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Potential of metastin and metastin receptor as biomarkers for urological cancers

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World Journal of Clinical Urology 2013年第2期2卷 10-14页

作者： Sunao shoji Haruhiro Sato Tetsuro Tomonaga Hakushi Kim Shuichi Soeda Mayura Nakano Toyoaki Uchida Toshiro Terachi Koichi Takeya Department of Urology Tokai University Hachioji Hospital Department of Internal Medicine Tokai University School of Medicine Department of Urology Tokai University Oiso Hospital Department of Urology Numazu City Hospital Department of Urology Tokai University School of Medicine Department of Natural Products and Medical Chemistry School of PharmacyTokyo University of Pharmacy and Life Sciences

AIM: To investigate the current state of the research of metastin and metastin receptor in the urological cancer ***: For analyzing the value of metastin and metastin receptor as molecular biomarkers for the patients with urological cancer, MEDLINE database searches were performed using these terms: metastin, KISS1, kisspeptin, renal(cell) carcinoma(RCC), kidney cancer or urothelial cancer or bladder cancer or prostate cancer or testicular cancer(tumor). Since the articles were evaluated by the validity of the articlesbased on plausibility, credibility, and evidence levels, the articles were graded according to their level of evidence, using the grading system defined by the Oxford Centre for Evidence-based Medicine. RESULTS: A total of six clinical studies published by individual institutions between 2003 and 2013 were included in this review. The article numbers for each of the evidence levels 2a and 2b were three(50%) and three(50%), respectively. Immunohistochemistry and reverse transcriptase-polymerase chain reaction using tumor tissues were performed to analyze in five articles(83%) and in one article(17%). The value of metastin and/or metastin receptor as molecular biomarkers in clear cell RCC, upper tract urothelial carcinoma, and bladder cancer was evaluated by multivariate analysis. Low expression of metastin receptor in clear cell RCC and low expression of metastin in upper tract urothelial carcinoma were significant risk factors for metastasis, and low metastin expression was an independent prognostic factor in bladder cancer. CONCLUSION: Metastin and metastin receptor have potential as suitable molecular biomarkers for urological cancers. However, future studies of metastin and metastin receptor should undergo external validation to ensure consistency across different patient series, since individual institutional studies lack generalization.

关键词： KISS-1 Metastin Metastin receptor Metastasis Renal cell carcinoma Upper tract urothelial carcinoma Bladder cancer

Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-like peptide-1

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世界糖尿病杂志：英文版（电子版） 2016年第11期7卷 230-238页

作者： Akifumi Kushiyama Takako Kikuchi Kentaro Tanaka Tazu Tahara Toshiko Takao Yukiko Onishi Yoko Yoshida shoji Kawazu Yasuhiko Iwamoto Division of Diabetes and Metabolism Institute for Adult Diseases Asahi Life Foundation Department of Nephrology School of Medicine Faculty of Medicine Toho University

AIM: To investigate whether active glucagon-like peptide-1(GLP-1) is a prediction Factor of Effect of sitagliptin on patients with type 2 diabetes mellitus(GLP-1 FEST:UMIN000010645). METHODS: Seventy-six patients with type 2 diabetes, who had insufficient glycemic control [Hemoglobin A1c(Hb A1c) ≥ 7%] in spite of treatment with metformin and/or sulfonylurea, were included in the investigation. Patients were divided into three groups by tertiles of fasting plasma active GLP-1 level, before the administration of 50 mg sitagliptin. RESULTS: At baseline, body mass index, serum UA, insulin and HOMA-IR were higher in the high active GLP-1 group than in the other two groups. The high active GLP-1 group did not show any decline of Hb A1c(7.6% ± 1.4% to 7.5% ± 1.5%), whereas the middle and low groups indicated significant decline of Hb A1c(7.4 ± 0.7 to 6.8 ± 0.6 and 7.4 ± 1.2 to 6.9 ± 1.3, respectively) during six months. Only the low and middle groups showed a significant increment of active GLP-1, C-peptide level, a decreased log and proinsulin/insulin ratio after administration. In logistic analysis, the low or middle group is a significantexplanatory variable for an Hb A1 c decrease of ≥ 0.5%, and its odds ratio is 4.5(1.40-17.6)(P = 0.01) against the high active GLP-1 group. This remains independent when adjusted for Hb A1 c level before administration, patients' medical history, medications, insulin secretion and insulin ***: Plasma fasting active GLP-1 is an independent predictive marker for the efficacy of dipeptidyl peptidase 4 inhibitor sitagliptin.

关键词： Dipeptidyl peptidase-4 inhibitor Active form glucagon-like peptide-1 Hemoglobin A1c Regression analysis

Intronic pentanucleotide TTTCA repeat insertion in SAMD12 gene causes familial cortical myoclonic tremor with epilepsy type 1

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Intronic pentanucleotide TTTCA repeat insertion in SAMD12 ge...

Multicenter cooperative observational study of idiopathic pulmonary fibrosis with non-small cell lung cancer

2018年浙江省神经病学学术年会

作者： Zhidong Cen Zhengwen Jiang You Chen Xiaosheng Zheng Fei Xie Xiaodong Yang Xingjiao Lu Zhiyuan Ouyang Hongwei Wu Si Chen Houmin Yin Xia Qiu Shuang Wang Meiping Ding Yelei Tang Feng Yu Caihua Li Tao Wang Hiroyuki Ishiura shoji Tsuji Chuan Jiao Chunyu Liu Jianfeng Xiao Wei Luo Department of Neurology Second Affiliated Hospital School of Medicine Zhejiang University Intensive Care Unit Zhejiang Hospital Department of Neurology Sir Run Run Shaw Hospital School of Medicine Zhejiang University Department of Neurology Ruijin Hospital School of Medicine Shanghai Jiao Tong University Department of Neurology Zhejiang Hospital Department of Neurology Lishui People’s Hospital Cancer Institute Key Laboratory of Cancer Prevention and Intervention China National Ministry of Education Second Affiliated Hospital School of Medicine Zhejiang University Department of Neurology Faculty of Medicine The University of Tokyo Department of Molecular Neurology Graduate School of Medicine The University of Tokyo International University of Health and Welfare Graduate School Center for Medical Genetics School of Life Sciences Central South University Department of Psychiatry SUNY Upstate Medical University Department of Neurology University of Tennessee Health Science Center

Familial cortical myoclonic tremor with epilepsy is an autosomal dominant neurodegenerative disease, characterized by cortical tremor and epileptic seizures. Although four subtypes(type 1-4) mapped on different chromosomes(8 q24, 2 p11.1-q12.2, 5 p15.31-p15.1 and 5 p15.31-p15.1) have been reported, the causative gene has not yet been identified. Here, we report the genetic study in a cohort of twenty Chinese pedigrees with familial cortical myoclonic tremor with epilepsy. Linkage and haplotype analysis in 11 pedigrees revealed maximum two-point LOD scores from 1.64 to 3.77(LOD scores in 5 pedigrees were > 3.0) in chromosomal region 8 q24 and narrowed the candidate region to an interval of 4.9 Mb. Using whole-genome sequencing, long-range PCR and repeat-primed PCR, we identified an intronic pentanucleotide(TTTCA)n insertion in SAMD12 gene as the cause, which was cosegregated with the disease among the 11 pedigrees mapped on 8 q24 and additional 7 un-mapped pedigrees. Only 2 pedigrees did not detect this(TTTCA)n insertion. Repeat-primed PCR revealed that the sizes of(TTTCA)n insertion in all affected members were larger than 105 repeats. The same pentanucleotide insertion(ATTTCATTTC) 58 has been reported to form RNA foci resulting in neurotoxicity in spinocerebellar ataxia type 37, which suggests the similar pathogenic process in familial cortical myoclonic tremor with epilepsy type 1.

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World Journal of Respirology 2016年第1期6卷 42-48页

作者： Noriyuki Ebi shoji Tokunaga Kazunobu Itoh Isamu Okamoto Nobutaka Edakuni Shinji Fujii Kentaro Watanabe Shinichiro Hayashi Takashige Maeyama Yoichi Nakanishi Department of Respiratory Oncology Iizuka Hospital Department of Medical Informatics Kyushu University Hospital Division of Respiratory Medicine Shinbeppu Hospital Research Institute for Diseases of the Chest Graduate School of Medical SciencesKyushu University Division of Respirology Neurology and Rheumatology Department of Medicine Kurume University School of Medicine Division of Respiratory Disease Kumamoto Regional Medical Center Department of Respiratory Medicine Fukuoka University Hospital Department of Internal Medicine Faculty of MedicineSaga University

AIM: To research the natural course of idiopathic pulmonary fibrosis(IPF) with advanced non-small cell lung cancer(NSCLC) and the association between acuteMETHODS: From May 2007 through April 2011, 17 CT naive patients with IPF and advanced NSCLC were enrolled. Patients were classified into best supportive care(BSC) group or CT group based on the patient's preference. Patients in the CT group received carboplatin(CBDCA)(AUC 5-6) plus paclitaxel(PTX)(175-200 mg/m2) on day 1 of each 21-d cycle as first-line ***: All patients but one chose the CT group. In the CT group, the objective response rate was 38%. The most frequent toxicity ≥ grade 3 was neutropenia(88%). Two patients(12.5%) developed AE-IPF. The median progression-free survival, the median survival time and the 1-year survival rate were 4.1 mo, 8.7 mo and 35%, respectively. Second-line CT-related AE and CT-unrelated AE occurred in 2 and 3 patients(1: BSC group; 2: CT group), respectively. Seven(41%) of all patients developed AE-IPF throughout the clinical course, and 6 of 7 patients with AE-IPF died within one ***: The incidence of AE-IPF was higher among IPF patients with advanced NSCLC than among those without NSCLC. CBDCA plus PTX regimen was tolerable and effective. However, AE-IPF has a fatal toxicity with or without CT in IPF patients with advanced NSCLC.

关键词： Non-small cell lung cancer Chemotherapy Idiopathic pulmonary fibrosis Acute exacerbation Best supportive care

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辣椒子叶培养形成不定芽的研究

湖南农业大学学报(自然科学版) 1987年第4期 74-74页

作者： Prapa Sripichitt ,Eiji Nawata ,shoji Shigenaga ,何立珍

本文通过辣椒品种“Yatsufusa”的子叶培养,研究了不定芽的形成与一些因素的关系。把带有子叶柄的辣椒子叶培养在附加0.01～1.00mg/l IAA或者NAA的MS培养基上,1～2周内产生愈伤组织及根。愈伤组织在子叶柄横切面上形成,根产生在切面的... 详细信息

本文通过辣椒品种“Yatsufusa”的子叶培养,研究了不定芽的形成与一些因素的关系。把带有子叶柄的辣椒子叶培养在附加0.01～1.00mg/l IAA或者NAA的MS培养基上,1～2周内产生愈伤组织及根。愈伤组织在子叶柄横切面上形成,根产生在切面的周边及子叶中脉的位置上。IAA诱导产生的根细长而且侧根少;NAA诱导产生的根粗短,侧根多。随着生长素的浓度从0.01mg/l增至1.00mg/l,产生根的数量也随之增多。但是,在上述只有生长素的培养基上培养辣椒子叶外植体,没有形成不定芽。

关键词：不定芽外植体辣椒茄果类子叶培养

ND3基因突变导致Leber遗传性视神经病伴肌张力障碍

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ND3基因突变导致Leber遗传性视神经病伴肌张力障碍

第九次全国神经病学学术大会

作者：王康高宗良王国相陈先文金淼刘兴洲杜皓萍孙劭杰顾卫红娄晋宁高桥佑二 shoji Tsuji 中日友好医院神经内科安徽医科大学附属医院神经内科东京大学附病院神经内科

本研究首次应用微阵列技术,第一次在世界上发现:线粒体ND3基因突变导致Leber遗传性视神经病伴肌张力障碍。研究背景:Leber遗传性视神经病伴肌张力障碍(Leber Hereditary Optic Neuropathy and Dystonia,LDYT)是一种独特的氧化磷酸化疾病...

本研究首次应用微阵列技术,第一次在世界上发现:线粒体ND3基因突变导致Leber遗传性视神经病伴肌张力障碍。研究背景:Leber遗传性视神经病伴肌张力障碍(Leber Hereditary Optic Neuropathy and Dystonia,LDYT)是一种独特的氧化磷酸化疾病,其突出特点是视神经病与肌张力障碍及其他神经系统障碍的多变组合,已发现的家系由线粒体ND6 或ND4基因突变导致。材料和方法:在一个有43人的中国汉人家系里,6人表现童年发病的肌张力障碍伴青春期或成年发病的视神经萎缩,12人仅表现成年发病的视神经萎缩,部分患者伴色盲。肌张力障碍患者的头部CT和MRI提示基底节区对称性坏死,累及壳核、苍白球和尾状核。线粒体DNA芯片(Mitochondrial resequencing 2．0 array,AffymetrixTM)被用于测定全线粒体基因组序列,所发现的碱基改变再用直接测序法证实。线粒体DNA芯片技术中所使用的PCR引物所在区域经重新设计的PCR反应扩增后直接测序。结果:在所检测患者的线粒体DNA内未发现任何已知突变,在所发现的8个未报道过的新变异中,只有G10197A是非同义突变,该家系所有患者携带G10197A突变,该突变导致ND3蛋白质第47位残基的高度保守丙氨酸被苏氨酸取代,在父系亲属、101例正常对照及67例其他线粒体病患者中均无此突变存在。讨论:该家系临床特征符合LDYT,具有表型的高度变异性,与已报道的家系一致。该家系的外显率高达85．7％(男性81．8％,女性90％), 是十分不同寻常的,这可能与所有突变携带者都是纯合状态有关。ND3第47位残基从进化保守性来看属于高度保守的氨基酸,从氨基酸性质来看,丙氨酸是疏水性脂肪族侧链氨基酸,而苏氨酸是带羟基侧链的亲水性氨基酸,二者性质大相径庭。因此,G10197A突变的致病性是较为肯定的。ND3基因突变被报道与Leigh病和Leigh样脑病相关,有作者认为也可能是部分LHON的致病基因,本文是首次有关ND3突变导致LDYT的报道。

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高钛高炉渣在微波场中的加热行为

钢铁钒钛 2006年第1期27卷 12-16,20页

作者：陈艳白晨光何宜柱吉川日升谷口尚司安徽工业大学材料科学与工程学院安徽马鞍山243002 重庆大学材料科学与工程学院重庆400044 日本东北大学材料开发系

为在高钛高炉渣中引发微裂纹、有效降低其研磨难度,进行了微波加热高钛高炉渣的实验。在引发裂纹的过程中发现其不仅能被微波场有效加热,且有热失控现象发生。为探讨微波加热高钛高炉渣的机理以及产生热失控现象的原因,对不同种类的合... 详细信息

为在高钛高炉渣中引发微裂纹、有效降低其研磨难度,进行了微波加热高钛高炉渣的实验。在引发裂纹的过程中发现其不仅能被微波场有效加热,且有热失控现象发生。为探讨微波加热高钛高炉渣的机理以及产生热失控现象的原因,对不同种类的合成炉渣进行了微波加热实验。实验表明渣中CaTiO3对有效加热高钛高炉渣起到重要作用。利用Network Analyzer测量了其介电常数。测量结果表明CaTiO3的介电常数远远大于一般材料,定量说明了在微波场中CaTiO3对加热高钛高炉渣的作用。此外,实验测得CaTiO3的介电常数随温度的升高而增大,这种正反馈加热方式正是高钛高炉渣在微波场中发生热失控的主要原因之一。

关键词：高钛高炉渣微波热失控钙钛矿(CaTiO3) 介电常数

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苯并(a)芘诱导肺癌细胞发生上皮细胞-间质转换(EMT)

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现代泌尿外科杂志 2008年第2期13卷 153-153页

作者： Ichiro Yoshino Takuro Kometani Fumihiro shoji 曾津贺大林

上皮细胞-间质转换(EMT)已经被认为存在于多种肿瘤的发生和进展过程中。但对于吸烟导致的肺癌与EMT的关系目前仍未阐明。在该实验研究中,作者采用支气管肺泡细胞癌A549细胞系,并用与肺癌和吸烟有着密切关系的苯并(a)芘干预24h,观察和分... 详细信息

上皮细胞-间质转换(EMT)已经被认为存在于多种肿瘤的发生和进展过程中。但对于吸烟导致的肺癌与EMT的关系目前仍未阐明。在该实验研究中,作者采用支气管肺泡细胞癌A549细胞系,并用与肺癌和吸烟有着密切关系的苯并(a)芘干预24h,观察和分析细胞的形态学改变、细胞增殖活性以及EMT相关基因表达的变化。[第一段]

关键词： EMT 相关基因肺癌细胞间质苯并取代基

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利用中国甘蔗渣原料生产活性炭

沈阳化工学院学报 2001年第3期15卷 174-178页

作者：夏嘉安野田清香川诏士关东学院大学工学部工业化学科

以中国甘蔗渣为原料生产活性炭的研究 ,生产出具有比表面积 1 0 96× 1 0 3m2 /kg的活性炭 .处理甘蔗渣的生产工艺是活化温度 80 0℃ ,升温速度 5℃ /min .保持时间 1 0h、水通入流量为6kg/kg甘蔗渣 .同时进行增加活性炭强度的实验 ,... 详细信息

以中国甘蔗渣为原料生产活性炭的研究 ,生产出具有比表面积 1 0 96× 1 0 3m2 /kg的活性炭 .处理甘蔗渣的生产工艺是活化温度 80 0℃ ,升温速度 5℃ /min .保持时间 1 0h、水通入流量为6kg/kg甘蔗渣 .同时进行增加活性炭强度的实验 ,强度约为商品椰子壳活性炭强度的 1 / 3 .

关键词：中国吸附活性炭甘蔗渣原料

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