safety Beijing Key Laboratory Beijing 100191China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China Civil Aviation University of China Tianjin 300300China Aero Engine Academy of China Beijing 101304China School of Energy and Power Engineering Beihang UniversityBeijing 100191China Beihang Hangzhou Innovation Institute Yuhang Hangzhou 310052China

The in-cylinder gas exchange process is crucial to the power performance of two-stroke aircraft piston engines,which is easily influenced by complex factors such as high-altitude performance variation and in-cylinder flow *** paper reviews the development history and characteristics of gas exchange types,as well as the current state of theory and the validation methods of gas exchange technology,while also discusses the trends of cutting-edge technologies in the *** paper provides a theoretical foundation for the optimization and engineering design of gas exchange systems and,more importantly,points out that the innovation of gas exchange types,the modification of theoretical models,and the technology of variable airflow organization are the key future research directions in this field.

关键词： Aircraft piston engine Aircraft power systems Gas exchange High-altitude performance In-cylinder flow Two-stroke Unmanned Aerial Vehicles(UAVs)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：