检索结果-南通市图书馆

New scoring system for intra-abdominal injury diagno- sis after blunt trauma

Chinese Journal of Traumatology 2014年第1期17卷 19-24页

作者： Majid sho.Jaee Gholamreza Faridaalaee Mahmoud Yousefifard Mehdi Yaseri Aft Arhami Dolatabadi AnitaSabzghabaei Ali Malekirastekenari Emergency Medicine Department Shahid Beheshti University of Medical Sciences Tehran Iran Emergency Medicine Department Urmia University of Medical Sciences Urmia Iran Department of Physiology School of Medicine Tehran University of Medical Sciences Tehran Iran Department of Epidemiology and Biostatistics Tehran University of Medical Sciences Tehran Iran

Objective： An accurate scoring system for intra-abdominal injury （IAI） based on clinical manifesta- tion and examination may decrease unnecessary CT scans, save time, and reduce healthcare cost. This study is de- signed to provide a new scoring system for a better diagno- sis of IAI after blunt trauma. Methods： This prospective observational study was performed from April 2011 to October 2012 on patients aged above 18 years and suspected with blunt abdominal trauma （BAT） admitted to the emergency department （ED） of Imam Hussein Hospital and shohadaye Hafte Tir Hospital. All patients were assessed and treated based on Advanced Trauma Life Support and ED protocol. Diagnosis was done according to CT scan findings, which was considered as the gold standard. Data were gathered based on patient＇s history, physical exam, ultrasound and CT scan findings by a general practitioner who was not blind to this study. Chi- square test and logistic regression were done. Factors with significant relationship with CT scan were imported in multi- variate regression models, where a coefficient （13） was given based on the contribution of each of them. Scoring systemwas developed based on the obtained total [3 of each factor. Results： Altogether 261 patients （80.1% male） were enrolled （48 cases of IAI）. A 24-point blunt abdominal trauma scoring system （BATSS） was developed. Patients were di- vided into three groups including low （score〈8）, moderate （8≤score〈12） and high risk （score≥ 12）. In high risk group immediate laparotomy should be done, moderate group needs further assessments, and low risk group should be kept under observation. Low risk patients did not show positive CT-scans （specificity 100%）. Conversely, all high risk patients had positive CT-scan findings （sensitivity 100%）. The receiver operating characteristic curve indicated a close relationship between the results of CT scan and BATSS （sensitivity=99.3%）. Conclusion： The present scoring system furnishes a high precisio

关键词： Abdominal injuries Tomography, X-ray computed Diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel Treatment of Hepatitis C Virus Infection for Patients with Renal Impairment

引用

Journal of Clinical and Translational Hepatology 2016年第4期4卷 320-327页

作者： Goki Suda Koji Ogawa Megumi Kimura Masato Nakai Takuya sho Kenichi Morikawa Naoya Sakamoto Department of Gastroenterology and Hepatology Graduate School of Medicine Hokkaido University Hokkaido Japan

Prevalence of hepatitis C virus (HCV) infection is high in patients with end-stage renal dysfunction,including patients undergoing hemodialysis (HD).The HCV infection itself can cause glomerulonephritis and puts individuals at increased risk of developing end-stage renal disease;fortunately,successful HCV eradication sometimes restore HCV-related renal ***,the prognosis of dialysis patients infected with HCV is significantly worse and the renal allograft survival in HCV-infected patients is also worse than in dialysis patients without HCV *** life prognosis is favorable,therefore,anti-HCV therapy is strongly recommended for HCV-infected patients with severe renal *** standard therapy for HCV-infected patients with severe renal dysfunction has historically been interferon-based ***,this therapy remains ineffective in achieving high,sustained viral response rates and the rate of adverse events and treatment discontinuation due to treatment-induced adverse events continues to be high in patients with severe renal *** and effective anti-HCV therapies are urgently needed,and crucial,for patients with severe renal ***,direct-acting antivirals (DAAs) that specifically target viral proteins have been developed,and these targets include the NS3,NS5A,and NS5B of *** trials have revealed high efficacy and safety of the DAA-based therapies,but patients with severe renal dysfunction were not included in the majority of these ***,several recent reports have shown high efficacy and safety for some regimens of DAA combination therapy for HCV-infected patients with severe renal *** this review,we discuss novel treatments for HCV-infected patients with severe renal dysfunction and the pharmacokinetics of these drugs.

关键词： DAAs HCV Hemodialysis CKD

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Placement of percutaneous transhepatic biliary stent using a silicone drain with channels

引用

World Journal of Gastroenterology 2009年第33期15卷 4201-4203页

作者： Hiroshi Yoshida Yasuhiro Mamada Nobuhiko Taniai sho Mineta Yoshiaki Mizuguchi Yoichi Kawano Junpei Sasaki Yoshiharu Nakamura Takayuki Aimoto Takashi Tajiri Department of Surgery Nippon Medical School

This report describes a method for percutaneous transhepatic biliary stenting with a BLAKE Silicone Drain, and discusses the usefulness of placement of the drain connected to a J-VAC Suction Reservoir for the treatment of stenotic hepaticojejunostomy. Percutaneous transhepatic biliary drainage was performed under ultrasonographic guidance in a patient with stenotic hepaticojejunostomy after hepatectomy for hepatic hilum malignancy. The technique used was as follows. After dilatation of the drainage root, an 11-FF tube with several side holes was passed through the stenosis of the hepaticojejunostomy. A 10-Fr BLAKE Silicone Drain is flexible, which precludes onestep insertion. One week after insertion of the 11-Fr tube, a 0.035-inch guidewire was inserted into the tube. After removal of the 11-Fr tube, the guidewire was put into the channel of a 10-Fr BLAKE Silicone Drain. The drain was inserted into the jejunal limb through the intrahepatic bile duct and was connected to a J-VAC Suction Reservoir. Low-pressure continued suction was applied. Patients can be discharged after insertion of the 10-Fr BLAKE Silicone Drain connected to the J-VAC Suction Reservoir. Placement of a percutaneous transhepaUc biliary stent using a 10-Fr BLAKE Silicone Drain connected to a J-VAC Suction Reservoir is useful for the treatment of stenotic hepaticojejunostomy.

关键词： Biliary tract Drainage Hepaticojejunostomy Stenosis Stents

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

阿伦狄克酸对脑缺血再灌注损伤食蟹猴模型的神经保护作用

引用

中国药理学与毒理学杂志 2024年第4期38卷 241-248页

作者：王向伟周永馨庄永杰陈继巧毛佳静周静邓志豪邢柳柳周业明付立杰布瑞迅药业(南通)有限公司江苏南通226133

目的评价阿伦狄克酸对食蟹猴脑缺血再灌注损伤(CIRI)的治疗作用。方法9只健康雄性食蟹猴,通过阻断左侧大脑中动脉4 h后再灌注建立CIRI模型。脑梗死72 h后,随机分为模型〔20%(W∶V)Solutol HS15和10%(V∶V)PEG400〕、模型+阿伦狄克酸钙10... 详细信息

目的评价阿伦狄克酸对食蟹猴脑缺血再灌注损伤(CIRI)的治疗作用。方法9只健康雄性食蟹猴,通过阻断左侧大脑中动脉4 h后再灌注建立CIRI模型。脑梗死72 h后,随机分为模型〔20%(W∶V)Solutol HS15和10%(V∶V)PEG400〕、模型+阿伦狄克酸钙10和30 mg·kg^(-1)组,每组3只,口服给药,每天2次,连续28 d。治疗期间,通过一系列神经行为学检查,如上肢采食技能测试和笼旁行为观察,及大脑梗死体积和脑水肿体积磁共振数据评估神经损伤和恢复。结果模型组食蟹猴在CIRI后表现出自然自发性恢复。与模型组相比,模型+阿伦狄克酸钙30 mg·kg^(-1)组行为学、上肢活动和脑病变体积明显恢复(P<0.05),模型+阿伦狄克酸钙10 mg·kg^(-1)组无明显改善。结论阿伦狄克酸可缩小CIRI食蟹猴模型脑梗死面积,改善神经行为活动和骨骼肌协调功能。

关键词：阿伦狄克酸脑缺血再灌注损伤神经行为学食蟹猴

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Medial tibial plateau morphology and stress fracture location:A magnetic resonance imaging study

引用

World Journal of Orthopedics 2017年第6期8卷 484-490页

作者： Kiminori Yukata Issei Yamanaka Yuzuru Ueda sho Nakai Hiroyoshi Ogasa Yosuke Oishi Jun-ichi Hamawaki Department of Orthopedic Surgery Yamaguchi University Graduate School of Medicine

AIM To determine the location of medial tibial plateau stress fractures and its relationship with tibial plateau morphology using magnetic resonance imaging(MRI).METHODS A retrospective review of patients with a diagnosis of stress fracture of the medial tibial plateau was performed for a 5-year period. Fourteen patients [three female and 11 male, with an average age of 36.4 years(range, 15-50 years)], who underwent knee MRI, were included. The appearance of the tibial plateau stress fracture and the geometry of the tibial plateau were reviewed and measured on *** Thirteen of 14 stress fractures were linear, and one of them stellated on MRI images. The location of fractures was classified into three types. Three fractures were located anteromedially(AM type), six posteromedially(PM type), and five posteriorly(P type) at the medial tibial plateau. In addition, tibial posterior slope at the medial tibial plateau tended to be larger when the fracture was located more posteriorly on *** We found that MRI showed three different localizations of medial tibial plateau stress fractures, which were associated with tibial posterior slope at the medial tibial plateau.

关键词： Magnetic resonance imaging Runner Stress fracture Tibial plateau Tibial posterior slope

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Streaming Caused by Oscillatory Flow in Peripheral Airways of Human Lung

引用

Open Journal of Fluid Dynamics 2016年第3期6卷 242-261页

作者： Bing Han Hiroyuki Hirahara sho Yoshizaki Graduate School of Science and Engineering Saitama University Saitama City Japan

Oscillatory flow facilitates gas exchange in human respiration system. In the present study, both numerical calculation and PIV (Particle Image Velocimetry) measurement indicate that, under the application of HFOV (High Frequency Oscillatory Ventilation), apparent steady streaming is caused and augmented in distal airways by the continuous oscillation, i.e., the core air moves downwards and the peripheral air evacuates upwards within bronchioles. The net flow of steady streaming serves to overcome the lack of tidal volume in HFOV and delivers fresh air into deeper lung region. Also, numerical calculations reveal that the intensity of steady streaming is mainly influenced by the geometry of airways with provided oscillatory frequency and tidal volume, and it rises with Re and Wo up to a Re of about 124 and Wo of about 5. Steady streaming is considered as an important factor for the ventilation efficiency of HFOV.

关键词： Oscillatory Flow Steady Streaming HFOV Bronchioles Womersley Number

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Topical odour management in burn patients

引用

Burns & Trauma 2021年第1期9卷 311-317页

作者： Kenji Hayashida sho Yamakawa Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane693-0021Japan

Preventing microbial colonization or infections that cause offensive smells may lead to odor *** both anaerobic and aerobic bacteria cause the release of malodor from wounds,the most direct way of avoiding or eliminating wound odor is to prevent or eradicate the responsible infection through the debridement of necrotic ***,some burn patients with malodorous wounds are unable to undergo debridement due to systemic conditions,especially in the acute ***,the optimal drug doses and dressings to ensure the efficacy and cost-effectiveness of odorous burn wound management is *** purpose of this commentary is to outline the odor management options available for burn patients,focusing on topical *** potential therapies for treating odorous wounds after burn injuries are suggested.

关键词： Odour Wounds Topical management Burns Natural substance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rice Stomatal Closure Requires Guard Cell Plasma Membrane ATP-Binding Cassette Transporter RCN1/OsABCG5

引用

Molecular Plant 2016年第3期9卷 417-427页

作者： Shuichi Matsuda sho Takano Moeko Sato Kaoru Furukawa Hidetaka Nagasawa shoko Yoshikawa Jun Kasuga Yoshihiko Tokuji Kazufumi Yazaki Mikio Nakazono Itsuro Takamure Kiyoaki Kato Department of Agro-environmental Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Department of Food Science Obihiro University of Agricultural and Veterinary Medicine 2-11 Nishi Inada Obihiro Hokkaido 080-0834 Japan Research Institute for Sustainable Humanosphere Kyoto University Gokasho Uji Kyoto 611-0011 Japan Graduate School of Bioagricultural Sciences Nagoya University Furo-cho Chikusa Nagoya Aichi 464-8601 Japan Graduate School of Agriculture Hokkaido University Kita 9 Nishi 9 Kita-ku Sapporo Hokkaido 060-8589 Japan

Water stress is one of the major environmental stresses that affect agricultural production worldwide. Water loss from plants occurs primarily through stomatal pores. Here, we report that an Oryza sativa half-size ATP-binding cassette （ABC） subfamily G protein, RCN 1/OsABCG5, is involved in stomatal closure mediated by phytohormone abscisic acid （ABA） accumulation in guard cells. We found that the GFP-RCN1/ OsABCG5-fusion protein was localized at the plasma membrane in guard cells. The percentage of guard cell pairs containing both ABA and GFP-RCN1/OsABCG5 increased after exogenous ABA treatment, whereas they were co-localized in guard cell pairs regardless of whether exogenous ABA was applied. ABA application resulted in a smaller increase in the percentage of guard cell pairs containing ABA in rcnl mutant （A684P） and RCN1-RNAi than in wild-type plants. Furthermore, polyethylene glycol （drought stress）-inducible ABA accumulation in guard cells did not occur in rcnl mutants. Stomata closure mediated by exogenous ABA application was strongly reduced in rcnl mutants. Finally, rcnl mutant plants had more rapid water loss from detached leaves than the wild-type plants. These results indicate that in response to drought stress, RCN1/OsABCG5 is involved in accumulation of ABA in guard cells, which is indispensable for stomatal closure.

关键词： stomatal closure abscisic acid ABC transporter rice drought stress

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

植物乳杆菌对鼠肠氧化应激及炎症反应的影响

植物乳杆菌对鼠肠氧化应激及炎症反应的影响

引用

作者： Takami sho 上海交通大学

学位级别：硕士

本文研究了2株乳杆菌的抗氧化能力,明确了植物乳杆菌Lactobacillus plantarum CGMCC 1.557和干酪乳杆菌Lactobacillus casei CGMCC 1.570的全发酵培养物及其组分的自由基清除率和抗氧化酶活性。考察了植物乳杆菌对diquat诱导的鼠肠道氧... 详细信息

本文研究了2株乳杆菌的抗氧化能力,明确了植物乳杆菌Lactobacillus plantarum CGMCC 1.557和干酪乳杆菌Lactobacillus casei CGMCC 1.570的全发酵培养物及其组分的自由基清除率和抗氧化酶活性。考察了植物乳杆菌对diquat诱导的鼠肠道氧化应激及炎症反应的影响,并进一步探究了其可能的作用机制。首先,就上述2株乳杆菌的抗氧化能力,本研究测定了2株乳杆菌全发酵培养物及其不同组分(发酵上清液、菌体悬浮液、胞内提取物)的1,1-二苯基-2-三硝基苯肼(DPPH)、O·和·OH的清除率以及总超氧化物歧化酶(T-SOD)、过氧化氢酶(CAT)和谷胱甘肽过氧化物酶(GSH-Px)的活性。结果表明,2株乳杆菌的全发酵培养物对3种自由基的清除率均显著高于阳性对照维生素C(P0.05);模型组小鼠血清和结肠内丙二醛(MDA)和O·含量显著增加(P0.05);小鼠回结肠在diquat诱导下发生了严重的炎症性组织损伤,并且不同剂量的植物乳杆菌可以不同程度地保护粘膜层,组织病理学评分差异有显著性(P<0.05);小鼠回结肠内IL-1β、IL-18和TNF-α的含量在diquat诱导下整体没有显著增加;在diquat诱导下,小鼠回结肠内NLRP3炎性小体激活通路的上游蛋白NF-κB在转录水平上被显著激活(P<0.05),但中下游通路蛋白NLRP3、ASC、Caspase-1等都没有被显著激活。综上研究,植物乳杆菌在体内外都具有良好的抗氧化能力,可以有效缓解diquat诱导的小鼠肠道氧化应激及炎症反应,以高剂量处理的效果更明显,但具体缓解机制有待进一步研究。

关键词：乳杆菌小鼠肠道氧化应激炎症反应 NLRP3

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Response evaluation of a compact and highly efficient neutron diffractometer for compact accelerator neutron sources

引用

辐射防护 2020年第6期40卷 540-544页

作者： sho Imai Kenichi Watanabe Astushi Yamazaki Sachiko Yoshihashi Akira Uritani Seiji Tasaki Setsuo Satoh Nagoya University Furo-choChikusa-kuNagoya464-8603Japan Kyoto University YoshidahonmachiSakyo-kuKyoto606-8501Japan High Energy Accelerator Research Organization Oh-hoTsukuba305-0801Japan

We fabricated the spheroid neutron diffractometer with 79 neutron detector rings using the transparent rubber sheet type Eu:LiCaAlF6 scintillators and wavelength-shifting *** confirmed that the fabricated detector shows a clear neutron peak and can discriminate neutron and gamma-ray events in a signal pulse *** additionally checked that the fabricated diffractometer can detect a neutron diffraction peak of ferrite powder at Kyoto University Accelerator-driven Neutron ***,it can be expected that crystal structural analysis will be possible even by small accelerator neutron sources.

关键词： TRUST Eu:LiCAF scintillator neutron diffractometer neutron detector time-of-flight KUANS LiTA12

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：