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Thermal stability of the Cr-coated zirconium alloy microstructure prepared by pulsed laser deposition

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Tungsten 2024年第2期6卷 333-341页

作者： Bo Li Hui-Long Yang Reuben Holmes Li-Juan Cui sho Kano Hiroaki Abe Department of Nuclear Engineering and Management The University of TokyoTokyo 113-8656Japan School of Nuclear Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Nuclear Professional School The University of TokyoIbaraki 319-1188Japan

Cr-coated zirconium alloy was prepared by pulsed laser deposition(PLD)for the application of accident-tolerant fuel cladding in light water *** microstructural characteristics of the Cr coating and its evolution with temperature were investigated using grazing incidence X-ray diff raction and in situ heating transmission electron microscopy(TEM).Results show that the microstructure of the laser-deposited Cr coatings consists mainly of fine and non-specific shaped nano-crystals in the inner layer and columnar crystals in the outer *** recrystallization of the Cr-coating layer starts at 300–400℃ to release the high strain introduced by PLD,and the grain coalescence starts at temperatures>400°*** annealing,the(110)-texture gradually intensifi es because of its high reticular density and low close-packed ***,in situ heating TEM observation shows the presence of cavities on the Cr–Zr interface,which may result from the interdiff usion and/or the transformation from amorphous to crystalline.

关键词： Accident tolerant fuel Crcoating Interface Microstructure Pulsed laser deposition

Small molecular decoys in Alzheimer's disease

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Neural Regeneration Research 2024年第8期19卷 1658-1659页

作者： sho Oasa Valentina L.Kouznetsova Igor F.Tsigelny Lars Terenius Department of Clinical Neuroscience Center for Molecular MedicineKarolinska InstitutetStockholmSweden San Diego Supercomputer Center University of California San DiegoLa JollaCAUSA Department of Neurosciences University of California San DiegoLa JollaCAUSA Department of Clinical Neuroscience Karolinska University HospitalKarolinska InstitutetStockholmSweden

Recent progress in the treatment of Alzheimer’s disease(AD)using antibodies against amyloid sustains amyloid generation as a key process in *** formation starts with two amyloidbeta(Aβ)molecules interacting(dimer formation)followed by an accelerating build-up of socalled protofibrils,which turn into fibrils,which accumulate in the characteristic plaques.

关键词： Alzheimer decoy Aβ

Transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata Takeshi Sudo sho Tazuma Naoki Tanimine Takashi Onoe Yosuke Shimizu Atsushi Yamaguchi Kazuya Kuraoka Shinya Takahashi Hirotaka Tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BTC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** To determine transmembrane serine protease 4(TMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BTC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between TMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BTC,46(54%)were *** TMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the TMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the TMPRSS4-positive group(median survival time:25.3 months vs not reached,P<0.001;median survival time:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated TMPRSS4 positivity,pT3/T4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).TMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION TMPRSS4 is a potential prognostic biomarker of radical resection for BTC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection Transmembrane serine protease 4

High-grade pancreatic intraepithelial neoplasia diagnosed based on changes in magnetic resonance cholangiopancreatography findings:A case report

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World Journal of Clinical Cases 2024年第8期12卷 1487-1496页

作者： Nao Furuya Atsushi Yamaguchi Naohiro Kato Syuhei Sugata Takuro Hamada Takeshi Mizumoto Yuzuru Tamaru Ryusaku Kusunoki Toshio Kuwai Hirotaka Kouno Kazuya Kuraoka Yoshiyuki Shibata sho Tazuma Takeshi Sudo Hiroshi Kohno Shiro Oka Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Gastroenterology Hiroshima University HospitalHiroshima 734-8551HiroshimaJapan Department of Pathology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterKure 737-0023HiroshimaJapan

BACKGROUND High-grade pancreatic intraepithelial neoplasia(PanIN)exhibits no mass and is not detected by any examination ***,it can be diagnosed by pancreatic juice cytology from indirect *** previous cases were diagnosed based on findings of a focal stricture of the main pancreatic duct(MPD)and caudal MPD dilatation and subsequent pancreatic juice cytology using endoscopic retrograde cholangiopancreatography(ERCP).We experienced a case of high-grade PanIN with an unclear MPD over a 20-mm range,but without caudal MPD dilatation on magnetic resonance cholangiopancreatography(MRCP).CASE SUMMARY A 60-year-old female patient underwent computed tomography for a follow-up of uterine cancer post-excision,which revealed pancreatic *** revealed an unclear MPD of the pancreatic body at a 20-mm length without caudal MPD ***,course observation was *** 24 mo,MRCP revealed an increased caudal MPD caliber and a larger pancreatic *** performed ERCP and detected atypical cells suspected of adenocarcinoma by serial pancreatic juice aspiration cytology *** performed a distal pancreatectomy and obtained a histopathological diagnosis of high-grade *** parenchyma invasion was not observed,and curative resection was *** High-grade Pan-IN may cause MPD narrowing in a long range without caudal MPD dilatation.

关键词： Pancreatic cancer Pancreatic intraepithelial neoplasm High-grade pancreatic intraepithelial neoplasm Magnetic resonance cholangiopancreatography Carcinoma in situ Case report

Advances in surgical applications of growth factors for wound healing

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Burns & Trauma 2019年第1期7卷 85-97页

作者： sho Yamakawa Kenji Hayashida Division of Plastic and Reconstructive Surgery Shimane University Faculty of Medicine89-1 Enya-choIzumoShimane 693-8501Japan

Growth factors have recently gained clinical importance for wound *** of recombinant growth factors has been shown to mimic cellmigration,proliferation,and differentiation in vivo,allowing for external modulation of the healing *** drug delivery systems can enhance the biological activity of these growth factors,which have a very short in vivo half-life after topical *** the basic mechanisms of these growth factors are well understood,most have yet to demonstrate a significant impact in animal studies or small-sized clinical *** this review,we emphasized currently approved growth factor therapies,including a sustained release system for growth factors,emerging therapies,and future research possibilities combined with surgical *** seeking to understand wound healing at a systemic level are currently ***,further research and consideration in surgery will be needed to provide definitive confirmation of the efficacy of growth factor therapies for intractable wounds.

关键词： Wound healing Growth factor Surgical application

Reductive transformation of CO_2:Fluoride-catalyzed reactions with waste silicon-based reducing agents

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Chinese Journal of Catalysis 2017年第3期38卷 434-439页

作者： Ken Motokura Masaki Naijo sho Yamaguchi Akimitsu Miyaji Toshihide Baba 东京工业大学材料和化工技术学院化工科学与工程系日本横滨226-8502

CO_2 is one of the most important ＂renewable＂ carbon *** transform CO_2 to useful organic compounds,we examined the reactivity of two model silicon-based ＂waste＂ materials,disilanes and metallic Si powder,as reducing *** these reactions,fluoride salts were found to be active catalysts：CO_2 was converted to formic acid at atmospheric pressure in the presence of H_2O as a proton source and the silicon-based reducing *** on in-situ NMR and kinetics analyses,a hydrosilane and penta-coordinate Si species are proposed as the reaction intermediate and active species,respectively.

关键词： Carbon dioxide Fluoride Homogeneous catalysis Formic acid Disilane

Dorsal hand reconstruction with radial artery perforator-based adipofascial flap

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Plastic and Aesthetic Research 2020年第5期7卷 15-25页

作者： sho Yamakawa Kenji Hayashida Division of Plastic and Reconstructive Surgery Shimane University HospitalIzumoShimane 693-8501Japan

Reconstruction of dorsal hand soft tissue defects after severe injury is challenging for *** on the degree of defect,extensor tendon reconstruction may also be *** reconstruction methods are commonly performed to cover dorsal hand defects,such as skin grafting and distant,free,or local *** them,free vascularized flap transplantation is an ideal procedure because the major vessels that feed the local flap may have been damaged,and the affected limb can be reconstructed using a flow-through *** free flap surgery has advanced,few surgeons can choose this option due to its technical difficulty and *** the other hand,distant flaps have been commonly used for the reconstruction of dorsal hand defects,and local flaps,such as reverse forearm flaps and retrograde posterior interosseous flaps,do not require microvascular ***,they have some problems;distant flaps require at least two surgeries,reverse forearm flaps sacrifice major vessels and leave a scar at the donor site,and retrograde posterior interosseous flaps require meticulous dissection of the vascular *** radial artery perforator-based adipofascial flap is a versatile flap that is safe and easy to elevate without sacrificing the radial *** addition,elevating it as an adipofascial flap enables surgeons to avoid an unacceptable donor *** present two cases,demonstrating the usefulness of this pedicled perforator flap.

关键词： Perforator dorsal hand reconstruction adipofascial flap hand replantation color Doppler ultrasonography

Management of neuroendocrine liver metastasis:Searching for new prognostic factor and appraising repeat hepatectomy

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Hepatobiliary Surgery and Nutrition 2021年第3期10卷 410-412页

作者： Junichi Arita sho Kiritani Kiyoshi Hasegawa Hepato-Biliary and Pancreatic Surgery Division Department of SurgeryGraduate School of MedicineUniversity of TokyoTokyoJapan

Gastro-enteric and pancreatic neuroendocrine neoplasm(NEN)is categorized as a borderline malignant tumor and was historically called carcinoid,meaning *** tumors usually grow slower than most carcinoma tumors originat... 详细信息

关键词： organs metastasis liver neoplasm

Development of Helicobacter pylori treatment: How do we manage antimicrobial resistance?

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World Journal of Gastroenterology 2019年第16期25卷 1907-1912页

作者： sho Suzuki Mitsuru Esaki Chika Kusano Hisatomo Ikehara Takuji Gotoda Division of Gastroenterology and Hepatology Department of Medicine Nihon University School of Medicine

Helicobacter pylori(H. pylori) antimicrobial resistance is an urgent, global issue. In2017, the World Health Organization designated clarithromycin-resistant *** as a high priority bacterium for antibiotic research and development. In addition to clarithromycin, resistance to metronidazole and fluoroquinolones has also increased worldwide. Recent international guidelines for management of *** infection recommend bismuth or non-bismuth quadruple therapy for 14 d as a first-line treatment for H. pylori in areas of high clarithromycin and/or metronidazole resistance. Although these treatment regimens provide acceptable H. pylori eradication rates, the regimens used should not contribute to future resistance of H. pylori to antimicrobials. Moreover, these regimens can promote resistance, due to prolonged therapy with multiple antibiotics. A new strategy that can eradicate H. pylori as well as reduce the antibiotics used is required to prevent future antimicrobial resistance in H. pylori. Dual-therapy with vonoprazan and amoxicillin could be a breakthrough for H. pylori eradication in an era of growing antimicrobial resistance. This regimen may provide a satisfactory eradication rate of H. pylori and also minimize antimicrobial resistance due to single antibiotic use and the strong inhibitory effect of vonoprazan on gastric acid secretion.

关键词： Helicobacter pylori Antibiotic resistance Antimicrobial resistance Dual therapy Vonoprazan