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Status of the neonatal follow‑up system in China:survey and analysis

World Journal of Pediatrics 2023年第11期19卷 1104-1110页

作者： Qi Zhou Yun Cao Lan Zhang Nurya Erejep Wen‑Long Xiu Jing‑Yun Shi Rui Cheng Wen‑Hao Zhou shoo klee Department of Neonatology Children’s Hospital of Fudan University399 Wanyuan RdMinhang DistrictShanghai 201102China Department of Neonatology Children’s Hospital of XinjiangUrumqiChina Department of Neonatology Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics&Gynecology and PediatricsFujian Medical UniversityFuzhouChina Department of Neonatology Gansu Provincial Maternal and Child Care HospitalLanzhouChina Department of Neonatology Nanjing Children’s HospitalNanjingChina Department of Pediatrics Mount Sinai HospitalTorontoONCanada

Background There is little information about neonatal follow-up programs(NFUPs)in *** study aimed to conduct a survey of hospitals participating in the Chinese Neonatal Network(CHNN)to determine the status of NFUPs,including resources available,criteria for enrollment,neurodevelopmental assessments,and duration of *** We conducted a descriptive study using an online survey of all 72 hospitals participating in CHNN in *** survey included 15 questions that were developed based on the current literature and investigators’knowledge about followup practices in *** Sixty-four(89%)of the 72 hospitals responded to the survey,with an even distribution of children’s(31%),maternity(33%)and general(36%)*** but one(98%)hospital had NFUPs,with 44(70%)being established after *** criteria for follow-up were variable,but common criteria included very preterm infants<32 weeks or<2000 g birth weight(100%),small for gestational age(97%),hypoxic ischemic encephalopathy(98%)and postsurgery(90%).The average follow-up rate was 70%(range:7.5%–100%).Only 12%of hospitals followed up with patients for more than 24 *** was significant variation in neurodevelopmental assessments,follow-up schedule,composition of staff,and clinic facilities and *** of the staff had received formal training,and only four hospitals had sent staff to foreign hospitals as *** There is significant variation in eligibility criteria,duration of follow-up,types of assessments,staffing,training and facilities *** and standardization are urgently needed.

关键词： Follow-up Neonate Survey

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Variations in length of stay among survived very preterm infants admitted to Chinese neonatal intensive care units

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World Journal of Pediatrics 2022年第2期18卷 126-134页

作者： Min Zhang Yan-Chen Wang Jin-Xing Feng Ai-Zhen Yu Jing-Wei Huang Si-Yuan Jiang Xin-Yue Gu Jian-Hua Sun Yun Cao Wen-Hao Zhou shoo klee Li-Li Wang Rong Yin Division of Neonatology The First Affiliated Hospital of Anhui Medical UniversityNo.218Jixi RoadShushan DistrictHefei 230022China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren's Hospital of Fudan UniversityShanghai 201102China Division of Neonatology Shenzhen Children's HospitalShenzhen 518038China Division of Neonatology.Children's Hospital of Fudan University 399 Wanyuan RoadMinhang DistrictShanghai 201102China Division of Neonatology Shanghai Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Maternal-Infants Care Research Centre and Department of Pediatrics Mount Sinai HospitalTorontoON M5G 1X5.Canada Professor Emeritus University of Toronto.TorontoON M5T 3M7Canada

Background This study aimed to describe length of stay(LOS)to discharge and site variations among very preterm infants(VPIs)admitted to 57 Chinese neonatal intensive care units(NICUs)and to investigate factors associated with LOS for *** This retrospective multicenter cohort study enrolled all infants<32 weeks’gestation and admitted to 57 NICUs which had participated in the Chinese Neonatal Network,within 7 days after birth in *** criteria included major congenital anomalies,NICU deaths,discharge against medical advice,transfer to non-participating hospitals,and missing discharge *** multivariable linear models were used to estimate the association of infant characteristics and *** A total of 6580 infants were included in our *** overall median LOS was 46 days[interquartile range(IQR):35-60],and the median corrected gestational age at discharge was 36 weeks(IQR:35-38).LOS and corrected gestational age at discharge increased with decreasing gestational *** median corrected gestational age at discharge for infants at 24 weeks,25 weeks,26 weeks,27-28 weeks,and 29-31 weeks were 41 weeks,39 weeks,38 weeks,37 weeks and 36 weeks,*** site variation of LOS was identified with observed median LOS from 33 to 71 days in different *** The study provided concurrent estimates of LOS for VPIs which survived in Chinese NICUs that could be used as references for medical staff and *** variation of LOS independent of infant characteristics existed,indicating variation of care practices requiring further investigation and quality improvement.

关键词： Length of stay to discharge home Neonatal intensive care Preterm Risk factors

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Use of antenatal corticosteroids among infants with gestational age at 24 to 31 weeks in 57 neonatal intensive care units of China: a cross-sectional study

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Chinese Medical Journal 2023年第7期136卷 822-829页

作者： Jing Zhao Zongtai Feng Yun Dai Wanxian Zhang Siyuan Jiang Yanchen Wang Xinyue Gu Jianhua Sun Yun Cao shoo klee Xiuying Tian Zuming Yang on behalf of the Chinese Neonatal Network(CHNN) Division of Neonatology Tianjin Central Hospital of Obstetrics and GynecologyTianjin 300052China Tianjin Key Laboratory of Human Development and Reproductive Regulation Tianjin 300052China Nankai University Maternity Hospital Tianjin 300052China Division of Neonatology The Affiliated Suzhou Hospital of Nanjing Medical UniversitySuzhouJiangsu 215002China Division of Neonatology Children’s Hospital of Fudan UniversityShanghai 201102China NHC Key Laboratory of Neonatal Diseases Fudan UniversityChildren’s Hospital of Fudan UniversityShanghai 201102China Department of Neonatology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China Maternal-Infants Care Research Centre Mount Sinai HospitalTorontoON M5G 1X5Canada University of Toronto TorontoON M5T 3M7Canada 不详

Background:Antenatal corticosteroids(ACS)can significantly improve the outcomes of preterm *** study aimed to describe the ACS use rates among preterm infants admitted to Chinese neonatal intensive care units(NICU)and to explore perinatal factors associated with ACS use,using the largest contemporary cohort of very preterm infants in ***:This cross-sectional study enrolled all infants born at 24^(+0)to 31^(+6)weeks and admitted to 57 NICUs of the Chinese Neonatal Network from January 1st,2019 to December 30th,*** ACS administration was defined as at least one dose of dexamethasone and betamethasone given before *** logistic regressions were applied to determine the association between perinatal factors and ACS ***:A total of 7828 infants were enrolled,among which 6103(78.0%)infants received *** use rates increased with increasing gestational age(GA),from 177/259(68.3%)at 24 to 25 weeks’gestation to 3120/3960(78.8%)at 30 to 31 weeks’*** infants exposed to ACS,2999 of 6103(49.1%)infants received a single complete course,and 33.4%(2039/6103)infants received a partial *** use rates varied from 30.2%to 100%among different *** regression showed that increasing GA,born in hospital(inborn),increasing maternal age,maternal hypertension and premature rupture of membranes were associated with higher likelihood to receive ***:The use rate of ACS remained low for infants at 24 to 31 weeks’gestation admitted to Chinese NICUs,with fewer infants receiving a complete *** use rates varied significantly among different *** are urgently needed to propose improvement measures and thus improve the usage of ACS.

关键词： Infant,newborn Antenatal corticosteroids Adrenal cortex hormones Betamethasone Dexamethasone Gestational age Maternal age Very preterm infant Intensive care unit,neonatal China

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中国新生儿协作网出生胎龄22~25周超早产儿出院预后及治疗现状

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中华儿科杂志 2024年第1期62卷 22-28页

作者：蒋思远杨传忠田秀英陈冬梅杨祖铭石静云徐发林莫艳顾昕玥 Lee shoo K. 周文浩曹云国家儿童医学中心、复旦大学附属儿科医院新生儿科上海201102 南方医科大学附属深圳妇幼保健院新生儿科深圳518000 天津市中心妇产科医院、南开大学附属妇产科医院新生儿科天津300199 泉州市妇幼保健院儿童医院新生儿科泉州362017 苏州市立医院、南京医科大学附属苏州医院新生儿科苏州215001 甘肃省妇幼保健院、甘肃省中心医院新生儿科兰州730050 郑州大学附属第三医院(河南省妇幼保健院)儿科郑州450052 广西壮族自治区妇幼保健院、广西壮族自治区儿童医院新生儿医疗中心南宁530005 国家儿童医学中心、复旦大学附属儿科医院国家卫生健康委员会新生儿疾病重点实验室上海201102 加拿大西奈山医院母婴健康研究中心多伦多M5G 1X5 广州市妇女儿童医疗中心新生儿医学中心广州510623

目的描述2019—2021年中国新生儿协作网(CHNN)各单位收治的出生胎龄22~25周超早产儿的出院预后和治疗现状以及3年变化趋势。方法基于CHNN极早产儿队列的横断面研究,纳入2019—2021年CHNN各单位新生儿重症监护病房(NICU)收治的963例出生... 详细信息

目的描述2019—2021年中国新生儿协作网(CHNN)各单位收治的出生胎龄22~25周超早产儿的出院预后和治疗现状以及3年变化趋势。方法基于CHNN极早产儿队列的横断面研究,纳入2019—2021年CHNN各单位新生儿重症监护病房(NICU)收治的963例出生胎龄22~25周的超早产儿。排除出生24 h后入院及转运至非CHNN医院治疗的超早产儿。根据出生胎龄和入院年份分组,描述不同组超早产儿围生期救治、存活率、并发症发生率及NICU治疗情况。采用χ^(2)检验、Kruskal-Wallis秩和检验进行组间比较,采用Cochran-Armitage和Jonckheere-Terpstra趋势检验进行不同年份间趋势分析。结果963例超早产儿中男588例(61.1%),出生胎龄25.0(24.4,25.6)周,出生体重770(680,840)g。出生胎龄22、23、24、25周的超早产儿分别有29例(3.0%)、88例(9.1%)、264例(27.4%)、582例(60.4%)。2019—2021年3年间超早产儿病例数量逐年增加(分别为285、312、366例)。母亲产前激素和硫酸镁的应用率分别为67.7%(615/908)和51.1%(453/886)。产房中无创呼气末正压和气管插管应用率分别为20.8%(200/963)和69.5%(669/963),延迟脐带结扎和脐带挤压应用率分别为19.0%(149/784)和30.4%(241/794)。2019—2021年3年间母亲产前激素、产前硫酸镁应用、产房无创呼气末正压应用率均有增加趋势(均P0.05)。积极治疗后存活超早产儿中,仅11.5%(45/392)出院时无并发症存活。中重度支气管肺发育不良[67.3%(264/392)]和严重早产儿视网膜病[61.5%(241/392)]是常见的两类并发症,重度脑室内出血或脑室旁白质软化、坏死性小肠结肠炎和败血症的发生率分别为15.3%(60/392)、5.9%(23/392)和19.1%(75/392)。积极治疗后存活超早产儿中,83.7%(328/392)接受有创机械通气治疗,时长为22(10,42)d。存活超早产儿的住院时长为97(86,116)d。结论CHNN各单位NICU收治的出生胎龄22~25周超早产儿数量2019—2021年逐年增加,但出院时存活率尤其是无并发症存活率仍有很大的提升空间;多项可改善超早产儿预后的最佳临床实践实施情况有待改进.

关键词：婴儿,早产存活率预后并发症

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种植固定修复后食物嵌塞的发生原因及防治

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中国实用口腔科杂志 2024年第1期17卷 26-32页

作者：葛严军潘韶霞北京大学口腔医学院·口腔医院修复科国家口腔疾病临床医学研究中心口腔数字化医疗技术和材料国家工程实验室口腔数字医学北京市重点实验室北京100081

食物嵌塞是一种常见的种植固定修复后并发症,发生率高,危害大。目前临床上最常用的分类方式是将其分为垂直型、水平型和混合型3种。种植体周软硬组织、种植体及其上部修复体、邻牙、对颌牙、咬合、牙齿排列以及患者个人习惯等诸多因素... 详细信息

食物嵌塞是一种常见的种植固定修复后并发症,发生率高,危害大。目前临床上最常用的分类方式是将其分为垂直型、水平型和混合型3种。种植体周软硬组织、种植体及其上部修复体、邻牙、对颌牙、咬合、牙齿排列以及患者个人习惯等诸多因素都会引起或加重食物嵌塞的发生。临床尚无简单有效的治疗手段,应以预防为主,在明确成因后综合运用修复、牙周、正畸等多学科手段解决。

关键词：种植固定修复食物嵌塞邻接触丧失发生原因咬合

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A general strategy towards controllable replication of butterfly wings for robust light photocatalysis

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Journal of Materials Science & Technology 2022年第10期105卷 286-292页

作者： Minmin Zhu Haizhong Zhang shoo Wen Long Favier Yida Zhao Huilu Guo Zehui Du College of Physics and Information Engineering Fuzhou UniversityFuzhou 350116China FZU-Jinjiang Joint Institute of Microelectronics Jinjiang Science and Education ParkFuzhou UniversityJinjiang 362200China Temasek Laboratories Research Techno Plaza50 Nanyang DriveSingapore 637553Singapore

Large-scale replication of the hierarchical microstructure of bio-template is a long-standing challenge due to the large shrinkage when the bio-templates are burned *** this work,TiO_(2) based biomimetic metamaterials have been successfully synthesized by sputtering technique,followed by tape assisted transferring and thermal oxidation ***-like arrays of the scale replicas with ridge-lamellae hierarchical microstructures have been obtained and exhibit bright blue-purple structure *** interestingly,they exhibit signifcantly enhanced photocatalytic activity to decompose methylene blue under solar light illumination,with the degradation rate of methylene blue almost fve times that of TiO_(2) thin flms with the same sample *** enhancement on the visible light photocatalytic activity in TiO_(2) replicas can be attributed to a synergy effect of the presence of Ti^(3+) doping,the air-TO_(2) interaction,and hierarchical *** controlling factors that affect the microstructure,structural color and photocatalytic activity of the TiO_(2) replicas have been discussed in *** work offers a scalable and precise approach to replicate various bio-templates based on transition metal oxides,such as ZnO,Fe_(3)O_(4),CoO,and VO_(2),thereby providing the new opportunity for infrared sensing,photocatalytic and photonic applications.

关键词： Photocatalysis Biomimetic metamaterial TiO_(2) Structural color Sputtering

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Breaking down barriers: enabling care-by-parent in neonatal intensive care units in China

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World Journal of Pediatrics 2017年第2期13卷 144-151页

作者： Xiao-Ying Li shoo Lee Hua-Feng Yu Xiang Y Ye Ruth Warre Xiang-Hong Liu Jian-Hong Liu Neonatalogy Department Qilu Children’s Hospital Shandong UniversityJinanChina Maternal—Infant Care Research Centre Mount Sinai HospitalTorontoOntarioCanada Department of Pediatrics University ofTorontoOntarioCanada

Background:Denying parents access to their infant in the Neonatal Intensive Care Unit (NICU) is a standard practice in most hospitals across *** is not usually permitted or may be strictly limited,and NICU care for most neonates is provided by health-care professionals with little participation of the *** exception to this rule is the level 2 'Room-In' ward in Qilu Children's Hospital,Shandong University,where parents have 24-hour access to their infants and participate in providing ***:This retrospective cohort study compared the outcomes of infants who were admitted to the NICU and remained there throughout their stay (NICU-NICU group,n=428),admitted to the NICU and then transferred to the Room-In ward (NICU-RIn group,n=1018),or admitted straight to the Room-In ward (RIn only group,n=629).Results:There were no significant differences in the rates of nosocomial infection,bronchopulmonary dysplasia,intraventricular hemorrhage,and retinopathy of prematurity between the NICU-NICU and NICURIn *** rate of necrotizing enterocolitis was significantly lower in the NICU-RIn group (P=0.04),while weight gain and duration of hospital stay were significantly higher (both P<0.001).Rates of adverse outcomes were lower in RIn-only infants due to their low severity of illness on ***:Allowing parents access to their infant in the NICU is feasible and safe in China,and may result in improvements in infant *** studies are required to generate stronger evidence that can inform changes to neonatal care in China.

关键词： care-by-parent family-centered care infant newborn neonatal intensive care unit parental involvement

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Efficacy of an Infection Control Programme in Reducing Ventilator-associated Pneumonia in a Chinese NICU

Efficacy of an Infection Control Programme in Reducing Venti...

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中华医学会第十七次全国儿科学术大会

作者： Lee shoo Kamaludden Majeeda Department of Neonatology Children’s Hospital of Fudan UniversityShanghaiChina

Objective To evaluate the efficacy of an infection control programme in reducing ventilator-associated pneumonia (VAP) in a Chinese neonatal intensive care units(NICU). Methods All neonates who received mechanical ventilation for at least 48h and,hospitalized in the NICU for≥5d during three epochs were included in this *** first phase was from Feb 1,2006 to Jan 1,2007;the second phase was from Aug 1,2008 to July 31,2009 and the third phase was from Jan 1,2010 to Dec 31,***

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基于真实世界的新生儿临床研究:推动最佳医疗实践和质量改进

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中华围产医学杂志 2022年第8期25卷 565-569页

作者：曹云 shoo K Lee 周文浩复旦大学附属儿科医院(国家儿童医学中心)新生儿科上海201102 国家卫生健康委员会新生儿疾病重点实验室上海201102 加拿大多伦多大学多伦多M5S2E8 加拿大多伦多西奈山医院多伦多M5G1Z5

基于真实世界的研究结论已成为医疗产品评审和监管的依据。不断更新迭代的诊疗技术为真实世界研究提供了更多的应用场景。新生儿疾病的发生发展与生命其他阶段显著不同, 早期高质量的临床管理对生命远期的影响极其深远, 故需要通过真实... 详细信息

基于真实世界的研究结论已成为医疗产品评审和监管的依据。不断更新迭代的诊疗技术为真实世界研究提供了更多的应用场景。新生儿疾病的发生发展与生命其他阶段显著不同, 早期高质量的临床管理对生命远期的影响极其深远, 故需要通过真实世界研究为临床诊疗提供坚实的证据。本文主要通过介绍中国新生儿协作网的应用及其带来的挑战与思考, 以及在此基础上进一步结合中国新生儿基因组计划的多组学数据整合应用, 探索实现新生儿期高质量医疗实践的最佳路径。

关键词：重症监护病房新生儿新生儿护理临床研究卫生保健质量质量改进

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加拿大渥太华大学附属医院和东安大略儿童医院NICU临床Fellow培训见闻

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中国当代儿科杂志 2011年第4期13卷 351-353页

作者：刘玲刘建平陈超曹云 shoo LEE 贵阳市妇幼保健院新生儿科贵州贵阳550003 西安市儿童医院新生儿科陕西西安710003 复旦大学附属儿科医院新生儿科上海201102 加拿大新生儿协作网

近年来随着我国经济的快速发展和国际交往的日益频繁,作为一名新生儿科医师,本人有幸参加了第三期中国加拿大新生儿协作网联合举办的高级临床新生儿医师培训项目,于2007年7月至2008年6月到加拿大新生儿重症监护病房学习工作1年,现将本... 详细信息

近年来随着我国经济的快速发展和国际交往的日益频繁,作为一名新生儿科医师,本人有幸参加了第三期中国加拿大新生儿协作网联合举办的高级临床新生儿医师培训项目,于2007年7月至2008年6月到加拿大新生儿重症监护病房学习工作1年,现将本人在国外工作学习的见闻和感受介绍如下。

关键词：培训项目大学附属医院加拿大新生儿重症监护病房 NICU 儿童医院临床儿科医师

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